FB2020_01, released Feb 12, 2020

Gene: Dmel\Toll-6

Open Close
General Information
Symbol
Dmel\Toll-6
Species
D. melanogaster
Name
Toll-6
Annotation Symbol
CG7250
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036494
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Toll-6 (Toll-6) encodes a member of the Toll-like receptor family. It has neurotrophin receptor activity and contributes to dendrite guidance. Genetic interaction with 18w and Tollo suggests a Toll-6 role in convergent extension during early embryogenesis. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

Tl-6

Key Links
Genomic Location
Cytogenetic map
71C2-71C2
Sequence location
3L:15,336,692..15,344,315 [+]
Recombination map

3-43

RefSeq locus
NT_037436 REGION:15336692..15344315
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Toll-like receptor family. (Q9VUN0)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
neurotrophin receptor activity
Predictions / Assertions
heparin binding; Roundabout binding
Summaries
Gene Group (FlyBase)
TOLL RECEPTORS -
The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).
Protein Function (UniProtKB)
Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
(UniProt, Q9VUN0)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Toll-6 or the JBrowse view of Dmel\Toll-6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

<new comment>

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Toll-6-RA
FBtr0075614
NM_079357
5517
1514
Toll-6-RB
FBtr0306307
NM_001259836
5746
1514
Toll-6-RC
FBtr0306308
NM_001259837
7624
1514
Additional Transcript Data and Comments
Reported size (kB)

8.6, 6.4 (northern blot)

(Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Toll-6-PA
FBpp0075367
170.2
1514
6.45
NP_524081
AAF49645
Toll-6-PB
FBpp0297410
170.2
1514
6.45
NP_001246765
AFH04436
Toll-6-PC
FBpp0297411
170.2
1514
6.45
NP_001246766
AFH04437
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1514 aa isoforms: Toll-6-PA, Toll-6-PB, Toll-6-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

1514 (aa)

(Tauszig et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
neurotrophin receptor activity
inferred from mutant phenotype
(McIlroy et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
heparin binding
inferred from biological aspect of ancestor with PANTHER:PTN002911633
(assigned by GO_Central )
(Gaudet et al., 2011)
Roundabout binding
inferred from biological aspect of ancestor with PANTHER:PTN002911633
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
axis elongation
inferred from genetic interaction with FLYBASE:18w; FB:FBgn0004364, FLYBASE:Tollo; FB:FBgn0029114
(Paré et al., 2014)
convergent extension
inferred from genetic interaction with FLYBASE:18w; FB:FBgn0004364, FLYBASE:Tollo; FB:FBgn0029114
(Paré et al., 2014)
dendrite guidance
inferred from mutant phenotype
(Ward et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
signal transduction
inferred from electronic annotation with InterPro:IPR000157
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)
maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic stage 5
organism | pair rule expression pattern
(Kambris et al., 2002)
embryonic stage 6
organism | segment polarity expression pattern
(Kambris et al., 2002)
embryonic stage 11
embryonic neuroblast
(Kambris et al., 2002)
embryonic stage 10 -- 13
embryonic/larval neuron | subset
(Kambris et al., 2002)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Tauszig et al., 2000)
embryonic stage
(Tauszig et al., 2000)
Additional Descriptive Data

Toll-6 is expressed dynamically through much of embryogenesis. Expression begins at the cellular blastoderm stage in several bands, the most anterior bands appearing first. At the beginning of germ band extension, a pattern of alternating strong and weak stripes is seen. At the extended germ band stage, expression is strongest in delaminating neuroblasts. At germ band retraction, expression is weaker and is mostly in the CNS. Double staining with an anti-eve antibody shows that Toll-6 is expressed in a subset of CNS neurons and in elav negative cells that may be lateral glia.

(Kambris et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
pharate adult stage P8
antennal lobe glomerulus DA1
(Ward et al., 2015)
antennal lobe glomerulus VA1d
(Ward et al., 2015)
antennal lobe glomerulus VA1v
(Ward et al., 2015)
antennal lobe glomerulus DL3
(Ward et al., 2015)
antennal lobe glomerulus DC3
(Ward et al., 2015)
antennal lobe glomerulus DC1
(Ward et al., 2015)
antennal lobe glomerulus DA4l
(Ward et al., 2015)
antennal lobe glomerulus DA4m
(Ward et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Toll-6 protein is enriched in glomeruli of the lateral antennal lobe, which are all innervated by trichoid olfactory receptor neurons.

