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Gene Dmel\Dcp2

General Information
Symbol	Dmel\Dcp2	Species	D. melanogaster
Name	Decapping protein 2	Annotation symbol	CG6169
Feature type	protein_coding_gene	FlyBase ID	FBgn0036534
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	dDcp2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	72A1-72A1	Sequence location	3L:15,811,834..15,819,523 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Decapping protein 2 is referred to in FlyBase by the symbol Dmel\Dcp2 (CG6169, FBgn0036534). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: m7G(5')pppN diphosphatase activity; protein binding. There is experimental evidence that it is involved in the biological process: nuclear-transcribed mRNA catabolic process; regulation of cytoplasmic mRNA processing body assembly; gene silencing by miRNA; deadenylation-dependent decapping of nuclear-transcribed mRNA. 9 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: NUDIX hydrolase domain; NUDIX hydrolase domain-like; NUDIX hydrolase, conserved site; mRNA decapping protein 2, Box A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Dcp2. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Dcp2. Gene sequence location is 3L:15811834..15819523.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72A1-72A1   Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dcp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dcp2-RA FBtr0075538  NM_140548   3665   791 Dcp2-RB FBtr0075539  NM_168634   2850   564 Dcp2-RD FBtr0100528  NM_001014585   2690   564 Dcp2-RE FBtr0304975  NM_001259847   5934   792
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dcp2-PA   FBpp0075293   87.5   791   10.11     NP_648805   AAF49579 Dcp2-PB   FBpp0075294   63.3   564   10.10     NP_730074   AAN11769 Dcp2-PD   FBpp0099969   63.3   564   10.10     NP_001014585   AAX52744 Dcp2-PE   FBpp0293514   87.6   792   10.11     NP_001246776   AFH04447
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NUDIX hydrolase domain (IPR000086) mRNA decapping protein 2, Box A (IPR007722) NUDIX hydrolase domain-like (IPR015797) NUDIX hydrolase, conserved site (IPR020084)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263927   AA390813   AA439506   AA802328   AA802413   AA820575   AE014296 AAF49579   AE014296 AAN11769   AE014296 AAX52744   AE014296 AFH04447   AI107445   AI109057   AI237914   AI296023   AI455462   AI532039   AW941210   AX094049   AX094134   AY094746 AAM11099   BE662218   BG632211   BG637083   BI234640   BI236642   BI485739   BI578837   BI636734   BP543252   BP559272   BQ102737   BT004829 AAO45185   BT016065 AAV36950   CA807218   CK131727   CK660015   CO177156   CO187937   CO188825   CO190546   CO194964   CO264675   CO265011   CO267355   CO272686   CO275039   CO277931   CO279191   CO279271   CO282878   CO290182   CO290610   CO291550   CO291778   CO292052   CO294687   CO296129   CO298519   CO298913   CO312087   CO312708   CO313024   CO318297   CO319429   CO320565   CO325071   CO328202   CO333529   CO333790   CO340573   CO341417   CO341543   CZ467929   CZ477946   EC057680   EC058907   EC060980   EC063908   EC071109   EC076294   EC079455   EC082025   EC083299   EC090527   EC195584   EC197294   EC197484   EC198737   EC198806   EC199388   EC200932   EC201032   EC202445   EC202579   EC205107   EC207668   EC209922   EC212358   EC213828   EC213860   EC215737   EC217145   EC221337   EC222976   EC224579   EC224744   EC227155   EC227669   EC228852   EC229169   EC229804   EC230048   EC230782   EC233873   EC245036   EC246957   EC247883   EC254642   EC255969   EC257152   EC257622   EC259931   EV595147   FD585597   FD586451
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86NM7 Q9VUU4 Q8T3N6 Q5U127 Q7KUN5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Lin et al., 2008) cytoplasmic mRNA processing body inferred from direct assay (Eulalio et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (54) central nervous system, larvae L3  (97) central nervous system, pupae P8  (80) head, virgin 1-day female  (37) head, virgin 4-day female  (31) head, virgin 20-day female    20 head, mated 1-day female  (30) head, mated 4-day female  (27) head, mated 20-day female    23 head, mated 1-day male  (42) head, mated 4-day male  (38) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  (99) digestive