Gene Dmel\CG6175

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General Information

Symbol

Dmel\CG6175

Species

D. melanogaster

Name

Annotation symbol

CG6175

Feature type

protein_coding_gene

FlyBase ID

FBgn0036152

Gene Model Status

Current

Stock availability

4 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

68C1-68C2

Sequence location

3L:11,281,036..11,289,019 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG6175 (FBgn0036152). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; imaginal disc-derived wing morphogenesis. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: MADF domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1638873_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6175. Gene sequence location is 3L:11281036..11289019.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

Controlled Vocabulary Terms

regulation of cell cycle

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

68C1-68C2

Limits computationally determined from genome sequence between P{PZ}l(3)01239⁰¹²³⁹&P{lacW}l(3)01239^j9B4 and P{PZ}CycA⁰²⁴⁶¹&P{PZ}CycA⁰³⁹⁴⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG6175 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG6175-RB

FBtr0076183

NM_140200

2792

558

CG6175-RC

FBtr0333388

NM_001274778

3923

558

CG6175-RD

FBtr0333389

NM_001274779

3956

569

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG6175-PB

FBpp0075913

61.6

558

6.61

NP_648457

AAF50073

CG6175-PC

FBpp0305580

61.6

558

6.61

NP_001261707

AGB94401

CG6175-PD

FBpp0305581

63.0

569

6.61

NP_001261708

AGB94402

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

MADF domain (IPR006578)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Comment:rapidly degraded

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

organism | faint & ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

organism | faint & ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

epipharynx primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

hypopharynx proper primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic epipharynx

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		7.675
Larval Midgut		30.1
Larval Hindgut		44.4
Larval Malpighian Tubules		27.9
Larval Fat Body		16.9
Larval Salivary Gland		31
Larval Trachea		18.15
Larval Carcass		31.425
Adult Head		31.7
Adult Eye		19.075
Adult Brain		14.9
Adult Thoracic-Abdominal Ganglion		12
Adult Crop		45.3
Adult Midgut		27.1
Adult Hindgut		39.4
Adult Malpighian Tubules		36.6
Adult Fat Body		74.9
Adult Salivary Gland		38.8
Adult Heart		10.575
Adult VirginFemale Spermatheca		58.1
Adult InseminatedFemale Spermatheca		44.1
Adult Ovary		92.6
Adult Testis		6.4
Adult Male Accessory Gland		67.1
Adult Carcass		26.6
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	31.7
NA	Eye	19.075
NA	Brain	14.9
7.675	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	12
NA	Crop	45.3
30.1	Midgut	27.1
44.4	Hindgut	39.4
27.9	Malpighian Tubules	36.6
16.9	Fat Body	74.9
31	Salivary Gland	38.8
NA	Heart	10.575
18.15	Trachea	NA
NA	VirginFemale Spermatheca	58.1
NA	InseminatedFemale Spermatheca	44.1
NA	Ovary	92.6
NA	Testis	6.4
NA	Male Accessory Gland	67.1
31.425	Carcass	26.6

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		(51)
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		(43)
ovary, mated 4-day female		(70)
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		(51)
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		(43)
ovary, mated 4-day female		(70)
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		3
head, virgin 1-day female		12
head, virgin 4-day female		17
head, virgin 20-day female		9
head, mated 1-day female		18
head, mated 4-day female		16
head, mated 20-day female		9
head, mated 1-day male		18
head, mated 4-day male		16
head, mated 20-day male		16
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		51
digestive system, larvae L3 wandering		7
digestive system, 1-day adult		7
digestive system, 4-day adult		11
digestive system, 20-day adult		9
fat body, larvae L3 wandering		5
fat body, white prepupae		7
fat body, pupae P8		10
carcass, larvae L3 wandering		9
carcass, 1-day adult		12
carcass, 4-day adult		14
carcass, 20-day adult		11
ovary, virgin 4-day female		43
ovary, mated 4-day female		70
testis, mated 4-day male		5
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		24
embryo 02-04hr		10
embryo 04-06hr		2
embryo 06-08hr		3
embryo 08-10hr		5
embryo 10-12hr		14
embryo 12-14hr		13
embryo 14-16hr		21
embryo 16-18hr		19
embryo 18-20hr		13
embryo 20-22hr		11
embryo 22-24hr		10
larva L1		6
larva L2		6
larva L3 12hr old		6
larva L3 puffstage 1-2		3
larva L3 puffstage 3-6		4
larva L3 puffstage 7-9		5
white prepupae new		12
white prepupae 12hr		6
white prepupae 24hr		4
pupae 2d postWPP		7
pupae 3d postWPP		6
pupae 4d postWPP		10
adult male 01day		7
adult male 05day		7
adult male 30day		8
adult female 01day		20
adult female 05day		23
adult female 30day		21
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		4
embryonic 1182-4H		1
embryonic GM2		17
embryonic Kc167		8
embryonic S1		3
embryonic S3		14
leg disc CME L1		6
wing disc CME-W2		4
wing disc ML-DmD8		1
wing disc ML-DmD9		11
wing disc ML-DmD16-c3		4
wing disc ML-DmD21		2
wing disc ML-DmD32		6
haltere disc ML-DmD17-c3		1
eye-antennal disc ML-DmD11		10
antennal disc ML-DmD20-c5		4
mixed discs ML-DmD4-c1		5
CNS ML-DmBG1-c1		3
CNS ML-DmBG2-c2		5
tumorous blood cells mbn2		6
ovary fGS/OSS		1
ovary OSC		2
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(42)
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		(48)
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		(36)
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		(27)
Ethanol 2.5% 3 hrs, larvae L3		(37)
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(49)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(34)
Paraquat 5 mM 48 hrs, 4-day adult		(44)
Paraquat 10 mM 48 hrs, 4-day adult		(30)
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(42)
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		(48)
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		(36)
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		(37)
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(49)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(34)
Paraquat 5 mM 48 hrs, 4-day adult		(44)
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		42
cold shock, 4-day adult		24
heat shock, 4-day adult		20
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		6
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		48
Copper 0.5 mM 12 hrs, larvae L3		15
Copper 15 mM 48 hrs, 4-day adult		36
Zinc 5 mM 12 hrs, larvae L3		19
Zinc 4.5 mM 48 hrs, 4-day adult		27
Ethanol 2.5% 3 hrs, larvae L3		37
Ethanol 5% 3 hrs, larvae L3		10
Ethanol 10% 3 hrs, larvae L3		8
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		49
Caffeine 25 mg/ml 48 hrs, 4-day adult		34
Paraquat 5 mM 48 hrs, 4-day adult		44
Paraquat 10 mM 48 hrs, 4-day adult		30
Rotenone 2 μg 12 hrs, larvae L3		6
Rotenone 8 μg 12 hrs, larvae L3		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE07996

