FB2021_01, released Feb 18, 2021

Gene: Dmel\CG5114

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General Information
Symbol
Dmel\CG5114
Species
D. melanogaster
Name
Annotation Symbol
CG5114
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036460
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
71A4-71A4
Sequence location
3L:14,982,835..14,984,486 [+]
Recombination map

3-42

RefSeq locus
NT_037436 REGION:14982835..14984486
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\CG5114 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG5114-RA
FBtr0075624
NM_140474
1440
425
CG5114-RB
FBtr0309064
NM_001259831
1500
445
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG5114-PA
FBpp0075377
47.5
425
4.25
NP_648731
AAF49689
CG5114-PB
FBpp0301081
49.8
445
4.35
NP_001246760
AFH04431
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG5114 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG5114 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG5114
Transgenic constructs containing regulatory region of CG5114
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation
Gene disrupted in
Df(3L)Exel6125
(Ryder, 2004.4.26)
Df(3L)Exel6126
(Ryder, 2004.4.26)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AAMP
15 of 15
Yes
Yes
Hsap\NWD2
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aamp
14 of 15
Yes
Yes
Mmus\Nwd2
2 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Aamp
12 of 13
Yes
Yes
Rnor\Nwd2
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\aamp
13 of 12
Yes
Yes
Xtro\thul16
1 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\aamp
14 of 15
Yes
Yes
Drer\nwd2
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\Y111B2A.12
12 of 15
Yes
Yes
Cele\ZK430.7
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G71840
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SQT1
13 of 15
Yes
Yes
Scer\MDV1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAC25H1.08c
10 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A0M )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004093
Drosophila simulans
Dsim\GD14515
Drosophila sechellia
Dsec\GM25495
Drosophila erecta
Dere\GG15707
Drosophila yakuba
Dyak\GE22038
Drosophila ananassae
Dana\GF23794
Drosophila pseudoobscura pseudoobscura
Dpse\GA18669
Drosophila persimilis
Dper\GL24686
Drosophila willistoni
Dwil\GK10547
Drosophila virilis
Dvir\GJ11602
Drosophila mojavensis
Dmoj\GI11348
Drosophila grimshawi
Dgri\GH16663
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508AY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017722
Glossina morsitans
Tsetse fly
Gmor\GMOY010389
Glossina morsitans
Tsetse fly
Gmor\GMOY008296
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04645
Mayetiola destructor
Hessian fly
Mdes\Mdes015354
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008147
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014159
Anopheles darlingi
American malaria mosquito
Adar\ADAC004326
Anopheles gambiae
Malaria mosquito
Agam\AGAP011387
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015011
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08O8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003177
Danaus plexippus
Monarch butterfly
Dple\DPOGS211189-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012436
Apis florea
Little honeybee
Aflo\2886797988
Apis mellifera
Western honey bee
Amel\LOC410350
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21896
Bombus terrestris
Buff-tailed bumblebee
Bter\15211582
Linepithema humile
Argentine ant
Lhum\LH12205
Linepithema humile
Argentine ant
Lhum\LH12215
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003d7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015530
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06198
Tribolium castaneum
Red flour beetle
Tcas\TC013192
Pediculus humanus
Human body louse
Phum\PHUM463240
Rhodnius prolixus
Kissing bug
Rpro\RPRC015403
Cimex lectularius
Bed bug
Clec\CLEC008946
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02742
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08585
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15821
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08808
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07680
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08JT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW017622
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_187565
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G093C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aamp
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027737gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006701
Gallus gallus
Domestic chicken
Ggal\AAMP
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AAMP; angio associated migratory cell protein
    15 of 15
    603488
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-42

        Cytogenetic map
        71A4-71A4
        Sequence location
        3L:14,982,835..14,984,486 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        71A4-71A4
        Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-42

        (FlyBase, 2016)

        3-36.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (4)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (75)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        dsRNA made from templates generated with primers directed against this gene in combination with dsRNA against gig results in suppression of the final average cell size, with it being closer to the control average cell size, rather than the average cell size resulting from knockdown of the candidate gene alone.

        (Guertin et al., 2006)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 37 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (1)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (27)