system, larvae L3 wandering  (31) digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae  (43) fat body, pupae P8  (54) carcass, larvae L3 wandering  (51) carcass, 1-day adult  (27) carcass, 4-day adult  (27) carcass, 20-day adult    21 ovary, virgin 4-day female  (93) ovary, mated 4-day female  (85) testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (54) central nervous system, larvae L3  (97) central nervous system, pupae P8  (80) head, virgin 1-day female  (37) head, virgin 4-day female  31 head, virgin 20-day female    20 head, mated 1-day female  30 head, mated 4-day female  27 head, mated 20-day female    23 head, mated 1-day male  (42) head, mated 4-day male  (38) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    25 salivary gland, white prepupae  (99) digestive system, larvae L3 wandering  31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae  (43) fat body, pupae P8  (54) carcass, larvae L3 wandering  (51) carcass, 1-day adult  27 carcass, 4-day adult  27 carcass, 20-day adult    21 ovary, virgin 4-day female  (93) ovary, mated 4-day female  (85) testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    54 central nervous system, larvae L3    97 central nervous system, pupae P8    80 head, virgin 1-day female    37 head, virgin 4-day female    31 head, virgin 20-day female    20 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    23 head, mated 1-day male    42 head, mated 4-day male    38 head, mated 20-day male    36 salivary gland, larvae L3 wandering    25 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    16 digestive system, 4-day adult    20 digestive system, 20-day adult    15 fat body, larvae L3 wandering    13 fat body, white prepupae    43 fat body, pupae P8    54 carcass, larvae L3 wandering    51 carcass, 1-day adult    27 carcass, 4-day adult    27 carcass, 20-day adult    21 ovary, virgin 4-day female    93 ovary, mated 4-day female    85 testis, mated 4-day male    24 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  (37) embryo 04-06hr  (50) embryo 06-08hr  (41) embryo 08-10hr  (41) embryo 10-12hr    25 embryo 12-14hr  (41) embryo 14-16hr    23 embryo 16-18hr  (28) embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9  (38) white prepupae new  (45) white prepupae 12hr  (42) white prepupae 24hr  (48) pupae 2d postWPP  (49) pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day  (33) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  (37) embryo 04-06hr  (50) embryo 06-08hr  (41) embryo 08-10hr  (41) embryo 10-12hr    25 embryo 12-14hr  (41) embryo 14-16hr    23 embryo 16-18hr  28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9  (38) white prepupae new  (45) white prepupae 12hr  (42) white prepupae 24hr  (48) pupae 2d postWPP  (49) pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day  (33) adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    37 embryo 04-06hr    50 embryo 06-08hr    41 embryo 08-10hr    41 embryo 10-12hr    25 embryo 12-14hr    41 embryo 14-16hr    23 embryo 16-18hr    28 embryo 18-20hr    23 embryo 20-22hr    16 embryo 22-24hr    24 larva L1    14 larva L2    15 larva L3 12hr old    10 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    24 larva L3 puffstage 7-9    38 white prepupae new    45 white prepupae 12hr    42 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    25 pupae 4d postWPP    13 adult male 01day    18 adult male 05day    18 adult male 30day    16 adult female 01day    19 adult female 05day    33 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC    122 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  (28) embryonic 1182-4H  (51) embryonic GM2  (56) embryonic Kc167  (34) embryonic S1  (36) embryonic S3  (47) leg disc CME L1  (37) wing disc CME-W2  (42) wing disc ML-DmD8  (79) wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21    15 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (68) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (32) CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (35) ovary fGS/OSS  (76) ovary OSC  (122) ovary OSS  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC  (122) ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC    122 ovary OSS    62 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC    122 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (39) Schneider line 