(Ward et al., 2015)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.un}Toll-6MI02127-TG4.un
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval motor neuron
(Ulian-Benitez et al., 2017)
Reporter: P{GawB}D42
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
motor neuron
(Yeh et al., 1995)
adult stage
motor neuron
(Wittmann et al., 2001)
motor neuron | subset
(Boerner and Duch, 2010, Nitz et al., 2002)
adult brain | restricted
(Nitz et al., 2002)
indirect flight muscle motor neuron MN1
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN2
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN3
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN4
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN5
(Boerner and Duch, 2010)
adult antennal lobe commissure | restricted
(Ward et al., 2015)
adult antennal lobe projection neuron | subset
(Ward et al., 2015)
adult brain
(Legan et al., 2008)
ventral nerve cord
(Legan et al., 2008)
adult fat body
(Legan et al., 2008)
adult oenocyte
(Legan et al., 2008)
larval stage
motor neuron
(Hazelett et al., 2012, Nitz et al., 2002)
pupal stage P6 -- pharate adult stage P15
indirect flight muscle motor neuron MN5
(Vonhoff et al., 2013)
third instar larval stage
embryonic/larval motor neuron
(Coyne et al., 2014)
embryonic/larval salivary gland
(Ruppert et al., 2017)
ventral nerve cord
(Sanyal, 2009)
embryonic/larval brain
(Sanyal, 2009)
motor neuron
(Sanyal, 2009)
RP2 motor neuron
(Sanyal, 2009)
aCC neuron
(Sanyal, 2009)
sensory neuron
(Sanyal, 2009)
pharate adult stage P8
antennal lobe glomerulus DA1
(Ward et al., 2015)
antennal lobe glomerulus VA1d
(Ward et al., 2015)
antennal lobe glomerulus VA1v
(Ward et al., 2015)
antennal lobe glomerulus DL3
(Ward et al., 2015)
antennal lobe glomerulus DC3
(Ward et al., 2015)
antennal lobe glomerulus DC1
(Ward et al., 2015)
antennal lobe glomerulus DA4l
(Ward et al., 2015)
antennal lobe glomerulus DA4m
(Ward et al., 2015)
late embryonic stage
(Gustafson and Boulianne, 1996)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Toll-6 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Toll-6
Transgenic constructs containing regulatory region of Toll-6
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4e22c
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
decreased cell death, with Scer\GAL4elav-C155
increased cell death | pupal stage, with Scer\GAL4elav.PU
increased cell number | third instar larval stage, with Scer\GAL4elav.PU
neuroanatomy defective, with Scer\GAL4elav-C155
neuroanatomy defective | adult stage
neuroanatomy defective | adult stage, with Scer\GAL4AM29
neuroanatomy defective | adult stage, with Scer\GAL4elav-C155
neuroanatomy defective | adult stage, with Scer\GAL4GMR71D09
neuroanatomy defective | adult stage | somatic clone
neuroanatomy defective | larval stage (with Df(3L)BSC578)
size defective | larval stage (with Df(3L)BSC578)
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult abdomen, with Scer\GAL432B
adult abdomen, with Scer\GAL471B
adult abdomen, with Scer\GAL4da.G32
adult antennal lobe projection neuron DA1 lPN | somatic clone
adult antennal lobe projection neuron DC3 adPN | somatic clone
adult antennal lobe projection neuron VA1d adPN
adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4elav-C155
adult antennal lobe projection neuron VA1d adPN | somatic clone
adult antennal lobe projection neuron VA1v vPN | somatic clone
adult antennal lobe projection neuron VM6+VP1 adPN, with Scer\GAL4GMR71D09
adult olfactory receptor neuron Or67a, with Scer\GAL4AM29
adult olfactory receptor neuron Or88a
adult olfactory receptor neuron Or88a, with Scer\GAL4elav-C155
axon | larval stage (with Df(3L)BSC578)
dendrite, with Scer\GAL4GMR71D09
dendrite | somatic clone
embryonic/larval central nervous system, with Scer\GAL4elav-C155
eye, with Scer\GAL432B
eye, with Scer\GAL4da.G32
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4lz-gal4
eye, with Scer\GAL4ptc-559.1
leg, with Scer\GAL432B
leg, with Scer\GAL4ptc-559.1
macrochaeta | ectopic, with Scer\GAL432B
macrochaeta | ectopic, with Scer\GAL4da.G32
neuromuscular junction | larval stage, with Scer\GAL4Toll-6-D42
neuromuscular junction | larval stage (with Df(3L)BSC578)
neuron | supernumerary | third instar larval stage, with Scer\GAL4elav.PU
presynaptic active zone | larval stage, with Scer\GAL4Toll-6-D42
presynaptic active zone | larval stage (with Df(3L)BSC578)
trichogen cell, with Scer\GAL4pnr-MD237
type I bouton | larval stage (with Df(3L)BSC578)
ventral nerve cord | pupal stage, with Scer\GAL4elav.PU
ventral nerve cord | third instar larval stage, with Scer\GAL4elav.PU
wing, with Scer\GAL4dpp.PS
wing, with Scer\GAL4ptc-559.1
wing disc, with Scer\GAL4dpp.PS
wing vein, with Scer\GAL4da.G32
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (36)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TLR3
2 of 15
Yes
No
 
