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Gene Dmel\Toll-6

General Information
Symbol	Dmel\Toll-6	Species	D. melanogaster
Name	Toll-6	Annotation symbol	CG7250
Feature type	protein_coding_gene	FlyBase ID	FBgn0036494
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Tl-6
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	71C2-71C2	Sequence location	3L:15,329,770..15,337,417 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Toll-6 is referred to in FlyBase by the symbol Dmel\Toll-6 (CG7250, FBgn0036494). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane signaling receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: signal transduction. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Interleukin-1 receptor, type I/Toll precursor; Leucine-rich repeat; Leucine-rich repeat, typical subtype; Leucine-rich repeat-containing N-terminal; Toll/interleukin-1 receptor homology (TIR) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624790_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Toll-6. Gene sequence location is 3L:15329770..15337417.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN50942 HFA11304 BKN51325 BKN25856
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71C2-71C2   Limits computationally determined from genome sequence between P{lacW}cp309s2172&P{lacW}l(3)j2A2j2A2 and P{EP}Tfb2EP572
Experimentally Determined Cytological Location
Cytogenetic map Notes References 71C1-71D2     (Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Toll-6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	<new comment>
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Toll-6-RA FBtr0075614  NM_079357   5513   1514 Toll-6-RB FBtr0306307     5768   1514 Toll-6-RC FBtr0306308     7622   1514
Additional Transcript Data & Comments
Reported size (kB)	8.6, 6.4 (northern blot) (Tauszig et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Toll-6-PA   FBpp0075367   170.2   1514   6.45     NP_524081   AAF49645 Toll-6-PB   FBpp0297410   170.2   1514   6.45       Toll-6-PC   FBpp0297411   170.2   1514   6.45
Additional Polypeptide Data & Comments
Reported size (kDa)	1514 (aa) (Tauszig et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591) Interleukin-1 receptor, type I/Toll precursor (IPR004075) Leucine-rich repeat-containing N-terminal (IPR000372)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141322   AA141757   AA390640   AA568033   AA978580   AE014296 AAF49645   AF247766 AAF86226   AW941695   AY061099 AAL28647   BG638629   BI356994   BI361432   BI363491   BP555100   BT011445   BT057976   CO186013   CO262393   CO273513   CO286742   CO291322   CO298933   CO300619   CO302088   CO306959   CO311531   CO326753   CO330419   EC058072   EC062533   EC062731   EC064872   EC067468   EC070498   EC088770   EC202308   EC217589   EC229000   EC237402   EC242409   EC256872   GH754010   GH754412   GH758267   GH759130   GH760120   GH771441   GH771938   GH774407   GH774750   GH774949   GH775950   GH777028   GH777080   GH777728   GH778668   GH781034   GH782197   GH782991   GH784024   GH786030   GH786058   GH791523   GH791742   GH792704   GH792834   GH794270   GH795099   GH796901   GH798127   GH798520   GH798636   GH799608   GH800350   GH801311   GH801413   GH802580   GH807209   GH807254   GH808110   GH809227   GH809728   GH810877   GH811801   GH812663   GH817718   GH818728   GH819367   GH820262   GH821400   GH823886   GH824267   GH824752   GH826123   GH826549   GH827367   GH827703   GH828524   GH829015   GH829632   GH829956   GH830828   GH831349   GH831590   GH832861   GH833128   GH833923   GH838492   GH841189   GH841456   GH841630   GH841648   GH841664   GH842711   GH843416   GH843828   GH844815   GH844875   GH845116   GH845871   GH846124   GH846518   GH847666   GH847963   GH850310   GH850627   GH851789   GH852685   GH853027   GH855574   GH855966   GH857014   GH859719   GH861670   GH862081   GH862665   GH865878   GH867172   GH868644   GH868966   GH872837   GH872855   GH873229   GH873882   GH875099   GH875360   GH876603   GH880405   GH880779   GH882792   GH883417   GH883510   GH883623   GH885025   GH885220   GH886190   GH887263   GH889748   GH889949   GH890741   GH891435   GH892684   GH893734   GH895071   GH896004   GH897087   GH897416   GH900893   GH901949   GH903909   GH905637   GH907668   GH907681   GH907739   GH909514   GH909766   GH910014   GH910853   GH910922   GH910946   GH911431   GH912390   GH914077   GH914308   GH915080   GH916162   GH916359   GH918885   GH920048   GH921034   GH923990   GH928315   GH930396   GH930658   GH932133   GH933134   GH933597   GH935635
