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Gene Dmel\CG10973

General Information
Symbol	Dmel\CG10973	Species	D. melanogaster
Name		Annotation symbol	CG10973
Feature type	protein_coding_gene	FlyBase ID	FBgn0036306
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69E1-69E1	Sequence location	3L:12,746,332..12,747,857 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10973 (FBgn0036306). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; Nucleotide exchange factor Fes1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult midgut, larval hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1634437_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG10973. Gene sequence location is 3L:12746332..12747857.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA09813 BKN24093
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69E1-69E1   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10973 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10973-RA FBtr0075950  NM_140337   1079   255 CG10973-RB FBtr0100354  NM_001038913   986   306
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10973-PA   FBpp0075682   28.4   255   4.91     NP_648594   AAF49888 CG10973-PB   FBpp0099759   34.0   306   4.98     NP_001034002   ABC66152
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Nucleotide exchange factor Fes1 (IPR013918)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141110   AA141954   AA695115   AA949966   AE014296 AAF49888   AE014296 ABC66152   AW942895   AY061359 AAL28907   BI363358   BI363514   BI364941   BI632548   CO332018   EC067775   EV596392   FD585576   FD585987   FD585997   FD586400   FD586401   FD586436   FD586437   FD586472   FD586488   FD586508   FD586580   FD587186   GH739027   GH739713   GH740061   GH740370   GH741928   GH742059   GH742326   GH743334   GH743388   GH744295   GH745901   GH746287   GH746331   GH746374   GH762646   GH762796   GH763176   GH763366   GH763384   GH763504   GH764043   GH766758   GH766807   GH768447   GH769372   GH779407   GH779584   GH779661
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95RI2 Q9VU07
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036306    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036306 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036306 expression level Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1660) embryo 02-04hr  (1753) embryo 04-06hr  (1823) embryo 06-08hr  (1528) embryo 08-10hr  (1811) embryo 10-12hr  (1535) embryo 12-14hr  (1805) embryo 14-16hr  (763) embryo 16-18hr  (867) embryo 18-20hr  (717) embryo 20-22hr  (990) embryo 22-24hr  (1302) larva L1  (1305) larva L2  (1223) larva L3 12hr old  (967) larva L3 puffstage 1-2  (703) larva L3 puffstage 3-6  (866) larva L3 puffstage 7-9  (1382) white prepupae new  (1175) white prepupae 12hr  (1204) white prepupae 24hr  (1299) pupae 2d postWPP  (1199) pupae 3d postWPP  (905) pupae 4d postWPP  (628) adult male 01day  (848) adult male 05day  (975) adult male 30day  (787) adult female 01day  (891) adult female 05day  (1742) adult female 30day  (1480) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1660) embryo 02-04hr  (1753) embryo 04-06hr  (1823) embryo 06-08hr  (1528) embryo 08-10hr  (1811) embryo 10-12hr  (1535) embryo 12-14hr  (1805) embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day  (1742) adult female 30day  1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036306 expression level Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1660) embryo 02-04hr  (1753) embryo 04-06hr  (1823) embryo 06-08hr  (1528) embryo 08-10hr  (1811) embryo 10-12hr  (1535) embryo 12-14hr  (1805) embryo 14-16hr  (763) embryo 16-18hr  (867) embryo 18-20hr  (717) embryo 20-22hr  (990) embryo 22-24hr  (1302) larva L1  (1305) larva L2  (1223) larva L3 12hr old  (967) larva L3 puffstage 1-2  (703) larva L3 puffstage 3-6  (866) larva L3 puffstage 7-9  (1382) white prepupae new  (1175) white prepupae 12hr  (1204) white prepupae 24hr  (1299) pupae 2d postWPP  (1199) pupae 3d postWPP  (905) pupae 4d postWPP  (628) adult male 01day  (848) adult male 05day  (975) adult male 30day  (787) adult female 01day  (891) adult female 05day  (1742) adult female 30day  (1480) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1660 embryo 02-04hr  1753 embryo 04-06hr  1823 embryo 06-08hr  1528 embryo 08-10hr  1811 embryo 10-12hr  1535 embryo 12-14hr  1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day  1742 adult female 30day  1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1660 embryo 02-04hr    1753 embryo 04-06hr    1823 embryo 06-08hr    1528 embryo 08-10hr    1811 embryo 10-12hr    1535 embryo 12-14hr    1805 embryo 14-16hr    763 embryo 16-18hr    867 embryo 18-20hr    717 embryo 20-22hr    990 embryo 22-24hr    1302 larva L1    1305 larva L2    1223 larva L3 12hr old    967 larva L3 puffstage 1-2    703 larva L3 puffstage 3-6    866 larva L3 puffstage 7-9    1382 white prepupae new    1175 white prepupae 12hr    1204 white prepupae 24hr    1299 pupae 2d postWPP    1199 pupae 3d postWPP    905 pupae 4d postWPP    628 adult male 01day    848 adult male 05day    975 adult male 30day    787 adult female 01day    891 adult female 05day    1742 adult female 30day    1480 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036306    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036306 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult midgut, larval hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036306 expression level Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036306 expression level Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    174.825 Larval Midgut    88 Larval Hindgut    106.2 Larval Malpighian Tubules    69.2 Larval Fat Body    66.2 Larval Salivary Gland    145.3 Larval Trachea    116.775 Larval Carcass    106.525 Adult Head    91.2 Adult Eye    101.075 Adult Brain    102.5 Adult Thoracic-Abdominal Ganglion    105.2 Adult Crop    149.4 Adult Midgut    109.2 Adult Hindgut    93.5 Adult Malpighian Tubules    76.1 Adult Fat Body    154.7 Adult Salivary Gland    102.8 Adult Heart    122.925 Adult VirginFemale Spermatheca    86.1 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    168.7 Adult Testis    151.3 Adult Male Accessory Gland    128.9 Adult Carcass    85 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    91.2   NA  Eye    101.075   NA  Brain    102.5   174.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    105.2   NA  Crop    149.4   88  Midgut    109.2   106.2  Hindgut    93.5   69.2  Malpighian Tubules    76.1   66.2  Fat Body    154.7   145.3  Salivary Gland    102.8   NA  Heart    122.925   116.775  Trachea    NA   NA  VirginFemale Spermatheca    86.1   NA  InseminatedFemale Spermatheca    115.3   NA  Ovary    168.7   NA  Testis    151.3   NA  Male Accessory Gland    128.9   106.525  Carcass    85 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036306 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10973-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10973GD7153 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG10973 Class Mutagen Stocks Known lesion CG10973G18338 P-element activity 1 -- CG10973MI01719 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10973 Class Mutagen Stocks Known lesion CG10973GD7153 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG10973KK104957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6117 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7153} NA P{KK104957} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG10973G18338 NA miscellaneous insertions Mi{MIC}CG10973MI01719 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011989, InterPro:IPR016024 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10973 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036306 DroID - A comprehensive database of gene and protein interactions. • FBgn0036306 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39447
