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Gene Dmel\mop

General Information
Symbol	Dmel\mop	Species	D. melanogaster
Name	myopic	Annotation symbol	CG9311
Feature type	protein_coding_gene	FlyBase ID	FBgn0036448
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	70F4-70F5	Sequence location	3L:14,762,441..14,769,243 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene myopic is referred to in FlyBase by the symbol Dmel\mop (CG9311, FBgn0036448). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process: positive regulation of epidermal growth factor receptor signaling pathway; antimicrobial peptide production; spindle assembly; regulation of growth; positive regulation of Toll signaling pathway. 17 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: BRO1 domain; Protein-tyrosine phosphatase, receptor/non-receptor type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval hindgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635842_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mop. Gene sequence location is 3L:14762441..14769243.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Gilbert et al., 2011, Dev. Cell 20(5): 700--712
FB2012_01	Controlled Vocabulary Terms regulation of growth Alleles mop[sfv3] mop[sfv11] Sequence features BKN20331 BKN60341 BKN60220 HFA11065
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70F4-70F5   Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mop for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mop-RA FBtr0075700  NM_140465   5975   1833
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mop-PA   FBpp0075450   200.3   1833   6.39     NP_648722   AAF49705
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) BRO1 domain (IPR004328)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49705   AI531824   AI532693   AI534714   AI543010   AI543603   AI543774   AW944284   AY052076 AAK93500   BE975952   BE976067   BG640764   BI584193   BI587285   BI588053   BI590853   BQ103126   CA804603   CO185131   CO185734   CO189303   CO275622   CO276085   CO303501   CO310594   CO316261   CO334001   CZ477503   EC051229   EC055246   EC056532   EC056869   EC066472   EC071492   EC077655   EC083770   EC194835   EC202098   EC208838   EC217404   EC230375   EC240281   EC240738   EC251325   EC252699   EV583731   EY198862
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q960G3 Q9VUH6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036448    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036448 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036448 expression level Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2942) embryo 02-04hr  (2690) embryo 04-06hr  (894) embryo 06-08hr  (968) embryo 08-10hr  (1325) embryo 10-12hr  (929) embryo 12-14hr  (1242) embryo 14-16hr  (1193) embryo 16-18hr  (1083) embryo 18-20hr  (826) embryo 20-22hr  (1352) embryo 22-24hr  (1288) larva L1  (538) larva L2  (631) larva L3 12hr old  (624) larva L3 puffstage 1-2  (1040) larva L3 puffstage 3-6  (2791) larva L3 puffstage 7-9  (5228) white prepupae new  (5263) white prepupae 12hr  (3090) white prepupae 24hr  (2341) pupae 2d postWPP  (1555) pupae 3d postWPP  (876) pupae 4d postWPP  (776) adult male 01day  (1074) adult male 05day  (1222) adult male 30day  (1234) adult female 01day  (1536) adult female 05day  (2549) adult female 30day  (2459) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2942) embryo 02-04hr  (2690) embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6  (2791) larva L3 puffstage 7-9  (5228) white prepupae new  (5263) white prepupae 12hr  (3090) white prepupae 24hr  (2341) pupae 2d postWPP  (1555) pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day  (1536) adult female 05day  (2549) adult female 30day  (2459) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036448 expression level Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2942) embryo 02-04hr  (2690) embryo 04-06hr  (894) embryo 06-08hr  (968) embryo 08-10hr  (1325) embryo 10-12hr  (929) embryo 12-14hr  (1242) embryo 14-16hr  (1193) embryo 16-18hr  (1083) embryo 18-20hr  (826) embryo 20-22hr  (1352) embryo 22-24hr  (1288) larva L1  (538) larva L2  (631) larva L3 12hr old  (624) larva L3 puffstage 1-2  (1040) larva L3 puffstage 3-6  (2791) larva L3 puffstage 7-9  (5228) white prepupae new  (5263) white prepupae 12hr  (3090) white prepupae 24hr  (2341) pupae 2d postWPP  (1555) pupae 3d postWPP  (876) pupae 4d postWPP  (776) adult male 01day  (1074) adult male 05day  (1222) adult male 30day  (1234) adult female 01day  (1536) adult female 05day  (2549) adult female 30day  (2459) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2942) embryo 02-04hr  (2690) embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6  (2791) larva L3 puffstage 7-9  (5228) white prepupae new  (5263) white prepupae 12hr  (3090) white prepupae 24hr  2341 pupae 2d postWPP  1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day  1536 adult female 05day  (2549) adult female 30day  2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2942 embryo 02-04hr    2690 embryo 04-06hr    894 embryo 06-08hr    968 embryo 08-10hr    1325 embryo 10-12hr    929 embryo 12-14hr    1242 embryo 14-16hr    1193 embryo 16-18hr    1083 embryo 18-20hr    826 embryo 20-22hr    1352 embryo 22-24hr    1288 larva L1    538 larva L2    631 larva L3 12hr old    624 larva L3 puffstage 1-2    1040 larva L3 puffstage 3-6    2791 larva L3 puffstage 7-9    5228 white prepupae new    5263 white prepupae 12hr    3090 white prepupae 24hr    2341 pupae 2d postWPP    1555 pupae 3d postWPP    876 pupae 4d postWPP    776 adult male 01day    1074 adult male 05day    1222 adult male 30day    1234 adult female 01day    1536 adult female 05day    2549 adult female 30day    2459 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036448    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036448 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval hindgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036448 expression level Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules    1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut  (692.9) Larval Malpighian Tubules  (1058.7) Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye  505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules  1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules    1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036448 expression level Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules    1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut  692.9 Larval Malpighian Tubules  (1058.7) Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye  505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules  1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.625 Larval Midgut    482 Larval Hindgut    692.9 Larval Malpighian Tubules    1058.7 Larval Fat Body    295.1 Larval Salivary Gland    384.3 Larval Trachea    382.675 Larval Carcass    286.525 Adult Head    232.6 Adult Eye    505.65 Adult Brain    267.2 Adult Thoracic-Abdominal Ganglion    334.2 Adult Crop    313.2 Adult Midgut    252.8 Adult Hindgut    343 Adult Malpighian Tubules    349.7 Adult Fat Body    139.4 Adult Salivary Gland    322.1 Adult Heart    230 Adult VirginFemale Spermatheca    214.7 Adult InseminatedFemale Spermatheca    212.8 Adult Ovary    424.9 Adult Testis    140.1 Adult Male Accessory Gland    376 Adult Carcass    155.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    232.6   NA  Eye    505.65   NA  Brain    267.2   346.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    334.2   NA  Crop    313.2   482  Midgut    252.8   692.9  Hindgut    343   1058.7  Malpighian Tubules    349.7   295.1  Fat Body    139.4   384.3  Salivary Gland    322.1   NA  Heart    230   382.675  Trachea    NA   NA  VirginFemale Spermatheca    214.7   NA  InseminatedFemale Spermatheca    212.8   NA  Ovary    424.9   NA  Testis    140.1   NA  Male Accessory Gland    376   286.525  Carcass    155.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9311-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act.PU mopdsRNA.Scer\UAS.WIZ lethal, with Scer\GAL4tub.PU mopdsRNA.Scer\UAS.WIZ lethal | pupal stage, with Scer\GAL4pnr-MD237 mopGD6113 lethal | recessive mopsfv3 mopsfv11 lethal | recessive | second instar larval stage mopd10921 mopf02540 Other Phenotypes Allele increased cell death | somatic clone mopT612 increased cell number | pupal stage, with Scer\GAL4GMR.PFa mopKK100235 size defective | adult stage | somatic clone mopsfv3 visible | somatic clone mopT612 Phenotype manifest in Allele eye | somatic clone mopsfv3 eye disc | somatic clone mopT612 eye photoreceptor cell | somatic clone mopT612 mopT482 inter-ommatidial cell | pupal stage | supernumerary, with Scer\GAL4GMR.PFa mopKK100235 wing vein | somatic clone mopT612