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0036152

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG6175-RB

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | recessive

CG6175⁰⁹

Other Phenotypes

Allele

behavior defective | recessive

CG6175^BG01733

Phenotype manifest in

Allele

Classical Alleles ( 7 )

For All Classical Alleles Show

Allele of CG6175	Mutagen	Stocks	Known lesion
CG6175^KG05833	P-element activity	2	--
CG6175⁰⁹		1	Yes
CG6175^MI00369		1	--
CG6175^BG01733		0	--
CG6175^e00969	piggyBac transposase	0	--
CG6175^e01797	piggyBac transposase	0	--
CG6175^EP3405		0	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG6175	Class	Mutagen	Stocks	Known lesion
CG6175^NIG.6175R		in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{NIG.6175R}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}CG6175^EP3405

P{EP}EP1137

miscellaneous insertions

Mi{MIC}CG6175^MI00369

P{GT1}CG6175^BG01733

P{SUPor-P}CG6175^KG05833

P{UASp-YFP.Rab8}CG6175⁰⁹

PBac{RB}CG6175^e00969

PBac{RB}CG6175^e01797

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 3 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Carreira et al., 2011)

inter-male aggressive behavior

inferred from mutant phenotype

(Edwards et al., 2009)

regulation of cell cycle

inferred from direct assay

(Guest et al., 2011)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG6175 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

64643

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0036152

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

39271

Orthologs

OrthoDB Orthologs (11) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6MW8ST

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG695XP2

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (EOG6MW8ST)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila virilis

Drosophila mojavensis

Dmoj\GI13705

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (EOG695XP2)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI083604

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI41347

Bombyx mori

Silkmoth

Bmor\BGIBMGA008732

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19411

Drosophila persimilis

Dper\GL22835

Drosophila willistoni

Dwil\GK17163

Drosophila virilis

Dvir\GJ14046

Drosophila mojavensis

Dmoj\GI13705

Drosophila grimshawi

Dgri\GH14852

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Bloomington

30973

y¹ w^*; Mi{MIC}CG6175^MI00369

23272

y¹ w^*; P{UASp-YFP.Rab8}CG6175⁰⁹/TM3, Sb¹

15102

y¹; P{SUPor-P}CG6175^KG05833 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

111670

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}CG6175^KG05833 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

Genomic Clones ( 1 )

BACR23K09

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 16 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE07996

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0036152

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

39271

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: CG6175 anon-WO0257455.23

(FlyBase, 1996-)

Additional comments

Source for merge of CG6175 anon-WO0257455.23 was sequence comparison (date:051113).

(FlyBase, 1996-)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

39271

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

MADF domain (IPR006578)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE07996

Linkouts

BioGRID - A database of protein and genetic interactions

•

64643

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0036152

DRSC - Results from RNAi screens.

•

FBgn0036152

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0036152

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG6175-RB

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0036152

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

39271

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

39271

modMine - Data generated by the modENCODE project.

•

FBgn0036152

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

anon-WO0257455.23

CG6175

(Cao et al., 2008, Zhang et al., 2007, Guest et al., 2011, González et al., 2008, Edwards et al., 2009, Morozova et al., 2007, Carreira et al., 2011, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

FBgn0063796

References ( 20 )

Research paper

Carreira et al., 2011, BMC Dev. Biol. 11: 32: Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273]
Guest et al., 2011, BMC Syst. Biol. 5(1): 65: A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913]
Blanco et al., 2010, BMC Dev. Biol. 10: 94: Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812]
Edwards et al., 2009, BMC Biol. 7: 29: Mutations in many genes affect aggressive behavior in Drosophila melanogaster. [FBrf0208496]
Cao et al., 2008, Genetics 178(3): 1457--1471: Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. [FBrf0205107]
González et al., 2008, PLoS Biol. 6(10): e251: High rate of recent transposable element-induced adaptation in Drosophila melanogaster. [FBrf0206197]
Morozova et al., 2007, Genome Biol. 8(10): R231: Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster. [FBrf0205161]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Zhang et al., 2007, Genetics 176(2):: Supplement to Zhang et al., 2007. [FBrf0203184]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Bellen, 2010.4.14, BDGP_2010_0415.GDP.xml: BDGP_2010_0415.GDP.xml [FBrf0210544]
Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file): Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340]
Gene Disruption Project members, 2001-, (Computer file): (Computer file) [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]

Patent

Kamdar et al., 2002.7.25, World Patent 02057455:: Nucleic acid sequences from Drosophila melanogaster that encode proteins essential for larval viability and uses thereof. [FBrf0159502]