2 Sg4  28 embryonic 1182-4H  (51) embryonic GM2  (56) embryonic Kc167  (34) embryonic S1  (36) embryonic S3  (47) leg disc CME L1  (37) wing disc CME-W2  (42) wing disc ML-DmD8  (79) wing disc ML-DmD9  (61) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21    15 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (68) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  32 CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (35) ovary fGS/OSS  (76) ovary OSC  (122) ovary OSS  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC  122 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    39 Schneider line 2 Sg4    28 embryonic 1182-4H    51 embryonic GM2    56 embryonic Kc167    34 embryonic S1    36 embryonic S3    47 leg disc CME L1    37 wing disc CME-W2    42 wing disc ML-DmD8    79 wing disc ML-DmD9    61 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    15 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    68 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    32 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    35 ovary fGS/OSS    76 ovary OSC    122 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  (29) heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3  (27) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (92) Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  (50) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (60) Caffeine 25 mg/ml 48 hrs, 4-day adult  (37) Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  29 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3  27 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (70) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (92) Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  (50) Ethanol 2.5% 3 hrs, larvae L3  (47) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (60) Caffeine 25 mg/ml 48 hrs, 4-day adult  (37) Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    29 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    27 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    70 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    92 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    50 Ethanol 2.5% 3 hrs, larvae L3    47 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    60 Caffeine 25 mg/ml 48 hrs, 4-day adult    37 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    14 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM04208 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036534 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6169-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD Dcp2GS3219 lethal, with Scer\GAL4c355 Dcp2GS3219 lethal, with Scer\GAL4dpp.blk1 Dcp2GS3219 lethal, with Scer\GAL4hs.2sev Dcp2GS3219 lethal | pupal stage, with Scer\GAL4pnr-MD237 Dcp2GD11844 Phenotype manifest in Allele cytoplasmic mRNA processing body | germline clone Dcp2de21
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Dcp2 Class Mutagen Stocks Known lesion Dcp2BG01766 1 -- Dcp2c02419 piggyBac transposase 1 -- Dcp2e00034 piggyBac transposase 1 -- Dcp2GS3219 Delta2-3 1 Yes Dcp2de21 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dcp2 Class Mutagen Stocks Known lesion Dcp2GD11844 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp2HMS00115 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp2KK101790 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dcp2dsRNA.cMa in vitro construct - RNAi 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11844} NA P{KK101790} NA P{TRiP.HMS00115} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}Dcp2BG01766 NA PBac{PB}Dcp2c02419 NA PBac{RB}Dcp2e00034 NA insertion of mobile activating element P{GSV1}Dcp2GS3219 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
m7G(5')pppN diphosphatase activity inferred from direct assay (Lin et al., 2008) protein binding inferred from physical interaction with UniProtKB:Q9VKK1 (assigned by UniProtKB) (Jinek et al., 2008)
Biological Process
CV term Evidence References
