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Gene Dmel\Bmcp

General Information
Symbol	Dmel\Bmcp	Species	D. melanogaster
Name	Bmcp	Annotation symbol	CG7314
Feature type	protein_coding_gene	FlyBase ID	FBgn0036199
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	dmUCP5
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68D3-68D3	Sequence location	3L:11,714,020..11,721,218 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bmcp is referred to in FlyBase by the symbol Dmel\Bmcp (CG7314, FBgn0036199). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: regulation of metabolic process. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Mitochondrial carrier domain; Mitochondrial carrier protein; Mitochondrial substrate/solute carrier. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult female reproductive system. Gene sequence location is 3L:11714020..11721218.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN20958 HFA10808
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68D3-68D3   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Bmcp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Transposon inserted in 3' UTR
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Bmcp-RA FBtr0076114  NM_168472   1632   303 Bmcp-RB FBtr0076115  NM_140244   1701   303
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Bmcp-PA   FBpp0075845   33.5   303   9.93     NP_729738   AAN11881 Bmcp-PB   FBpp0075846   33.5   303   9.93     NP_648501   AAF50019
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial carrier protein (IPR002067) Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME07314
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141058   AA142277   AA567852   AA695733   AA696722   AA949318   AE014296 AAF50019   AE014296 AAN11881   AI113642   AI114037   AI402226   AI405082   AI456694   AI541729   AY051433 AAK92857   BG636903   BH011507   BI605334   BI612152   BI627374   BI633938   BI637924   BI638385   BI638404   CK661130   CO177650   CO184365   CO189271   CO189989   CO192074   CO262888   CO263222   CO271451   CO271623   CO272744   CO280819   CO281472   CO289197   CO304540   CO305880   CO308671   CO311439   CO313540   CO313835   CO315331   CO320077   CO322445   CO332468   CO332953   CO333996   CO342160   EC057362   EC070656   EC071862   EC076293   EC196737   GH945578   GH952404   GH955831   GH956452   GH976382
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K566
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036199    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036199 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036199 expression level Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (358) embryo 02-04hr  (352) embryo 04-06hr  (429) embryo 06-08hr  (566) embryo 08-10hr  (743) embryo 10-12hr  (814) embryo 12-14hr  (712) embryo 14-16hr  (558) embryo 16-18hr  (480) embryo 18-20hr  (451) embryo 20-22hr  (551) embryo 22-24hr  (625) larva L1  (905) larva L2  (739) larva L3 12hr old  (487) larva L3 puffstage 1-2  (383) larva L3 puffstage 3-6  (476) larva L3 puffstage 7-9  (559) white prepupae new  (655) white prepupae 12hr  (541) white prepupae 24hr  (597) pupae 2d postWPP  (564) pupae 3d postWPP  (477) pupae 4d postWPP  (274) adult male 01day  (618) adult male 05day  (714) adult male 30day  (634) adult female 01day  (438) adult female 05day  (397) adult female 30day  (443) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036199 expression level Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (358) embryo 02-04hr  (352) embryo 04-06hr  (429) embryo 06-08hr  (566) embryo 08-10hr  (743) embryo 10-12hr  (814) embryo 12-14hr  (712) embryo 14-16hr  (558) embryo 16-18hr  (480) embryo 18-20hr  (451) embryo 20-22hr  (551) embryo 22-24hr  (625) larva L1  (905) larva L2  (739) larva L3 12hr old  (487) larva L3 puffstage 1-2  (383) larva L3 puffstage 3-6  (476) larva L3 puffstage 7-9  (559) white prepupae new  (655) white prepupae 12hr  (541) white prepupae 24hr  (597) pupae 2d postWPP  (564) pupae 3d postWPP  (477) pupae 4d postWPP  (274) adult male 01day  (618) adult male 05day  (714) adult male 30day  (634) adult female 01day  (438) adult female 05day  (397) adult female 30day  (443) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    358 embryo 02-04hr    352 embryo 04-06hr    429 embryo 06-08hr    566 embryo 08-10hr    743 embryo 10-12hr    814 embryo 12-14hr    712 embryo 14-16hr    558 embryo 16-18hr    480 embryo 18-20hr    451 embryo 20-22hr    551 embryo 22-24hr    625 larva L1    905 larva L2    739 larva L3 12hr old    487 larva L3 puffstage 1-2    383 larva L3 puffstage 3-6    476 larva L3 puffstage 7-9    559 white prepupae new    655 white prepupae 12hr    541 white prepupae 24hr    597 pupae 2d postWPP    564 pupae 3d postWPP    477 pupae 4d postWPP    274 adult male 01day    618 adult male 05day    714 adult male 30day    634 adult female 01day    438 adult female 05day    397 adult female 30day    443 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036199    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036199 