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Gene Dmel\CG6512

General Information
Symbol	Dmel\CG6512	Species	D. melanogaster
Name		Annotation symbol	CG6512
Feature type	protein_coding_gene	FlyBase ID	FBgn0036702
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	74A1-74A2	Sequence location	3L:17,231,713..17,235,228 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6512 (FBgn0036702). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity; ATPase activity. There is experimental evidence that it is involved in the biological process: lateral inhibition. 4 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; chaeta. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: AAA+ ATPase domain; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Peptidase M41; Peptidase M41, FtsH extracellular; Peptidase, FtsH. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval hindgut, adult Malpighian tubules, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1634899_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG6512. Gene sequence location is 3L:17231713..17235228.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 74A1-74A2   Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6512 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene model reviewed during 5.40 Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6512-RA FBtr0075251  NM_168720   3105   826 CG6512-RB FBtr0075252  NM_168722   2816   697
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6512-PA   FBpp0075012   89.7   826   9.45     NP_730248   AAF49365 CG6512-PB   FBpp0075013   76.1   697   7.11     NP_730250   AAN11704
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M41 (IPR000642) AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Peptidase, FtsH (IPR005936) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Peptidase M41, FtsH extracellular (IPR011546) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06512
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695607   AA697882   AA698707   AA978543   AE014296 AAF49365   AE014296 AAN11704   AI257053   AI259942   AI292541   AI292582   AI295816   AI297739   AI297813   AI402828   AI530867   AI532297   AI532785   AI945092   AW944191   AY084199 AAL89937   BE975219   BF485577   BF486402   BF489641   BF490093   BF490917   BF491902   BF492730   BF492731   BF493571   BF493577   BF493677   BF493923   BF494538   BF494771   BF496729   BF497578   BF497591   BF499503   BF500353   BF501457   BF503735   BF504270   BF504881   BF504907   BF505617   BF505625   BF505801   BG640257   BI163560   BI163723   BI165492   BI166328   BI167621   BI168639   BI169818   BI169870   BI231515   BI233245   BI243591   BI354011   BI354540   BI356441   BI362973   BI362983   BI370408   BI372606   BI375706   BI482259   BI482958   BI485107   BI485795   BI564994   BI576908   BI577635   BI580787   BI580795   BI580888   BI586107   BI606510   BI608330   BI612803   BI619957   BI622468   BI627569   BI629077   BI637251   CK605521   CK605522   CK660183   CL527736   CO186436   CO189278   CO274664   CO280545   CO310289   CO317150   EC052217   EC053246   EC053744   EC054223   EC055299   EC080352   EC089511   EC233816   EC238002   EC242152   EC247958   GH754796   GH755788   GH756270   GH756404   GH756923   GH759083   GH759937   GH770447   GH771124   GH771932   GH773105   GH777255   GH779917   GH780879   GH782704   GH786848   GH789542   GH791194   GH794538   GH801032   GH802879   GH805641   GH807064   GH808803   GH809744   GH815161   GH820141   GH822871   GH827979   GH833563   GH834020   GH835725   GH835958   GH837067   GH838162   GH840402   GH842650   GH847053   GH847919   GH848345   GH848933   GH849265   GH850577   GH852082   GH852154   GH854879   GH855824   GH858277   GH861834   GH865396   GH871257   GH872145   GH873900   GH874583   GH876425   GH880758   GH882844   GH884885   GH891897   GH892468   GH893221   GH901475   GH908611   GH908969   GH912444   GH913846   GH922484   GH922494   GH930465   GH931841   GH932894   GH934626
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQQ9 Q8T4G5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval hindgut, adult Malpighian tubules, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut  (542.8) Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass  520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion  (612.4) Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules  (743.3) Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis  (796.2) Adult Male Accessory Gland    315.6 Adult Carcass  (626.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut  542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass  520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion  612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules  743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis  796.2 Adult Male Accessory Gland    315.6 Adult Carcass  626.