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Gene Dmel\TORC

General Information
Symbol	Dmel\TORC	Species	D. melanogaster
Name	TORC	Annotation symbol	CG6064
Feature type	protein_coding_gene	FlyBase ID	FBgn0036746
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dTORC
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	74E4-74E5	Sequence location	3L:17,654,728..17,661,494 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene TORC is referred to in FlyBase by the symbol Dmel\TORC (CG6064, FBgn0036746). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: cAMP response element binding protein binding. There is experimental evidence that it is involved in the biological process: response to starvation; response to oxidative stress. 12 alleles are reported. The phenotypes of these alleles are annotated with: eye; interommatidial bristle; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: Transducer of regulated CREB activity; Transducer of regulated CREB activity, C-terminal; Transducer of regulated CREB activity, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624928_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TORC. Gene sequence location is 3L:17654728..17661494.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms cAMP response element binding protein binding protein homotetramerization positive regulation of CREB transcription factor activity References FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
FB2012_01	Sequence features HFA10578 BKN26414
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 74E4-74E5   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TORC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD02553 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TORC-RA FBtr0075196  NM_140744   3307   797
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TORC-PA   FBpp0074960   86.2   797   7.18     NP_649001   AAF49313
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transducer of regulated CREB activity, N-terminal (IPR024783) Transducer of regulated CREB activity, C-terminal (IPR024785) Transducer of regulated CREB activity (IPR024786)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697870   AE014296 AAF49313   AI454989   AW941511   BI243698   BP541729   BP552804   CO265757   CO298136   CO326436   CO336657   CQ888318   EC072854   EC199903   EC256829   EC262364   EL882161   EV583020   EW713171
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVJ8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036746    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036746 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036746 expression level Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2638) embryo 02-04hr  (1933) embryo 04-06hr  (662) embryo 06-08hr  (992) embryo 08-10hr  (1182) embryo 10-12hr  (797) embryo 12-14hr  (936) embryo 14-16hr  (1441) embryo 16-18hr  (1129) embryo 18-20hr  (1409) embryo 20-22hr  (1621) embryo 22-24hr  (1369) larva L1  (1036) larva L2  (480) larva L3 12hr old  (635) larva L3 puffstage 1-2  (342) larva L3 puffstage 3-6  (911) larva L3 puffstage 7-9  (961) white prepupae new  (1199) white prepupae 12hr  (948) white prepupae 24hr  (1124) pupae 2d postWPP  (919) pupae 3d postWPP  (705) pupae 4d postWPP  (885) adult male 01day  (830) adult male 05day  (987) adult male 30day  (1067) adult female 01day  (1713) adult female 05day  (1863) adult female 30day  (1975) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2638) embryo 02-04hr  (1933) embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr  1441 embryo 16-18hr    1129 embryo 18-20hr  1409 embryo 20-22hr  (1621) embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day  (1713) adult female 05day  (1863) adult female 30day  (1975) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036746 expression level Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2638) embryo 02-04hr  (1933) embryo 04-06hr  (662) embryo 06-08hr  (992) embryo 08-10hr  (1182) embryo 10-12hr  (797) embryo 12-14hr  (936) embryo 14-16hr  (1441) embryo 16-18hr  (1129) embryo 18-20hr  (1409) embryo 20-22hr  (1621) embryo 22-24hr  (1369) larva L1  (1036) larva L2  (480) larva L3 12hr old  (635) larva L3 puffstage 1-2  (342) larva L3 puffstage 3-6  (911) larva L3 puffstage 7-9  (961) white prepupae new  (1199) white prepupae 12hr  (948) white prepupae 24hr  (1124) pupae 2d postWPP  (919) pupae 3d postWPP  (705) pupae 4d postWPP  (885) adult male 01day  (830) adult male 05day  (987) adult male 30day  (1067) adult female 01day  (1713) adult female 05day  (1863) adult female 30day  (1975) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2638) embryo 02-04hr  1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr  1441 embryo 16-18hr    1129 embryo 18-20hr  1409 embryo 20-22hr  1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day  1713 adult female 05day  1863 adult female 30day  1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2638 embryo 02-04hr    1933 embryo 04-06hr    662 embryo 06-08hr    992 embryo 08-10hr    1182 embryo 10-12hr    797 