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Gene Dmel\TSG101

General Information
Symbol	Dmel\TSG101	Species	D. melanogaster
Name	tumor suppressor protein 101	Annotation symbol	CG9712
Feature type	protein_coding_gene	FlyBase ID	FBgn0036666
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	ept, dTsg101, vps23
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	73D1-73D1	Sequence location	3L:16,835,399..16,837,685 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, FBgn0036666). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of growth; negative regulation of growth of symbiont in host; regulation of JAK-STAT cascade; negative regulation of imaginal disc growth; maintenance of apical/basal cell polarity. 8 alleles are reported. The phenotypes of these alleles are annotated with: yolk granule; oocyte; vesicle. It has one annotated transcript and one annotated polypeptide. Protein features are: Steadiness box; Tetratricopeptide-like helical; Ubiquitin E2 variant, N-terminal; Ubiquitin-conjugating enzyme/RWD-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult Malpighian tubules, adult heart, larval fat body, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640247_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TSG101. Gene sequence location is 3L:16835399..16837685.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466
FB2012_01	Sequence features HFA11098
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 73D1-73D1   Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TSG101 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TSG101-RA FBtr0075329  NM_079396   1752   408
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TSG101-PA   FBpp0075088   45.2   408   6.32     NP_524120   AAF49406
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin E2 variant, N-terminal (IPR008883) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) Steadiness box (IPR017916) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA951728   AE014296 AAF49406   AF315343 AAG29564   AI110074   AI297906   AI387669   AI403122   AI515482   AI944688   AY122227 AAM52739   BF486224   BF488098   BF502840   BG636513   BI229055   BI240326   BI368647   BI566952   BI571503   BI579556   BI585542   BI588356   BI588753   BI593066   BI613318   BI637764   BP544110   CA807819   CO153278   CO153913   CO178344   CO192058   CO263955   CO276955   CO338647   CZ483456   CZ483457   DQ017452 AAY82230   DQ017453 AAY82231   EC063838   EC083746   EC085243   EC195115   EC195808   EC216514   EC234253   EC240903   EC265442   EC267336   GH748136   GH782419   GH787311   GH788599   GH807346   GH812159   GH824827   GH829677   GH836828   GH843025   GH860815   GH861137   GH866607   GH885198   GH891273   GH901995   GH910839   GH916309   GH917339   GH937651   GH940516
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q3YNA6 Q8MQZ0 Q9VVA7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036666    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036666 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036666 expression level Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2962) embryo 02-04hr  (3353) embryo 04-06hr  (2774) embryo 06-08hr  (2692) embryo 08-10hr  (2626) embryo 10-12hr  (2370) embryo 12-14hr  (2449) embryo 14-16hr  (1479) embryo 16-18hr  (1749) embryo 18-20hr  (1753) embryo 20-22hr  (1335) embryo 22-24hr  (1552) larva L1  (1421) larva L2  (1411) larva L3 12hr old  (1321) larva L3 puffstage 1-2  (2263) larva L3 puffstage 3-6  (3140) larva L3 puffstage 7-9  (4570) white prepupae new  (4573) white prepupae 12hr  (4447) white prepupae 24hr  (5145) pupae 2d postWPP  (5726) pupae 3d postWPP  (5020) pupae 4d postWPP  (3842) adult male 01day  (5937) adult male 05day  (7515) adult male 30day  (7239) adult female 01day  (1942) adult female 05day  (2464) adult female 30day  (2550) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2962) embryo 02-04hr  (3353) embryo 04-06hr  (2774) embryo 06-08hr  (2692) embryo 08-10hr  (2626) embryo 10-12hr  (2370) embryo 12-14hr  (2449) embryo 14-16hr  1479 embryo 16-18hr  (1749) embryo 18-20hr  (1753) embryo 20-22hr    1335 embryo 