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95RV9 Q9NBK9 Q9VUN0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Tauszig et al., 2000) embryonic stage -- adult stage     (Tauszig et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036494    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036494 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036494 expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (1783) embryo 04-06hr  (6894) embryo 06-08hr  (6990) embryo 08-10hr  (4418) embryo 10-12hr  (1656) embryo 12-14hr  (1540) embryo 14-16hr  (1003) embryo 16-18hr  (763) embryo 18-20hr  (836) embryo 20-22hr  (569) embryo 22-24hr  (667) larva L1  (517) larva L2  (154) larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9  101 white prepupae new  (131) white prepupae 12hr  (191) white prepupae 24hr  (284) pupae 2d postWPP  (363) pupae 3d postWPP  (234) pupae 4d postWPP    97 adult male 01day  107 adult male 05day  105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr  (1783) embryo 04-06hr  (6894) embryo 06-08hr  (6990) embryo 08-10hr  (4418) embryo 10-12hr  (1656) embryo 12-14hr  (1540) embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036494 expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  113 embryo 02-04hr  (1783) embryo 04-06hr  (6894) embryo 06-08hr  (6990) embryo 08-10hr  (4418) embryo 10-12hr  (1656) embryo 12-14hr  (1540) embryo 14-16hr  (1003) embryo 16-18hr  (763) embryo 18-20hr  (836) embryo 20-22hr  (569) embryo 22-24hr  (667) larva L1  (517) larva L2  (154) larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9  101 white prepupae new  131 white prepupae 12hr  (191) white prepupae 24hr  (284) pupae 2d postWPP  (363) pupae 3d postWPP  (234) pupae 4d postWPP    97 adult male 01day  107 adult male 05day  105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr  1783 embryo 04-06hr  (6894) embryo 06-08hr  (6990) embryo 08-10hr  (4418) embryo 10-12hr  1656 embryo 12-14hr  1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    1783 embryo 04-06hr    6894 embryo 06-08hr    6990 embryo 08-10hr    4418 embryo 10-12hr    1656 embryo 12-14hr    1540 embryo 14-16hr    1003 embryo 16-18hr    763 embryo 18-20hr    836 embryo 20-22hr    569 embryo 22-24hr    667 larva L1    517 larva L2    154 larva L3 12hr old    45 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    86 larva L3 puffstage 7-9    101 white prepupae new    131 white prepupae 12hr    191 white prepupae 24hr    284 pupae 2d postWPP    363 pupae 3d postWPP    234 pupae 4d postWPP    97 adult male 01day    107 adult male 05day    105 adult male 30day    97 adult female 01day    65 adult female 05day    18 adult female 30day    14 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036494    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036494 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036494 expression level Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036494 expression level Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    28.85 Larval Midgut    4.2 Larval Hindgut    1.4 Larval Malpighian Tubules    2.8 Larval Fat Body    2.1 Larval Salivary Gland    0.9 Larval Trachea    2.35 Larval Carcass    0.925 Adult Head    4.9 Adult Eye    3.925 Adult Brain    62.2 Adult Thoracic-Abdominal Ganglion    36.9 Adult Crop    4.3 Adult Midgut    0.8 Adult Hindgut    0.7 Adult Malpighian Tubules    1.3 Adult Fat Body    5.2 Adult Salivary Gland    5.3 Adult Heart    1.075 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    1.2 Adult Testis    2.1 Adult Male Accessory Gland    3.5 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.9   NA  Eye    3.925   NA  Brain    62.2   28.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    36.9   NA  Crop    4.3   4.2  Midgut    0.8   1.4  Hindgut    0.7   2.8  Malpighian Tubules    1.3   2.1  Fat Body    5.2   0.9  Salivary Gland    5.3   NA  Heart    1.075   2.35  Trachea    NA   NA  VirginFemale Spermatheca    5.3   NA  InseminatedFemale Spermatheca    3.6   NA  Ovary    1.2   NA  Testis    2.1   NA  Male Accessory Gland    3.5   0.925  Carcass    1.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036494 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7250-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Toll-6 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Toll-6GD35 Toll-6GD2531 Toll-6GD14438 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Toll-6GD14438 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Toll-6GD14438
