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Gene Dmel\CrzR

General Information
Symbol	Dmel\CrzR	Species	D. melanogaster
Name	Corazonin receptor	Annotation symbol	CG10698
Feature type	protein_coding_gene	FlyBase ID	FBgn0036278
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	GRHRII, DCR, crzR
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69B2-69B2	Sequence location	3L:12,332,216..12,344,644 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene GRHRII is referred to in FlyBase by the symbol Dmel\GRHRII (CG10698, FBgn0036278). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptide receptor activity; corazonin receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: G-protein coupled receptor signaling pathway. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult salivary gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629066_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of GRHRII. Gene sequence location is 3L:12332216..12344644.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69B2-69B2   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References 69B1-69B1     (Cazzamali, 2001.4.25)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CrzR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Stop-codon suppression (UGA) postulated; FBrf0216885. gene_with_stop_codon_read_through ; SO:0000697 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CrzR-RA FBtr0075989  NM_140314   3238   579 CrzR-RB FBtr0330069  NM_001274826   3238   644
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CrzR-PA   FBpp0075721   64.1   579   9.18     NP_648571   AAF49928 CrzR-PB   FBpp0303102   70.7   644   8.12     NP_001261755   AGB94448
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) GPCR, rhodopsin-like, 7TM (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49928   AF373862 AAM21341   AF522192   AE014296 AGB94448   AX254629   AX254630   AY071408 AAL49030   BI364333   BI365918   CO315856   DD177558   EC238422   FE863517   FE863592   FE863671   FE863777   FE863903   GH739552   GH746972   GH769458
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTW7 Q8MX81 Q8ITC8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult heart, adult salivary gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland  (979) Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body  (578.5) Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland  (979) Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body  578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.925 Larval Midgut    3.3 Larval Hindgut    5.2 Larval Malpighian Tubules    2.1 Larval Fat Body    5.6 Larval Salivary Gland    979 Larval Trachea    10.325 Larval Carcass    10.65 Adult Head    71.9 Adult Eye    39.775 Adult Brain    55 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    11.9 Adult Midgut    1.5 Adult Hindgut    6.2 Adult Malpighian Tubules    4.4 Adult Fat Body    578.5 Adult Salivary Gland    138.4 Adult Heart    405.75 Adult VirginFemale Spermatheca    8.2 Adult InseminatedFemale Spermatheca    10 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    2.8 Adult Carcass    409.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    71.9   NA  Eye    39.775   NA  Brain    55   77.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    40   NA  Crop    11.9   3.3  Midgut    1.5   5.2  Hindgut    6.2   2.1  Malpighian Tubules    4.4   5.6  Fat Body    578.5   979  Salivary Gland    138.4   NA  Heart    405.75   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    8.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.7   NA  Testis    2.5   NA  Male Accessory Gland    2.8   no informative data  Carcass    409.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    5 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    4 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    6 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    7 adult female 01day    5 adult female 05day    2 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RE49422 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036278 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10698-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CrzR Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CrzRGD652 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CrzR Class Mutagen Stocks Known lesion CrzRMB00838 1 -- CrzRMI03082 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CrzR Class Mutagen Stocks Known lesion CrzRGD652 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CrzRGL00706 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrzRJF02042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrzRKK112825 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{CrzR-GAL4.3.5} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CrzRMB00838 No miscellaneous insertions Mi{MIC}CrzRMI03082 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
corazonin receptor activity inferred from direct assay (Johnson et al., 2003, Park et al., 2002)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from direct assay (Park et al., 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
adipokinetic hormone binding inferred from sequence or structural similarity with GRHR (Staubli et al., 2002) adipokinetic hormone receptor activity inferred from sequence or structural similarity with GRHR (Staubli et al., 2002) corazonin receptor activity non-traceable author statement (Park, 2002.6.19) gonadotropin-releasing hormone receptor activity inferred from sequence or structural similarity with GRHR (Brody and Cravchik, 2000) G-protein coupled receptor activity non-traceable author statement (Cazzamali, 2001.4.25) neuropeptide receptor activity inferred from sequence or structural similarity (Hewes and Taghert, 2001) protein-hormone receptor activity inferred from sequence or structural similarity with EMBL:L33789 (FlyBase, 1992-)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from sequence or structural similarity (Hewes and Taghert, 2001) inferred from sequence or structural similarity with GRHR (Brody and Cravchik, 2000, Staubli et al., 2002) non-traceable author statement (Cazzamali, 2001.4.25, Park, 2002.6.19)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Hewes and Taghert, 2001, Park, 2002.6.19) inferred from sequence or structural similarity with GRHR (Brody and Cravchik, 2000, Staubli et al., 2002) non-traceable author statement (Cazzamali, 2001.4.25) integral to plasma membrane inferred by curator from GO:0035237|GO:0007186 (Park et al., 2002) inferred from sequence model (Park et al., 2002)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis, 2011.11.18) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CrzR - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrzR - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrzR - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CrzR - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CrzR allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036278 DroID - A comprehensive database of gene and protein interactions. • FBgn0036278 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39409