Hsap\TLR7
2 of 15
Yes
Yes
Hsap\TLR9
2 of 15
Yes
Yes
Hsap\CD180
1 of 15
No
No
Hsap\CHADL
1 of 15
No
No
Hsap\CPN2
1 of 15
No
No
Hsap\FBXL13
1 of 15
No
No
Hsap\FBXL14
1 of 15
No
No
Hsap\GP5
1 of 15
No
No
Hsap\IL1RAPL2
1 of 15
No
Yes
 
Hsap\LGI1
1 of 15
No
Yes
Hsap\LGI2
1 of 15
No
Yes
Hsap\LGI3
1 of 15
No
Yes
Hsap\LGI4
1 of 15
No
Yes
Hsap\LGR6
1 of 15
No
No
Hsap\LINGO3
1 of 15
No
No
Hsap\LRFN1
1 of 15
No
No
Hsap\LRFN5
1 of 15
No
Yes
Hsap\LRRC15
1 of 15
No
No
Hsap\LRRN3
1 of 15
No
No
Hsap\LRRTM1
1 of 15
No
No
Hsap\LRRTM2
1 of 15
No
No
Hsap\LRRTM3
1 of 15
No
No
Hsap\LRRTM4
1 of 15
No
No
Hsap\LRTM1
1 of 15
No
Yes
Hsap\LRTM2
1 of 15
No
No
Hsap\SLIT1
1 of 15
No
No
Hsap\SLIT2
1 of 15
No
No
Hsap\SLIT3
1 of 15
No
No
Hsap\TLR1
1 of 15
No
No
 
Hsap\TLR2
1 of 15
No
No
 
Hsap\TLR4
1 of 15
No
No
Hsap\TLR5
1 of 15
No
No
Hsap\TLR6
1 of 15
No
No
Hsap\TLR8
1 of 15
No
No
 
