Gene Dmel\CG10948

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General Information

Symbol

Dmel\CG10948

Species

D. melanogaster

Name

Annotation symbol

CG10948

Feature type

protein_coding_gene

FlyBase ID

FBgn0036317

Gene Model Status

Current

Stock availability

2 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

69E6-69E6

Sequence location

3L:12,837,354..12,843,217 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG10948 (FBgn0036317). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1636182_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG10948. Gene sequence location is 3L:12837354..12843217.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69E6-69E6

Limits computationally determined from genome sequence between P{PZ}l(3)06924⁰⁶⁹²⁴ and P{lacW}RpS12^s2783

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG10948 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG10948-RB

FBtr0075938

NM_140349

2797

437

CG10948-RC

FBtr0075939

NM_168524

2904

804

CG10948-RD

FBtr0273237

NM_168525

2870

797

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG10948-PB

FBpp0075670

48.1

437

7.93

NP_648606

AAN11865

CG10948-PC

FBpp0075671

90.1

804

6.38

NP_729844

AAF49873

CG10948-PD

FBpp0271745

89.3

797

6.38

NP_729845

AAN11866

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA recognition motif domain (IPR000504)

Nucleotide-binding, alpha-beta plait (IPR012677)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult mushroom body | restricted

(Kobayashi et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		197.325
Larval Midgut		20.8
Larval Hindgut		59.8
Larval Malpighian Tubules		42.4
Larval Fat Body		71.7
Larval Salivary Gland		89.5
Larval Trachea		75.55
Larval Carcass		39.275
Adult Head		60.9
Adult Eye		61.5
Adult Brain		332.8
Adult Thoracic-Abdominal Ganglion		193.5
Adult Crop		64.5
Adult Midgut		21.6
Adult Hindgut		56.7
Adult Malpighian Tubules		89.2
Adult Fat Body		57
Adult Salivary Gland		86.2
Adult Heart		48.65
Adult VirginFemale Spermatheca		58.6
Adult InseminatedFemale Spermatheca		72.3
Adult Ovary		109.8
Adult Testis		111.3
Adult Male Accessory Gland		70.2
Adult Carcass		56.7
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	60.9
NA	Eye	61.5
NA	Brain	332.8
197.325	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	193.5
NA	Crop	64.5
20.8	Midgut	21.6
59.8	Hindgut	56.7
42.4	Malpighian Tubules	89.2
71.7	Fat Body	57
89.5	Salivary Gland	86.2
NA	Heart	48.65
75.55	Trachea	NA
NA	VirginFemale Spermatheca	58.6
NA	InseminatedFemale Spermatheca	72.3
NA	Ovary	109.8
NA	Testis	111.3
NA	Male Accessory Gland	70.2
39.275	Carcass	56.7

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(31)
central nervous system, larvae L3		(44)
central nervous system, pupae P8		(42)
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		(35)
head, mated 4-day male		(33)
head, mated 20-day male		(38)
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		(27)
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		(44)
central nervous system, pupae P8		(42)
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		(35)
head, mated 4-day male		(33)
head, mated 20-day male		(38)
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		31
central nervous system, larvae L3		44
central nervous system, pupae P8		42
head, virgin 1-day female		21
head, virgin 4-day female		22
head, virgin 20-day female		13
head, mated 1-day female		19
head, mated 4-day female		19
head, mated 20-day female		13
head, mated 1-day male		35
head, mated 4-day male		33
head, mated 20-day male		38
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		9
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		5
digestive system, 20-day adult		4
fat body, larvae L3 wandering		7
fat body, white prepupae		16
fat body, pupae P8		27
carcass, larvae L3 wandering		23
carcass, 1-day adult		9
carcass, 4-day adult		10
carcass, 20-day adult		8
ovary, virgin 4-day female		25
ovary, mated 4-day female		26
testis, mated 4-day male		10
accessory gland, mated 4-day male		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, at stages throughout the pupal period.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		15
embryo 02-04hr		8
embryo 04-06hr		14
embryo 06-08hr		15
embryo 08-10hr		18
embryo 10-12hr		17
embryo 12-14hr		21
embryo 14-16hr		15
embryo 16-18hr		14
embryo 18-20hr		11
embryo 20-22hr		9
embryo 22-24hr		11
larva L1		11
larva L2		7
larva L3 12hr old		6
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		11
larva L3 puffstage 7-9		15
white prepupae new		14
white prepupae 12hr		16
white prepupae 24hr		26
pupae 2d postWPP		22
pupae 3d postWPP		17
pupae 4d postWPP		11
adult male 01day		11
adult male 05day		12
adult male 30day		11
adult female 01day		10
adult female 05day		13
adult female 30day		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		(28)
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		(27)
ovary OSC		(30)
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		12
Schneider line 2 Sg4		8
embryonic 1182-4H		14
embryonic GM2		14
embryonic Kc167		15
embryonic S1		11
embryonic S3		13
leg disc CME L1		12
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		21
wing disc ML-DmD16-c3		17
wing disc ML-DmD21		9
wing disc ML-DmD32		9
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		13
antennal disc ML-DmD20-c5		7
mixed discs ML-DmD4-c1		11
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		15
tumorous blood cells mbn2		8
ovary fGS/OSS		27
ovary OSC		30
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		9
cold shock, 4-day adult		7
heat shock, 4-day adult		12
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		12
Cadmium 50 mM 48 hrs, 4-day adult		14
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		6
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		18
Ethanol 2.5% 3 hrs, larvae L3		18
Ethanol 5% 3 hrs, larvae L3		7
Ethanol 10% 3 hrs, larvae L3		6
Caffeine 1.5 mg/ml 4 hrs, larvae L3		8
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		16
Caffeine 25 mg/ml 48 hrs, 4-day adult		10
Paraquat 5 mM 48 hrs, 4-day adult		19
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		5
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0036317