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10869 Dere\GG13807 Dgri\GH16834 Dmoj\GI13055 Dper\GL24934 Dpse\GA10680 Dsec\GM24633 Dsim\GD12702 Dvir\GJ13802 Dwil\GK20262 Dyak\GE20100
Curated drosophilid orthologs	Dpse\GA10680
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001800-PA Aedes aegypti (mosquito) AGAP008392-PA Anopheles gambiae (mosquito) XP_393027.2 Apis mellifera (honey bee) XP_001948321.1 Acyrthosiphon pisum (pea aphid) At3g09350.1 Arabidopsis thaliana (wall cress) 125073 Branchiostoma floridae (lancelet) BGIBMGA013070-PA Bombyx mori (silk worm) ENSBTAP00000004752 Bos taurus (bovine) CAL0000409 Candida albicans (a form of yeast) ENSCAFP00000030265 Canis familiaris (dog) CAGL0K12144g Candida glabrata (haploid yeast) CPIJ000357 Culex pipens (mosquito) ENSCPOP00000015229 Cavia porcellus (guinea pig) 21393 Capitella spl (polychaete worm) DDB0186116 Dictyostelium discoideum (amoeba) DEHA2F15180g Debaryomyces Hansenii (yeast) 64425 Daphnia pulex (daphnia) ENSDARP00000025210 Danio rerio (zebra fish) ENSGACP00000017130 Gymnopilus aculeatus (mushroom) GL50803_15089 Giardia lamblia (flagellated protozoan) 166151 Hypsipyla robusta (cedar shoot borer) ENSP00000255631 Homo sapiens (human) ISCW015701-PA Ixodes scapularis (deer tick) KLLA0E11375g Kluyveromyces lactis (yeast) 181506 Lottia gigantea (owl limpet) ENSMODP00000020468 Monodelphis domestica (gray opossum) ENSMUSP00000078886 Mus musculus (house mouse) 237262 Nematostella vectensis (starlet anemone) XP_001605940.1 Nasonia vitripennis (wasp) ENSORLP00000014376 Oryzias latipes (japanese killifish) LOC_Os03g60780.1 Oryza sativa (asian rice) 23326 Ostreococcus tauri (green alga) PFD0525w Plasmodium falciparum (protozoal parasite) PHUM008961-PA Pediculus humanus (human body louse) 138923 Physcomitrella patens (moss) 75222 Phytophthora ramorum (sudden oak death pathogen) 141673 Phytophthora sojae (root rot pathogen) 576815 Populus trichocarpa (black cottonwood) PVX_000720 Plasmodium vivax (protozoal parasite) ENSRNOP00000024251 Rattus norvegicus (norway rat) 4130596 Sorghum bicolor (sorghum) YBR101C Saccharomyces cerevisiae (budding yeast) Smp_066950 Schistosoma mansoni (trematode parasite) SPBC3B9.01 Schizosaccharomyces pombe (fission yeast) XP_971541.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014577 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020404 Takifugu rubripes (pufferfish Takifugu) 3712.m00004 Tetrahymena thermophila (ciliate protozoa) 89137.m00142 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049581 Xenopus tropicalis (frog) YALI0F11121g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11475 NV10146 LH16990 ISCW015701 ISCW006573 FBgn0237423 FBgn0222259 FBgn0201021 FBgn0184429 FBgn0179496 JGI_V11_64425 FBgn0070736 FBgn0162521 FBgn0135812 FBgn0124305 FBgn0106070 FBgn0087909 CPIJ000357 BGIBMGA013070 ACYPI008753 GB15809 AGAP008392 AAEL001800 PHUM368990 GLEAN_12099
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26933 y1 w*; P{EP}CG10973G18338 34240 y1 w*; Mi{MIC}CG10973MI01719 CG10984MI01719
VDRC	v100869 P{KK104957}VIE-260B v41464 w1118 P{GD7153}v41464 v41463 w1118; P{GD7153}v41463
Genomic Clones ( 1 )
	BACR20I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 52 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28549
Other clones	DPiM_LD28549
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02164 RE48144 RE48341 RE50144 SD26355
Other clones	274803 CK00062 CK01206 Dmel_neb_016313_0913_2047 EK302324 RM02672 RM02772 RM02871 RM02872 RM02971 RM02972 RM03072 RM03171 RM03172 RM03271 RM03272 RM03371 RP001001025 RP001002748 RP001002916 RP001004465 RP001004833 RP001006657 RP001007397 RP001008360 RP001010070 RP001013092 RP001015301 RP001015433 RP001015937 RP001022540 RP001023829 RP001028087 RP001031175 RP001032042 RP001035012 RP001035691 RP001041332 RP001042401 RP001044135 RP001044955 RP001048846 RP001049659 RP001055735 RP001056201
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036306 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39447
