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Gene Dmel\Smn

General Information
Symbol	Dmel\Smn	Species	D. melanogaster
Name	survival motor neuron	Annotation symbol	CG16725
Feature type	protein_coding_gene	FlyBase ID	FBgn0036641
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	dSMN, l(3)73Ao
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	73A9-73A9	Sequence location	3L:16,573,498..16,574,374 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene survival motor neuron is referred to in FlyBase by the symbol Dmel\Smn (CG16725, FBgn0036641). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: alpha-actinin binding. There is experimental evidence that it is involved in the biological process: ribonucleoprotein complex assembly; spliceosomal snRNP assembly; neuromuscular junction development; skeletal muscle thin filament assembly. 25 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; dorsal medial muscle; striated muscle thin filament; posterior crossvein; NMJ bouton; wing vein L4; indirect flight muscle motor neuron; indirect flight muscle. It has one annotated transcript and one annotated polypeptide. Protein features are: Survival motor neuron; Tudor domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626813_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Smn. Gene sequence location is 3L:16573498..16574374.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Sen et al., 2011, J. Cell Biol. 192(3): 481--495 Cauchi, 2011, Cell Biol. Int. 35(12): 1233--1238 Sequence features HFA10223 BKN26152
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 73A9-73A9   Limits computationally determined from genome sequence between P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532 and P{PZ}Baldspot02281
Experimentally Determined Cytological Location
Cytogenetic map Notes References 73A7-73A7     (Miguel-Aliaga, 2000.8.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Smn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Smn-RA FBtr0075395  NM_079388   877   226
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Smn-PA   FBpp0075153   24.6   226   4.93     NP_524112   AAF49446
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tudor domain (IPR002999) Survival motor neuron (IPR010304)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA820135   AE014296 AAF49446   AF296281 AAG17893   AI455341   AI456812   AI515935   AI518549   AY058529 AAL13758   BG636148   BI172510   BI351737   BI373196   BP560188   CO178310   CO195384   CO261810   CO263081   CO316640   CO316674   EC078042   EC195798   EC215391   EC240889   EL870491
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VV74
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 12   organism | ubiquitous   (Miguel-Aliaga et al., 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036641    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036641 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036641 expression level Developmental Stage   Expression Level embryo 00-02hr    10522 embryo 02-04hr    14862 embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10522) embryo 02-04hr  (14862) embryo 04-06hr  (8410) embryo 06-08hr  (5512) embryo 08-10hr  (6341) embryo 10-12hr  (6160) embryo 12-14hr  (3073) embryo 14-16hr  (3286) embryo 16-18hr  (2223) embryo 18-20hr  (1370) embryo 20-22hr  (1842) embryo 22-24hr  (1520) larva L1  (1071) larva L2  (982) larva L3 12hr old  (959) larva L3 puffstage 1-2  (1614) larva L3 puffstage 3-6  (2726) larva L3 puffstage 7-9  (3115) white prepupae new  (2925) white prepupae 12hr  (3185) white prepupae 24hr  (3882) pupae 2d postWPP  (2856) pupae 3d postWPP  (1333) pupae 4d postWPP  (1494) adult male 01day  (1929) adult male 05day  (2867) adult male 30day  (2559) adult female 01day  (3035) adult female 05day  (5144) adult female 30day  (5516) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10522) embryo 02-04hr  (14862) embryo 04-06hr  (8410) embryo 06-08hr  (5512) embryo 08-10hr  (6341) embryo 10-12hr  (6160) embryo 12-14hr  (3073) embryo 14-16hr  (3286) embryo 16-18hr  (2223) embryo 18-20hr    1370 embryo 20-22hr  (1842) embryo 22-24hr  (1520) larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2  (1614) larva L3 puffstage 3-6  (2726) larva L3 puffstage 7-9  (3115) white prepupae new  (2925) white prepupae 12hr  (3185) white prepupae 24hr  (3882) pupae 2d postWPP  (2856) pupae 3d postWPP    1333 pupae 4d postWPP  1494 adult male 01day  (1929) adult male 05day  (2867) adult male 30day  (2559) adult female 01day  (3035) adult female 05day  (5144) adult female 30day  (5516) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10522 embryo 02-04hr  (14862) embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10522 embryo 02-04hr    14862 embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036641 expression level Developmental Stage   Expression Level embryo 00-02hr    10522 embryo 02-04hr    14862 embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (10522) embryo 02-04hr  (14862) embryo 04-06hr  (8410) embryo 06-08hr  (5512) embryo 08-10hr  (6341) embryo 10-12hr  (6160) embryo 12-14hr  (3073) embryo 14-16hr  (3286) embryo 16-18hr  (2223) embryo 18-20hr  (1370) embryo 20-22hr  (1842) embryo 22-24hr  (1520) larva L1  (1071) larva L2  (982) larva L3 12hr old  (959) larva L3 puffstage 1-2  (1614) larva L3 puffstage 3-6  (2726) larva L3 puffstage 7-9  (3115) white prepupae new  (2925) white prepupae 12hr  (3185) white prepupae 24hr  (3882) pupae 2d postWPP  (2856) pupae 3d postWPP  (1333) pupae 4d postWPP  (1494) adult male 01day  (1929) adult male 05day  (2867) adult male 30day  (2559) adult female 01day  (3035) adult female 05day  (5144) adult female 30day  (5516) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (10522) embryo 02-04hr  (14862) embryo 04-06hr  (8410) embryo 06-08hr  (5512) embryo 08-10hr  (6341) embryo 10-12hr  (6160) embryo 12-14hr  (3073) embryo 14-16hr  (3286) embryo 16-18hr  2223 embryo 18-20hr    1370 embryo 20-22hr  1842 embryo 22-24hr  1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2  1614 larva L3 puffstage 3-6  (2726) larva L3 puffstage 7-9  (3115) white prepupae new  (2925) white prepupae 12hr  (3185) white prepupae 24hr  (3882) pupae 2d postWPP  (2856) pupae 3d postWPP    1333 pupae 4d postWPP  1494 adult male 01day  1929 adult male 05day  (2867) adult male 30day  (2559) adult female 01day  (3035) adult female 05day  (5144) adult female 30day  (5516) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  10522 embryo 02-04hr  14862 embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10522 embryo 02-04hr    14862 embryo 04-06hr    8410 embryo 06-08hr    5512 embryo 08-10hr    6341 embryo 10-12hr    6160 embryo 12-14hr    3073 embryo 14-16hr    3286 embryo 16-18hr    2223 embryo 18-20hr    1370 embryo 20-22hr    1842 embryo 22-24hr    1520 larva L1    1071 larva L2    982 larva L3 12hr old    959 larva L3 puffstage 1-2    1614 larva L3 puffstage 3-6    2726 larva L3 puffstage 7-9    3115 white prepupae new    2925 white prepupae 12hr    3185 white prepupae 24hr    3882 pupae 2d postWPP    2856 pupae 3d postWPP    1333 pupae 4d postWPP    1494 adult male 01day    1929 adult male 05day    2867 adult male 30day    2559 adult female 01day    3035 adult female 05day    5144 adult female 30day    5516 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036641    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036641 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036641 expression level Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (575.225) Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary  (665) Adult Testis  (580.7) Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036641 expression level Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary  665 Adult Testis  580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    575.225 Larval Midgut    110.1 Larval Hindgut    140.3 Larval Malpighian Tubules    165.9 Larval Fat Body    222.1 Larval Salivary Gland    279.7 Larval Trachea    315.025 Larval Carcass    184.375 Adult Head    127.3 Adult Eye    197.5 Adult Brain    169.1 Adult Thoracic-Abdominal Ganglion    173.2 Adult Crop    95.5 Adult Midgut    98.3 Adult Hindgut    97.1 Adult Malpighian Tubules    120.5 Adult Fat Body    81.1 Adult Salivary Gland    114 Adult Heart    81.775 Adult VirginFemale Spermatheca    137.5 Adult InseminatedFemale Spermatheca    149.9 Adult Ovary    665 Adult Testis    580.7 Adult Male Accessory Gland    324.7 Adult Carcass    96.