deadenylation-dependent decapping of nuclear-transcribed mRNA inferred from direct assay (Lin et al., 2008) gene silencing by miRNA inferred from mutant phenotype (Rehwinkel et al., 2005) nuclear-transcribed mRNA catabolic process inferred from mutant phenotype (Bönisch et al., 2007) NOT nuclear-transcribed mRNA catabolic process, nonsense-mediated decay inferred from mutant phenotype (Rehwinkel et al., 2005) regulation of cytoplasmic mRNA processing body assembly inferred from mutant phenotype (Lin et al., 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Lin et al., 2008) cytoplasmic mRNA processing body inferred from direct assay (Eulalio et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
manganese ion binding inferred from electronic annotation with InterPro:IPR007722 (FlyBase Curators et al., 2004-) RNA binding inferred from electronic annotation with InterPro:IPR007722 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dcp2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036534 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39722
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68D1FB Dipteran inclusive ortholog search EOG6SBF6T Insect inclusive ortholog search EOG6V6XCJ Arthropod inclusive ortholog search EOG63FFCR Metazoa inclusive ortholog search EOG6HTNKN
Orthologs in Drosophila Species (EOG68D1FB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dcp2     Drosophila simulans   Dsim\GD12535 Y   Drosophila sechellia   Dsec\GM24463 Y   Drosophila erecta   Dere\GG13519 Y   Drosophila yakuba   Dyak\GE22821 Y   Drosophila ananassae   Dana\GF10373 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19405 Y   Drosophila persimilis   Dper\GL24929 Y   Drosophila willistoni   Dwil\GK20641 Y   Drosophila mojavensis   Dmoj\GI13619 Y   Drosophila grimshawi   Dgri\GH14473 Y
Orthologs in non-Drosophila Dipterans (EOG6SBF6T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015607   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000783   Anopheles gambiae Malaria mosquito  Agam\AGAP011114   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012496   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019463
Orthologs in non-Dipteran Insects (EOG6V6XCJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49222   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000497   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13733   Atta cephalotes Leafcutter ant  Acep\ACEP23136   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15559   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12622   Linepithema humile Argentine ant  Lhum\LH16743   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22492   Solenopsis invicta Red fire ant  Sinv\SINV22258   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003937   Bombyx mori Silkmoth  Bmor\BGIBMGA007193   Pediculus humanus Human body louse  Phum\PHUM243220   Tribolium castaneum Red flour beetle  Tcas\TC000167
Orthologs in non-Insect Arthropods (EOG63FFCR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_222252   Ixodes scapularis Deer tick  Isca\ISCW015751
Orthologs in non-Arthropod Metazoa (EOG6HTNKN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F52G2.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026788gn   Danio rerio Zebrafish  Drer\dcp2   Danio rerio Zebrafish  Drer\dcp2   Xenopus tropicalis Western clawed frog  Xtro\dcp2   Gallus gallus Domestic chicken  Ggal\DCP2   Mus musculus House mouse  Mmus\Dcp2   Rattus norvegicus Norway rat  Rnor\Dcp2   Homo sapiens Human  Hsap\ENSG00000172795
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000172795
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12535 Drosophila sechellia Dsec\GM24463 Drosophila erecta Dere\GG13519 Drosophila yakuba Dyak\GE22821 Drosophila ananassae Dana\GF10373 Drosophila pseudoobscura pseudoobscura Dpse\GA19405 Drosophila persimilis Dper\GL24929 Drosophila willistoni Dwil\GK20641 Drosophila virilis Dvir\GJ13955 Drosophila mojavensis Dmoj\GI13619 Drosophila grimshawi Dgri\GH14473
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	34806 y1 sc* v1; P{TRiP.HMS00115}attP2 12794 w1118; P{GT1}Dcp2BG01766/TM3, Sb1 Ser1
Harvard	- PBac{PB}Dcp2c02419 - PBac{RB}Dcp2e00034
Kyoto	200560 y1 w67c23; P{GSV1}Dcp2GS3219/TM3, Sb1 Ser1
VDRC	v105130 P{KK101790}VIE-260B v22272 w1118 P{GD11844}v22272
Genomic Clones ( 1 )
	BACR06P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 112 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM04208 LP11827 SD14939
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07564 GM01515 GM05518 LD07107 LD09720 LD14093 LP09813 LP12720 LP18229 RE30374 RE32722 RE69075 RE72767 SD03391 SD18542
