FB2022_02, released March 29, 2022

Gene: Dmel\Toll-6

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General Information
Symbol
Dmel\Toll-6
Species
D. melanogaster
Name
Toll-6
Annotation Symbol
CG7250
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036494
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Toll-6 (Toll-6) encodes a member of the Toll-like receptor family. It has neurotrophin receptor activity and contributes to dendrite guidance. Genetic interaction with 18w and Tollo suggests a Toll-6 role in convergent extension during early embryogenesis. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Tl-6

Key Links
Genomic Location
Cytogenetic map
71C2-71C2
Sequence location
Recombination map
3-43
RefSeq locus
NT_037436 REGION:15336692..15344315
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables neurotrophin receptor activity
inferred from mutant phenotype
(McIlroy et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables heparin binding
inferred from biological aspect of ancestor with PANTHER:PTN002911633
(assigned by GO_Central )
(Gaudet et al., 2011)
enables Roundabout binding
inferred from biological aspect of ancestor with PANTHER:PTN002911633
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in axis elongation
inferred from genetic interaction with FLYBASE:Tollo; FB:FBgn0029114, FLYBASE:18w; FB:FBgn0287775
(Paré et al., 2014)
involved_in convergent extension
inferred from genetic interaction with FLYBASE:Tollo; FB:FBgn0029114, FLYBASE:18w; FB:FBgn0287775
(Paré et al., 2014)
involved_in dendrite guidance
inferred from mutant phenotype
(Ward et al., 2015)
involved_in regulation of synaptic plasticity
inferred from genetic interaction with FLYBASE:spz5; FB:FBgn0035379, FLYBASE:kek6; FB:FBgn0039862
(Ulian-Benitez et al., 2017)
involved_in signal transduction
inferred from mutant phenotype
(Chowdhury et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN002911625
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Toll-like receptor family. (Q9VUN0)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Toll-6 (Toll-6) encodes a member of the Toll-like receptor family. It has neurotrophin receptor activity and contributes to dendrite guidance. Genetic interaction with 18w and Tollo suggests a Toll-6 role in convergent extension during early embryogenesis. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
TOLL RECEPTORS -
The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).
Protein Function (UniProtKB)
Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
(UniProt, Q9VUN0)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Toll-6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VUN0)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

<new comment>

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Toll-6-RA
FBtr0075614
NM_079357
5517
1514
Toll-6-RB
FBtr0306307
NM_001259836
5746
1514
Toll-6-RC
FBtr0306308
NM_001259837
7624
1514
Additional Transcript Data and Comments
Reported size (kB)

8.6, 6.4 (northern blot)

(Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Toll-6-PA
FBpp0075367
170.2
1514
6.45
NP_524081
AAF49645
Toll-6-PB
FBpp0297410
170.2
1514
6.45
NP_001246765
AFH04436
Toll-6-PC
FBpp0297411
170.2
1514
6.45
NP_001246766
AFH04437
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1514 aa isoforms: Toll-6-PA, Toll-6-PB, Toll-6-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

1514 (aa)

(Tauszig et al., 2000)
Comments
External Data
Domain

The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

(UniProt, Q9VUN0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
organism | pair rule expression pattern
(Kambris et al., 2002)
embryonic stage 6
organism | segment polarity expression pattern
(Kambris et al., 2002)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
labial sensory complex primordium

Comment: reported as labial complex specific anlage

(Fisher et al., 2012)
maxillary sensory complex primordium

Comment: reported as maxillary organ specific anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 10 -- 13
embryonic/larval neuron | subset
(Kambris et al., 2002)
embryonic stage 11
embryonic neuroblast
(Kambris et al., 2002)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Tauszig et al., 2000)
embryonic stage -- adult stage
(Tauszig et al., 2000)
Additional Descriptive Data

Toll-6 is expressed dynamically through much of embryogenesis. Expression begins at the cellular blastoderm stage in several bands, the most anterior bands appearing first. At the beginning of germ band extension, a pattern of alternating strong and weak stripes is seen. At the extended germ band stage, expression is strongest in delaminating neuroblasts. At germ band retraction, expression is weaker and is mostly in the CNS. Double staining with an anti-eve antibody shows that Toll-6 is expressed in a subset of CNS neurons and in elav negative cells that may be lateral glia.