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    127.3   NA  Eye    197.5   NA  Brain    169.1   575.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.2   NA  Crop    95.5   110.1  Midgut    98.3   140.3  Hindgut    97.1   165.9  Malpighian Tubules    120.5   222.1  Fat Body    81.1   279.7  Salivary Gland    114   NA  Heart    81.775   315.025  Trachea    NA   NA  VirginFemale Spermatheca    137.5   NA  InseminatedFemale Spermatheca    149.9   NA  Ovary    665   NA  Testis    580.7   NA  Male Accessory Gland    324.7   184.375  Carcass    96.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16725-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Smn Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav.PLu SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ lethal, with Scer\GAL4how-24B SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive Smn73Ao lethal | larval stage (with Smn73Ao) Smnf05960 SmnX7 lethal | larval stage (with Smnf05960) Smn73Ao SmnX7 lethal | larval stage (with SmnX7) Smn73Ao Smnf05960 lethal | larval stage | recessive Smn73Ao SmnB Smnf01109 Smnf05960 SmnPL00733 SmnX7 lethal | pharate adult stage SmnE2 lethal | pupal stage, with Scer\GAL4Act.PU SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ lethal | recessive Smn73Ao lethal | recessive | second instar larval stage Smn73Ao Smnf01109 Smnf05960 semi-viable Smnf01109 semi-viable (with Smn73Ao) Smnf01109 semi-viable (with Smnf01109) Smn73Ao Smnf05960 SmnX7 semi-viable (with Smnf05960) Smnf01109 semi-viable (with SmnX7) Smnf01109 viable SmnE33 viable, with Scer\GAL4pnr-MD237 SmnGD9191 Sterility Allele female sterile | germline clone | recessive Smn73Ao fertile SmnE33 Other Phenotypes Allele developmental rate defective | larval stage SmnE2 SmnPL00733 flight defective SmnE2 flightless SmnE33 increased cell death SmndsRNA.cIa jumping defective SmnE2 SmnE33 locomotor behavior defective | larval stage Smn73Ao SmnB Smnf01109 Smnf05960 SmnPL00733 neuroanatomy defective | adult stage SmnE33 neuroanatomy defective | third instar larval stage Smnf01109 neuroanatomy defective | third instar larval stage, with Scer\GAL4Act.PU SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ neuroanatomy defective | third instar larval stage, with Scer\GAL4elav.PLu SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ neuroanatomy defective | third instar larval stage, with Scer\GAL4how-24B SmndsRNA.C.Scer\UAS.WIZ SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ neuroanatomy defective | third instar larval stage (with Smn73Ao) Smnf01109 neuroanatomy defective | third instar larval stage (with Smnf01109) Smn73Ao neurophysiology defective Smn73Ao small body | larval stage Smn73Ao Smnf01109 Smnf05960 SmnPL00733 uncoordinated | larval stage | recessive Smn73Ao visible, with Scer\GAL4en-e16E SmndsRNA.N.Scer\UAS.WIZ Phenotype manifest in Allele dorsal medial muscle SmnE33 indirect flight muscle SmnE33 indirect flight muscle motor neuron SmnE33 NMJ bouton Smn73Ao Smnf01109 NMJ bouton, with Scer\GAL4Act.PU SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ SmndsRNA.C.Scer\UAS.WIZ NMJ bouton, with Scer\GAL4elav.PLu SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ SmndsRNA.C.Scer\UAS.WIZ NMJ bouton, with Scer\GAL4how-24B SmndsRNA.FL.Scer\UAS.WIZ SmndsRNA.N.Scer\UAS.WIZ SmndsRNA.C.Scer\UAS.WIZ NMJ bouton (with Smn73Ao) Smnf01109 NMJ bouton (with Smnf01109) Smn73Ao posterior crossvein, with Scer\GAL4en-e16E SmndsRNA.N.Scer\UAS.WIZ striated muscle thin filament SmnE33 wing vein L4, with Scer\GAL4en-e16E SmndsRNA.N.Scer\UAS.WIZ wing vein L5, with Scer\GAL4en-e16E SmndsRNA.N.Scer\UAS.WIZ