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult female reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036199 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7314-RB;CG7314-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable BmcpBG02446 Other Phenotypes Allele stress response defective BmcpBG02446 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Bmcp Class Mutagen Stocks Known lesion BmcpBG02446 P-element activity 1 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Bmcp Class Mutagen Stocks Known lesion BmcpGD1569 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes BmcpScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes BmcpScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1569} NA P{UAS-Bmcp.B} NA P{UAS-Bmcp.FT} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}BmcpBG02446 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of metabolic process inferred from mutant phenotype (Sanchez-Blanco et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR002067 (FlyBase Curators et al., 2004-) transmembrane transporter activity inferred from sequence or structural similarity (Nelson, 2000.4.10) inferred from sequence or structural similarity with UniProtKB:O95258 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR002067 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrial envelope inferred from sequence or structural similarity (Nelson, 2000.4.10) mitochondrial inner membrane inferred from sequence or structural similarity with UniProtKB:O95258 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Bmcp allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036199 DroID - A comprehensive database of gene and protein interactions. • FBgn0036199 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39322
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25285 Dere\GG15525 Dgri\GH15075 Dmoj\GI13724 Dper\GL20712 Dpse\GA20254 Dsec\GM25293 Dsim\GD14324 Dvir\GJ14070 Dwil\GK10490 Dyak\GE21842
Curated drosophilid orthologs	Dpse\GA20254
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011842-PA Aedes aegypti (mosquito) AGAP011839-PA Anopheles gambiae (mosquito) XP_397152.2 Apis mellifera (honey bee) XP_001952016.1 Acyrthosiphon pisum (pea aphid) 23336 Batrachochytrium dendrobatidis (chytrid fungus) 113966 Branchiostoma floridae (lancelet) 277098 Branchiostoma floridae (lancelet) BGIBMGA006075-PA Bombyx mori (silk worm) ENSBTAP00000021981 Bos taurus (bovine) ENSCAFP00000034105 Canis familiaris (dog) CPIJ012095 Culex pipens (mosquito) ENSCPOP00000003866 Cavia porcellus (guinea pig) 178931 Capitella spl (polychaete worm) DDB0233499 Dictyostelium discoideum (amoeba) 316658 Daphnia pulex (daphnia) ENSDARP00000091036 Danio rerio (zebra fish) ENSECAP00000014902 Equus caballus (horse) ENSGACP00000027542 Gymnopilus aculeatus (mushroom) ENSGALP00000039783 Gallus gallus (chicken) ENSP00000311856 Homo sapiens (human) 162365 Lottia gigantea (owl limpet) ENSMODP00000024716 Monodelphis domestica (gray opossum) ENSMMUP00000020558 Macaca mulatta (rhesus monkey) ENSMUSP00000022580 Mus musculus (house mouse) 186944 Nematostella vectensis (starlet anemone) XP_001606647.1 Nasonia vitripennis (wasp) ENSOANP00000024547 Ornithorynchus anatinus (platypus) ENSORLP00000013832 Oryzias latipes (japanese killifish) PHUM002914-PA Pediculus humanus (human body louse) ENSPPYP00000006080 Pongo pygmaeus (orangutan) ENSPTRP00000009945 Pan troglodytes (chimpanzee) ENSRNOP00000009637 Rattus norvegicus (norway rat) XP_001195421.1 Strongylocentrotus purpuratus (purple sea urchin) 50836 Trichoplax adhaerens (metazoa) XP_969628.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010406 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023156 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032112 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11706 LH12764 FBgn0239085 FBgn0212505 FBgn0201288 FBgn0186009 FBgn0180153 JGI_V11_316658 FBgn0080249 FBgn0158307 FBgn0136479 FBgn0122550 FBgn0107773 FBgn0102277 CPIJ012095 BGIBMGA006075 ACYPI007724 GB10357 AGAP011839 AAEL011842 PB20889 PHUM363940 GLEAN_13313
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	12688 w1118; P{GT1}BmcpBG02446
Genomic Clones ( 2 )
	BACR06H19 BACR48G03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10708
Other clones	DPiM_GH10708
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10039 GH24995 GM04392 GM08252 HL01888 LD28168 LD36802 LP20296 RH40558 RH68665 RH70921 SD06789 SD14724 SD20090 SD20661 SD20683 SD28144
Other clones	9121 102825 CK01.21D.F9 CK01.103A.C4 CK00489 CK01126 EC27976 EC32787 EK043736 EK045843 EK053963 EK070427 EK086642 EK087820 EK103460 EK104058 EK108240 EK154938 EK157245 EK188142 EK224554 EK233327 EK234158 EK245039 EK249619 EK259058 EK261053 EK282104 EK303539 EK305234 EK308548 EP13964 RP004078616 RP004090458 RP004144475 RP004229520 RP004321365
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036199 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39322
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Bmcp CG7314 (Hanak and Jezek, 2001)
Source for database merge of
Additional comments
Other Comments