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62JPB1 Dipteran inclusive ortholog search EOG6C881N Insect inclusive ortholog search EOG6T7707 Arthropod inclusive ortholog search EOG62FR0C Metazoa inclusive ortholog search EOG6Z3K7W
Orthologs in Drosophila Species (EOG62JPB1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CrzR     Drosophila simulans   Dsim\GD12727 Y   Drosophila sechellia   Dsec\GM24664 Y   Drosophila erecta   Dere\GG13838 Y   Drosophila yakuba   Dyak\GE20128 Y   Drosophila ananassae   Dana\GF24986 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10504 Y   Drosophila persimilis   Dper\GL24963 Y   Drosophila willistoni   Dwil\GK12785 Y   Drosophila virilis   Dvir\GJ12227 Y   Drosophila mojavensis   Dmoj\GI12336 Y   Drosophila grimshawi   Dgri\GH16073 Y
Orthologs in non-Drosophila Dipterans (EOG6C881N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011475   Anopheles gambiae Malaria mosquito  Agam\30E5.2   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016679   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016678
Orthologs in non-Dipteran Insects (EOG6T7707)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Crzr   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018344   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20707   Atta cephalotes Leafcutter ant  Acep\ACEP20546   Atta cephalotes Leafcutter ant  Acep\ACEP20549   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12990   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15765   Linepithema humile Argentine ant  Lhum\LH17719   Solenopsis invicta Red fire ant  Sinv\SINV17586   Solenopsis invicta Red fire ant  Sinv\SINV17575   Solenopsis invicta Red fire ant  Sinv\SINV12156   Bombyx mori Silkmoth  Bmor\BGIBMGA001531   Pediculus humanus Human body louse  Phum\PHUM307450
Orthologs in non-Insect Arthropods (EOG62FR0C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_312207   Ixodes scapularis Deer tick  Isca\ISCW006208   Ixodes scapularis Deer tick  Isca\ISCW010571   Ixodes scapularis Deer tick  Isca\ISCW006212
Orthologs in non-Arthropod Metazoa (EOG6Z3K7W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027749gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12727 Drosophila sechellia Dsec\GM24664 Drosophila erecta Dere\GG13838 Drosophila yakuba Dyak\GE20128 Drosophila ananassae Dana\GF24986 Drosophila pseudoobscura pseudoobscura Dpse\GA10504 Drosophila persimilis Dper\GL24963 Drosophila willistoni Dwil\GK12785 Drosophila virilis Dvir\GJ12227 Drosophila mojavensis Dmoj\GI12336 Drosophila grimshawi Dgri\GH16073
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	26017 y1 v1; P{TRiP.JF02042}attP2 40188 y1 w*; Mi{MIC}CrzRMI03082 22910 y1 w67c23; Mi{ET1}CrzRMB00838 42751 y1 v1; P{TRiP.GL00706}attP2/TM3, Sb1
VDRC	v108506 P{KK112825}VIE-260B v44309 w1118; P{GD652}v44309/CyO v44310 w1118; P{GD652}v44310/TM3 v46713 w1118; P{GD652}v46713/TM3
Genomic Clones ( 2 )
	BACR26C20 BACR48J05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 13 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE49422
Other clones	DPiM_RE49422
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE51322
Other clones	160034 EK262811 RM07444 RM07544 RM07744 RM07844 RM08044 RP001033647 RP001035616 RP001036367
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036278 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39409
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GRHRII CG10698 (FlyBase, 1996-)
Source for database merge of	Source for merge of: GRHRII anon-WO0170980.196 anon-WO0170980.197 (FlyBase, 1996-)
Additional comments	Source for merge of GRHRII anon-WO0170980.196 anon-WO0170980.197 was sequence comparison (date:051113). (FlyBase, 1996-) Source for identity of GRHRII CG10698 was sequence comparison (date:020504). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140314 NM_001274826 RefSeq (Proteins) • NP_648571 NP_001261755 DDBJ / EMBL / GenBank • AAF49928 AAL49030 AAM21341 AAN10045 AF373862 AF522192 AGB94448 AX254629 AX254630 AY071408 BI364333 DD177558 Entrez Gene - A searchable database of RefSeq genes. • 39409 UniProtKB/TrEMBL • Q8ITC8 Q8MX81 Q9VTW7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) GPCR, rhodopsin-like, 7TM (IPR017452) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE49422
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036278 DroID - A comprehensive database of gene and protein interactions. • FBgn0036278 DRSC - Results from RNAi screens. • FBgn0036278 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036278 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10698-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036278 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39409 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39409 modMine - Data generated by the modENCODE project. • FBgn0036278
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-WO0170980.196   anon-WO0170980.197   CG10698 (Johnson et al., 2003, Johnson et al., 2003, Park et al., 2002, Cazzamali et al., 2002, Hewes and Taghert, 2001, Perkins et al., 1.15.2009, Johnson et al., 2008, Keleman et al., 2009.8.5, Staubli et al., 2002, Ni et al., 2010.12.1) crzR (Tayler et al., 2012, Tayler et al., 2012) Crz-R (Johnson et al., 2008) CrzR   DCR (Cazzamali et al., 2003, Cazzamali et al., 2002) DGRHRII (Cazzamali, 2001.4.25) GRHRII (Bellen et al., 2011, Jungreis, 2011.11.18, Edwards et al., 2009, Mackay et al., 2012) GRHRII_Dro (Metpally and Sowdhamini, 2005)
Name Synonym	Corazonin receptor (Veenstra et al., 2008, ) Drm-AKH receptor-2 (Staubli et al., 2002) Drosophila Corazonin Receptor (Cazzamali et al., 2002) GRHRII
Secondary FlyBase IDs
	FBgn0046552 FBgn0046553
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers ( 3 )
	Mackay et al., 2012, Nature 482(7384): 173--178 The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Tayler et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20697--20702 A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. [FBrf0220217] Bellen et al., 2011, Genetics 188(3): 731--743 The Drosophila gene disruption project: progress using transposons with distinctive site specificities. [FBrf0214229] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...