FlyBase Gene Report: Dmel\Mip

General Information

Symbol

Dmel\Mip

Species

D. melanogaster

Name

Myoinhibiting peptide precursor

Annotation Symbol

CG6456

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036713

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Ligand for the sex peptide receptor (SPR) (PubMed:20308537, PubMed:20458515, PubMed:25333796). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat (PubMed:25333796). May also have a regulatory role in gut motility (PubMed:11181081). (UniProt, Q9VVF7)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

drostatin-B2, AstB, myoinhibitory peptide, AstB-1, Allatostatin B

Key Links

Genomic Location

Cytogenetic map

74A5-74A5

Sequence location

3L:17,344,947..17,349,666 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17344947..17349666

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables G protein-coupled receptor binding

inferred from physical interaction with FLYBASE:SPR; FB:FBgn0029768

(Kim et al., 2010)

enables signaling receptor binding

inferred from direct assay

(assigned by UniProt )

(Williamson et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables neuropeptide hormone activity

non-traceable author statement

(Hewes and Taghert, 2001, vanden Broeck, 2001)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Kim et al., 2010)

involved_in negative regulation of eating behavior

inferred from mutant phenotype

(Min et al., 2016)

involved_in neuropeptide signaling pathway

inferred from direct assay

(assigned by UniProt )

(Williamson et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in negative regulation of juvenile hormone biosynthetic process

non-traceable author statement

(assigned by UniProt )

(Lenz et al., 2000)

involved_in neuropeptide signaling pathway

non-traceable author statement

(vanden Broeck, 2001)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Reiher et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from sequence model

(FlyBase Curators, 2011-)

Gene Group (FlyBase)

NEUROPEPTIDES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NEUROPEPTIDES -: Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).

Protein Function (UniProtKB)

(UniProt, Q9VVF7)

Summary (Interactive Fly)

ancestral ligand for the Sex peptide receptor - acts directly in the polyamine-detecting olfactory and taste neurons - regulation of polyamine attraction, stabilization of sleep

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mip for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mip-RA

FBtr0075241

NM_140714

1396

211

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Mip-PA

FBpp0075003

23.4

211

9.51

NP_648971

AAF49354

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

Small Mip-derived neuropeptides identified by 2D capillary LC/ESI-MS/MS: AWKSMNVAW, DQWQKLHGGW-amide.

(Baggerman et al., 2005)

Small Mip-derived neuropeptides identified by LC-MS/MS: AWKSMNVAW-amide, DQWQKLHGGW-amide.

(Baggerman et al., 2002)

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VVF7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mip using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mip_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 16 -- 17

VUM4 interneuron of embryonic labial segment

(Fontana and Crews, 2012)

RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral midline of embryo

(Fontana and Crews, 2012)

Additional Descriptive Data

Mip transcript is co-expressed with Mip protein in 52 neurons of the adult brain.

(Min et al., 2016)

Mip is expressed in one cell in the midline of the mandibular segment and one cell in the midline of the labial segment that was identified as VUM interneuron 1 (iVUM4 in paper).

(Fontana and Crews, 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval anterior midgut | posterior

(Veenstra, 2009)

embryonic/larval copper cell

(Veenstra, 2009)

embryonic/larval midgut large flat cell

(Veenstra, 2009)

larval midgut neutral region

(Veenstra, 2009)

larval midgut transition region

(Veenstra, 2009)

adult stage

adult brain | restricted

(Min et al., 2016, Kahsai and Winther, 2011, Carlsson et al., 2010)

adult antennal lobe glomerulus | subset

(Carlsson et al., 2010)

fan-shaped body | restricted

(Kahsai and Winther, 2011)

adult pars intercerebralis

(Kahsai and Winther, 2011)

adult optic lobe

(Kahsai and Winther, 2011)

adult gnathal ganglion

(Kahsai and Winther, 2011)

midgut

Comment: in posterior midgut, weak

(Veenstra et al., 2008)

adult antennal lobe | restricted

(Min et al., 2016)

adult subesophageal zone | restricted

(Min et al., 2016)

superior medial protocerebrum | restricted

(Min et al., 2016)

lobe system of adult mushroom body | restricted

(Min et al., 2016)

calyx of adult mushroom body | restricted

(Min et al., 2016)

posterior superior lateral protocerebrum | restricted

(Min et al., 2016)

adult fruitless vMT1 neuron

(Min et al., 2016)

adult central nervous system

(Kim et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval midgut

Comment: peptides

(Reiher et al., 2011)

wandering third instar larval stage

embryonic/larval central nervous system

(Baggerman et al., 2005, Baggerman et al., 2002)

adult stage

adult midgut

Comment: peptides

(Reiher et al., 2011)

Additional Descriptive Data

Mip protein is expressed in around 70 neurons of the adult brain innervating the adult antennal lobe and subesophageal zone.

