FB2025_01 , released February 20, 2025
Gene: Dmel\Adgf-A
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General Information
Symbol
Dmel\Adgf-A
Species
D. melanogaster
Name
Adenosine deaminase-related growth factor A
Annotation Symbol
CG5992
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036752
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
75A1-75A1
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17751731..17764158
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables adenosine deaminase activity
inferred from direct assay
(Zurovec et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables adenosine deaminase activity
inferred from biological aspect of ancestor with PANTHER:PTN000150817
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006331
(InterPro Project Members, 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in adenosine catabolic process
inferred from direct assay
(Zurovec et al., 2002)
involved_in cellular response to sucrose starvation
inferred from mutant phenotype
(Zuberova et al., 2010)
involved_in hemocyte differentiation
inferred from mutant phenotype
(Dolezal et al., 2005)
involved_in larval lymph gland hemopoiesis
inferred from genetic interaction with FLYBASE:bip1; FB:FBgn0026263
(Mondal et al., 2014)
involved_in positive regulation of cell population proliferation
inferred from direct assay
(Zurovec et al., 2002)
involved_in regulation of carbohydrate metabolic process
inferred from mutant phenotype
(Zuberova et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in adenosine catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000150817
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006331
(InterPro Project Members, 2004-)
involved_in inosine biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000150817
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Zurovec et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000150875
(GO Reference Genome Project, 2011-)
located_in extracellular space
inferred from electronic annotation with InterPro:IPR006331, InterPro:IPR013659
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
adenosine deaminase activity
RHEA 24408:
Summaries
Gene Snapshot
Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ADENOSINE DEAMINASES -
Adenosine deaminases catalyze the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine.
Summary (Interactive Fly)

a secreted enzyme that converts extracellular adenosine into inosine - regulates adenosine levels - opposes the effects of Hedgehog signaling within the hematopoietic progenitor cells - regulates energy allocation during immune response

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Adgf-A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VVK5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Shares 5' UTR with upstream gene.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Adgf-A-RA
FBtr0075190
NM_079406
2588
553
Adgf-A-RB
FBtr0075191
NM_206397
2584
553
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Adgf-A-PA
FBpp0074955
62.8
553
5.37
Q9VVK5
NP_524130
AAF49306
Adgf-A-PB
FBpp0089360
62.8
553
5.37
Q9VVK5
NP_996119
AAS64976
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

553 aa isoforms: Adgf-A-PA, Adgf-A-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adgf-A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.55

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
plasmatocyte primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Zurovec et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Adgf-A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Adgf-A
Transgenic constructs containing regulatory region of Adgf-A
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel9005
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
melanotic mass phenotype
Phenotype manifest in
Allele
melanotic mass
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\ADA2
13 of 14
Yes
Yes
1  
Hsap\ADA
2 of 14
No
Yes
Hsap\AMPD1
2 of 14
No
No
Hsap\AMPD2
2 of 14
No
No
1  
Hsap\AMPD3
2 of 14
No
No
Hsap\ADAL
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (5)
Rnor\Adal
2 of 14
Yes
No
Rnor\Ada
2 of 14
Yes
Yes
Rnor\Ampd1
2 of 14
Yes
No
Rnor\Ampd2
2 of 14
Yes
No
Rnor\Ampd3
2 of 14
Yes
No
Mus musculus (laboratory mouse) (5)
Mmus\Adal
2 of 14
Yes
No
Mmus\Ada
2 of 14
Yes
Yes
Mmus\Ampd1
2 of 14
Yes
No
Mmus\Ampd2
2 of 14
Yes
No
Mmus\Ampd3
2 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\ada2
6 of 13
Yes
Yes
Xtro\adal
1 of 13
No
No
Xtro\ada
1 of 13
No
Yes
Xtro\hes6.2
1 of 13
No
No
Xtro\kif5a
1 of 13
No
No
Xtro\mphosph8
1 of 13
No
Yes
Danio rerio (Zebrafish) (8)
Drer\ada2a
13 of 14
Yes
Yes
Drer\ada2b
13 of 14
Yes
Yes
Drer\ada
2 of 14
No
Yes
Drer\adal
2 of 14
No
No
Drer\ampd3a
2 of 14
No
No
Drer\ampd3b
2 of 14
No
No
Drer\ampd1
1 of 14
No
No
Drer\ampd2b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\adal-1
2 of 14
Yes
No
Cele\adah-1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (4)
Agam\AgaP_AGAP006906
12 of 12
Yes
Yes
Agam\AgaP_AGAP006907
12 of 12
Yes
Yes
Agam\AgaP_AGAP005283
5 of 12
No
No
Agam\AgaP_AGAP005158
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT4G04880
3 of 13
Yes
No
Atha\FAC1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\AAH1
4 of 13
Yes
No
Scer\AMD1
1 of 13
No
No
Scer\YBR284W
1 of 13
No
No
Scer\YJL070C
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPBC1683.02
2 of 12
Yes
No
Spom\ada1
1 of 12
No
No
Spom\dea2
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\add
3 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Adgf-A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
Adgf-B
13 of 13
Adgf-E
13 of 13
Adgf-D
9 of 13
Adgf-C
8 of 13
Adgf-A2
7 of 13
Ada
4 of 13
AMPdeam
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    ADA2; adenosine deaminase 2
    model of  Sneddon syndrome
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADA2; adenosine deaminase 2
    13 of 14
    607575
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    RNA-RNA
    Physical Interaction
    Assay
    References
    Adgf-A - mir-8
    quantitative reverse transcription pcr
    (Lee et al., 2015)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    bip1
    suppressible
    Adgf-A
    (Mondal et al., 2014)
    cact
    suppressible
    Adgf-A
    (Dolezal et al., 2005)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-45
    Cytogenetic map
    75A1-75A1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    75A1-75A1
    Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    75A-75A
    (Maier, 2001.1.18)
    Experimentally Determined Recombination Data
    Location