22-24hr  (1552) larva L1  1421 larva L2  1411 larva L3 12hr old    1321 larva L3 puffstage 1-2  (2263) larva L3 puffstage 3-6  (3140) larva L3 puffstage 7-9  (4570) white prepupae new  (4573) white prepupae 12hr  (4447) white prepupae 24hr  (5145) pupae 2d postWPP  (5726) pupae 3d postWPP  (5020) pupae 4d postWPP  (3842) adult male 01day  (5937) adult male 05day  (7515) adult male 30day  (7239) adult female 01day  (1942) adult female 05day  (2464) adult female 30day  (2550) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036666 expression level Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2962) embryo 02-04hr  (3353) embryo 04-06hr  (2774) embryo 06-08hr  (2692) embryo 08-10hr  (2626) embryo 10-12hr  (2370) embryo 12-14hr  (2449) embryo 14-16hr  (1479) embryo 16-18hr  (1749) embryo 18-20hr  (1753) embryo 20-22hr  (1335) embryo 22-24hr  (1552) larva L1  (1421) larva L2  (1411) larva L3 12hr old  (1321) larva L3 puffstage 1-2  (2263) larva L3 puffstage 3-6  (3140) larva L3 puffstage 7-9  (4570) white prepupae new  (4573) white prepupae 12hr  (4447) white prepupae 24hr  (5145) pupae 2d postWPP  (5726) pupae 3d postWPP  (5020) pupae 4d postWPP  (3842) adult male 01day  (5937) adult male 05day  (7515) adult male 30day  (7239) adult female 01day  (1942) adult female 05day  (2464) adult female 30day  (2550) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2962) embryo 02-04hr  (3353) embryo 04-06hr  (2774) embryo 06-08hr  (2692) embryo 08-10hr  (2626) embryo 10-12hr  2370 embryo 12-14hr  2449 embryo 14-16hr  1479 embryo 16-18hr  1749 embryo 18-20hr  1753 embryo 20-22hr    1335 embryo 22-24hr  1552 larva L1  1421 larva L2  1411 larva L3 12hr old    1321 larva L3 puffstage 1-2  2263 larva L3 puffstage 3-6  (3140) larva L3 puffstage 7-9  (4570) white prepupae new  (4573) white prepupae 12hr  (4447) white prepupae 24hr  (5145) pupae 2d postWPP  (5726) pupae 3d postWPP  (5020) pupae 4d postWPP  (3842) adult male 01day  (5937) adult male 05day  (7515) adult male 30day  (7239) adult female 01day  1942 adult female 05day  2464 adult female 30day  (2550) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2962 embryo 02-04hr    3353 embryo 04-06hr    2774 embryo 06-08hr    2692 embryo 08-10hr    2626 embryo 10-12hr    2370 embryo 12-14hr    2449 embryo 14-16hr    1479 embryo 16-18hr    1749 embryo 18-20hr    1753 embryo 20-22hr    1335 embryo 22-24hr    1552 larva L1    1421 larva L2    1411 larva L3 12hr old    1321 larva L3 puffstage 1-2    2263 larva L3 puffstage 3-6    3140 larva L3 puffstage 7-9    4570 white prepupae new    4573 white prepupae 12hr    4447 white prepupae 24hr    5145 pupae 2d postWPP    5726 pupae 3d postWPP    5020 pupae 4d postWPP    3842 adult male 01day    5937 adult male 05day    7515 adult male 30day    7239 adult female 01day    1942 adult female 05day    2464 adult female 30day    2550 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036666    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036666 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult Malpighian tubules, adult heart, larval fat body, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036666 expression level Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis    1428.7 Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules  (935.2) Larval Fat Body  (545.4) Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye  (634.275) Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion  (559.4) Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules  (769.3) Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart  (550.7) Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis  (1428.7) Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis  (1428.7) Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis    1428.7 Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036666 expression level Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis    1428.7 Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules  (935.2) Larval Fat Body  545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye  634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion  559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules  769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart  550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis  (1428.7) Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis  1428.7 Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    503.35 Larval Midgut    341.3 Larval Hindgut    435.4 Larval Malpighian Tubules    935.2 Larval Fat Body    545.4 Larval Salivary Gland    339.7 Larval Trachea    471.05 Larval Carcass    278.375 Adult Head    340.6 Adult Eye    634.275 Adult Brain    480.5 Adult Thoracic-Abdominal Ganglion    559.4 Adult Crop    372.5 Adult Midgut    309.4 Adult Hindgut    324.8 Adult Malpighian Tubules    769.3 Adult Fat Body    234 Adult Salivary Gland    273 Adult Heart    550.7 Adult VirginFemale Spermatheca    220.6 Adult InseminatedFemale Spermatheca    199.1 Adult Ovary    274.5 Adult Testis    1428.7 Adult Male Accessory Gland    186.3 Adult Carcass    321 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    340.6   NA  Eye    634.275   NA  Brain    480.5   503.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    559.4   NA  Crop    372.5   341.3  Midgut    309.4   435.4  Hindgut    324.8   935.2  Malpighian Tubules    769.3   545.4  Fat Body    234   339.7  Salivary Gland    273   NA  Heart    550.7   471.05  Trachea    NA   NA  VirginFemale Spermatheca    220.6   NA  InseminatedFemale Spermatheca    199.1   NA  Ovary    274.5   NA  Testis    1428.7   NA  Male Accessory Gland    186.3   278.375  Carcass    321 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036666 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9712-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for TSG101 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | first instar larval stage | recessive TSG1012 lethal | pupal stage, with Scer\GAL4pnr-MD237 TSG101GD14295 lethal | pupal stage | somatic clone TSG1012 lethal | somatic clone TSG1012 semi-lethal | embryonic stage | recessive TSG1012 semi-lethal | somatic clone | wandering third instar larval stage TSG1012 Other Phenotypes Allele hyperplasia | adult stage | cell non-autonomous | somatic clone TSG1012 hyperplasia | cell non-autonomous | somatic clone | wandering third instar larval stage TSG1012 large body | larval stage | somatic clone TSG1012 large body | somatic clone | wandering third instar larval stage TSG1012 Phenotype manifest in Allele eye | somatic clone TSG1012 eye-antennal disc | cell non-autonomous | somatic clone TSG1012 eye disc | somatic clone TSG1012 eye photoreceptor cell | cell non-autonomous | somatic clone TSG1012 eye photoreceptor cell | somatic clone TSG1012 head | somatic clone TSG1012 ommatidium | cell non-autonomous | somatic clone TSG1012 oocyte TSG1012 rhabdomere & eye photoreceptor cell | somatic clone TSG1012 vesicle TSG1012 yolk granule TSG1012
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of TSG101 Class Mutagen Stocks Known lesion TSG101e00381 1 -- TSG101f00976 piggyBac transposase 1 -- TSG1012 ethyl methanesulfonate 0 Yes TSG101P26 hypomorphic allele - genetic evidence P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TSG101 Class Mutagen Stocks Known lesion TSG101GD14295 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TSG101GLV21075 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TSG101hs.PM in vitro construct - regulatory fusion 0 Yes TSG101MtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9002 (Ryder, 2004.4.26, Moberg et al., 2005) Df(3L)Exel9003 (Ryder, 2004.4.26) Df(3L)Exel9004 (Ryder, 2004.4.26, Moberg et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14295} NA P{TRiP.GLV21075} NA heat-shock construct P{hs-TSG101.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}TSG101e00381 NA PBac{WH}TSG101f00976 NA insertion of mobile activating element P{EPgy2}TSG101P26 NA P{GSV1}EP-666EP-666 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Vps28 (Sevrioukov et al., 2005)
Biological Process
CV term Evidence References
