FB2020_06, released Dec 22, 2020

Gene: Dmel\Cpr72Ec

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General Information
Symbol
Dmel\Cpr72Ec
Species
D. melanogaster
Name
Cuticular protein 72Ec
Annotation Symbol
CG4784
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036619
Gene Model Status
Current
Stock Availability
2 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
72E2-72E2
Sequence location
3L:16,365,894..16,367,340 [-]
Recombination map

3-44

RefSeq locus
NT_037436 REGION:16365894..16367340
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables structural constituent of eye lens
inferred from direct assay
(Stahl et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables structural constituent of chitin-based larval cuticle
inferred from sequence model
(Karouzou et al., 2007)
enables structural constituent of cuticle
inferred from electronic annotation with InterPro:IPR000618
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in chitin-based cuticle development
inferred from sequence model
(Karouzou et al., 2007)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in chitin-based extracellular matrix
inferred from sequence model
(Karouzou et al., 2007)
located_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN000955699
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in extracellular space
inferred from sequence model
(Liu et al., 2006)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CPR CUTICLE PROTEIN FAMILY -
The largest cuticle protein family, the CPR family, contain a 35 amino acid R&R consensus (named after Rebers and Riddiford, PMID:2462055), which in an extended form has been shown to bind chitin (PMID:15475300). (Adapted from FBrf0242484.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cpr72Ec for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cpr72Ec-RA
FBtr0075424
NM_140627
1447
429
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cpr72Ec-PA
FBpp0075182
50.6
429
5.15
NP_648884
AAF49476
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cpr72Ec using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
eye
(Xu et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pharate adult stage P8
interommatidial cell
(Stahl et al., 2017)
pigment cell
(Stahl et al., 2017)
cone cell
(Stahl et al., 2017)
photoreceptor cell
(Stahl et al., 2017)
Additional Descriptive Data

Cpr72Ec is expressed in all cell types of the eye, with particularly high expression in higher order interommatidial pigment cells, and weaker expression in cone cells, primary pigment cells and photoreceptors. It's expression is eye-specific.

(Stahl et al., 2017)

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cpr72Ec in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cpr72Ec
Transgenic constructs containing regulatory region of Cpr72Ec
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\Y39B6A.10
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190F2S )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010712
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012387
Drosophila simulans
Dsim\GD12478
Drosophila sechellia
Dsec\GM24409
Drosophila erecta
Dere\GG13459
Drosophila yakuba
Dyak\GE22906
Drosophila ananassae
Dana\GF24387
Drosophila pseudoobscura pseudoobscura
Dpse\GA18429
Drosophila persimilis
Dper\GL18001
Drosophila willistoni
Dwil\GK20818
Drosophila virilis
Dvir\GJ12623
Drosophila mojavensis
Dmoj\GI16874
Drosophila grimshawi
Dgri\GH15596
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AGN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022300
Glossina morsitans
Tsetse fly
Gmor\GMOY010403
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09530
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BVN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08400
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0B98 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW019781
Ixodes scapularis
Black-legged tick
Isca\ISCW016310
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73244.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73249.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g02090
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_246873
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303722
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (44)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cpr67B
3 of 10
Cpr72Ea
3 of 10
Cpr72Eb
3 of 10
Ccp84Aa
2 of 10
Ccp84Ab
2 of 10
Ccp84Ac
2 of 10
Ccp84Ad
2 of 10
Ccp84Ae
2 of 10
Ccp84Af
2 of 10
Ccp84Ag
2 of 10
CG42367
2 of 10
Cpr5C
2 of 10
Cpr30B
2 of 10
Cpr30F
2 of 10
Cpr31A
2 of 10
Cpr35B
2 of 10
Cpr66Cb
2 of 10
Cpr76Bd
2 of 10
Cpr92F
2 of 10
Crys
2 of 10
Edg84A
2 of 10
CG13670
1 of 10
CG16800
1 of 10
CG34461
1 of 10
CG34462
1 of 10
Cpr23B
1 of 10
Cpr50Ca
1 of 10
Cpr50Cb
1 of 10
Cpr51A
1 of 10
Cpr56F
1 of 10
Cpr57A
1 of 10
Cpr62Ba
1 of 10
Cpr62Bb
1 of 10
Cpr62Bc
1 of 10
Cpr64Aa
1 of 10
Cpr64Ab
1 of 10
Cpr64Ac
1 of 10
Cpr64Ad
1 of 10
Cpr66D
1 of 10
Cpr76Ba
1 of 10
Cpr76Bb
1 of 10
Cpr76Bc
1 of 10
Cpr92A
1 of 10
resilin
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-44

    Cytogenetic map
    72E2-72E2
    Sequence location
    3L:16,365,894..16,367,340 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    72E2-72E2
    Limits computationally determined from genome sequence between P{lacW}l(3)s3123s3123 and P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-44

    (FlyBase, 2016)

    3-38.6

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (2)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (15)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Cpr72Ec CG4784

      (Willis, 2007.1.3)
      Source for database merge of
      Additional comments
      Other Comments

      Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

      (Claridge-Chang et al., 2001)

      Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

      (McDonald and Rosbash, 2001)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 26 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Synonyms and Secondary IDs (4)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (49)