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General Information
Symbol
Dmel\Ir68b
Species
D. melanogaster
Name
Ionotropic receptor 68b
Annotation Symbol
CG17152
Feature Type
FlyBase ID
FBgn0036250
Gene Model Status
Stock Availability
Gene Snapshot
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:12,125,487..12,127,394 [-]
Recombination map

3-38

RefSeq locus
NT_037436 REGION:12125487..12127394
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:Ir92a; FB:FBgn0038789
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Group (FlyBase)
    DIVERGENT IONOTROPIC RECEPTORS -
    Divergent Ionotropic Receptors (IR), members of the IR family of ligand-gated ion channels, are largely species-specific, with low amino acid sequence identity. Expressed in gustatory organs, they are believed to be taste receptors. (Adapted from FBrf0211681).
    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\Ir68b for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.46

    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0076026
    1908
    635
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0075758
    73.3
    635
    8.61
    Polypeptides with Identical Sequences

    There is only one protein coding transcript and one polypeptide associated with this gene

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
     
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir68b using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    Reporter: P{Ir68b-GAL4.637}
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\Ir68b in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Flygut - An atlas of the Drosophila adult midgut
    Images
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 0 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 3 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Ir68b
    Transgenic constructs containing regulatory region of Ir68b
    Deletions and Duplications ( 1 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Phenotype manifest in
    Allele
    Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (19)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    2 of 15
    Yes
    No
    1 of 15
    No
    No
    1  
    1 of 15
    No
    No
    2  
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1  
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1 of 15
    No
    No
    1  
    1 of 15
    No
    No
    1 of 15
    No
    Yes
    1 of 15
    No
    No
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (18)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    1 of 15
    Yes
    No
    2  
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    Yes
    1 of 15
    Yes
    No
    Rattus norvegicus (Norway rat) (15)
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    No
    1 of 13
    Yes
    Yes
    Xenopus tropicalis (Western clawed frog) (10)
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    1 of 12
    Yes
    No
    Danio rerio (Zebrafish) (31)
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    Yes
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    1 of 15
    Yes
    No
    Caenorhabditis elegans (Nematode, roundworm) (1)
    1 of 15
    Yes
    No
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919081T )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07AO )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Danaus plexippus
    Monarch butterfly
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Nasonia vitripennis
    Parasitic wasp
    Tribolium castaneum
    Red flour beetle
    Tribolium castaneum
    Red flour beetle
    Tribolium castaneum
    Red flour beetle
    Cimex lectularius
    Bed bug
    Zootermopsis nevadensis
    Nevada dampwood termite
    Zootermopsis nevadensis
    Nevada dampwood termite
    Zootermopsis nevadensis
    Nevada dampwood termite
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X075R )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Ixodes scapularis
    Black-legged tick
    Ixodes scapularis
    Black-legged tick
    Stegodyphus mimosarum
    African social velvet spider
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (66)
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    2 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
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    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    1 of 10
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map

      3-38

      Cytogenetic map
      Sequence location
      3L:12,125,487..12,127,394 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      68F4-68F4
      Limits computationally determined from genome sequence between P{PZ}rols08232&P{lacW}l(3)j2D3j2D3 and P{PZ}l(3)0508805088
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (2)
      Genomic Clones (11)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: Ir68b CG17152

                Source for database merge of
                Additional comments

                The Ir68b gene, one of 44 "divergent" ionotropic receptor genes in D. melanogaster, may have been derived from an ancestral ionotropic receptor gene by retroposition, and in some cases, subsequent gene duplication.

                Other Comments
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 16 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Synonyms and Secondary IDs (7)
                Reported As
                Name Synonyms
                CG17152
                Ionotropic receptor 68b
                ionotropic receptor 68b
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (16)