(Kambris et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
pharate adult stage P8
antennal lobe glomerulus DA1
(Ward et al., 2015)
antennal lobe glomerulus VA1d
(Ward et al., 2015)
antennal lobe glomerulus VA1v
(Ward et al., 2015)
antennal lobe glomerulus DL3
(Ward et al., 2015)
antennal lobe glomerulus DC3
(Ward et al., 2015)
antennal lobe glomerulus DC1
(Ward et al., 2015)
antennal lobe glomerulus DA4l
(Ward et al., 2015)
antennal lobe glomerulus DA4m
(Ward et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Toll-6 protein is enriched in glomeruli of the lateral antennal lobe, which are all innervated by trichoid olfactory receptor neurons.

(Ward et al., 2015)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.0}Toll-6MI02127-TG4.0
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval motor neuron
(Ulian-Benitez et al., 2017)
Reporter: P{GawB}D42
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
motor neuron
(Yeh et al., 1995)
late embryonic stage
(Gustafson and Boulianne, 1996)
larval stage
motor neuron
(Hazelett et al., 2012, Nitz et al., 2002)
third instar larval stage
embryonic/larval motor neuron
(Coyne et al., 2014)
embryonic/larval salivary gland
(Ruppert et al., 2017)
larval ventral nerve cord
(Sanyal, 2009)
embryonic/larval brain
(Sanyal, 2009)
motor neuron
(Sanyal, 2009)
RP2 motor neuron
(Sanyal, 2009)
aCC neuron
(Sanyal, 2009)
sensory neuron
(Sanyal, 2009)
pupal stage P6 -- pharate adult stage P15
indirect flight muscle motor neuron MN5
(Vonhoff et al., 2013)
pharate adult stage P8
antennal lobe glomerulus DA1
(Ward et al., 2015)
antennal lobe glomerulus VA1d
(Ward et al., 2015)
antennal lobe glomerulus VA1v
(Ward et al., 2015)
antennal lobe glomerulus DL3
(Ward et al., 2015)
antennal lobe glomerulus DC3
(Ward et al., 2015)
antennal lobe glomerulus DC1
(Ward et al., 2015)
antennal lobe glomerulus DA4l
(Ward et al., 2015)
antennal lobe glomerulus DA4m
(Ward et al., 2015)
adult stage
motor neuron
(Wittmann et al., 2001)
motor neuron | subset
(Boerner and Duch, 2010, Nitz et al., 2002)
adult brain | restricted
(Nitz et al., 2002)
indirect flight muscle motor neuron MN1
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN2
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN3
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN4
(Boerner and Duch, 2010)
indirect flight muscle motor neuron MN5
(Boerner and Duch, 2010)
adult antennal lobe commissure | restricted
(Ward et al., 2015)
adult antennal lobe projection neuron | subset
(Ward et al., 2015)
adult brain
(Legan et al., 2008)
larval ventral nerve cord
(Legan et al., 2008)
adult fat body
(Legan et al., 2008)
adult oenocyte
(Legan et al., 2008)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Toll-6 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Toll-6
Transgenic constructs containing regulatory region of Toll-6
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4e22c
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Scer\GAL4AM29