maintenance of apical/basal cell polarity inferred from mutant phenotype (Moberg et al., 2005) negative regulation of growth inferred from mutant phenotype (Moberg et al., 2005) negative regulation of growth of symbiont in host inferred from mutant phenotype (Philips et al., 2008) negative regulation of imaginal disc growth inferred from mutant phenotype (Moberg et al., 2005) regulation of JAK-STAT cascade inferred from mutant phenotype (Moberg et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein modification process inferred from electronic annotation with InterPro:IPR008883 (FlyBase Curators et al., 2004-) protein transport inferred from electronic annotation with InterPro:IPR008883 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TSG101 allele Gene References unspecified Stat92E (Moberg et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65180 DroID - A comprehensive database of gene and protein interactions. • FBgn0036666 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39881
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23934 Dere\GG13581 Dgri\GH16594 Dmoj\GI12442 Dper\GL20850 Dpse\GA28575 Dsec\GM25660 Dsim\GD14667 Dvir\GJ12339 Dwil\GK16611 Dyak\GE19877
Curated drosophilid orthologs	Dpse\GA21983
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012515-PA Aedes aegypti (mosquito) AGAP005934-PA Anopheles gambiae (mosquito) XP_392951.2 Apis mellifera (honey bee) XP_001945873.1 Acyrthosiphon pisum (pea aphid) At3g12400.1 Arabidopsis thaliana (wall cress) 90872 Batrachochytrium dendrobatidis (chytrid fungus) 276977 Branchiostoma floridae (lancelet) XP_001893236.1 Brugia malayi (roundworm nematode) BGIBMGA004136-PA Bombyx mori (silk worm) ENSBTAP00000018032 Bos taurus (bovine) CN17682 Caenorhabditis brenneri (small nematode) CBP31274 Caenorhabditis briggsae (nematode) CE34675 Caenorhabditis elegans (worm) ENSCAFP00000013702 Canis familiaris (dog) CAGL0H03927g Candida glabrata (haploid yeast) JA09625 Caenorhabditis japonica (nematode) CMK136C Cyanidioschyzon merolae (red alga) CPIJ006913 Culex pipens (mosquito) ENSCPOP00000010792 Cavia porcellus (guinea pig) 155778 Capitella spl (polychaete worm) DDB0234022 Dictyostelium discoideum (amoeba) DEHA2G11726g Debaryomyces Hansenii (yeast) 65881 Daphnia pulex (daphnia) ENSDARP00000013839 Danio rerio (zebra fish) ENSECAP00000004256 Equus caballus (horse) XP_649501 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014982 Gymnopilus aculeatus (mushroom) ENSGALP00000010193 Gallus gallus (chicken) 185660 Hypsipyla robusta (cedar shoot borer) ENSP00000251968 Homo sapiens (human) ISCW014292-PA Ixodes scapularis (deer tick) KLLA0D04752g Kluyveromyces lactis (yeast) 119455 Lottia gigantea (owl limpet) LmjF32.0985 Leishmania major (virus) ENSMODP00000007950 Monodelphis domestica (gray opossum) ENSMMUP00000019178 Macaca mulatta (rhesus monkey) ENSMUSP00000014546 Mus musculus (house mouse) 244032 Nematostella vectensis (starlet anemone) XP_001599563.1 Nasonia vitripennis (wasp) ENSOANP00000013298 Ornithorynchus anatinus (platypus) LOC_Os02g58640.1 Oryza sativa (asian rice) 31474 Ostreococcus tauri (green alga) PHUM010756-PA Pediculus humanus (human body louse) PP28626 Pristionchus pacificus (nematode) 170379 Physcomitrella patens (moss) ENSPPYP00000003942 Pongo pygmaeus (orangutan) 79629 Phytophthora ramorum (sudden oak death pathogen) 132761 Phytophthora sojae (root rot pathogen) 178315 Populus trichocarpa (black cottonwood) ENSPTRP00000005961 Pan troglodytes (chimpanzee) ENSRNOP00000018194 Rattus norvegicus (norway rat) 4885400 Sorghum bicolor (sorghum) YCL008C Saccharomyces cerevisiae (budding yeast) 33034 Trichoplax adhaerens (metazoa) TA06765 Theileria annulata (apicomplexan parasite) XP_972705.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014331 Tetraodon nigroviridis (green spotted pufferfish) 23630 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027688 Takifugu rubripes (pufferfish Takifugu) 248.m00036 Tetrahymena thermophila (ciliate protozoa) YALI0F19272g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18313 NV17371 LH17679 ISCW014292 FBgn0237207 FBgn0218613 FBgn0199585 FBgn0186345 FBgn0180517 FBgn0249935 JGI_V11_65881 FBgn0158445 FBgn0135199 FBgn0124065 FBgn0105851 FBgn0100928 CPIJ015378 CPIJ006913 BGIBMGA004136 ACYPI000238 GB17037 AGAP005934 AAEL012515 PHUM537110 GLEAN_02425