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140337 NM_001038913 RefSeq (Proteins) • NP_648594 NP_001034002 DDBJ / EMBL / GenBank • AA949966 AAF49888 AAF49888.1 AAL28907 ABC66152 AW942895 AY061359 Entrez Gene - A searchable database of RefSeq genes. • 39447 UniProtKB/TrEMBL • Q9VU07 Q95RI2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Nucleotide exchange factor Fes1 (IPR013918)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036306 DroID - A comprehensive database of gene and protein interactions. • FBgn0036306 DRSC - Results from RNAi screens. • FBgn0036306 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036306 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10973-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036306 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39447 InParanoid A subset of ortholog calls from InParanoid. • AAEL001800-PA Aedes aegypti (mosquito) AGAP008392-PA Anopheles gambiae (mosquito) XP_393027.2 Apis mellifera (honey bee) XP_001948321.1 Acyrthosiphon pisum (pea aphid) At3g09350.1 Arabidopsis thaliana (wall cress) 125073 Branchiostoma floridae (lancelet) BGIBMGA013070-PA Bombyx mori (silk worm) ENSBTAP00000004752 Bos taurus (bovine) CAL0000409 Candida albicans (a form of yeast) ENSCAFP00000030265 Canis familiaris (dog) CAGL0K12144g Candida glabrata (haploid yeast) CPIJ000357 Culex pipens (mosquito) ENSCPOP00000015229 Cavia porcellus (guinea pig) 21393 Capitella spl (polychaete worm) DDB0186116 Dictyostelium discoideum (amoeba) DEHA2F15180g Debaryomyces Hansenii (yeast) 64425 Daphnia pulex (daphnia) ENSDARP00000025210 Danio rerio (zebra fish) ENSGACP00000017130 Gymnopilus aculeatus (mushroom) GL50803_15089 Giardia lamblia (flagellated protozoan) 166151 Hypsipyla robusta (cedar shoot borer) ENSP00000255631 Homo sapiens (human) ISCW015701-PA Ixodes scapularis (deer tick) KLLA0E11375g Kluyveromyces lactis (yeast) 181506 Lottia gigantea (owl limpet) ENSMODP00000020468 Monodelphis domestica (gray opossum) ENSMUSP00000078886 Mus musculus (house mouse) 237262 Nematostella vectensis (starlet anemone) XP_001605940.1 Nasonia vitripennis (wasp) ENSORLP00000014376 Oryzias latipes (japanese killifish) LOC_Os03g60780.1 Oryza sativa (asian rice) 23326 Ostreococcus tauri (green alga) PFD0525w Plasmodium falciparum (protozoal parasite) PHUM008961-PA Pediculus humanus (human body louse) 138923 Physcomitrella patens (moss) 75222 Phytophthora ramorum (sudden oak death pathogen) 141673 Phytophthora sojae (root rot pathogen) 576815 Populus trichocarpa (black cottonwood) PVX_000720 Plasmodium vivax (protozoal parasite) ENSRNOP00000024251 Rattus norvegicus (norway rat) 4130596 Sorghum bicolor (sorghum) YBR101C Saccharomyces cerevisiae (budding yeast) Smp_066950 Schistosoma mansoni (trematode parasite) SPBC3B9.01 Schizosaccharomyces pombe (fission yeast) XP_971541.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014577 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000020404 Takifugu rubripes (pufferfish Takifugu) 3712.m00004 Tetrahymena thermophila (ciliate protozoa) 89137.m00142 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000049581 Xenopus tropicalis (frog) YALI0F11121g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39447 modMine - Data generated by the modENCODE project. • FBgn0036306 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11475 NV10146 LH16990 ISCW015701 ISCW006573 FBgn0237423 FBgn0222259 FBgn0201021 FBgn0184429 FBgn0179496 JGI_V11_64425 FBgn0070736 FBgn0162521 FBgn0135812 FBgn0124305 FBgn0106070 FBgn0087909 CPIJ000357 BGIBMGA013070 ACYPI008753 GB15809 AGAP008392 AAEL001800 PHUM368990 GLEAN_12099
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10973 (Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 10 )
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Bellen, 2011.1.31, set919.xml set919.xml [FBrf0212923] Bellen, 2009.2.6, BDGP_2009_0206.GenExel.xml BDGP_2009_0206.GenExel.xml [FBrf0206623] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]