	Bmcp is important to maintain metabolic homeostasis. (Sanchez-Blanco et al., 2006) Bmcp mutants are highly sensitive to starvation stress. (Sanchez-Blanco et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140244 NM_168472 RefSeq (Proteins) • NP_648501 NP_729738 DDBJ / EMBL / GenBank • AAF50019 AAK92857 AAN11881 AI114037 AI402226 AY051433 BH011507 Entrez Gene - A searchable database of RefSeq genes. • 39322 UniProtKB/TrEMBL • Q7K566
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mitochondrial carrier protein (IPR002067) Mitochondrial substrate/solute carrier (IPR018108) Mitochondrial carrier domain (IPR023395) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME07314
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036199 DroID - A comprehensive database of gene and protein interactions. • FBgn0036199 DRSC - Results from RNAi screens. • FBgn0036199 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036199 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7314-RB;CG7314-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036199 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39322 InParanoid A subset of ortholog calls from InParanoid. • AAEL011842-PA Aedes aegypti (mosquito) AGAP011839-PA Anopheles gambiae (mosquito) XP_397152.2 Apis mellifera (honey bee) XP_001952016.1 Acyrthosiphon pisum (pea aphid) 23336 Batrachochytrium dendrobatidis (chytrid fungus) 113966 Branchiostoma floridae (lancelet) 277098 Branchiostoma floridae (lancelet) BGIBMGA006075-PA Bombyx mori (silk worm) ENSBTAP00000021981 Bos taurus (bovine) ENSCAFP00000034105 Canis familiaris (dog) CPIJ012095 Culex pipens (mosquito) ENSCPOP00000003866 Cavia porcellus (guinea pig) 178931 Capitella spl (polychaete worm) DDB0233499 Dictyostelium discoideum (amoeba) 316658 Daphnia pulex (daphnia) ENSDARP00000091036 Danio rerio (zebra fish) ENSECAP00000014902 Equus caballus (horse) ENSGACP00000027542 Gymnopilus aculeatus (mushroom) ENSGALP00000039783 Gallus gallus (chicken) ENSP00000311856 Homo sapiens (human) 162365 Lottia gigantea (owl limpet) ENSMODP00000024716 Monodelphis domestica (gray opossum) ENSMMUP00000020558 Macaca mulatta (rhesus monkey) ENSMUSP00000022580 Mus musculus (house mouse) 186944 Nematostella vectensis (starlet anemone) XP_001606647.1 Nasonia vitripennis (wasp) ENSOANP00000024547 Ornithorynchus anatinus (platypus) ENSORLP00000013832 Oryzias latipes (japanese killifish) PHUM002914-PA Pediculus humanus (human body louse) ENSPPYP00000006080 Pongo pygmaeus (orangutan) ENSPTRP00000009945 Pan troglodytes (chimpanzee) ENSRNOP00000009637 Rattus norvegicus (norway rat) XP_001195421.1 Strongylocentrotus purpuratus (purple sea urchin) 50836 Trichoplax adhaerens (metazoa) XP_969628.1 Tribolium castaneum (red flour beetle) ENSTNIP00000010406 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023156 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000032112 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39322 modMine - Data generated by the modENCODE project. • FBgn0036199 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11706 LH12764 FBgn0239085 FBgn0212505 FBgn0201288 FBgn0186009 FBgn0180153 JGI_V11_316658 FBgn0080249 FBgn0158307 FBgn0136479 FBgn0122550 FBgn0107773 FBgn0102277 CPIJ012095 BGIBMGA006075 ACYPI007724 GB10357 AGAP011839 AAEL011842 PB20889 PHUM363940 GLEAN_13313
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Bmcp (Sanchez-Blanco et al., 2006, Deloger et al., 2009, Lipatov et al., 2005, Fernández-Ayala et al., 2010) CG7314 (Hanak and Jezek, 2001, Deloger et al., 2009, Cammarato et al., 2011) DmBMCP (Hanak and Jezek, 2001) dmUCP5 (Sokolova, 2005) DmUCP5 (Sanchez-Blanco et al., 2004, Besson et al., 2010) UCP5 (Sanchez-Blanco et al., 2006) ucp5 (Sanchez-Blanco et al., 2006)
Name Synonym	Bmcp (Lipatov et al., 2005, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 20 )
Research paper	Besson et al., 2010, Hum. Mol. Genet. 19(17): 3372--3382 Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease. [FBrf0211472] Fernández-Ayala et al., 2010, PLoS ONE 5(1): e8549 Gene expression in a Drosophila model of mitochondrial disease. [FBrf0209705] Deloger et al., 2009, Gene 439(1-2): 55--62 Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster. [FBrf0207990] Sanchez-Blanco et al., 2006, Genetics 172(3): 1699--1710 Involvement of Drosophila uncoupling protein 5 in metabolism and aging. [FBrf0190770] Lipatov et al., 2005, BMC Biol. 3: 24 Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. [FBrf0189752] Sokolova, 2005, FEBS Lett. 579(2): 313--317 Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. [FBrf0188468] Hanak and Jezek, 2001, FEBS Lett. 495(3): 137--141 Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. [FBrf0135768]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903] Nelson, 2000.4.10, Mitochondrial carrier genes. Mitochondrial carrier genes. [FBrf0126915]
Abstract	Sanchez-Blanco et al., 2004, A. Dros. Res. Conf. 45: 263B The Newly Characterized Drosophila Uncoupling Protein 5 and its Involvement in Aging. [FBrf0173771]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]