abnormal neuroanatomy | adult stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR71D09
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage (with Df(3L)BSC578)
abnormal size | larval stage (with Df(3L)BSC578)
decreased cell death, with Scer\GAL4elav-C155
increased cell death | pupal stage, with Scer\GAL4elav.PU
increased cell number | third instar larval stage, with Scer\GAL4elav.PU
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult abdomen, with Scer\GAL432B
adult abdomen, with Scer\GAL471B
adult abdomen, with Scer\GAL4da.G32
adult antennal lobe projection neuron DA1 lPN | somatic clone
adult antennal lobe projection neuron DC3 adPN | somatic clone
adult antennal lobe projection neuron VA1d adPN
adult antennal lobe projection neuron VA1d adPN, with Scer\GAL4elav-C155
adult antennal lobe projection neuron VA1d adPN | somatic clone
adult antennal lobe projection neuron VA1v vPN | somatic clone
adult antennal lobe projection neuron VM6 adPN, with Scer\GAL4GMR71D09
adult olfactory receptor neuron Or67a, with Scer\GAL4AM29
adult olfactory receptor neuron Or88a
adult olfactory receptor neuron Or88a, with Scer\GAL4elav-C155
axon | larval stage (with Df(3L)BSC578)
dendrite, with Scer\GAL4GMR71D09
dendrite | somatic clone
embryonic/larval central nervous system, with Scer\GAL4elav-C155
epithelial cell of wing disc | somatic clone, with Scer\GAL4Act5C.PP
eye, with Scer\GAL432B
eye, with Scer\GAL4da.G32
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4lz-gal4
eye, with Scer\GAL4ptc-559.1
larval ventral nerve cord | pupal stage, with Scer\GAL4elav.PU
larval ventral nerve cord | third instar larval stage, with Scer\GAL4elav.PU
leg, with Scer\GAL432B
leg, with Scer\GAL4ptc-559.1
macrochaeta | ectopic, with Scer\GAL432B
macrochaeta | ectopic, with Scer\GAL4da.G32
neuromuscular junction | larval stage, with Scer\GAL4Toll-6-D42
neuromuscular junction | larval stage (with Df(3L)BSC578)
neuron | increased number | third instar larval stage, with Scer\GAL4elav.PU
presynaptic active zone | larval stage, with Scer\GAL4Toll-6-D42
presynaptic active zone | larval stage (with Df(3L)BSC578)
trichogen cell, with Scer\GAL4pnr-MD237
type I bouton | larval stage (with Df(3L)BSC578)
wing, with Scer\GAL4dpp.PS
wing, with Scer\GAL4ptc-559.1
wing disc, with Scer\GAL4dpp.PS
wing vein, with Scer\GAL4da.G32
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TLR3
2 of 15
Yes
No
1  
Hsap\TLR7
2 of 15
Yes
No
Hsap\TLR9
2 of 15
Yes
No
Hsap\CD180
1 of 15
No
No
Hsap\CHADL
1 of 15
No
No
Hsap\CPN2
1 of 15
No
No
Hsap\FBXL13
1 of 15
No
No
Hsap\FBXL14
1 of 15
No
No
Hsap\GP5
1 of 15
No
No
Hsap\IL1RAPL2
1 of 15
No
Yes
1  
Hsap\LGI1
1 of 15
No
No
Hsap\LGI2
1 of 15
No
Yes
Hsap\LGI3
1 of 15
No
Yes
Hsap\LGI4
1 of 15
No
No
Hsap\LGR6
1 of 15
No
No
Hsap\LINGO3
1 of 15
No
No
Hsap\LRFN1
1 of 15
No
No
Hsap\LRFN5
1 of 15
No
Yes
Hsap\LRRC15
1 of 15
No
No
Hsap\LRRN3
1 of 15
No
No
Hsap\LRTM1
1 of 15
No
Yes
Hsap\LRTM2
1 of 15
No
No
Hsap\SLIT1
1 of 15
No
No
Hsap\SLIT2
1 of 15
No
No
Hsap\SLIT3
1 of 15
No
No
Hsap\TLR1