(Min et al., 2016)

Mip protein is detected in most layers of the fan-shaped body, which the authors identify as layers 2-7, in a columnar organisation. The strongest staining is observed in layer 5, where it co-localises with Scer\GAL4^c205. Co-localisation with Scer\GAL4^ChAT.7.4 is detected in a group of 4 neurons in the dorsolateral protocerebrum and their projections in the fan-shaped body.

(Kahsai and Winther, 2011)

Mip peptides were detected in extracts from adult and larval midguts.

(Reiher et al., 2011)

Mip protein is expressed in 10-15 local neurons that innervate most adult antennal lobe glomeruli. These neurons have their cell bodies in one lateral cluster. Four to five of these neurons co-express Scer\GAL4^ChAT.7.4.

(Carlsson et al., 2010)

Strong immunoreactivity was observed in the adult CNS but not in male reproductive organs.

(Kim et al., 2010)

Mip is expressed in a group of 7-30 large endocrine cells in the larval anterior midgut in a region just before the copper cells of the middle midgut. It is also expressed in up to 20 smaller cells in the copper cell region that tend to more numerous at the posterior end of the middle midgut. It is also expressed in a group of cells in the anterior region of the posterior midgut

(Veenstra, 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Reiher et al., 2011)

Expression Deduced from Reporters

Reporter: P{Mip-GAL4.M}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

adult abdominal ventral anterior lateral (female) dsx/Mip neuron

(Jang et al., 2017)

adult abdominal ventral anterior medial (female) Mip neuron

(Jang et al., 2017)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mip in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mip

View exonic expression by tissue for Dmel\Mip

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036713

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39933/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036713

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036713

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036713

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6456

Flygut - An atlas of the Drosophila adult midgut

FBgn0036713

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Mip

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mip

Transgenic constructs containing regulatory region of Mip

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6131

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Mip^GD2689

Other Phenotypes

Allele

abnormal feeding behavior | adult stage

Mip¹

abnormal feeding behavior | adult stage (with Df(3L)BSC432)

Mip¹

abnormal proboscis extension reflex | adult stage

Mip¹

abnormal sleep | adult stage

Mip^attP

visible

Mip¹

visible, with Scer\GAL4^Mip.PM

Mip^KK106116

visible, with Scer\GAL4^pnr-MD237

Mip^GD2689

visible (with Df(3L)BSC432)

Mip¹

Phenotype manifest in

Allele

adult abdomen

Mip¹

chaeta | increased number, with Scer\GAL4^pnr-MD237

Mip^GD2689

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (0)

No records found.

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (0)

No records found.

Rattus norvegicus (Norway rat) (0)

No records found.

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (0)

No records found.

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\nlp-38

2 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190G56 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19609

Drosophila persimilis

Dper\GL15492

Drosophila willistoni

Dwil\GK20345

Drosophila virilis

Dvir\GJ13034

Drosophila mojavensis

Dmoj\GI12893

Drosophila grimshawi

Dgri\GH14915

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AEK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018786

Glossina morsitans

Tsetse fly

Gmor\GMOY012234

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07111

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012139

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000669

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0OYP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009464

Danaus plexippus

Monarch butterfly

Dple\DPOGS204635-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010575

Apis florea

Little honeybee

Aflo\2147606081

Apis florea

Little honeybee

Aflo\2178826259

Apis florea

Little honeybee

Aflo\2147583713

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03373

Tribolium castaneum

Red flour beetle

Tcas\TC007661

Pediculus humanus

Human body louse

Phum\PHUM005290

Rhodnius prolixus

Kissing bug

Rpro\RPRC003421

Cimex lectularius

Bed bug

Clec\CLEC001012

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007510

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0P9F )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007238

Ixodes scapularis

Black-legged tick

Isca\MIP

Ixodes scapularis

Black-legged tick

Isca\ISCW021391

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67054.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur10g00930

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_305794

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G12MK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_024381gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1670

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_443

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_009687gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006831gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_012967gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003108gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_3030

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_795

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_025101gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_016182gn