embryo 12-14hr    936 embryo 14-16hr    1441 embryo 16-18hr    1129 embryo 18-20hr    1409 embryo 20-22hr    1621 embryo 22-24hr    1369 larva L1    1036 larva L2    480 larva L3 12hr old    635 larva L3 puffstage 1-2    342 larva L3 puffstage 3-6    911 larva L3 puffstage 7-9    961 white prepupae new    1199 white prepupae 12hr    948 white prepupae 24hr    1124 pupae 2d postWPP    919 pupae 3d postWPP    705 pupae 4d postWPP    885 adult male 01day    830 adult male 05day    987 adult male 30day    1067 adult female 01day    1713 adult female 05day    1863 adult female 30day    1975 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036746    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036746 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036746 expression level Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036746 expression level Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    120.9   NA  Eye    115.275   NA  Brain    337.4   211.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    267.9   NA  Crop    193   109.7  Midgut    108.8   161.1  Hindgut    169.1   158.3  Malpighian Tubules    179.4   130.7  Fat Body    181.7   181.9  Salivary Gland    281.2   NA  Heart    146.75   137.625  Trachea    NA   NA  VirginFemale Spermatheca    177.4   NA  InseminatedFemale Spermatheca    153.5   NA  Ovary    189.8   NA  Testis    59.5   NA  Male Accessory Gland    236.8   152.35  Carcass    154.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6064-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 TORCGD11806 viable TORC25-3 Sterility Allele fertile TORC25-3 Other Phenotypes Allele short lived TORC25-3 TORCA4-32 stress response defective TORC25-3 TORCA4-32 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF TORCScer\UAS.cWa TORCScer\UAS.T:Zzzz\FLAG TORCS157D.Scer\UAS.T:Zzzz\FLAG interommatidial bristle, with Scer\GAL4GMR.PF TORCScer\UAS.T:Zzzz\FLAG TORCS157D.Scer\UAS.T:Zzzz\FLAG ommatidium, with Scer\GAL4GMR.PF TORCScer\UAS.T:Zzzz\FLAG TORCS157D.Scer\UAS.T:Zzzz\FLAG
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of TORC Class Mutagen Stocks Known lesion TORCEY00004 P-element activity 1 Yes TORC25-3 Delta2-3 0 Yes TORCA4-32 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TORC Class Mutagen Stocks Known lesion TORCGD11806 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TORCHM05069 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TORCKK106414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TORCdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TORCS157D.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TORCScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes TORCScer\UAS.pIa in vitro construct - regulatory fusion 0 Yes TORCScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TORCScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9005 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11806} NA P{KK106414} NA P{TRiP.HM05069} NA P{UAS-TORC.dsRNA} NA P{UAS-TORC.eGFP} NA P{UAS-TORC.W} NA P{UAS-TORC-FLAG.S157D} NA P{UAS-TORC-FLAG} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}TORCEY00004 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to oxidative stress inferred from mutant phenotype (Wang et al., 2008) response to starvation inferred from mutant phenotype (Choi et al., 2011, Wang et al., 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Bittinger et al., 2004) nucleus inferred from direct assay (Bittinger et al., 2004)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cAMP response element binding protein binding inferred from electronic annotation with InterPro:IPR024783 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
positive regulation of CREB transcription factor activity inferred from electronic annotation with InterPro:IPR024786 (FlyBase Curators et al., 2004-) protein homotetramerization inferred from electronic annotation with InterPro:IPR024783 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TORC allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036746 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39970
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11499 Dere\GG15792 Dgri\GH15344 Dmoj\GI12949 Dper\GL25225 Dpse\GA19332 Dsec\GM24316 Dsim\GD12387 Dvir\GJ13091 Dwil\GK12332 Dyak\GE22130
Curated drosophilid orthologs	Dpse\GA19332