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Toll-6 Class Mutagen Stocks Known lesion Toll-6MI02127 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Toll-6 Class Mutagen Stocks Known lesion Toll-6GD14438 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Toll-6GD35 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Toll-6GD2531 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-6KK105856 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD35} NA P{GD2531} NA P{GD14438} NA P{KK105856} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}Toll-6MI02127 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
transmembrane signaling receptor activity inferred from electronic annotation with InterPro:IPR004075 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lemaitre, 2000.12.20) non-traceable author statement (Tauszig, 2000.3.23)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) innate immune response inferred from electronic annotation with InterPro:IPR004075 (FlyBase Curators et al., 2004-) signal transduction inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Lemaitre, 2000.12.20) intracellular inferred from electronic annotation with InterPro:IPR000157 (FlyBase Curators et al., 2004-) intrinsic to membrane inferred from electronic annotation with InterPro:IPR004075 (FlyBase Curators et al., 2004-) plasma membrane non-traceable author statement (Tauszig, 2000.3.23)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Toll-6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64985 DroID - A comprehensive database of gene and protein interactions. • FBgn0036494 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39663
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23695 Dere\GG15893 Dgri\GH14533 Dmoj\GI13107 Dper\GL24793 Dpse\GA20210 Dsec\GM25524 Dsim\GD14538 Dvir\GJ13853 Dwil\GK20408 Dyak\GE22235
Curated drosophilid orthologs	Dpse\GA20210
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000671-PA Aedes aegypti (mosquito) AGAP012387-PA Anopheles gambiae (mosquito) XP_393712.2 Apis mellifera (honey bee) XP_001947324.1 Acyrthosiphon pisum (pea aphid) At1g55610.1 Arabidopsis thaliana (wall cress) BGIBMGA011084-PA Bombyx mori (silk worm) CPIJ018343 Culex pipens (mosquito) ENSORLP00000016852 Oryzias latipes (japanese killifish) LOC_Os02g01800.1 Oryza sativa (asian rice) LOC_Os02g11980.1 Oryza sativa (asian rice) LOC_Os02g12030.1 Oryza sativa (asian rice) LOC_Os02g12450.1 Oryza sativa (asian rice) LOC_Os03g21730.1 Oryza sativa (asian rice) LOC_Os09g25540.1 Oryza sativa (asian rice) PHUM005274-PA Pediculus humanus (human body louse) 672125 Populus trichocarpa (black cottonwood) 5049474 Sorghum bicolor (sorghum) XP_001199902.1 Strongylocentrotus purpuratus (purple sea urchin) XP_797719.2 Strongylocentrotus purpuratus (purple sea urchin) 53792 Trichoplax adhaerens (metazoa) XP_971999.1 Tribolium castaneum (red flour beetle) 83450.m00066 Trichomonas vaginalis (parasitic flagellated protozoan) 86622.m00205 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50556 LH19752 ISCW022740 ISCW020989 FBgn0239461 FBgn0222405 FBgn0201072 FBgn0186219 FBgn0180381 JGI_V11_65779 FBgn0080205 FBgn0162381 FBgn0135864 FBgn0122009 FBgn0108128 FBgn0100689 CPIJ018343 BGIBMGA011084 ACYPI005417 GB17781 TOLL6 PB23004 PHUM108410 GLEAN_04895
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	34467 y1 w*; Mi{MIC}Toll-6MI02127/TM3, Sb1 Ser1
VDRC	v928 w1118; P{GD35}v928 v927 w1118; P{GD35}v927/CyO v27102 w1118; P{GD14438}v27102 v27103 w1118; P{GD14438}v27103 v7995 w1118; P{GD2531}v7995/CyO
Genomic Clones ( 2 )
	BACR11F16 BACR17F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 191 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08841 RE48314
Other clones	FI02055
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL01202 RE43327 RE45643
Other clones	54881 57779 102264 102537 117523 145262 192315 214211.57 CK01.14D.F12 CK01.19A.C7 CK01.61A.F3 CK01.101A.H5 CK01588 CK02379 EK015154 EK063722 EK077631 EK085231 EK111302 EK174137 EK178820 EK183030 EK225210 EK252858 EK295228 EP04548 FGM233D12 LD31282 RP003020746 RP003026712 RP003034385 RP003037668 RP003038658 RP003042319 RP003057015 RP003057555 RP003067114 RP003072536 RP003075548 RP003079440 RP003085574 RP003088193 RP003096764 RP003101670 RP003110886 RP003113919 RP003124775 RP003125774 RP003127163 RP003132261 RP003133879 RP003135778 RP003139677 RP003141540 RP003145503 RP003148375 RP003156228 RP003156912 RP003157021 RP003165137 RP003171170 RP003171629 RP003171942 RP003172108 RP003178830 RP003181101 RP003187566 RP003191854 RP003196651 RP003199140 RP003200595 RP003200709 RP003202245 RP003204302 RP003218548 RP003219217 RP003221022 RP003223371 RP003225231 RP003225290 RP003226322 RP003240216 RP003241170 RP003242010 RP003242946 RP003244784 RP003247607 RP003271110 RP003281844 RP003283190 RP003284924 