• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Crtc

General Information
Symbol	Dmel\Crtc	Species	D. melanogaster
Name	CREB-regulated transcription coactivator	Annotation symbol	CG6064
Feature type	protein_coding_gene	FlyBase ID	FBgn0036746
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	TORC, dTORC
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	74E4-74E5	Sequence location	3L:17,653,208..17,662,334 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CREB-regulated transcription coactivator is referred to in FlyBase by the symbol Dmel\Crtc (CG6064, FBgn0036746). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: cAMP response element binding protein binding. There is experimental evidence that it is involved in the biological process: response to starvation; response to oxidative stress. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye; interommatidial bristle; ommatidium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Transducer of regulated CREB activity; Transducer of regulated CREB activity, C-terminal; Transducer of regulated CREB activity, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624928_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TORC. Gene sequence location is 3L:17653208..17662334.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 74E4-74E5   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Crtc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Stop-codon suppression (UGA) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone LD02553 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Crtc-RA FBtr0075196  NM_140744   4147   797 Crtc-RB FBtr0330162  NM_001275068   5667   889
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Crtc-PA   FBpp0074960   86.2   797   7.18     NP_649001   AAF49313 Crtc-PB   FBpp0303195   96.0   889   6.34     NP_001261997   AGB94690
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transducer of regulated CREB activity, N-terminal (IPR024783) Transducer of regulated CREB activity, C-terminal (IPR024785) Transducer of regulated CREB activity (IPR024786)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440340   AA697870   AA801745   AA802084   AA802627   AE014296 AAF49313   AE014296 AGB94690   AI109981   AI293462   AI389778   AI454989   AI516388   AW941511   BI171791   BI243698   BI483704   BI486334   BI579096   BP541729   BP552804   BP554852   CO178960   CO265757   CO298136   CO326436   CO335744   CO336657   CQ888318   EC072854   EC081200   EC199903   EC256829   EC262364   EC265932   EG974128   EL882161   ES696251   ES696252   ES696253   ES696254   ES696276   EV583020   EV593099   EV596182   EW713171
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVJ8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Bittinger et al., 2004) nucleus inferred from direct assay (Bittinger et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.225 Larval Midgut    109.7 Larval Hindgut    161.1 Larval Malpighian Tubules    158.3 Larval Fat Body    130.7 Larval Salivary Gland    181.9 Larval Trachea    137.625 Larval Carcass    152.35 Adult Head    120.9 Adult Eye    115.275 Adult Brain    337.4 Adult Thoracic-Abdominal Ganglion    267.9 Adult Crop    193 Adult Midgut    108.8 Adult Hindgut    169.1 Adult Malpighian Tubules    179.4 Adult Fat Body    181.7 Adult Salivary Gland    281.2 Adult Heart    146.75 Adult VirginFemale Spermatheca    177.4 Adult InseminatedFemale Spermatheca    153.5 Adult Ovary    189.8 Adult Testis    59.5 Adult Male Accessory Gland    236.8 Adult Carcass    154.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    120.9   NA  Eye    115.275   NA  Brain    337.4   211.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    267.9   NA  Crop    193   109.7  Midgut    108.8   161.1  Hindgut    169.1   158.3  Malpighian Tubules    179.4   130.7  Fat Body    181.7   181.9  Salivary Gland    281.2   NA  Heart    146.75   137.625  Trachea    NA   NA  VirginFemale Spermatheca    177.4   NA  InseminatedFemale Spermatheca    153.5   NA  Ovary    189.8   NA  Testis    59.5   NA  Male Accessory Gland    236.8   152.35  Carcass    154.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  (27) ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    17 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    8 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    12 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    14 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    27 ovary, mated 4-day female    24 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    22 embryo 02-04hr    17 embryo 04-06hr    6 embryo 06-08hr    9 embryo 08-10hr    11 embryo 10-12hr    7 embryo 12-14hr    10 embryo 14-16hr    11 embryo 16-18hr    10 embryo 18-20hr    12 embryo 20-22hr    14 embryo 22-24hr    14 larva L1    9 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    12 white prepupae 12hr    9 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    8 adult male 30day    8 adult female 01day    13 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    20 embryonic Kc167    6 embryonic S1    11 embryonic S3    8 leg disc CME L1    8 wing disc CME-W2    7 wing disc ML-DmD8    9 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    3 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    8 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    7 ovary fGS/OSS    19 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    21 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    16 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    20 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD02553 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6064-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 CrtcGD11806 viable Crtc25-3 Sterility Allele fertile Crtc25-3 Other Phenotypes Allele short lived Crtc25-3 CrtcA4-32 stress response defective Crtc25-3 CrtcA4-32 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF CrtcScer\UAS.cWa CrtcScer\UAS.T:Zzzz\FLAG CrtcS157D.Scer\UAS.T:Zzzz\FLAG interommatidial bristle, with Scer\GAL4GMR.PF CrtcScer\UAS.T:Zzzz\FLAG CrtcS157D.Scer\UAS.T:Zzzz\FLAG ommatidium, with Scer\GAL4GMR.PF CrtcScer\UAS.T:Zzzz\FLAG CrtcS157D.Scer\UAS.T:Zzzz\FLAG