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSBTAP00000050880 Bos taurus (bovine) CN06510 Caenorhabditis brenneri (small nematode) CE36335 Caenorhabditis elegans (worm) ENSCAFP00000025646 Canis familiaris (dog) JA06508 Caenorhabditis japonica (nematode) CPIJ001572 Culex pipens (mosquito) ENSCPOP00000008152 Cavia porcellus (guinea pig) RP48515 Caenorhabditis remanei (nematode) 312063 Daphnia pulex (daphnia) ENSDARP00000070472 Danio rerio (zebra fish) ENSECAP00000020891 Equus caballus (horse) ENSGACP00000020489 Gymnopilus aculeatus (mushroom) ENSGALP00000005227 Gallus gallus (chicken) ENSP00000357622 Homo sapiens (human) ENSMODP00000021609 Monodelphis domestica (gray opossum) ENSMMUP00000006627 Macaca mulatta (rhesus monkey) ENSMUSP00000029545 Mus musculus (house mouse) 247638 Nematostella vectensis (starlet anemone) XP_001600735.1 Nasonia vitripennis (wasp) ENSORLP00000009879 Oryzias latipes (japanese killifish) PHUM006271-PA Pediculus humanus (human body louse) ENSPPYP00000000929 Pongo pygmaeus (orangutan) ENSPTRP00000043879 Pan troglodytes (chimpanzee) ENSRNOP00000021700 Rattus norvegicus (norway rat) XP_969415.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012703 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036086 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024465 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19475 PB19469 NV30166 NV17963 LH21632 ISCW013361 FBgn0239359 FBgn0214342 FBgn0200319 FBgn0184119 FBgn0179180 JGI_V11_312063 FBgn0079329 FBgn0162809 FBgn0135706 FBgn0122816 FBgn0108031 FBgn0100891 FBgn0088539 CPIJ001572 BGIBMGA004050 ACYPI41396 GB11949 AGAP008677 AAEL008842 PHUM039200 GLEAN_09383
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28886 y1 v1; P{TRiP.HM05069}attP2 16534 y1 w67c23; P{EPgy2}TORCEY00004
VDRC	v100974 P{KK106414}VIE-260B v27545 w1118; P{GD11806}v27545
Genomic Clones ( 2 )
	BACR15E10 BACR44L18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03371 RE41414
Other clones	33074 53411 214563.53 558094 Dmel_dig_014930_0581_2194 EK143554 EK171554 EN12957 EP03922 FGC004G07 FGM220H07 IP11935 LD02553
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39970
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TORC CG6064 (Iourgenko et al., 2003)
Source for database merge of
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) TORC can activate transcription from a reporter driven by cAMP response elements. (Iourgenko et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140744 RefSeq (Proteins) • NP_649001 DDBJ / EMBL / GenBank • AAF49313 AI454989 AW941511 CQ888318 Entrez Gene - A searchable database of RefSeq genes. • 39970 UniProtKB/TrEMBL • Q9VVJ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transducer of regulated CREB activity, N-terminal (IPR024783) Transducer of regulated CREB activity, C-terminal (IPR024785) Transducer of regulated CREB activity (IPR024786)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036746 DRSC - Results from RNAi screens. • FBgn0036746 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6064-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39970 InParanoid A subset of ortholog calls from InParanoid. • ENSBTAP00000050880 Bos taurus (bovine) CN06510 Caenorhabditis brenneri (small nematode) CE36335 Caenorhabditis elegans (worm) ENSCAFP00000025646 Canis familiaris (dog) JA06508 Caenorhabditis japonica (nematode) CPIJ001572 Culex pipens (mosquito) ENSCPOP00000008152 Cavia porcellus (guinea pig) RP48515 Caenorhabditis remanei (nematode) 312063 Daphnia pulex (daphnia) ENSDARP00000070472 Danio rerio (zebra fish) ENSECAP00000020891 Equus caballus (horse) ENSGACP00000020489 Gymnopilus aculeatus (mushroom) ENSGALP00000005227 Gallus gallus (chicken) ENSP00000357622 Homo sapiens (human) ENSMODP00000021609 Monodelphis domestica (gray opossum) ENSMMUP00000006627 Macaca mulatta (rhesus monkey) ENSMUSP00000029545 Mus musculus (house mouse) 247638 Nematostella vectensis (starlet anemone) XP_001600735.1 Nasonia vitripennis (wasp) ENSORLP00000009879 Oryzias latipes (japanese killifish) PHUM006271-PA Pediculus humanus (human body louse) ENSPPYP00000000929 Pongo pygmaeus (orangutan) ENSPTRP00000043879 Pan troglodytes (chimpanzee) ENSRNOP00000021700 Rattus norvegicus (norway rat) XP_969415.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012703 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000036086 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000024465 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/torc.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39970 modMine - Data generated by the modENCODE project. • FBgn0036746 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19475 PB19469 NV30166 NV17963 LH21632 ISCW013361 FBgn0239359 FBgn0214342 FBgn0200319 FBgn0184119 FBgn0179180 JGI_V11_312063 FBgn0079329 FBgn0162809 FBgn0135706 FBgn0122816 FBgn0108031 FBgn0100891 FBgn0088539 CPIJ001572 BGIBMGA004050 ACYPI41396 GB11949 AGAP008677 AAEL008842 PHUM039200 GLEAN_09383
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG6064 (Boutros et al., 2004, Iourgenko et al., 2003, Xu et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009) cg6064 (Wang et al., 2008) CRTC (Choi et al., 2011) dTORC (Bittinger, 2004, Bittinger et al., 2004, Iourgenko et al., 2003, Pospisilik et al., 2010) ORE-12 (Maia et al., 2007) TORC (Xu et al., 2008, Iijima et al., 2009, Maia et al., 2007, Wang et al., 2008)
Name Synonym	TORC
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) Computer file  ( 1 )
Recent research papers ( 2 )
	Choi et al., 2011, J. Biol. Chem. 286(4): 2658--2664 Drosophila Salt-inducible Kinase (SIK) Regulates Starvation Resistance through cAMP-response Element-binding Protein (CREB)-regulated Transcription Coactivator (CRTC). [FBrf0212827] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...