RP003286409 RP003291531 RP003294345 RP003294688 RP003295331 RP003295959 RP003299108 RP003309490 RP003310243 RP003313274 RP003313853 RP003317736 RP003324534 RP003326072 RP003326708 RP003330052 RP003339286 RP003339538 RP003342281 RP003343640 RP003346028 RP003348037 RP003348384 RP003348970 RP003354549 RP003370819 RP003379890 RP003381127 RP003405245 RP003406297 RP003410054 RP003412735 RP003422756 RP003427201 RP003427680 RP003432062 RP003453696 RP003454468 RP003456634 RP003460454 RP003461685 RP003469355 RP003486398 RP003490776 RP003493348 RP003501275 RP003502219 RP003503384 RP003503443 RP003508202 RP003516415 RP003518792 RP003527850 RP003538182 RP003542270 RP003544029 RP003545160 RP003545439 RP003546671 RP003549050 RP003549542 RP003556682 RP003557565 RP003574441 RP003579120 RP003581563 RP003583654 RP003584444 RP003586090 RP003587267 RP003589745 RP003596045 RP003597212 RP003598245 RP003598574 RP003602655 RP003618565 RP003620623 RP003620996 RP003621325 RP003621340 RP003622956 RP003627603 RP003640139 RP003641323 RP003644372 RP003644992 RP003645721 RP003647785 RP003648677 RP003664105 RP003665371 RP003665876 RP003672390
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036494 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39663
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Toll-6 CG7250 (Imler, 2000.10.17, FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Toll-6 CG7250 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079357 RefSeq (Proteins) • NP_524081 DDBJ / EMBL / GenBank • AA390640 AAF49645 AAF86226 AAL28647 AF247766 AW941695 AY061099 BI363491 Entrez Gene - A searchable database of RefSeq genes. • 39663 UniProtKB/TrEMBL • Q9NBK9 Q9VUN0 Q95RV9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591) Interleukin-1 receptor, type I/Toll precursor (IPR004075) Leucine-rich repeat-containing N-terminal (IPR000372)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64985 DroID - A comprehensive database of gene and protein interactions. • FBgn0036494 DRSC - Results from RNAi screens. • FBgn0036494 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036494 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7250-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036494 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39663 InParanoid A subset of ortholog calls from InParanoid. • AAEL000671-PA Aedes aegypti (mosquito) AGAP012387-PA Anopheles gambiae (mosquito) XP_393712.2 Apis mellifera (honey bee) XP_001947324.1 Acyrthosiphon pisum (pea aphid) At1g55610.1 Arabidopsis thaliana (wall cress) BGIBMGA011084-PA Bombyx mori (silk worm) CPIJ018343 Culex pipens (mosquito) ENSORLP00000016852 Oryzias latipes (japanese killifish) LOC_Os02g01800.1 Oryza sativa (asian rice) LOC_Os02g11980.1 Oryza sativa (asian rice) LOC_Os02g12030.1 Oryza sativa (asian rice) LOC_Os02g12450.1 Oryza sativa (asian rice) LOC_Os03g21730.1 Oryza sativa (asian rice) LOC_Os09g25540.1 Oryza sativa (asian rice) PHUM005274-PA Pediculus humanus (human body louse) 672125 Populus trichocarpa (black cottonwood) 5049474 Sorghum bicolor (sorghum) XP_001199902.1 Strongylocentrotus purpuratus (purple sea urchin) XP_797719.2 Strongylocentrotus purpuratus (purple sea urchin) 53792 Trichoplax adhaerens (metazoa) XP_971999.1 Tribolium castaneum (red flour beetle) 83450.m00066 Trichomonas vaginalis (parasitic flagellated protozoan) 86622.m00205 Trichomonas vaginalis (parasitic flagellated protozoan) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39663 modMine - Data generated by the modENCODE project. • FBgn0036494 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50556 LH19752 ISCW022740 ISCW020989 FBgn0239461 FBgn0222405 FBgn0201072 FBgn0186219 FBgn0180381 JGI_V11_65779 FBgn0080205 FBgn0162381 FBgn0135864 FBgn0122009 FBgn0108128 FBgn0100689 CPIJ018343 BGIBMGA011084 ACYPI005417 GB17781 TOLL6 PB23004 PHUM108410 GLEAN_04895
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	18w-like (Hynes and Zhao, 2000) CG7250 (Imler, 2000.10.17, Wasserman, 2000, Keleman et al., 2009.8.5) CT22359 (Hynes and Zhao, 2000) dTLR6 (Silverman and Maniatis, 2001) dToll6 (Singh et al., 2003) Tl-6 (Lemaitre, 2000.12.20, Khush and Lemaitre, 2000) toll (Janssens and Beyaert, 2002) Toll-6 (Swanson et al., 2009, McElwain et al., 2007, Anderson and Pick, 2008, Ooi et al., 2002, Tauszig-Delamasure et al., 2002) TOLL 6 (Christophides et al., 2002) toll-6 (Sanyal, 2009)
Name Synonym	Toll-6 (Tauszig, 2000.3.23, Cho et al., 2005) toll receptor (Haesemeyer M et al., 2007)
Secondary FlyBase IDs
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Review  ( 8 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...