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Smn Class Mutagen Stocks Known lesion Smn73Ao amorphic allele - genetic evidence 2 Yes Smnf05960 amorphic allele - genetic evidence, loss of function allele piggyBac transposase 2 Yes Smnf01109 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence 1 Yes SmnB amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes SmnE2 P-element activity 0 Yes SmnE33 P-element activity 0 Yes SmnPL00733 0 -- SmnX7 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Smn Class Mutagen Stocks Known lesion SmnGD9191 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmnJF02057 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmnKK106152 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SmndsRNA.C.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes SmndsRNA.cIa in vitro construct - RNAi 0 Yes SmndsRNA.FL.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes SmndsRNA.N.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes SmnHM05208 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SmnMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmnN.Scer\UAS in vitro construct - regulatory fusion 0 Yes SmnScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes SmnScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmnScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SmnT.Scer\UAS in vitro construct - regulatory fusion 0 Yes SmnΔC157.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes SmnΔN159.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes SmnΔN62.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)st4 (Bedian, 1998.10.2) Df(3L)st7 (Bedian, 1998.10.2) Df(3L)st62 (Bedian, 1998.10.2) Df(3L)st-b11 (Bedian, 1998.10.2) Df(3L)st-g24 (Chan et al., 2003) Df(3L)st-j7 (Bedian, 1998.10.2) Df(3L)st-j11 (Bedian, 1998.10.2)
Not disrupted in	Df(3L)st6 (Bedian, 1998.10.2) Df(3L)st-f13 (Bedian, 1998.10.2) Df(3L)th2 (Bedian, 1998.10.2) Df(3L)thSS102 (Bedian, 1998.10.2) Df(3L)VB-33 (Bedian, 1998.10.2)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9191} NA P{KK106152} NA P{TRiP.HM05208} NA P{TRiP.JF02057} NA P{UASp-Smn.YFP} NA P{UAS-Smn.FLAG} NA P{UAS-Smn.M} NA P{UAS-Smn.N} NA P{UAS-Smn.RNAi.C} NA P{UAS-Smn.RNAi.FL} NA P{UAS-Smn.RNAi.N} NA P{UAS-Smn.T} NA P{UAS-Smn.ΔC157} NA P{UAS-Smn.ΔN62} NA P{UAS-Smn.ΔN159} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Smnf01109 NA PBac{WH}Smnf05960 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}SmnPL00733 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
alpha-actinin binding inferred from physical interaction with Actn (Rajendra et al., 2007)
Biological Process
CV term Evidence References
neuromuscular junction development inferred from mutant phenotype (Chang et al., 2008) ribonucleoprotein complex assembly inferred from mutant phenotype (Shpargel et al., 2009) skeletal muscle thin filament assembly inferred from mutant phenotype (Rajendra et al., 2007) spliceosomal snRNP assembly inferred from mutant phenotype (Rajendra et al., 2007)
Cellular Component
CV term Evidence References
Cajal body inferred from direct assay (Liu et al., 2006, Shpargel et al., 2009, Chang et al., 2008, Liu and Gall, 2007) cytoplasm inferred from direct assay (Shpargel et al., 2009, Liu et al., 2006) cytoplasmic U snRNP body inferred from direct assay (Liu and Gall, 2007) I band inferred from direct assay (Rajendra et al., 2007) neuromuscular junction inferred from direct assay (Chang et al., 2008) nucleus inferred from direct assay (Rajendra et al., 2007) Z disc inferred from direct assay (Rajendra et al., 2007)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR010304 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Smn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65147 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036641 DroID - A comprehensive database of gene and protein interactions. • FBgn0036641 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39844
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10520 Dere\GG15871 Dgri\GH15580 Dmoj\GI16856 Dper\GL17981 Dpse\GA14108 Dsec\GM24389 Dsim\GD12460 Dvir\GJ12606 Dwil\GK19792 Dyak\GE22210
Curated drosophilid orthologs	Dpse\GA14108