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.6 Larval Midgut    438.4 Larval Hindgut    542.8 Larval Malpighian Tubules    387.2 Larval Fat Body    217.1 Larval Salivary Gland    452.5 Larval Trachea    276.375 Larval Carcass    520.775 Adult Head    311.8 Adult Eye    315.55 Adult Brain    498.1 Adult Thoracic-Abdominal Ganglion    612.4 Adult Crop    349.5 Adult Midgut    477.4 Adult Hindgut    386.4 Adult Malpighian Tubules    743.3 Adult Fat Body    372.8 Adult Salivary Gland    399.4 Adult Heart    299.075 Adult VirginFemale Spermatheca    323.9 Adult InseminatedFemale Spermatheca    349.7 Adult Ovary    341.7 Adult Testis    796.2 Adult Male Accessory Gland    315.6 Adult Carcass    626.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    311.8   NA  Eye    315.55   NA  Brain    498.1   346.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    612.4   NA  Crop    349.5   438.4  Midgut    477.4   542.8  Hindgut    386.4   387.2  Malpighian Tubules    743.3   217.1  Fat Body    372.8   452.5  Salivary Gland    399.4   NA  Heart    299.075   276.375  Trachea    NA   NA  VirginFemale Spermatheca    323.9   NA  InseminatedFemale Spermatheca    349.7   NA  Ovary    341.7   NA  Testis    796.2   NA  Male Accessory Gland    315.6   520.775  Carcass    626.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male    104 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male  (29) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult  (33) ovary, virgin 4-day female  (32) ovary, mated 4-day female  (29) testis, mated 4-day male  (104) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male  104 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male    104 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male    104 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male  29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult  (33) ovary, virgin 4-day female  32 ovary, mated 4-day female  29 testis, mated 4-day male  (104) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male  104 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    18 central nervous system, pupae P8    15 head, virgin 1-day female    21 head, virgin 4-day female    16 head, virgin 20-day female    20 head, mated 1-day female    18 head, mated 4-day female    14 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    24 head, mated 20-day male    29 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    19 digestive system, 4-day adult    20 digestive system, 20-day adult    21 fat body, larvae L3 wandering    12 fat body, white prepupae    12 fat body, pupae P8    14 carcass, larvae L3 wandering    20 carcass, 1-day adult    25 carcass, 4-day adult    24 carcass, 20-day adult    33 ovary, virgin 4-day female    32 ovary, mated 4-day female    29 testis, mated 4-day male    104 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr  (42) embryo 04-06hr  (34) embryo 06-08hr  (35) embryo 08-10hr  (36) embryo 10-12hr  (52) embryo 12-14hr  (41) embryo 14-16hr  (54) embryo 16-18hr  (52) embryo 18-20hr  (50) embryo 20-22hr  (44) embryo 22-24hr  (43) larva L1  (61) larva L2  (75) larva L3 12hr old  (60) larva L3 puffstage 1-2    25 larva L3 puffstage 3-6  (28) larva L3 puffstage 7-9  (29) white prepupae new  (28) white prepupae 12hr  (29) white prepupae 24hr  (39) pupae 2d postWPP  (58) pupae 3d postWPP  (75) pupae 4d postWPP  (59) adult male 01day  (82) adult male 05day  (84) adult male 30day  (87) adult female 01day  (52) adult female 05day  (51) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (61) embryo 02-04hr  (42) embryo 04-06hr  (34) embryo 06-08hr  (35) embryo 08-10hr  (36) embryo 10-12hr  (52) embryo 12-14hr  (41) embryo 14-16hr  (54) embryo 16-18hr  (52) embryo 18-20hr  (50) embryo 20-22hr  (44) embryo 22-24hr  (43) larva L1  (61) larva L2  (75) larva L3 12hr old  (60) larva L3 puffstage 1-2    25 larva L3 puffstage 3-6  28 larva L3 puffstage 7-9  29 white prepupae new  28 white prepupae 12hr  29 white prepupae 24hr  (39) pupae 2d postWPP  (58) pupae 3d postWPP  (75) pupae 4d postWPP  (59) adult male 01day  (82) adult male 05day  (84) adult male 30day  (87) adult female 01day  (52) adult female 05day  (51) adult female 30day  (53) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    61 embryo 02-04hr    42 embryo 04-06hr    34 embryo 06-08hr    35 embryo 08-10hr    36 embryo 10-12hr    52 embryo 12-14hr    41 embryo 14-16hr    54 embryo 16-18hr    52 embryo 18-20hr    50 embryo 20-22hr    44 embryo 22-24hr    43 larva L1    61 larva L2    75 larva L3 12hr old    60 larva L3 puffstage 1-2    25 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    29 white prepupae new    28 white prepupae 12hr    29 white prepupae 24hr    39 pupae 2d postWPP    58 pupae 3d postWPP    75 pupae 4d postWPP    59 adult male 01day    82 adult male 05day    84 adult male 30day    87 adult