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Gene Dmel\Hip1

General Information
Symbol	Dmel\Hip1	Species	D. melanogaster
Name	Huntingtin interacting protein 1	Annotation symbol	CG10971
Feature type	protein_coding_gene	FlyBase ID	FBgn0036309
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Hip1R
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69E2-69E2	Sequence location	3L:12,761,532..12,766,673 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Huntingtin interacting protein 1 is referred to in FlyBase by the symbol Dmel\Hip1 (CG10971, FBgn0036309). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. Based on sequence similarity, it is predicted to be involved in the biological process: cytoskeleton organization. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AP180 N-terminal homology (ANTH) domain; ENTH/VHS; Epsin-like, N-terminal; I/LWEQ domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1633204_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Hip1. Gene sequence location is 3L:12761532..12766673.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69E2-69E2   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hip1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 DGC clone appears problematic (LD08185): incomplete CDS; DGC:LD16566 okay.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hip1-RA FBtr0075948  NM_140340   4093   1124 Hip1-RB FBtr0075949  NM_168513   4099   1087
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hip1-PA   FBpp0075680   128.4   1124   5.46     NP_648597   AAF49885 Hip1-PB   FBpp0075681   124.3   1087   5.22     NP_729827   AAF49884
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • I/LWEQ domain (IPR002558) AP180 N-terminal homology (ANTH) domain (IPR011417) Epsin-like, N-terminal (IPR013809) ENTH/VHS (IPR008942)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264273   AA264439   AA390812   AA393013   AA441586   AA540726   AA950076   AE014296 AAF49884   AE014296 AAF49885   AW941676   AW942422   AY129439 AAM76181   AY129442 AAM76184   BG638224   BG638226   BI237088   BI356536   BI356758   BI363156   BI367068   BI370153   BI374478   BP552544   CA806560   CO187286   CO277264   CO277448   CO282165   CO282192   CO282194   CO309291   CO310067   CO339613   CO343184   EC084983   EC084990   EC195117   EC205189   EC209144   EC220627   EC224551   EC225052   EC229468   EC253705   EC260051
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86BS5 Q8MQJ8 Q8MQK1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut  (703) Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut  703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    252.35 Larval Midgut    703 Larval Hindgut    301.2 Larval Malpighian Tubules    194.1 Larval Fat Body    115.9 Larval Salivary Gland    138.2 Larval Trachea    143.525 Larval Carcass    90.35 Adult Head    88.5 Adult Eye    63.725 Adult Brain    155.6 Adult Thoracic-Abdominal Ganglion    194.4 Adult Crop    204 Adult Midgut    333.9 Adult Hindgut    173.4 Adult Malpighian Tubules    128.6 Adult Fat Body    40.8 Adult Salivary Gland    184.6 Adult Heart    84.2 Adult VirginFemale Spermatheca    60.9 Adult InseminatedFemale Spermatheca    83.9 Adult Ovary    270 Adult Testis    154 Adult Male Accessory Gland    89.1 Adult Carcass    56.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.5   NA  Eye    63.725   NA  Brain    155.6   252.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    194.4   NA  Crop    204   703  Midgut    333.9   301.2  Hindgut    173.4   194.1  Malpighian Tubules    128.6   115.9  Fat Body    40.8   138.2  Salivary Gland    184.6   NA  Heart    84.2   143.525  Trachea    NA   NA  VirginFemale Spermatheca    60.9   NA  InseminatedFemale Spermatheca    83.9   NA  Ovary    270   NA  Testis    154   NA  Male Accessory Gland    89.1   90.35  Carcass    56.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (53) digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  (27) ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (53) digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    11 central nervous system, pupae P8    14 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    3 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    53 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    13 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    6 carcass, larvae L3 wandering    8 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    27 ovary, mated 4-day female    17 testis, mated 4-day male    18 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    16 embryo 04-06hr    8 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    5 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    10 embryo 18-20hr    8 embryo 20-22hr    10 embryo 22-24hr    13 larva L1    3 larva L2    4 larva L3 12hr old    4 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    17 white prepupae new    15 white prepupae 12hr    13 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    9 pupae 4d postWPP    4 adult male 01day    7 adult male 05day    7 adult male 30day    5 adult female 01day    4 adult female 05day    11 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2  26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2  26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3  (31) eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  (38) ovary fGS/OSS    13 ovary OSC  26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2  26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2  