1 of 15
No
No
1  
Hsap\TLR2
1 of 15
No
No
1  
Hsap\TLR4
1 of 15
No
No
Hsap\TLR5
1 of 15
No
No
Hsap\TLR6
1 of 15
No
No
1  
Hsap\TLR8
1 of 15
No
No
1  
Hsap\TLR10
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (30)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tlr13
3 of 15
Yes
No
Mmus\Tlr3
2 of 15
No
No
Mmus\Tlr7
2 of 15
No
No
Mmus\Tlr9
2 of 15
No
No
Mmus\Cd180
1 of 15
No
No
Mmus\Igfals
1 of 15
No
No
Mmus\Il1rapl2
1 of 15
No
Yes
Mmus\Lgi1
1 of 15
No
No
Mmus\Lgi2
1 of 15
No
Yes
Mmus\Lgi3
1 of 15
No
Yes
Mmus\Lgi4
1 of 15
No
No
Mmus\Lgr4
1 of 15
No
No
Mmus\Lingo3
1 of 15
No
No
Mmus\Lrfn5
1 of 15
No
Yes
Mmus\Lrrn3
1 of 15
No
No
Mmus\Lrtm1
1 of 15
No
Yes
Mmus\Lrtm2
1 of 15
No
No
Mmus\Rtn4rl1
1 of 15
No
Yes
Mmus\Rtn4r
1 of 15
No
No
Mmus\Slit1
1 of 15
No
No
Mmus\Slit2
1 of 15
No
No
Mmus\Slit3
1 of 15
No
No
Mmus\Tlr1
1 of 15
No
No
Mmus\Tlr2
1 of 15
No
No
Mmus\Tlr4
1 of 15
No
No
Mmus\Tlr5
1 of 15
No
No
Mmus\Tlr6
1 of 15
No
No
Mmus\Tlr8
1 of 15
No
No
Mmus\Tlr11
1 of 15
No
No
Mmus\Tlr12
1 of 15
No
No
Rattus norvegicus (Norway rat) (31)
Rnor\Tlr3
2 of 13
Yes
No
Rnor\Tlr7
2 of 13
Yes
No
Rnor\Cd180
1 of 13
No
No
Rnor\Lgi1
1 of 13
No
No
Rnor\Lgi3
1 of 13
No
Yes
Rnor\Lgi4
1 of 13
No
No
Rnor\Lgr4
1 of 13
No
No
Rnor\Lgr6
1 of 13
No
No
Rnor\Lingo3
1 of 13
No
Yes
Rnor\LOC102547963
1 of 13
No
Yes
Rnor\Lrfn5
1 of 13
No
Yes
Rnor\Lrrn3
1 of 13
No
No
Rnor\Lrtm2
1 of 13
No
No
Rnor\Rtn4rl1
1 of 13
No
Yes
Rnor\Rtn4r
1 of 13
No
Yes
Rnor\Slit1
1 of 13
No
No
Rnor\Slit2
1 of 13
No
No
Rnor\Slit3
1 of 13
No
No
Rnor\Slitrk1
1 of 13
No
No
Rnor\Slitrk2
1 of 13
No
Yes
Rnor\Slitrk3
1 of 13
No
Yes
Rnor\Slitrk5
1 of 13
No
Yes
Rnor\Slitrk6
1 of 13
No
Yes
Rnor\Tlr2
1 of 13
No
No
Rnor\Tlr4
1 of 13
No
No
Rnor\Tlr5
1 of 13
No
No
Rnor\Tlr6
1 of 13
No
No
Rnor\Tlr8
1 of 13
No
No
Rnor\Tlr9
1 of 13
No
No
Rnor\Tlr11
1 of 13
No
No
Rnor\Tlr12
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\LOC100485164
2 of 12
Yes
No
Xtro\LOC100485706
2 of 12
Yes
No
Xtro\tlr3
2 of 12
Yes
No
Xtro\tlr7
2 of 12
Yes
No
Xtro\LOC100485201
1 of 12
No
No
Xtro\LOC100485512
1 of 12
No
No
Xtro\LOC100495326
1 of 12
No
No
Xtro\lrfn2
1 of 12
No
No
Xtro\lrfn5
1 of 12
No
Yes
Xtro\lrrc17
1 of 12
No
Yes
Xtro\lrrn1-like
1 of 12
No
No
Xtro\lrtm2
1 of 12
No
No
Xtro\rtn4rl1
1 of 12
No
Yes
Xtro\rtn4r
1 of 12
No
No
Xtro\slit1
1 of 12
No
No
Xtro\slit2
1 of 12
No
No
Xtro\slit3
1 of 12
No
No
Xtro\tlr2
1 of 12
No
No
Xtro\tlr5
1 of 12
No
No
Xtro\tlr6
1 of 12
No
No
Xtro\tlr9
1 of 12
No
No
Danio rerio (Zebrafish) (39)
Drer\tlr21
3 of 15
Yes
No
Drer\tlr3
2 of 15
No
No
Drer\tlr4ba
2 of 15
No
No
Drer\tlr4bb
2 of 15
No
No
Drer\tlr7
2 of 15
No
No
Drer\tlr20.2
2 of 15
No
No
Drer\cd180
1 of 15
No
No
Drer\lgi1a
1 of 15
No
No
Drer\lgi1b
1 of 15
No
No
Drer\lgi2a
1 of 15
No
Yes
Drer\lgi3
1 of 15
No
Yes
Drer\LOC572462
1 of 15
No
No
Drer\LOC100332583
1 of 15
No
No
Drer\lrfn4a
1 of 15
No
Yes
Drer\lrrc4bb
1 of 15
No
No
Drer\lrrc15
1 of 15
No
No
Drer\lrrc17
1 of 15
No
Yes
Drer\lrrn1
1 of 15
No
No
Drer\lrtm1
1 of 15
No
Yes
Drer\lrtm2a
1 of 15
No
No