female 01day    52 adult female 05day    51 adult female 30day    53 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    135 embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167    140 embryonic S1    113 embryonic S3    56 leg disc CME L1    151 wing disc CME-W2    113 wing disc ML-DmD8    61 wing disc ML-DmD9    106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21    102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    119 antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    157 tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (135) embryonic 1182-4H  (71) embryonic GM2  (73) embryonic Kc167  (140) embryonic S1  (113) embryonic S3  (56) leg disc CME L1  (151) wing disc CME-W2  (113) wing disc ML-DmD8  (61) wing disc ML-DmD9  (106) wing disc ML-DmD16-c3  (64) wing disc ML-DmD21  (102) wing disc ML-DmD32  (64) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (119) antennal disc ML-DmD20-c5  (71) mixed discs ML-DmD4-c1  (78) CNS ML-DmBG1-c1  (86) CNS ML-DmBG2-c2  (157) tumorous blood cells mbn2  (89) ovary fGS/OSS  (40) ovary OSC  (52) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4  (135) embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167  (140) embryonic S1  (113) embryonic S3    56 leg disc CME L1  (151) wing disc CME-W2  (113) wing disc ML-DmD8    61 wing disc ML-DmD9  106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21  102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11  (119) antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2  (157) tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    135 embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167    140 embryonic S1    113 embryonic S3    56 leg disc CME L1    151 wing disc CME-W2    113 wing disc ML-DmD8    61 wing disc ML-DmD9    106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21    102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    119 antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    157 tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    135 embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167    140 embryonic S1    113 embryonic S3    56 leg disc CME L1    151 wing disc CME-W2    113 wing disc ML-DmD8    61 wing disc ML-DmD9    106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21    102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    119 antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    157 tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (135) embryonic 1182-4H  (71) embryonic GM2  (73) embryonic Kc167  (140) embryonic S1  (113) embryonic S3  (56) leg disc CME L1  (151) wing disc CME-W2  (113) wing disc ML-DmD8  (61) wing disc ML-DmD9  (106) wing disc ML-DmD16-c3  (64) wing disc ML-DmD21  (102) wing disc ML-DmD32  (64) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (119) antennal disc ML-DmD20-c5  (71) mixed discs ML-DmD4-c1  (78) CNS ML-DmBG1-c1  (86) CNS ML-DmBG2-c2  (157) tumorous blood cells mbn2  (89) ovary fGS/OSS  (40) ovary OSC  (52) ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4  135 embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167  140 embryonic S1  113 embryonic S3    56 leg disc CME L1  (151) wing disc CME-W2  113 wing disc ML-DmD8    61 wing disc ML-DmD9  106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21  102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11  119 antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2  (157) tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    135 embryonic 1182-4H    71 embryonic GM2    73 embryonic Kc167    140 embryonic S1    113 embryonic S3    56 leg disc CME L1    151 wing disc CME-W2    113 wing disc ML-DmD8    61 wing disc ML-DmD9    106 wing disc ML-DmD16-c3    64 wing disc ML-DmD21    102 wing disc ML-DmD32    64 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    119 antennal disc ML-DmD20-c5    71 mixed discs ML-DmD4-c1    78 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    157 tumorous blood cells mbn2    89 ovary fGS/OSS    40 ovary OSC    52 ovary OSS    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3  (27) Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (32) Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3  (27) Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3  27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  32 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3  27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    27 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    21 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    23 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • SD01613 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036702 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6512-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG6512 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG6512GD3606 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG6512GD3606 Phenotype manifest in Allele chaeta, with Scer\GAL4pnr-MD237 CG6512GD3606 trichogen cell, with Scer\GAL4pnr-MD237 CG6512GD3606