Other clones	9043 16197 18795 20246 30933 31266 37786 41589 41698 55116 67410 70461 70534 71047 75296 78101 80267 97120 102835 104289 104863 105214 105776 166553 173909 181812 214257.54 214283.59 214309.62 214441.59 214477.53 272562 273610 283356 bs31g09 CK01.5C.E8 CK01.20D.D5 CK01.40D.H2 CK01.52A.F9 CK01.61C.E7 CK01.67A.C12 CK01.89D.E11 CK01.94A.H8 CK01.95D.E11 CK01.102D.D6 CK01.117C.E1 CK01.120D.G8 CK01.124A.D1 CK01.143A.G12 Dmel_neb_014613_0701_1873 EC39528 EK034946 EK042123 EK048520 EK052644 EK073264 EK074515 EK108043 EK116258 EK127827 EK133737 EK133932 EK139856 EK141227 EK149540 EK161555 EK173159 EK174108 EK195521 EK197623 EK198147 EK199061 EK207447 EK212764 EK227857 EK229731 EK230946 EK271416 EK278112 EK286245 EK307206 EK307962 EP08738 EP10925 EP12417 EP12638 ESG016d.E21_E11 FGC019E01 FGM319H07 GH05133 LD24376 RM03028 RM03227 UUGC0121
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036534 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39722
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dcp2 CG6169 (Rehwinkel et al., 2005)
Source for database merge of	Source for merge of: CG6169 BEST:LD07107 (Rana, 2004.7.8)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene is transfected into S2 cells to study the genes role in decapping. (Behm-Ansmant et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Rehwinkel et al., 2005) In contrast to the decapping enzymes in yeast and humans, the Dcp2 product does not seem to participate in the nonsense-mediated decay pathway. (Rehwinkel et al., 2005) Area matching Drosophila ESTs AI107445 and AA390813. (Davies, 2001.3.15, Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140548 NM_168634 NM_001014585 NM_001259847 RefSeq (Proteins) • NP_648805 NP_730074 NP_001014585 NP_001246776 DDBJ / EMBL / GenBank • AA263927 AA390813 AA802328 AAF49579 AAF49579.3 AAM11099 AAN11769 AAN11769.1 AAO45185 AAS64991 AAS64991.1 AAV36950 AAX52744 AFH04447 AI107445 AW941210 AX094049 AX094134 AY094746 BE662218 BG637083 BT004829 BT016065 CZ467929 CZ477946 Entrez Gene - A searchable database of RefSeq genes. • 39722 UniProtKB/TrEMBL • Q5U127 Q7KUN5 Q8T3N6 Q9VUU4 Q86NM7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NUDIX hydrolase domain (IPR000086) mRNA decapping protein 2, Box A (IPR007722) NUDIX hydrolase domain-like (IPR015797) NUDIX hydrolase, conserved site (IPR020084) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM04208
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036534 DRSC - Results from RNAi screens. • FBgn0036534 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036534 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6169-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036534 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39722 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39722 modMine - Data generated by the modENCODE project. • FBgn0036534
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BEST:LD07107   CG6169 (Lin et al., 2006, Maines et al., 2007, Ma et al., 2006, Keleman et al., 2009.8.5, Zhou et al., 2008, Beckstead et al., 2007, Jäger and Dorner, 2010, Ni et al., 2011.7.19) Dcp2 (Lin et al., 2008, Pressman et al., 2012, Tan et al., 2012) DCP2 (Rehwinkel et al., 2005, Tritschler et al., 2007, Eulalio et al., 2007, Bönisch et al., 2007, Tritschler et al., 2009, Jinek et al., 2008, Eulalio et al., 2007, Tritschler et al., 2008, Behm-Ansmant et al., 2006, Haas et al., 2010, Jäger and Dorner, 2010) DCp2p (Valencia-Sanchez et al., 2006) dDcp (Lin et al., 2008) dDcp2 (Seydoux and Braun, 2006, Lin et al., 2006, Lin et al., 2008, Lin et al., 2008) dDCP2 (Lim et al., 2009) LD07107 (Toba et al., 1999)
Name Synonym	CG6169   Decapping protein 2 (Lin et al., 2008, Tan et al., 2012)
Secondary FlyBase IDs
	FBgn0026583
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 )
Recent research papers ( 4 )
	Fisher et al., 2012, BMC Genomics 13: 506 Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. [FBrf0220361] Pressman et al., 2012, G3 (Bethesda) 2(4): 437--448 A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila. [FBrf0218180] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Weil et al., 2012, Nat. Cell Biol. 14(12): 1305--1315 Drosophila patterning is established by differential association of mRNAs with P bodies. [FBrf0220085] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...