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	35710 y1 sc* v1; P{TRiP.GLV21075}attP2
Harvard	- PBac{RB}TSG101e00381 - PBac{WH}TSG101f00976
VDRC	v23944 w1118; P{GD14295}v23944/CyO
Genomic Clones ( 1 )
	BACR48E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 62 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE26756
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT18675 AT20456 AT23186 GH09529 GH18254 GH22492 LD32419 LD47333 LP12350 RE37147 RE54653 RE73608 RH06637 RH10957 RH25148 RH29534 RH30168 RH36765 RH42447 SD14244 SD19834
Other clones	28853 51231 74524 273588 522238 522944 bs04c03 CK01.31C.G6 CK01.34D.C9 CK01.71A.E6 EC32741 EK056451 EK122501 EK136958 EN01633 EN03064 EN17303 ESG019d.E21_B01 FGC024B05 RP003017170 RP003043966 RP003118195 RP003150982 RP003181810 RP003222042 RP003241341 RP003269884 RP003291977 RP003315949 RP003316751 RP003342167 RP003434258 RP003451982 RP003464422 RP003491965 RP003559693 RP003574668 RP003581029 RP003656499 RP003665438
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036666 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39881
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TSG101 CG9712 (Laurencon, 2000.10.20)
Source for database merge of	Source for merge of: TSG101 ept (Moberg, 2005.6.19)
Additional comments
Other Comments
	Identification: In an ey-FLP system, based on its non-cell autonomous overgrowth phenotype. TSG101 is as member of a novel class of 'non-autonomous growth suppressor' genes. (Moberg et al., 2005) TSG101 is involved in ubiquitin-dependent regulation of proteins. (Moberg et al., 2005) TSG101 mutant cells in the eye-antennal disc survive poorly. The eyes and heads of flies that contain TSG101 mutant cells are dramatically overgrown, yet are composed of mostly wild type cells. TSG101 mutant cells hyperactivate N signaling and overproduce the secreted growth factor os. TSG101 mutant cells provoke local tissue hyperplasia and ectopic S phase entry in surrounding wild type cells; the resulting overgrowth is dependent upon signaling through the os-responsive JAK/STAT pathway. (Moberg et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079396 RefSeq (Proteins) • NP_524120 DDBJ / EMBL / GenBank • AAF49406 AAG29564 AAM52739 AAY82230 AAY82231 AF315343 AI110074 AI944688 AY122227 BI229055 CZ483456 CZ483457 DQ017452 DQ017453 Entrez Gene - A searchable database of RefSeq genes. • 39881 UniProtKB/TrEMBL • Q3YNA6 Q8MQZ0 Q9VVA7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin E2 variant, N-terminal (IPR008883) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) Steadiness box (IPR017916) Tetratricopeptide-like helical (IPR011990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65180 DroID - A comprehensive database of gene and protein interactions. • FBgn0036666 DRSC - Results from RNAi screens. • FBgn0036666 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036666 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9712-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036666 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39881 InParanoid A subset of ortholog calls from InParanoid. • AAEL012515-PA Aedes aegypti (mosquito) AGAP005934-PA Anopheles gambiae (mosquito) XP_392951.2 Apis mellifera (honey bee) XP_001945873.1 Acyrthosiphon pisum (pea aphid) At3g12400.1 Arabidopsis thaliana (wall cress) 90872 Batrachochytrium dendrobatidis (chytrid fungus) 276977 Branchiostoma floridae (lancelet) XP_001893236.1 Brugia malayi (roundworm nematode) BGIBMGA004136-PA Bombyx mori (silk worm) ENSBTAP00000018032 Bos taurus (bovine) CN17682 Caenorhabditis brenneri (small nematode) CBP31274 Caenorhabditis briggsae (nematode) CE34675 Caenorhabditis elegans (worm) ENSCAFP00000013702 Canis familiaris (dog) CAGL0H03927g Candida glabrata (haploid yeast) JA09625 Caenorhabditis japonica (nematode) CMK136C Cyanidioschyzon merolae (red alga) CPIJ006913 Culex pipens (mosquito) ENSCPOP00000010792 Cavia porcellus (guinea pig) 155778 Capitella spl (polychaete worm) DDB0234022 Dictyostelium discoideum (amoeba) DEHA2G11726g