Hsap\TLR10
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tlr13
4 of 15
Yes
No
Mmus\Tlr3
2 of 15
No
No
Mmus\Tlr7
2 of 15
No
Yes
Mmus\Tlr9
2 of 15
No
Yes
Mmus\Cd180
1 of 15
No
No
Mmus\Igfals
1 of 15
No
No
Mmus\Il1rapl2
1 of 15
No
Yes
Mmus\Lgi1
1 of 15
No
Yes
Mmus\Lgi2
1 of 15
No
Yes
Mmus\Lgi3
1 of 15
No
Yes
Mmus\Lgi4
1 of 15
No
Yes
Mmus\Lgr4
1 of 15
No
No
Mmus\Lingo3
1 of 15
No
No
Mmus\Lrfn5
1 of 15
No
Yes
Mmus\Lrrn3
1 of 15
No
No
Mmus\Lrrtm1
1 of 15
No
No
Mmus\Lrrtm2
1 of 15
No
No
Mmus\Lrrtm3
1 of 15
No
No
Mmus\Lrrtm4
1 of 15
No
No
Mmus\Lrtm1
1 of 15
No
Yes
Mmus\Lrtm2
1 of 15
No
Yes
Mmus\Rtn4rl1
1 of 15
No
Yes
Mmus\Rtn4r
1 of 15
No
Yes
Mmus\Slit1
1 of 15
No
No
Mmus\Slit2
1 of 15
No
No
Mmus\Slit3
1 of 15
No
No
Mmus\Tlr1
1 of 15
No
No
Mmus\Tlr2
1 of 15
No
No
Mmus\Tlr4
1 of 15
No
No
Mmus\Tlr5
1 of 15
No
No
Mmus\Tlr6
1 of 15
No
No
Mmus\Tlr8
1 of 15
No
No
Mmus\Tlr12
1 of 15
No
No
Rattus norvegicus (Norway rat) (33)
Rnor\Tlr3
2 of 13
Yes
No
Rnor\Tlr7
2 of 13
Yes
Yes
Rnor\Cd180
1 of 13
No
No
Rnor\Lgi1
1 of 13
No
Yes
Rnor\Lgi3
1 of 13
No
Yes
Rnor\Lgi4
1 of 13
No
Yes
Rnor\Lgr4
1 of 13
No
No
Rnor\Lgr6
1 of 13
No
No
Rnor\Lingo3
1 of 13
No
Yes
Rnor\LOC102547963
1 of 13
No
Yes
Rnor\Lrfn5
1 of 13
No
Yes
Rnor\Lrrn3
1 of 13
No
No
Rnor\LRRTM1
1 of 13
No
No
Rnor\Lrrtm2
1 of 13
No
No
Rnor\Lrrtm3
1 of 13
No
No
Rnor\Lrrtm4
1 of 13
No
No
Rnor\Lrtm2
1 of 13
No
No
Rnor\Rtn4rl1
1 of 13
No
Yes
Rnor\Rtn4r
1 of 13
No
Yes
Rnor\Slit1
1 of 13
No
No
Rnor\Slit2
1 of 13
No
No
Rnor\Slit3
1 of 13
No
No
Rnor\Slitrk1
1 of 13
No
Yes
Rnor\Slitrk2
1 of 13
No
Yes
Rnor\Slitrk3
1 of 13
No
Yes
Rnor\Slitrk5
1 of 13
No
Yes
Rnor\Slitrk6
1 of 13
No
Yes
Rnor\Tlr2
1 of 13
No
No
Rnor\Tlr4
1 of 13
No
No
Rnor\Tlr5
1 of 13
No
No
Rnor\Tlr8
1 of 13
No
No
Rnor\Tlr9
1 of 13
No
No
Rnor\Tlr12
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\LOC100485164
3 of 12
Yes
Yes
Xtro\LOC100485706
3 of 12
Yes
Yes
Xtro\tlr3
2 of 12
No
No
Xtro\tlr7
2 of 12
No
Yes
Xtro\LOC100485201
1 of 12
No
No
Xtro\LOC100485512
1 of 12
No
No
Xtro\LOC100495326
1 of 12
No
No
Xtro\LOC101730277
1 of 12
No
Yes
Xtro\lrfn2
1 of 12
No
Yes
Xtro\lrfn5
1 of 12
No
No
Xtro\lrrn1-like
1 of 12
No
Yes
Xtro\lrrtm1
1 of 12
No
Yes
Xtro\lrrtm3
1 of 12
No
Yes
Xtro\lrrtm4
1 of 12
No
Yes
Xtro\rtn4rl2
1 of 12
No
Yes
Xtro\tlr2
1 of 12
No
No
Xtro\tlr5
1 of 12
No
No
Xtro\tlr6
1 of 12
No
No
Xtro\tlr9
1 of 12
No
No
Danio rerio (Zebrafish) (46)
Drer\tlr21
3 of 15
Yes
No
Drer\tlr3
2 of 15
No
No
Drer\tlr4ba
2 of 15
No
No
Drer\tlr4bb
2 of 15
No
No
Drer\tlr7
2 of 15
No
Yes
Drer\cd180
1 of 15
No
No
Drer\chad
1 of 15
No
Yes
Drer\lgi1a
1 of 15
No
Yes
Drer\lgi1b
1 of 15
No
Yes
Drer\lgi2a
1 of 15
No
Yes
Drer\lgi3
1 of 15
No
Yes
Drer\LOC563710
1 of 15
No
No
Drer\LOC572462
1 of 15
No
No
Drer\LOC100332583
1 of 15
No
No
Drer\lrfn4a
1 of 15
No
Yes
Drer\lrrc4bb
1 of 15
No
No
Drer\lrrc15
1 of 15
No
No
Drer\lrrc17
1 of 15
No
Yes
Drer\lrrn1
1 of 15
No
No
Drer\lrrtm1
1 of 15
No
No
Drer\lrrtm2
1 of 15
No
Yes
Drer\lrrtm4
1 of 15
No
Yes
Drer\lrrtm4l1
1 of 15
No
Yes
Drer\lrrtm4l2
1 of 15
No
Yes
Drer\lrtm1
1 of 15
No
Yes
Drer\lrtm2a
1 of 15
No
Yes
Drer\rtn4r
1 of 15
No
Yes
Drer\rtn4rl1b
1 of 15
No
Yes
Drer\si:dkey-182i3.11
1 of 15
No
No
Drer\slit1a
1 of 15
No
No
Drer\slit2
1 of 15
No
No
Drer\slit3
1 of 15
No
No
Drer\tlr1
1 of 15
No
No
Drer\tlr2
1 of 15
No
No
Drer\tlr5a
1 of 15
No
No
Drer\tlr5b
1 of 15
No
No
Drer\tlr8b
1 of 15
No
No
Drer\tlr9
1 of 15
No
No
Drer\tlr18
1 of 15
No
No
Drer\tlr19
1 of 15
No
No
Drer\tlr20.2
1 of 15
No
No
Drer\tlr20.4
1 of 15
No
No
Drer\tlr22
1 of 15
No
No
Drer\vasna
1 of 15
No
Yes
Drer\zgc:101569
1 of 15
No
No
Drer\zmp:0000001073
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\tol-1
9 of 15
Yes
No
Cele\let-4
1 of 15
No
No
Cele\lron-5
1 of 15
No
Yes
Cele\pan-1
1 of 15
No
Yes
Cele\slt-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (22)
Atha\AT1G15740
1 of 9
Yes
No
Atha\AT1G74360
1 of 9
Yes
Yes
Atha\AT2G24230
1 of 9
Yes
Yes
Atha\AT4G23840
1 of 9
Yes
Yes
Atha\AT5G23340
1 of 9
Yes
No
Atha\AT5G58150
1 of 9
Yes
Yes
Atha\BRI1
1 of 9
Yes
Yes
Atha\BRL1
1 of 9
Yes
Yes
Atha\BRL2
1 of 9
Yes
Yes
Atha\BRL3
1 of 9
Yes
Yes
Atha\EBF1
1 of 9
Yes
No
Atha\EMS1
1 of 9
Yes
Yes
Atha\GHR1
1 of 9
Yes
No
Atha\PSKR1
1 of 9
Yes
Yes
Atha\PSKR2
1 of 9
Yes
Yes
Atha\PSY1R
1 of 9
Yes
Yes
Atha\RLP12
1 of 9
Yes
No
Atha\RLP19
1 of 9
Yes
No
Atha\RLP34
1 of 9
Yes
Yes
Atha\RLP35
1 of 9
Yes
No
Atha\RLP38
1 of 9
Yes
Yes
Atha\RLP53
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900IQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Toll-6
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012250
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011433
Drosophila simulans
Dsim\GD14538
Drosophila sechellia
Dsec\GM25524
Drosophila erecta
Dere\GG15893
Drosophila yakuba
Dyak\GE22235
Drosophila ananassae
Dana\GF23695