Drer\lrtm2b
1 of 15
No
Yes
Drer\rtn4r
1 of 15
No
Yes
Drer\rtn4rl1b
1 of 15
No
Yes
Drer\si:cabz01090165.1
1 of 15
No
No
Drer\si:dkey-182i3.11
1 of 15
No
No
Drer\slit1a
1 of 15
No
No
Drer\slit2
1 of 15
No
No
Drer\slit3
1 of 15
No
No
Drer\tlr1
1 of 15
No
No
Drer\tlr2
1 of 15
No
No
Drer\tlr5a
1 of 15
No
No
Drer\tlr5b
1 of 15
No
No
Drer\tlr8b
1 of 15
No
No
Drer\tlr9
1 of 15
No
No
Drer\tlr18
1 of 15
No
No
Drer\tlr19
1 of 15
No
No
Drer\tlr20.4
1 of 15
No
No
Drer\tlr22
1 of 15
No
No
Drer\vasna
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\tol-1
10 of 15
Yes
No
Cele\slt-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (23)
Atha\AT1G15740
1 of 9
Yes
No
Atha\AT1G74360
1 of 9
Yes
Yes
Atha\AT2G24230
1 of 9
Yes
Yes
Atha\AT4G23840
1 of 9
Yes
Yes
Atha\AT5G23340
1 of 9
Yes
No
Atha\AT5G58150
1 of 9
Yes
Yes
Atha\BRI1
1 of 9
Yes
Yes
Atha\BRL1
1 of 9
Yes
Yes
Atha\BRL2
1 of 9
Yes
Yes
Atha\BRL3
1 of 9
Yes
Yes
Atha\EBF1
1 of 9
Yes
No
Atha\EMS1
1 of 9
Yes
Yes
Atha\GHR1
1 of 9
Yes
No
Atha\PSKR1
1 of 9
Yes
Yes
Atha\PSKR2
1 of 9
Yes
Yes
Atha\PSY1R
1 of 9
Yes
Yes
Atha\RLP12
1 of 9
Yes
No
Atha\RLP19
1 of 9
Yes
No
Atha\RLP34
1 of 9
Yes
Yes
Atha\RLP35
1 of 9
Yes
No
Atha\RLP38
1 of 9
Yes
Yes
Atha\RLP40
1 of 9
Yes
No
Atha\RLP53
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (30)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Tollo
6 of 10
18w
5 of 10
Toll-7
5 of 10
Tl
4 of 10
Tehao
3 of 10
Toll-4
3 of 10
MstProx
2 of 10
rdo
2 of 10
2mit
1 of 10
caps
1 of 10
cDIP
1 of 10
CG4168
1 of 10
CG4950
1 of 10
CG5810
1 of 10
CG6749
1 of 10
CG7800
1 of 10
CG7896
1 of 10
CG16974
1 of 10
CG18249
1 of 10
CG18480
1 of 10
CG32055
1 of 10
CG42346
1 of 10
CG42709
1 of 10
chp
1 of 10
kek5
1 of 10
kek6
1 of 10
ltl
1 of 10
sli
1 of 10
Toll-9
1 of 10
trn
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Toll-6GD14438
ameliorates  carcinoma
modeled by Ras85DV12.UAS, l(2)gl4
(Mishra-Gorur et al., 2019)
modeled by Ras85DV12.UAS, scrib1
(Mishra-Gorur et al., 2019)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Toll-6|Tollo
suppressible
18w
(Tamada et al., 2021)
Toll-6
suppressible
kek6
(Ulian-Benitez et al., 2017)
Toll-6
enhanceable
Myd88
(Foldi et al., 2017)
Toll-6
suppressible
Toll-7
(Ward et al., 2015)
NT1|Toll-6
suppressible
Toll-7
(McIlroy et al., 2013)
Toll-6
suppressible
wek
(Foldi et al., 2017)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Myd88
enhanceable
Toll-6|Toll-7
(Foldi et al., 2017)
Myd88
enhanceable
Toll-6
(Foldi et al., 2017)
NT1|spz5
suppressible
Toll-6
(McIlroy et al., 2013)
spz
suppressible
Toll-6
(McIlroy et al., 2013)
Toll-7
enhanceable
Toll-6
(Yagi et al., 2010)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-43
Cytogenetic map
71C2-71C2
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
71C2-71C2
Limits computationally determined from genome sequence between P{lacW}cp309s2172&P{lacW}l(3)j2A2j2A2 and P{EP}Tfb2EP572
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
71C1-71D2
(Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location