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG6512 Class Mutagen Stocks Known lesion CG6512EY04074 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6512 Class Mutagen Stocks Known lesion CG6512GD3606 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6512HMS01331 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6512KK101663 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6131 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3606} NA P{KK101663} NA P{TRiP.HMS01331} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG6512EY04074 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from sequence or structural similarity with UniProtKB:Q01853 (FlyBase, 1992-) ATP binding inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR003959, InterPro:IPR003960, InterPro:IPR011546 (FlyBase Curators et al., 2004-) metalloendopeptidase activity inferred from sequence or structural similarity with UniProtKB:Q9Y4W6 (Sardiello et al., 2003.6.11) zinc ion binding inferred from electronic annotation with InterPro:IPR011546 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein catabolic process inferred from electronic annotation with InterPro:IPR005936 (FlyBase Curators et al., 2004-) proteolysis inferred from sequence or structural similarity with UniProtKB:Q9Y4W6 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from sequence or structural similarity with UniProtKB:Q01853 (FlyBase, 1992-) integral to membrane inferred from electronic annotation with InterPro:IPR011546 (FlyBase Curators et al., 2004-) mitochondrion inferred from sequence or structural similarity with UniProtKB:Q9Y4W6 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6512 - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6512 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6512 - ND75 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6512 - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6512 - lic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6512 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65212 DroID - A comprehensive database of gene and protein interactions. • FBgn0036702 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39922
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66Q7C3 Dipteran inclusive ortholog search EOG6933S2 Insect inclusive ortholog search EOG6NVXFC Arthropod inclusive ortholog search EOG6H9W1J Metazoa inclusive ortholog search EOG6SJJ6S
Orthologs in Drosophila Species (EOG66Q7C3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6512     Drosophila simulans   Dsim\GD12422 Y   Drosophila sechellia   Dsec\GM24348 Y   Drosophila erecta   Dere\GG15828 Y   Drosophila yakuba   Dyak\GE22168 Y   Drosophila ananassae   Dana\GF24400 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19652 Y   Drosophila persimilis   Dper\GL24707 Y   Drosophila willistoni   Dwil\GK18042 Y   Drosophila virilis   Dvir\GJ12976 Y   Drosophila mojavensis   Dmoj\GI12834 Y   Drosophila grimshawi   Dgri\GH15066 Y
Orthologs in non-Drosophila Dipterans (EOG6933S2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008565   Anopheles gambiae Malaria mosquito  Agam\AGAP006949   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006578
Orthologs in non-Dipteran Insects (EOG6NVXFC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552166   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016430   Acromyrmex echinatior Panamanian leafcutter ant  Aech\ftsH2   Atta cephalotes Leafcutter ant  Acep\ftsH1   Camponotus floridanus Florida carpenter ant  Cflo\ftsH2   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22801   Linepithema humile Argentine ant  Lhum\LH22244   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22874   Solenopsis invicta Red fire ant  Sinv\SINV19492   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005429   Bombyx mori Silkmoth  Bmor\BGIBMGA010088   Pediculus humanus Human body louse  Phum\PHUM474440   Tribolium castaneum Red flour beetle  Tcas\TC002463
Orthologs in non-Insect Arthropods (EOG6H9W1J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ftsH1   Ixodes scapularis Deer tick  Isca\ISCW009180