26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3  31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2  (38) ovary fGS/OSS    13 ovary OSC  26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    8 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    26 embryonic Kc167    22 embryonic S1    12 embryonic S3    19 leg disc CME L1    13 wing disc CME-W2    26 wing disc ML-DmD8    13 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    12 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    31 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    17 tumorous blood cells mbn2    38 ovary fGS/OSS    13 ovary OSC    26 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036309 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10971-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Hip1GD7152 Other Phenotypes Allele visible, with Scer\GAL4ap-md544 Hip1Scer\UAS.cMa Hip1ΔANTH.Scer\UAS visible, with Scer\GAL4pnr-MD237 Hip1Scer\UAS.cMa Hip1ΔANTH.Scer\UAS Phenotype manifest in Allele microchaeta & mesothoracic tergum, with Scer\GAL4ap-md544 Hip1Scer\UAS.cMa Hip1ΔANTH.Scer\UAS microchaeta & mesothoracic tergum, with Scer\GAL4pnr-MD237 Hip1Scer\UAS.cMa Hip1ΔANTH.Scer\UAS
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Hip1 Class Mutagen Stocks Known lesion Hip1MB04365 1 -- Hip1MI05905 1 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hip1 Class Mutagen Stocks Known lesion Hip1GD7152 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hip1HMS00508 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip1HMS01846 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip1KK100497 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hip1NIG.10971R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hip1Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Hip1ΔANTH.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6117 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100497} NA P{NIG.10971R} NA P{TRiP.HMS00508} NA P{TRiP.HMS01846} NA P{UAS-Hip1.M} NA P{UAS-Hip1.ΔANTH} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Hip1MB04365 No miscellaneous insertions Mi{MIC}Hip1MI05905 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR002558 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) phospholipid binding inferred from electronic annotation with InterPro:IPR011417 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cytoskeleton organization inferred from sequence or structural similarity with EMBL:AJ009556 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hip1 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Atpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG12262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG1371 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG1458 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG1667 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG16935 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG17259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG2051 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG32000 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG3523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG3702 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG4199 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG4729 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG5028 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG6907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - ClC-b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Cyp12d1-p anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Dhc64C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Gie anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Idh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Kap-α3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - LKR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - OstΔ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Past1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Pi3K68D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Prosβ7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rab9D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Ras64B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rpt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Sucb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - Vha68-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - ade5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - cni anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - hipk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - jagn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - mge anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - skap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hip1 - δCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hip1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64797 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036309 DroID - A comprehensive database of gene and protein interactions. • FBgn0036309 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39450
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65X8FJ Dipteran inclusive ortholog search EOG65HS5G Insect inclusive ortholog search EOG6FXQ3J Arthropod inclusive ortholog search EOG6H189R Metazoa inclusive ortholog search EOG6P5Z30
