drostatin-B2, AstB, AstB-1, myoinhibitory peptide, Allatostatin B
ancestral ligand for the Sex peptide receptor - acts directly in the polyamine-detecting olfactory and taste neurons - regulation of polyamine attraction, stabilization of sleep
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mip using the Feature Mapper tool.
Mip is expressed in one cell in the midline of the mandibular segment and one cell in the midline of the labial segment that was identified as VUM interneuron 1 (iVUM4 in paper).
Comment: in posterior midgut, weak
Comment: peptides
Comment: peptides
Mip protein is expressed in around 70 neurons of the adult brain innervating the adult antennal lobe and subesophageal zone.
Mip protein is detected in most layers of the fan-shaped body, which the authors identify as layers 2-7, in a columnar organisation. The strongest staining is observed in layer 5, where it co-localises with Scer\GAL4c205. Co-localisation with Scer\GAL4ChAT.7.4 is detected in a group of 4 neurons in the dorsolateral protocerebrum and their projections in the fan-shaped body.
Mip peptides were detected in extracts from adult and larval midguts.
Mip protein is expressed in 10-15 local neurons that innervate most adult antennal lobe glomeruli. These neurons have their cell bodies in one lateral cluster. Four to five of these neurons co-express Scer\GAL4ChAT.7.4.
Strong immunoreactivity was observed in the adult CNS but not in male reproductive organs.
Mip is expressed in a group of 7-30 large endocrine cells in the larval anterior midgut in a region just before the copper cells of the middle midgut. It is also expressed in up to 20 smaller cells in the copper cell region that tend to more numerous at the posterior end of the middle midgut. It is also expressed in a group of cells in the anterior region of the posterior midgut
GBrowse - Visual display of RNA-Seq signals
View Dmel\Mip in GBrowse 23-45
3-45
3-40.6
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: MIP CG6456
Source for identity of MIP CG6456 was sequence comparison ( date:001216 ).
Mip encodes a B-type prepro-allatostatin which contains one copy each of 5 putative allatostatins ("drostatin-B1" through to "drostatin-B5").