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008700-PA Aedes aegypti (mosquito) AGAP004011-PA Anopheles gambiae (mosquito) 104022 Branchiostoma floridae (lancelet) XP_001898700.1 Brugia malayi (roundworm nematode) BGIBMGA014402-PA Bombyx mori (silk worm) ENSBTAP00000007547 Bos taurus (bovine) CBP12921 Caenorhabditis briggsae (nematode) ENSCAFP00000031438 Canis familiaris (dog) CPIJ008880 Culex pipens (mosquito) ENSCPOP00000011091 Cavia porcellus (guinea pig) ENSCSAVP00000014330 Ciona savignyi (sedentary tunicate) 170515 Capitella spl (polychaete worm) 305990 Daphnia pulex (daphnia) ENSDARP00000017636 Danio rerio (zebra fish) ENSECAP00000013134 Equus caballus (horse) ENSGACP00000014003 Gymnopilus aculeatus (mushroom) ENSGALP00000003813 Gallus gallus (chicken) 158469 Hypsipyla robusta (cedar shoot borer) ENSP00000370083 Homo sapiens (human) ENSP00000370119 Homo sapiens (human) ISCW004969-PA Ixodes scapularis (deer tick) 234254 Lottia gigantea (owl limpet) ENSMODP00000001738 Monodelphis domestica (gray opossum) ENSMMUP00000026612 Macaca mulatta (rhesus monkey) ENSMUSP00000022147 Mus musculus (house mouse) XP_001599489.1 Nasonia vitripennis (wasp) ENSOANP00000002597 Ornithorynchus anatinus (platypus) ENSORLP00000013230 Oryzias latipes (japanese killifish) PHUM007806-PA Pediculus humanus (human body louse) ENSPPYP00000017360 Pongo pygmaeus (orangutan) ENSPTRP00000029048 Pan troglodytes (chimpanzee) ENSRNOP00000024456 Rattus norvegicus (norway rat) XP_781229.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000012783 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000039449 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16144 LH18915 ISCW007019 ISCW004969 FBgn0239437 FBgn0221790 FBgn0199845 FBgn0184189 FBgn0179252 JGI_V11_305990 FBgn0074138 FBgn0155584 FBgn0139602 FBgn0123051 FBgn0108107 FBgn0087561 CPIJ008880 BGIBMGA014402 GB13986 AGAP004011 AAEL008700 PB25609 PHUM234110
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	4802 Smn73Ao/TM6B, Tb1 26288 y1 v1; P{TRiP.JF02057}attP2 18923 w1118; PBac{WH}Smnf05960/TM6B, Tb1
Harvard	- PBac{WH}Smnf01109 - PBac{WH}Smnf05960
Kyoto	107890 Smn73Ao/TM6B, Tb1
VDRC	v100392 P{KK106152}VIE-260B v45447 w1118; P{GD9191}v45447/TM3
Genomic Clones ( 1 )
	BACR08H06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23602
Other clones	DPiM_LD23602
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM15941 LD36948 LD38096 LD41645 RE15025 RE60432 SD13747
Other clones	162337 162463 CK01.31A.B6 CK01.70D.H2 EC40239 EK056361 EK079806 EK087406 EK265535 EK265625 FGM325B08 IP02569
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036641 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39844 45748
Antibody Information
	monoclonal (Chang et al., 2008) polyclonal (Chang et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Smn CG16725 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Smn l(3)73Ao (Chan et al., 2003)
Additional comments	Source for identity of Smn CG16725 was sequence comparison (date:001007). (FlyBase, 1996-)
Other Comments
	Smn mutant animals show progressive loss of mobility and increasingly uncoordinated movement. (Thomas et al., 2007) Mutants show defects at the neuromuscular junction. (Chan et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079388 RefSeq (Proteins) • NP_524112 DDBJ / EMBL / GenBank • AA820135 AAF49446 AAG17893 AAL13758 AF296281 AI455341 AI456812 AI518549 AY058529 Entrez Gene - A searchable database of RefSeq genes. • 39844 UniProtKB/TrEMBL • Q9VV74
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tudor domain (IPR002999) Survival motor neuron (IPR010304)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65147 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036641 DroID - A comprehensive database of gene and protein interactions. • FBgn0036641 DRSC - Results from RNAi screens. • FBgn0036641 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036641 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16725-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036641 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39844 45748 InParanoid A subset of ortholog calls from InParanoid. • AAEL008700-PA Aedes aegypti (mosquito) AGAP004011-PA Anopheles gambiae (mosquito) 