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of mop Class Mutagen Stocks Known lesion mopd10921 P-element activity 1 Yes mopEY06090 P-element activity 1 -- mopf02540 1 Yes mopsfv11 hypomorphic allele - molecular evidence ethyl methanesulfonate 0 -- mopsfv3 hypomorphic allele - molecular evidence ethyl methanesulfonate 0 Yes mopT482 ethyl methanesulfonate 0 Yes mopT612 ethyl methanesulfonate 0 Yes mopT862 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mop Class Mutagen Stocks Known lesion mopGD6113 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mopHM05008 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mopHMS00706 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mopHMS00836 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mopKK100235 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mopCS.Scer\UAS in vitro construct - amino acid replacement 0 Yes mopdsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes mopScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes mopScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK100235} NA P{TRiP.HM05008} NA P{TRiP.HMS00706} NA P{TRiP.HMS00836} NA P{UAS-mop.CS} NA P{UAS-mop.FLAG} NA P{UAS-mop.M} NA P{UAS-mop.WIZ} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}mopf02540 NA insertion of mobile activating element P{EPgy2}mopEY06090 NA P{XP}mopd10921 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial peptide production inferred from mutant phenotype (Huang et al., 2010) positive regulation of epidermal growth factor receptor signaling pathway inferred from genetic interaction with Ras85D (Miura et al., 2008) positive regulation of Toll signaling pathway inferred from mutant phenotype (Huang et al., 2010) regulation of growth inferred from mutant phenotype (Gilbert et al., 2011) spindle assembly inferred from mutant phenotype (Chen et al., 2007)
Cellular Component
CV term Evidence References
endosome inferred from direct assay (Huang et al., 2010) ESCRT-0 complex inferred from direct assay (Huang et al., 2010) vesicle inferred from direct assay (Miura et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
protein tyrosine phosphatase activity inferred from sequence or structural similarity with EMBL:AF077000 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from electronic annotation with InterPro:IPR000242 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mop allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036448 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39610
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25181 Dere\GG13708 Dgri\GH16790 Dmoj\GI13450 Dper\GL26095 Dpse\GA23653 Dsec\GM24530 Dsim\GD12600 Dvir\GJ11811 Dwil\GK10583 Dyak\GE20003
Curated drosophilid orthologs	Dmir\CG9311 (Thornton, 2005.12.20)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010916-PA Aedes aegypti (mosquito) AGAP011586-PA Anopheles gambiae (mosquito) XP_623844.2 Apis mellifera (honey bee) 86740 Branchiostoma floridae (lancelet) BGIBMGA003089-PA Bombyx mori (silk worm) ENSBTAP00000003600 Bos taurus (bovine) CN16421 Caenorhabditis brenneri (small nematode) CE41728 Caenorhabditis elegans (worm) CPIJ011610 Culex pipens (mosquito) ENSCPOP00000020712 Cavia porcellus (guinea pig) ENSCSAVP00000002987 Ciona savignyi (sedentary tunicate) 228981 Capitella spl (polychaete worm) 194485 Daphnia pulex (daphnia) ENSDARP00000093424 Danio rerio (zebra fish) ENSECAP00000014531 Equus caballus (horse) ENSGACP00000017946 Gymnopilus aculeatus (mushroom) ENSP00000265562 Homo sapiens (human) ISCW004242-PA Ixodes scapularis (deer tick) KLLA0E23871g Kluyveromyces lactis (yeast) 38246 Monocosta brevicollis (choanoflagellate) ENSMODP00000017672 Monodelphis domestica (gray opossum) ENSMMUP00000018455 Macaca mulatta (rhesus monkey) ENSMUSP00000039580 Mus musculus (house mouse) ENSORLP00000019854 Oryzias latipes (japanese killifish) PHUM001964-PA Pediculus humanus (human body louse) PP00128 Pristionchus pacificus (nematode) ENSPPYP00000015571 Pongo pygmaeus (orangutan) ENSPTRP00000025639 Pan troglodytes (chimpanzee) ENSRNOP00000052992 Rattus norvegicus (norway rat) Smp_075810 Schistosoma mansoni (trematode parasite) XP_796684.2 Strongylocentrotus purpuratus (purple sea urchin) 60390 Trichoplax adhaerens (metazoa) XP_970590.1 Tribolium castaneum (red flour beetle) ENSTRUP00000003560 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056989 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH19872 LH19873 LH19869 ISCW004242 FBgn0237328 FBgn0212598 FBgn0199065 FBgn0184327 FBgn0179393 JGI_V11_194485 FBgn0245054 FBgn0245053 FBgn0163677 FBgn0136206 FBgn0124261 FBgn0105971 FBgn0102173 CPIJ011610 BGIBMGA003089 ACYPI49993 GB15714 GB15646 AGAP011586 AAEL010916 AAEL010914 PB19857 PB19859 PHUM135870 GLEAN_13860
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	28522 y1 v1; P{TRiP.HM05008}attP2 15817 y1 w67c23; P{EPgy2}mopEY06090 32916 y1 sc* v1; P{TRiP.HMS00706}attP2 34085 y1 sc* v1; P{TRiP.HMS00836}attP2
Harvard	- P{XP}mopd10921 - PBac{WH}mopf02540
VDRC	v104860 P{KK100235}VIE-260B v14173 w1118; P{GD6113}v14173 v14174 w1118; P{GD6113}v14174
Genomic Clones ( 2 )
	BACR11B23 BACR22J22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD03094