Drosophila pseudoobscura pseudoobscura
Dpse\GA20210
Drosophila persimilis
Dper\GL24793
Drosophila willistoni
Dwil\GK20408
Drosophila virilis
Dvir\GJ13853
Drosophila mojavensis
Dmoj\GI13107
Drosophila grimshawi
Dgri\GH14533
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500DJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022520
Glossina morsitans
Tsetse fly
Gmor\GMOY000089
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07009
Mayetiola destructor
Hessian fly
Mdes\Mdes005843
Mayetiola destructor
Hessian fly
Mdes\Mdes005842
Aedes aegypti
Yellow fever mosquito
Aaeg\TOLL6
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018343
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00D1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011085
Bombyx mori
Silkmoth
Bmor\BGIBMGA011084
Danaus plexippus
Monarch butterfly
Dple\DPOGS203198-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203200-PA
Heliconius melpomene
Postman butterfly
Hmel\TLR-D
Heliconius melpomene
Postman butterfly
Hmel\TLR-F
Heliconius melpomene
Postman butterfly
Hmel\TLR-B
Apis florea
Little honeybee
Aflo\3842004980
Apis florea
Little honeybee
Aflo\3326142260
Apis mellifera
Western honey bee
Amel\Toll-8
Apis mellifera
Western honey bee
Amel\Toll-6
Apis mellifera
Western honey bee
Amel\GB42391
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10653
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10655
Bombus terrestris
Buff-tailed bumblebee
Bter\15213496
Bombus terrestris
Buff-tailed bumblebee
Bter\15213502
Linepithema humile
Argentine ant
Lhum\LH19752
Linepithema humile
Argentine ant
Lhum\LH19746
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024d8
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG023102
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020216
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02320
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09495
Tribolium castaneum
Red flour beetle
Tcas\tollo
Tribolium castaneum
Red flour beetle
Tcas\Toll-6
Pediculus humanus
Human body louse
Phum\PHUM107160
Pediculus humanus
Human body louse
Phum\PHUM108410
Rhodnius prolixus
Kissing bug
Rpro\RPRC004104
Cimex lectularius
Bed bug
Clec\CLEC011496
Cimex lectularius
Bed bug
Clec\CLEC013100
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005417
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002754
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00888
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10041
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00OH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008376
Ixodes scapularis
Black-legged tick
Isca\ISCW020989
Ixodes scapularis
Black-legged tick
Isca\ISCW022740
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66468.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59381.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72911.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g04990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g01180
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_128614
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_65779
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_10255
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0137 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-TlrL_12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tlr132
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tlr066
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tlr041
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (31)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Tollo
6 of 10
Toll-7
5 of 10
18w
4 of 10
Tehao
2 of 10
Tl
2 of 10
atk
1 of 10
caps
1 of 10
CG4168
1 of 10
CG5810
1 of 10
CG6749
1 of 10
CG7509
1 of 10
CG7896
1 of 10
CG14762
1 of 10
CG18095
1 of 10
CG42346
1 of 10
CG42709
1 of 10
chp
1 of 10
Con
1 of 10
conv
1 of 10
Fili
1 of 10
Gp150
1 of 10
Grip128
1 of 10
haf
1 of 10
lbk
1 of 10
Lrt
1 of 10
MstProx
1 of 10
rdo
1 of 10
sli
1 of 10
Toll-4
1 of 10
Toll-9
1 of 10
trn
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Toll-6
    suppressible
    kek6
    (Ulian-Benitez et al., 2017)
    Toll-6
    enhanceable
    Myd88
    (Foldi et al., 2017)
    Toll-6
    suppressible
    Toll-7
    (Ward et al., 2015)
    NT1|Toll-6
    suppressible
    Toll-7
    (McIlroy et al., 2013)
    Toll-6
    suppressible
    wek
    (Foldi et al., 2017)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Myd88
    enhanceable
    Toll-6
    (Foldi et al., 2017)
    Myd88
    enhanceable
    Toll-6|Toll-7
    (Foldi et al., 2017)
    NT1|spz5
    suppressible
    Toll-6
    (McIlroy et al., 2013)
    spz
    suppressible
    Toll-6
    (McIlroy et al., 2013)
    Toll-7
    enhanceable
    Toll-6
    (Yagi et al., 2010)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-43