Ciona intestinalis

Vase tunicate

Cint\LOC100174990

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002666

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000022947

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008677

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028514

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000909

Gallus gallus

Domestic chicken

Ggal\NEFH

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000317

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000011306

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000314

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Mip - CCHa1-R

phenotype-based detection assay, fluorescence microscopy, inferred by author

(Johnson et al., 2003)

Mip - SPR

phenotype-based detection assay, inferred by author

(Lee et al., 2020, Kim et al., 2010)

Mip - awd

experimental knowledge based

(Guruharsha et al., 2011)

Mip - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

wit

suppressible

CCAP|Mip

(Veverytsa and Allan, 2011)

wit

suppressible

Mip

(Veverytsa and Allan, 2011)

wit

suppressible

Mip|Pburs

(Veverytsa and Allan, 2011)

wit

suppressible

CCAP|Mip|Pburs

(Veverytsa and Allan, 2011)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036713

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

74A5-74A5

Sequence location

3L:17,344,947..17,349,666 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

74A5-74A5

Limits computationally determined from genome sequence between P{PZ}Baldspot⁰²²⁸¹ and P{PZ}blot⁰¹⁶⁵⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-40.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Bloomington

51984

w¹¹¹⁸; P{Mip-GAL4.TH}2M

26246

y¹ v¹; P{TRiP.JF02145}attP2

84402

w^*; TI{2A-lexA::GAD}Mip^2A-lexA

81788

y¹ v¹; P{TKO.GS04834}attP40/CyO

37667

y¹ w^*; Mi{MIC}Mip^MI04416

51983

w¹¹¹⁸; P{Mip-GAL4.TH}1M/TM6B, Tb¹

84651

w^*; TI{2A-GAL4}Mip^2A-GAL4/TM3, Sb¹

41680

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02244}attP2

VDRC

v106076

P{KK106116}VIE-260B

v5294

w¹¹¹⁸; P{GD2689}v5294

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH11008

Other clones

DPiM_GH11008

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036713

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036713

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39933

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Park et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: MIP CG6456

(FlyBase, 1996-)

Source for database merge of

Additional comments

Source for identity of MIP CG6456 was sequence comparison ( date:001216 ).

(FlyBase, 1996-)

Other Comments

Mip encodes a B-type prepro-allatostatin which contains one copy each of 5 putative allatostatins ("drostatin-B1" through to "drostatin-B5").

(Williamson et al., 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39933

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VVF7

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036713

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036713

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39933/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036713

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mip_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036713

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036713

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6456

Flygut - An atlas of the Drosophila adult midgut

FBgn0036713

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39933

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6456

MARRVEL_MODEL - MARRVEL (model organism gene)

39933

modMine - A data warehouse for the modENCODE project

FBgn0036713

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036713

DRSC - Results frm RNAi screens

FBgn0036713

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036713

FlyMine - An integrated database for Drosophila genomics

FBgn0036713

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (54)

Reported As

Symbol Synonym

ASB

(Veenstra et al., 2008)

AST-B

(Santos et al., 2007, Nassel, 2002)

Ast-B

(Park et al., 2008)

AstB

(Obniski et al., 2018, Nässel and Winther, 2010, Veenstra, 2009, Johnson et al., 2005)

AstB-1

(Birse et al., 2006, Johnson et al., 2004, Johnson et al., 2003)

AstB/MIP

(Nässel and Zandawala, 2020)

CG6456

(Asahina and Anderson, 2013.9.23, Lemaitre and Miguel-Aliaga, 2013, Reiher et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Yew et al., 2009, Holloway et al., 2008, Wegener and Gorbashov, 2008, Vanden Broeck et al., 2001)

DAP-B

(Williamson et al., 2001)

DmMIP1

(Kim et al., 2010)

DmMIP2

(Kim et al., 2010)

DmMIP3

(Kim et al., 2010)

DmMIP4

(Kim et al., 2010)

DmMIP5

(Kim et al., 2010)

Drm-MIP

(vanden Broeck, 2001)

Drm-MIP-1

(vanden Broeck, 2001)

Drm-MIP-2

(Baggerman et al., 2002, vanden Broeck, 2001)

Drm-MIP-3

(vanden Broeck, 2001)

Drm-MIP-4

(vanden Broeck, 2001)

Drm-MIP-5

(Baggerman et al., 2002, vanden Broeck, 2001)

MIP-1

(Nässel and Winther, 2010)

MIP-2

(Nässel and Winther, 2010)

MIP-3

(Carlsson et al., 2010, Nässel and Winther, 2010)

MIP-4

(Nässel and Winther, 2010)

MIP-5

(Carlsson et al., 2010, Nässel and Winther, 2010)

MIP1