Orthologs in Drosophila Species (EOG65X8FJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hip1     Drosophila simulans   Dsim\GD12701 Y   Drosophila sechellia   Dsec\GM24632 Y   Drosophila erecta   Dere\GG13806 Y   Drosophila yakuba   Dyak\GE20099 Y   Drosophila ananassae   Dana\GF10868 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23562 Y   Drosophila persimilis   Dper\GL24933 Y   Drosophila willistoni   Dwil\GK20260 Y   Drosophila virilis   Dvir\GJ13799 Y   Drosophila mojavensis   Dmoj\GI11924 Y   Drosophila grimshawi   Dgri\GH16831 Y
Orthologs in non-Drosophila Dipterans (EOG65HS5G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010449   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014598   Anopheles gambiae Malaria mosquito  Agam\AGAP004801   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004416
Orthologs in non-Dipteran Insects (EOG6FXQ3J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55015   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004908   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23306   Atta cephalotes Leafcutter ant  Acep\ACEP25801   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13719   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16471   Linepithema humile Argentine ant  Lhum\LH26155   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27306   Solenopsis invicta Red fire ant  Sinv\SINV16527   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007315   Bombyx mori Silkmoth  Bmor\BGIBMGA005521   Pediculus humanus Human body louse  Phum\PHUM138710   Tribolium castaneum Red flour beetle  Tcas\TC011686
Orthologs in non-Insect Arthropods (EOG6H189R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\gyrA   Ixodes scapularis Deer tick  Isca\ISCW023307
Orthologs in non-Arthropod Metazoa (EOG6P5Z30)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y18D10A.22   Caenorhabditis elegans Nematode  Cele\hipr-1   Caenorhabditis elegans Nematode  Cele\tag-138   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010488gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010513gn   Danio rerio Zebrafish  Drer\zgc:158784   Danio rerio Zebrafish  Drer\hip1   Danio rerio Zebrafish  Drer\ENSDARG00000060627   Xenopus tropicalis Western clawed frog  Xtro\hip1r   Xenopus tropicalis Western clawed frog  Xtro\hip1   Gallus gallus Domestic chicken  Ggal\HIP1   Gallus gallus Domestic chicken  Ggal\HIP1R   Mus musculus House mouse  Mmus\Hip1   Mus musculus House mouse  Mmus\Hip1r   Rattus norvegicus Norway rat  Rnor\Hip1r   Rattus norvegicus Norway rat  Rnor\Hip1   Homo sapiens Human  Hsap\HIP1R   Homo sapiens Human  Hsap\HIP1
Human Orthologs (2)
Gene OMIM HGNC Hsap\HIP1R     Hsap\HIP1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12701 Drosophila sechellia Dsec\GM24632 Drosophila erecta Dere\GG13806 Drosophila yakuba Dyak\GE20099 Drosophila ananassae Dana\GF10868 Drosophila pseudoobscura pseudoobscura Dpse\GA23562 Drosophila persimilis Dper\GL24933 Drosophila willistoni Dwil\GK20260 Drosophila virilis Dvir\GJ13799 Drosophila mojavensis Dmoj\GI11924 Drosophila grimshawi Dgri\GH16831
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	24809 w1118; Mi{ET1}Hip1MB04365 38377 y1 v1; P{TRiP.HMS01846}attP40 42355 y1 w*; Mi{MIC}Hip1MI05905 32504 y1 sc* v1; P{TRiP.HMS00508}attP2
VDRC	v106978 P{KK100497}VIE-260B v16137 w1118; P{GD7152}v16137 v16138 w1118; P{GD7152}v16138
Genomic Clones ( 1 )
	BACR20I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 39 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08185 LD16566
Other clones	DPiM_LD16566
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03301 LD07971 LD09712 LD20482 LD30041 RE33246 RE42712 RE42961 RE47906 RE52742 RE56567 RE62078
Other clones	4662 5417 44193 44319 77883 97691 214213.41 214249.41 273886 CK01.32B.E8 CK01.34D.F6 EK027752 EK123617 EK124454 EK159701 EK159748 EK159750 EK217243 EK220354 EP02403 EP16247 ESG013d.E21_G11 FGM219D03 LD20514
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39450
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hip1 CG10971 (Moores et al., 2008)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140340 NM_168513 RefSeq (Proteins) • NP_648597 NP_729827 DDBJ / EMBL / GenBank • AA264439 AA441586 AAF49884 AAF49885 AAM76181 AAM76184 AW941676 AW942422 AY129439 AY129442 Entrez Gene - A searchable database of RefSeq genes. • 39450 UniProtKB/TrEMBL • Q8MQJ8 Q8MQK1 Q86BS5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • I/LWEQ domain (IPR002558) AP180 N-terminal homology (ANTH) domain (IPR011417) Epsin-like, N-terminal (IPR013809) ENTH/VHS (IPR008942)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64797 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036309 DroID - A comprehensive database of gene and protein interactions. • FBgn0036309 DRSC - Results from RNAi screens. • FBgn0036309 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036309 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10971-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036309 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39450 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39450 modMine - Data generated by the modENCODE project. • FBgn0036309
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG10971 (Moores et al., 2008, Bakal et al., 2007, Keleman et al., 2009.8.5, Kim et al., 2005, Ni et al., 2010.12.1, Japanese National Institute of Genetics, 2012.5.21) Hip1 (Moores et al., 2008) Hip1R (Serio et al., 2010, Reed et al., 2012)
Name Synonym	CG10971   Huntingtin interacting protein 1 (Moores et al., 2008, )
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Reed et al., 2012, Cell. Microbiol. 14(4): 529--545 Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. [FBrf0217748] Show all research papers ...