Orthologs in non-Arthropod Metazoa (EOG6SJJ6S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y47C4A.1 Y Caenorhabditis elegans Nematode  Cele\Y73B3A.21 Y Caenorhabditis elegans Nematode  Cele\spg-7 Y Caenorhabditis elegans Nematode  Cele\ppgn-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025264gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010966gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007208gn Y Danio rerio Zebrafish  Drer\wu:fd15f08 Y Danio rerio Zebrafish  Drer\ENSDARG00000079651 Y Danio rerio Zebrafish  Drer\si:ch211-12e1.4 Y Xenopus tropicalis Western clawed frog  Xtro\spg7 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000019846 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032431 Y Gallus gallus Domestic chicken  Ggal\AFG3L2 Y Gallus gallus Domestic chicken  Ggal\SPG7 Y Mus musculus House mouse  Mmus\Afg3l2 Y Mus musculus House mouse  Mmus\Spg7 Y Mus musculus House mouse  Mmus\Afg3l1 Y Rattus norvegicus Norway rat  Rnor\Afg3l1 Y Rattus norvegicus Norway rat  Rnor\Afg3l2 Y Rattus norvegicus Norway rat  Rnor\Spg7 Y Homo sapiens Human  Hsap\AFG3L2 Y Homo sapiens Human  Hsap\SPG7 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\AFG3L2     Hsap\SPG7
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12422 Drosophila sechellia Dsec\GM24348 Drosophila erecta Dere\GG15828 Drosophila yakuba Dyak\GE22168 Drosophila ananassae Dana\GF24400 Drosophila pseudoobscura pseudoobscura Dpse\GA19652 Drosophila persimilis Dper\GL24707 Drosophila willistoni Dwil\GK18042 Drosophila virilis Dvir\GJ12976 Drosophila mojavensis Dmoj\GI12834 Drosophila grimshawi Dgri\GH15066
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	34343 y1 sc* v1; P{TRiP.HMS01331}attP2 16590 y1 w67c23; P{EPgy2}CG6512EY04074/TM3, Sb1 Ser1
VDRC	v8515 w1118; P{GD3606}v8515
Genomic Clones ( 1 )
	BACR04J11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 173 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD01613
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01870 AT01877 AT02006 AT03206 AT03503 AT04925 AT05592 AT06958 AT07039 AT07877 AT07888 AT08193 AT10636 AT11776 AT11794 AT14069 AT15212 AT16805 AT19617 AT20687 AT25747 AT26375 AT27552 AT28669 GH15467 GH15519 GH22130 GM03116 GM25947 GM27221 HL03406 HL05517 LD30792 LP03469 LP05309 LP09565 LP12109 LP12207 LP18515 RE02984 RE03206 RE05409 RE06421 RE08043 RE09467 RE11103 RE11175 RE21986 RE29541 RE41278 RE42576 RE47670 RE47682 RE56916 RE59609 RE63570 RE64926 RE65768 RE68384 RE69140 RE71346 RE75021 RE75030 RE75134 RH12741 RH25849 RH33570 RH41774 RH51102 RH54342 RH57882 RH62607 RH68918 RH73018 SD03758 SD04403 SD11233 SD19212
Other clones	40145 98362 147680 163179 AT01158 AT02305 bs08h05 bs39h09 CK01.27B.E1 CK01.91B.E7 EC052217 EC053246 EC053744 EC054223 EC055299 EK019709 EK043749 EK115008 EK154317 EK221018 EK267221 RP003015363 RP003017718 RP003034837 RP003043039 RP003043738 RP003066172 RP003066745 RP003070592 RP003071029 RP003086351 RP003098534 RP003112394 RP003145188 RP003145275 RP003157222 RP003161534 RP003195338 RP003197014 RP003203091 RP003213651 RP003217994 RP003221521 RP003228628 RP003228826 RP003231386 RP003248363 RP003249049 RP003258936 RP003262052 RP003262919 RP003277148 RP003282383 RP003295041 RP003304448 RP003308019 RP003329052 RP003329904 RP003330808 RP003332322 RP003332465 RP003342322 RP003351288 RP003415556 RP003419197 RP003420199 RP003436367 RP003448162 RP003459631 RP003460887 RP003468674 RP003471662 RP003475065 RP003489532 RP003490282 RP003490782 RP003492444 RP003500410 RP003524241 RP003533942 RP003551208 RP003570258 RP003589334 RP003601820 RP003613009 RP003617547 RP003637709 RP003642423 RP003645708 RP003653120 RP003659271 RP003671164 RP003676914 UT01990
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036702 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39922
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168720 NM_168722 RefSeq (Proteins) • NP_730248 NP_730250 DDBJ / EMBL / GenBank • AAF49365 AAL89937 AAN11704 AI297813 AI530867 AI945092 AW944191 AY084199 CL527736 Entrez Gene - A searchable database of RefSeq genes. • 39922 UniProtKB/TrEMBL • Q8IQQ9 Q8T4G5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M41 (IPR000642) AAA+ ATPase domain (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Peptidase, FtsH (IPR005936) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Peptidase M41, FtsH extracellular (IPR011546) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME06512 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD01613
Linkouts
	BioGRID - A database of protein and genetic interactions • 65212 DroID - A comprehensive database of gene and protein interactions. • FBgn0036702 DRSC - Results from RNAi screens. • FBgn0036702 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036702 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6512-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036702 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39922 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39922 modMine - Data generated by the modENCODE project. • FBgn0036702
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG6512 (Gruenewald et al., 2009, Dorus et al., 2006, Dorus et al., 2006, Ni et al., 2010.12.1, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011) DmCG6512 (Frohlich, 2001)
Name Synonym
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 2 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...