3-43

(FlyBase, 2016)

3-36.9

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (14)
Genomic Clones (21)
cDNA Clones (181)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Mishra-Gorur et al., 2019, Ward A., 2015.10.7, Ward et al., 2015)
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Toll-6 CG7250

(Imler, 2000.10.17, FlyBase, 1996-)
Source for database merge of
Additional comments

The Toll-6 gene may have been derived from the Gp150 gene by retroposition.

(Pan and Zhang, 2009)

Source for identity of Toll-6 CG7250 was sequence comparison ( date:000721 ).

(FlyBase, 1996-)
Other Comments

Toll-6 acts cell autonomously to instruct the targeting of specific classes of projection neuron dendrites.

(Ward et al., 2015)

18w, Tollo, and Toll-6 act in combination to regulate axis elongation.

(Paré et al., 2014)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

(Kiger et al., 2003)
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 49 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (14)
Reported As
Symbol Synonym
18w-like
(Hynes and Zhao, 2000)
CG7250
(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Chen et al., 2007, Imler, 2000.10.17, Wasserman, 2000)
CT22359
(Hynes and Zhao, 2000)
TOLL 6
(Christophides et al., 2002)
Tl-6
(Khush and Lemaitre, 2000, Lemaitre, 2000.12.20)
Toll
(Wei et al., 2018)
Toll 6
(Chen et al., 2007)
Toll-6
(DeAngelis et al., 2021, Lavalou et al., 2021, Li and Hidalgo, 2021, Michki et al., 2021, Paraskevopoulos and McGuigan, 2021, Tamada et al., 2021, Iijima et al., 2020, Li et al., 2020, Mishra et al., 2020, Paré and Zallen, 2020, Sharrock and Sanson, 2020, Bali et al., 2019, Chowdhury et al., 2019, Kurmangaliyev et al., 2019, Mishra-Gorur et al., 2019, Paré et al., 2019, Casas-Tintó et al., 2017, Foldi et al., 2017, Gilmour et al., 2017, Levin and Malik, 2017, Ulian-Benitez et al., 2017, McLaughlin et al., 2016, Aradska et al., 2015, Neyen and Lemaitre, 2015, dos Santos, 2014, Moy et al., 2014, Paré et al., 2014, McIlroy et al., 2013, Ozkan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Nakamoto et al., 2012, Biehs et al., 2010, Yagi et al., 2010, Swanson et al., 2009, Anderson and Pick, 2008, McElwain et al., 2007, Ooi et al., 2002, Tauszig-Delamasure et al., 2002)
Toll6
(Dillard et al., 2021, Lima et al., 2021, Graham et al., 2019)
dTLR6
(Silverman and Maniatis, 2001)
dToll6
(Singh et al., 2003)
toll
(Janssens and Beyaert, 2002)
toll-6
(Ward A., 2015.10.7, Ward et al., 2015, Sanyal, 2009)
Name Synonyms
Toll-6
(Anthoney et al., 2018, Nie et al., 2018, Cho et al., 2005, Tauszig, 2000.3.23)
toll receptor
(Haesemeyer M et al., 2007)
Secondary FlyBase IDs
    Datasets (3)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (3)
    Result
    Result Type
    Title
    scRNAseq_2020_Cho_NI72LG_seq_clustering
    Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
    scRNAseq_2020_Cho_NI96HL_seq_clustering
    Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
    scRNAseq_2020_Cho_NI120HL_seq_clustering
    Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
    References (92)