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG10948-RB

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | pupal stage, with Scer\GAL4^pnr-MD237

CG10948^GD7139

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

CG10948^GD7139

viable

CG10948^c02658

Sterility

Allele

fertile

CG10948^c02658

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG10948	Class	Mutagen	Stocks	Known lesion
CG10948^c02658		piggyBac transposase	0	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG10948	Mutagen	Stocks	Known lesion
CG10948^GD7139	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG10948^KK100966	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
CG10948^NIG.10948R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD7139}

P{KK100966}

P{NIG.10948R}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}CG10948^c02658

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

nucleic acid binding

inferred from electronic annotation with InterPro:IPR000504

(FlyBase Curators et al., 2004-)

nucleotide binding

inferred from electronic annotation with InterPro:IPR012677

(FlyBase Curators et al., 2004-)

Biological Process ( 0 terms)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG10948 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

64806

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0036317

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

39459

Orthologs

OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6JM889

Dipteran inclusive ortholog search

EOG6BG947

Insect inclusive ortholog search

EOG6V9SKQ

Arthropod inclusive ortholog search

EOG6TQJR3

Metazoa inclusive ortholog search

EOG6SFNZZ

Orthologs in Drosophila Species (EOG6JM889)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10660

Drosophila persimilis

Dper\GL22894

Drosophila willistoni

Dwil\GK17355

Drosophila virilis

Dvir\GJ13981

Drosophila mojavensis

Dmoj\GI13647

Drosophila grimshawi

Dgri\GH14491

Orthologs in non-Drosophila Dipterans (EOG6BG947)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010200

Anopheles gambiae

Malaria mosquito

Agam\AGAP011541

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007879

Orthologs in non-Dipteran Insects (EOG6V9SKQ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC409757

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003362

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH15535

Atta cephalotes

Leafcutter ant

Acep\ACEP17737

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO12842

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO12841

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL23050

Linepithema humile

Argentine ant

Lhum\LH11806

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB24568

Solenopsis invicta

Red fire ant

Sinv\SINV18541

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006521

Bombyx mori

Silkmoth

Bmor\BGIBMGA011735

Pediculus humanus

Human body louse

Phum\PHUM233550

Tribolium castaneum

Red flour beetle

Tcas\TC000049

Orthologs in non-Insect Arthropods (EOG6TQJR3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_112196

Ixodes scapularis

Deer tick

Isca\ISCW016515

Orthologs in non-Arthropod Metazoa (EOG6SFNZZ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006440gn

Danio rerio

Zebrafish

Drer\enox1

Danio rerio

Zebrafish

Drer\AL929322.1

Xenopus tropicalis

Western clawed frog

Xtro\enox1

Gallus gallus

Domestic chicken

Ggal\ENOX2

Gallus gallus

Domestic chicken

Ggal\ENOX1

Mus musculus

House mouse

Mmus\ENSMUSG00000022012

Mus musculus

House mouse

Mmus\Enox2

Rattus norvegicus

Norway rat

Rnor\Enox1

Rattus norvegicus

Norway rat

Rnor\Enox2

Homo sapiens

Human

Hsap\ENOX1

Homo sapiens

Human

Hsap\ENSG00000165675

Human Orthologs (2)

Gene

OMIM

HGNC

Hsap\ENOX1

Hsap\ENSG00000165675

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10660

Drosophila persimilis

Dper\GL22894

Drosophila willistoni

Dwil\GK17355

Drosophila virilis

Dvir\GJ13981

Drosophila mojavensis

Dmoj\GI13647

Drosophila grimshawi

Dgri\GH14491

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v31388

w¹¹¹⁸; P{GD7139}v31388

v31386

w¹¹¹⁸; P{GD7139}v31386/TM3

Genomic Clones ( 1 )

BACR20B01

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 70 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0036317

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

39459

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

(Hansen et al., 2009)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

39459

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA recognition motif domain (IPR000504)

Nucleotide-binding, alpha-beta plait (IPR012677)

Linkouts

BioGRID - A database of protein and genetic interactions

•

64806

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0036317

DRSC - Results from RNAi screens.

•

FBgn0036317

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0036317

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG10948-RB

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0036317

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

39459

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

39459

modMine - Data generated by the modENCODE project.

•

FBgn0036317

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

cg10948

(Lasko, 2000)

CG10948

(Kobayashi et al., 2006, Sessions et al., 2009, Hansen et al., 2009, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

CT30663

(Ceriani et al., 2002)

Name Synonym

Secondary FlyBase IDs

References ( 18 )

Research paper

Hansen et al., 2009, PLoS Genet. 5(6): e1000525: Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. [FBrf0208149]
Sessions et al., 2009, Nature 458(7241): 1047--1050: Discovery of insect and human dengue virus host factors. [FBrf0207837]
Kobayashi et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(39): 14417--14422: Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. [FBrf0194633]
Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319: Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147]
Lasko, 2000, J. Cell Biol. 150(2): F51--F56: The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.: Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Abstract

Toba and White, 2003, A. Dros. Res. Conf. 44: 378C: Identification of ELAV interacting partners through yeast two-hybrid screening. [FBrf0154756]

FlyBase analysis

FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Curated genome annotation

FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.]: [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]