Tl-6
Please see the JBrowse view of Dmel\Toll-6 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
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Gene model reviewed during 5.46
Gene model reviewed during 5.55
8.6, 6.4 (northern blot)
1514 (aa)
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-6 using the Feature Mapper tool.
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as labial complex specific anlage
Comment: reported as maxillary organ specific anlage
Toll-6 is expressed dynamically through much of embryogenesis. Expression begins at the cellular blastoderm stage in several bands, the most anterior bands appearing first. At the beginning of germ band extension, a pattern of alternating strong and weak stripes is seen. At the extended germ band stage, expression is strongest in delaminating neuroblasts. At germ band retraction, expression is weaker and is mostly in the CNS. Double staining with an anti-eve antibody shows that Toll-6 is expressed in a subset of CNS neurons and in elav negative cells that may be lateral glia.
Toll-6 protein is enriched in glomeruli of the lateral antennal lobe, which are all innervated by trichoid olfactory receptor neurons.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Toll-6 in GBrowse 23-43
3-36.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Toll-6 CG7250
Source for identity of Toll-6 CG7250 was sequence comparison ( date:000721 ).
Toll-6 acts cell autonomously to instruct the targeting of specific classes of projection neuron dendrites.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.