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Crtc Class Mutagen Stocks Known lesion CrtcEY00004 P-element activity 1 Yes Crtc25-3 Delta2-3 0 Yes CrtcA4-32 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Crtc Class Mutagen Stocks Known lesion CrtcGD11806 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrtcHM05069 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrtcHMJ02217 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrtcKK106414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CrtcdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CrtcNIG.6064R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CrtcS157D.Scer\UAS.T:Zzzz\FLAG in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CrtcScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes CrtcScer\UAS.pIa in vitro construct - regulatory fusion 0 Yes CrtcScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CrtcScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9005 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.HMJ02217} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CrtcEY00004 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to oxidative stress inferred from mutant phenotype (Wang et al., 2008) response to starvation inferred from mutant phenotype (Choi et al., 2011, Wang et al., 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Bittinger et al., 2004) nucleus inferred from direct assay (Bittinger et al., 2004)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cAMP response element binding protein binding inferred from electronic annotation with InterPro:IPR024783 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
positive regulation of CREB transcription factor activity inferred from electronic annotation with InterPro:IPR024786 (FlyBase Curators et al., 2004-) protein homotetramerization inferred from electronic annotation with InterPro:IPR024783 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Crtc - Sik2 protein kinase assay, genetic interference, anti tag western blot (Choi et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Crtc allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036746 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39970
Orthologs
OrthoDB Orthologs (16) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XKVSX Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6B2RTS Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6XKVSX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Crtc     Drosophila simulans   Dsim\GD12387 Y   Drosophila sechellia   Dsec\GM24316 Y   Drosophila erecta   Dere\GG15792 Y   Drosophila yakuba   Dyak\GE22130 Y   Drosophila ananassae   Dana\GF23897     Drosophila ananassae   Dana\GF11499 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19332 Y   Drosophila persimilis   Dper\GL25225 Y   Drosophila willistoni   Dwil\GK12332 Y   Drosophila virilis   Dvir\GJ13091 Y   Drosophila mojavensis   Dmoj\GI12949 Y   Drosophila grimshawi   Dgri\GH15344 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6B2RTS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Atta cephalotes Leafcutter ant  Acep\ACEP22608   Acyrthosiphon pisum Pea aphid  Apim\ACYPI082053   Bombyx mori Silkmoth  Bmor\BGIBMGA004050
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12387 Drosophila sechellia Dsec\GM24316 Drosophila erecta Dere\GG15792 Drosophila yakuba Dyak\GE22130 Drosophila ananassae Dana\GF11499 Drosophila pseudoobscura pseudoobscura Dpse\GA19332 Drosophila persimilis Dper\GL25225 Drosophila willistoni Dwil\GK12332 Drosophila virilis Dvir\GJ13091 Drosophila mojavensis Dmoj\GI12949 Drosophila grimshawi Dgri\GH15344
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	28886 y1 v1; P{TRiP.HM05069}attP2 42561 y1 v1; P{TRiP.HMJ02217}attP40 16534 y1 w67c23; P{EPgy2}CrtcEY00004
VDRC	v100974 P{KK106414}VIE-260B v27545 w1118; P{GD11806}v27545
Genomic Clones ( 2 )
	BACR15E10 BACR44L18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 34 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09401 GH21037 GM03439 GM06028 HL03371 LD14916 LD42242 LP06615 RE13643 RE41414 RE66628 RE69754 RE73072
Other clones	33074 53411 214563.53 542688 558094 CK01.73C.D10 Dmel_dig_014930_0581_2194 Dmel_neb_007355_0695_3528 Dmel_neb_014123_0639_1133 EK058045 EK143554 EK171554 EN11121 EN12957 EP03922 FGC004G07 FGM220H07 FGM232A11 GM03829 IP11935 LD02553
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39970
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Crtc TORC (Shen and Montminy, 2012.7.17) Source for identity of: TORC CG6064 (Iourgenko et al., 2003)
Source for database merge of
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) TORC can activate transcription from a reporter driven by cAMP response elements. (Iourgenko et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140744 NM_001275068 RefSeq (Proteins) • NP_649001 NP_001261997 DDBJ / EMBL / GenBank • AAF49313 AGB94690 AI454989 AW941511 CQ888318 Entrez Gene - A searchable database of RefSeq genes. • 39970 UniProtKB/TrEMBL • Q9VVJ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transducer of regulated CREB activity, N-terminal (IPR024783) Transducer of regulated CREB activity, C-terminal (IPR024785) Transducer of regulated CREB activity (IPR024786) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02553
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036746 DRSC - Results from RNAi screens. • FBgn0036746 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6064-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39970 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/torc.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39970 modMine - Data generated by the modENCODE project. • FBgn0036746
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG6064 (Boutros et al., 2004, Iourgenko et al., 2003, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) cg6064 (Wang et al., 2008) CRTC (Choi et al., 2011) Crtc   dTORC (Bittinger, 2004, Bittinger et al., 2004, Iourgenko et al., 2003, Pospisilik et al., 2010) ORE-12 (Maia et al., 2007) TORC (Pezzulo et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Iijima et al., 2009, Maia et al., 2007, Wang et al., 2008)
Name Synonym	CREB-regulated transcription coactivator   TORC
Secondary FlyBase IDs
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Patent  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Hirano et al., 2013, Science 339(6118): 443--446 Fasting launches CRTC to facilitate long-term memory formation in Drosophila. [FBrf0220627] Pezzulo et al., 2012, PLoS ONE 7(8): e43777 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363] Choi et al., 2011, J. Biol. Chem. 286(4): 2658--2664 Drosophila Salt-inducible Kinase (SIK) Regulates Starvation Resistance through cAMP-response Element-binding Protein (CREB)-regulated Transcription Coactivator (CRTC). [FBrf0212827] Show all research papers ...