Debaryomyces Hansenii (yeast) 65881 Daphnia pulex (daphnia) ENSDARP00000013839 Danio rerio (zebra fish) ENSECAP00000004256 Equus caballus (horse) XP_649501 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014982 Gymnopilus aculeatus (mushroom) ENSGALP00000010193 Gallus gallus (chicken) 185660 Hypsipyla robusta (cedar shoot borer) ENSP00000251968 Homo sapiens (human) ISCW014292-PA Ixodes scapularis (deer tick) KLLA0D04752g Kluyveromyces lactis (yeast) 119455 Lottia gigantea (owl limpet) LmjF32.0985 Leishmania major (virus) ENSMODP00000007950 Monodelphis domestica (gray opossum) ENSMMUP00000019178 Macaca mulatta (rhesus monkey) ENSMUSP00000014546 Mus musculus (house mouse) 244032 Nematostella vectensis (starlet anemone) XP_001599563.1 Nasonia vitripennis (wasp) ENSOANP00000013298 Ornithorynchus anatinus (platypus) LOC_Os02g58640.1 Oryza sativa (asian rice) 31474 Ostreococcus tauri (green alga) PHUM010756-PA Pediculus humanus (human body louse) PP28626 Pristionchus pacificus (nematode) 170379 Physcomitrella patens (moss) ENSPPYP00000003942 Pongo pygmaeus (orangutan) 79629 Phytophthora ramorum (sudden oak death pathogen) 132761 Phytophthora sojae (root rot pathogen) 178315 Populus trichocarpa (black cottonwood) ENSPTRP00000005961 Pan troglodytes (chimpanzee) ENSRNOP00000018194 Rattus norvegicus (norway rat) 4885400 Sorghum bicolor (sorghum) YCL008C Saccharomyces cerevisiae (budding yeast) 33034 Trichoplax adhaerens (metazoa) TA06765 Theileria annulata (apicomplexan parasite) XP_972705.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014331 Tetraodon nigroviridis (green spotted pufferfish) 23630 Thalassiosira pseudonana (marine diatom) ENSTRUP00000027688 Takifugu rubripes (pufferfish Takifugu) 248.m00036 Tetrahymena thermophila (ciliate protozoa) YALI0F19272g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/tsg101erupted1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39881 modMine - Data generated by the modENCODE project. • FBgn0036666 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18313 NV17371 LH17679 ISCW014292 FBgn0237207 FBgn0218613 FBgn0199585 FBgn0186345 FBgn0180517 FBgn0249935 JGI_V11_65881 FBgn0158445 FBgn0135199 FBgn0124065 FBgn0105851 FBgn0100928 CPIJ015378 CPIJ006913 BGIBMGA004136 ACYPI000238 GB17037 AGAP005934 AAEL012515 PHUM537110 GLEAN_02425
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG9712 (Stuart et al., 2007, Molnar et al., 2006, Ni et al., 2011.7.19, Vidal et al., 2010) DmTSG101 (Laurencon, 2000.10.20) dTsg101 (Sevrioukov et al., 2005, Philips et al., 2008) dTSg101 (Sevrioukov et al., 2005) dVps23 (Akbar et al., 2007) ept (Moberg et al., 2005, Gilbert et al., 2007, Giebel and Wodarz, 2006, Irion and St Johnston, 2007, Irion and St Johnston, 2007, Moberg et al., 2005, Gilbert et al., 2009, Gilbert et al., 2009, Saj et al., 2010, Grusche et al., 2011) ESCRT-I (Vaccari et al., 2008) Tsg101 (Gilbert and Moberg, 2006, Spradling, 2006, Irion and St Johnston, 2007, Miura et al., 2008, Philips et al., 2008) TSG101 (Stuart et al., 2007, Molnar et al., 2006, Gilbert et al., 2009, Morozova et al., 2006, Vaccari et al., 2008) tsg101 (Menut et al., 2007, Vaccari et al., 2008, Gilbert et al., 2009, Vaccari et al., 2009, Vidal et al., 2010) vps23 (Ahmad et al., 2009, Uytterhoeven et al., 2011)
Name Synonym	erupted (Moberg et al., 2005, Gilbert et al., 2007, Giebel and Wodarz, 2006, Irion and St Johnston, 2007, Moberg et al., 2005, Haberman et al., 2008, Gilbert et al., 2009, Gilbert et al., 2009, Grusche et al., 2011) Erupted (Childress et al., 2006, Childress et al., 2007, Vaccari et al., 2009) tumor suppressor protein 101 (Laurencon, 2000.10.20) Tumor Susceptibility Gene-101 (Gilbert et al., 2009)
Secondary FlyBase IDs
	FBgn0082594
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Uytterhoeven et al., 2011, Cell 145(1): 117--132 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. [FBrf0213384] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Vidal et al., 2010, J. Cell Sci. 123(20): 3457--3466 Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. [FBrf0211993] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...