104022 Branchiostoma floridae (lancelet) XP_001898700.1 Brugia malayi (roundworm nematode) BGIBMGA014402-PA Bombyx mori (silk worm) ENSBTAP00000007547 Bos taurus (bovine) CBP12921 Caenorhabditis briggsae (nematode) ENSCAFP00000031438 Canis familiaris (dog) CPIJ008880 Culex pipens (mosquito) ENSCPOP00000011091 Cavia porcellus (guinea pig) ENSCSAVP00000014330 Ciona savignyi (sedentary tunicate) 170515 Capitella spl (polychaete worm) 305990 Daphnia pulex (daphnia) ENSDARP00000017636 Danio rerio (zebra fish) ENSECAP00000013134 Equus caballus (horse) ENSGACP00000014003 Gymnopilus aculeatus (mushroom) ENSGALP00000003813 Gallus gallus (chicken) 158469 Hypsipyla robusta (cedar shoot borer) ENSP00000370083 Homo sapiens (human) ENSP00000370119 Homo sapiens (human) ISCW004969-PA Ixodes scapularis (deer tick) 234254 Lottia gigantea (owl limpet) ENSMODP00000001738 Monodelphis domestica (gray opossum) ENSMMUP00000026612 Macaca mulatta (rhesus monkey) ENSMUSP00000022147 Mus musculus (house mouse) XP_001599489.1 Nasonia vitripennis (wasp) ENSOANP00000002597 Ornithorynchus anatinus (platypus) ENSORLP00000013230 Oryzias latipes (japanese killifish) PHUM007806-PA Pediculus humanus (human body louse) ENSPPYP00000017360 Pongo pygmaeus (orangutan) ENSPTRP00000029048 Pan troglodytes (chimpanzee) ENSRNOP00000024456 Rattus norvegicus (norway rat) XP_781229.2 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000012783 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000039449 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39844 modMine - Data generated by the modENCODE project. • FBgn0036641 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16144 LH18915 ISCW007019 ISCW004969 FBgn0239437 FBgn0221790 FBgn0199845 FBgn0184189 FBgn0179252 JGI_V11_305990 FBgn0074138 FBgn0155584 FBgn0139602 FBgn0123051 FBgn0108107 FBgn0087561 CPIJ008880 BGIBMGA014402 GB13986 AGAP004011 AAEL008700 PB25609 PHUM234110
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG16725 (Mount and Salz, 2000, Rajendra et al., 2007, Shpargel et al., 2009, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Gandhi et al., 2007, Perkins et al., 2009) DmSMN (Miguel-Aliaga et al., 2000) dSMN (Hua and Zhou, 2004, Thimmappaiaha and Matera, 2004, Ilangovan et al., 2003, Liu et al., 2006, Gonsalvez et al., 2006) l(3)73Ao (Chan et al., 2003, Bedian, 1998.10.2, ) smn (Chan et al., 2003, Thomas et al., 2004, Chan et al., 2002, Thomas et al., 2007, Lee et al., 2009) Smn (Thimmappaiaha et al., 2007, Rajendra et al., 2007, Chang et al., 2008, Shpargel et al., 2009, Gonsalvez et al., 2008, Lorbeck et al., 2010) SMN (Lee et al., 2007, Thomas et al., 2007, Tountas and Fortini, 2007, Liu et al., 2006, Matera, 2006, Cauchi et al., 2008, Liu et al., 2009, Lee et al., 2009, Kroiss et al., 2009, Liu and Gall, 2007, Cauchi et al., 2010, Friberg et al., 2010, Cauchi, 2011)
Name Synonym	survival motor neuron (Miguel-Aliaga, 2000.8.15, Matera, 2006, Chang et al., 2008, Lee et al., 2009, Gonsalvez et al., 2008, Cauchi et al., 2010, Lorbeck et al., 2010) Survival Motor Neuron (Lee et al., 2007, Thomas et al., 2007) survival of motor neurons (Liu et al., 2006, Liu and Gall, 2007)
Secondary FlyBase IDs
	FBgn0025499
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 8 )
	Cauchi, 2011, Cell Biol. Int. 35(12): 1233--1238 Gem formation upon constitutive Gemin3 overexpression in Drosophila. [FBrf0216668] Grice and Liu, 2011, PLoS Genet. 7(4): e1002030 Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila. [FBrf0213468] Sen et al., 2011, J. Cell Biol. 192(3): 481--495 Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling. [FBrf0212929] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cauchi et al., 2010, Exp. Cell Res. 316(14): 2354--2364 Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies. [FBrf0211219] Dimitriadi et al., 2010, PLoS Genet. 6(10): e1001172 Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects. [FBrf0212468] Friberg et al., 2010, Protein Sci. 19(10): 1906--1916 Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. [FBrf0211912] Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...