    Cytogenetic map
    71C2-71C2
    Sequence location
    3L:15,336,692..15,344,315 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    71C2-71C2
    Limits computationally determined from genome sequence between P{lacW}cp309s2172&P{lacW}l(3)j2A2j2A2 and P{EP}Tfb2EP572
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    71C1-71D2
    (Tauszig, 2000.3.23)
    Experimentally Determined Recombination Data
    Location

    3-43

    (FlyBase, 2016)

    3-36.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (21)
    cDNA Clones (181)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Mishra-Gorur et al., 2019, Ward A., 2015.10.7, Ward et al., 2015)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Toll-6 CG7250

    (Imler, 2000.10.17, FlyBase, 1996-)
    Source for database merge of
    Additional comments

    The Toll-6 gene may have been derived from the Gp150 gene by retroposition.

    (Pan and Zhang, 2009)

    Source for identity of Toll-6 CG7250 was sequence comparison ( date:000721 ).

    (FlyBase, 1996-)
    Other Comments

    Toll-6 acts cell autonomously to instruct the targeting of specific classes of projection neuron dendrites.

    (Ward et al., 2015)

    18w, Tollo, and Toll-6 act in combination to regulate axis elongation.

    (Paré et al., 2014)

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    (Kiger et al., 2003)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 44 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (14)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (77)