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH04536 RH23181 RH27823 RH29063 SD04281 SD07715 SD09568 SD10412 SD10671
Other clones	29082 99506 153678 160725 214417.63 283036 bs46b06 bs46g07 CK01.1D.E8 CK01.1D.G8 CK01.8C.G11 CK01.22D.H1 CK01.78A.C7 CK01.141D.H2 CK01.145C.B6 Dmel_dig_005491_0674_0757 EC29441 EC051229 EC055246 EC056532 EK011326 EK043847 EK118061 EK119639 EK222063 EK241902 EK264241 EK308556 ESG0114b.B21_G02 SD11910 UUGC0524
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39610
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mop CG9311 (Miura et al., 2008)
Source for database merge of
Additional comments
Other Comments
	mop promotes Egfr signaling. It acts on internalised Egfr protein, and may promote Egfr signaling by mediating its progression through the endocytic pathway. (Miura et al., 2008) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140465 RefSeq (Proteins) • NP_648722 DDBJ / EMBL / GenBank • AAF49705 AAK93500 AI531824 AW944284 AY052076 CZ477503 Entrez Gene - A searchable database of RefSeq genes. • 39610 UniProtKB/TrEMBL • Q9VUH6 Q960G3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) BRO1 domain (IPR004328)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036448 DRSC - Results from RNAi screens. • FBgn0036448 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036448 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9311-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036448 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39610 InParanoid A subset of ortholog calls from InParanoid. • AAEL010916-PA Aedes aegypti (mosquito) AGAP011586-PA Anopheles gambiae (mosquito) XP_623844.2 Apis mellifera (honey bee) 86740 Branchiostoma floridae (lancelet) BGIBMGA003089-PA Bombyx mori (silk worm) ENSBTAP00000003600 Bos taurus (bovine) CN16421 Caenorhabditis brenneri (small nematode) CE41728 Caenorhabditis elegans (worm) CPIJ011610 Culex pipens (mosquito) ENSCPOP00000020712 Cavia porcellus (guinea pig) ENSCSAVP00000002987 Ciona savignyi (sedentary tunicate) 228981 Capitella spl (polychaete worm) 194485 Daphnia pulex (daphnia) ENSDARP00000093424 Danio rerio (zebra fish) ENSECAP00000014531 Equus caballus (horse) ENSGACP00000017946 Gymnopilus aculeatus (mushroom) ENSP00000265562 Homo sapiens (human) ISCW004242-PA Ixodes scapularis (deer tick) KLLA0E23871g Kluyveromyces lactis (yeast) 38246 Monocosta brevicollis (choanoflagellate) ENSMODP00000017672 Monodelphis domestica (gray opossum) ENSMMUP00000018455 Macaca mulatta (rhesus monkey) ENSMUSP00000039580 Mus musculus (house mouse) ENSORLP00000019854 Oryzias latipes (japanese killifish) PHUM001964-PA Pediculus humanus (human body louse) PP00128 Pristionchus pacificus (nematode) ENSPPYP00000015571 Pongo pygmaeus (orangutan) ENSPTRP00000025639 Pan troglodytes (chimpanzee) ENSRNOP00000052992 Rattus norvegicus (norway rat) Smp_075810 Schistosoma mansoni (trematode parasite) XP_796684.2 Strongylocentrotus purpuratus (purple sea urchin) 60390 Trichoplax adhaerens (metazoa) XP_970590.1 Tribolium castaneum (red flour beetle) ENSTRUP00000003560 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000056989 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39610 modMine - Data generated by the modENCODE project. • FBgn0036448 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH19872 LH19873 LH19869 ISCW004242 FBgn0237328 FBgn0212598 FBgn0199065 FBgn0184327 FBgn0179393 JGI_V11_194485 FBgn0245054 FBgn0245053 FBgn0163677 FBgn0136206 FBgn0124261 FBgn0105971 FBgn0102173 CPIJ011610 BGIBMGA003089 ACYPI49993 GB15714 GB15646 AGAP011586 AAEL010916 AAEL010914 PB19857 PB19859 PHUM135870 GLEAN_13860
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG9311 (Wendler et al., 2010, Chen et al., 2007, Miura et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Brandt, 2006, Ni et al., 2010.12.1, Gilbert et al., 2011) mop (Miura et al., 2008, Huang et al., 2010, Gilbert et al., 2011) sfv (Gilbert et al., 2011)
Name Synonym	CG9311   myopic (Miura et al., 2008, Lee et al., 2009, Huang et al., 2010) slaughterhouse-five (Gilbert et al., 2011)
Secondary FlyBase IDs
References ( 27 )
Generate a list of	All references relating to this gene ( 27 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) Computer file  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Huang et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(18): 8322--8327 Endocytic pathway is required for Drosophila Toll innate immune signaling. [FBrf0210737] Wendler et al., 2010, EMBO J. 29(2): 304--314 A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. [FBrf0209739] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Show all research papers ...