    3-45

    (FlyBase, 2016)

    3-41.2

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (40)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Loss of Adgf-A function results in abnormal hemocyte development, leading to melanotic tumour formation, as well as fat body disintegration associated with death during the larval stage or delayed transition to the pupal stage of development.

          (Dolezal et al., 2005)
          Relationship to Other Genes
          Source for database merge of
          Additional comments

          One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by Msi and Adgf-A.

          (FlyBase Genome Annotators, 2006)
          Nomenclature History
          Source for database identify of

          Source for identity of: Adgf-A CG5992

          (Zurovec, 2001.3.14)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (14)
          Reported As
          Symbol Synonym
          ADGDF-A
          (Zurovec et al., 2002)
          ADGF
          (Ferguson and Martinez-Agosto, 2017)
          ADGF-A
          (Li et al., 2023, Ramond et al., 2020, Parsons and Foley, 2016, Lee et al., 2015, Mondal et al., 2014, Novakova and Dolezal, 2011, Fenckova and Dolezal, 2007, Wu and Silverman, 2007, Dolezelova et al., 2005, Dolezal et al., 2003, Maier et al., 2001, Zurovec, 2001.3.14)
          Adgf-A
          (Kharrat et al., 2022, Koranteng et al., 2022, Boumard and Bardin, 2021, Csordás et al., 2021, Morin-Poulard et al., 2021, Spierer et al., 2021, Yu et al., 2021, Geigges et al., 2020, Kurihara et al., 2020, Luo et al., 2020, Xu et al., 2020, Sharma et al., 2019, Early et al., 2017, Ferguson and Martinez-Agosto, 2017, Sidorov et al., 2015, Sieber and Spradling, 2015, Handke et al., 2013, Handler et al., 2013, Morin-Poulard et al., 2013, Amoyel and Bach, 2012, Fenckova and Dolezal, 2007, Fenckova and Dolezal, 2007, Rehwinkel et al., 2004)
          Adgf-a
          (Wertheim et al., 2011)
          AdgfA
          (Fleischmannova et al., 2012)
          CG5992
          (Palu and Thummel, 2016, Cammarato et al., 2011, Novakova and Dolezal, 2011, Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Piacentini et al., 2009, Toledano-Katchalski et al., 2007, Zurovec et al., 2002, Charlab et al., 2001)
          adgf-a
          (Dolezal et al., 2008, Zuberova and Dolezal, 2008, Zuberova and Dolezal, 2007)
          adgfA
          (Lin et al., 2021)
          adgfa
          (Maier, 2001.1.18)
          Name Synonyms
          Adenosine Deaminase Growth Factor-A
          (Parsons and Foley, 2016)
          Adenosine deaminase-related growth factor A
          (Cammarato et al., 2011, Wertheim et al., 2011, Zurovec et al., 2001)
          Ado deaminase growth factor-A
          (Sidorov et al., 2015)
          adenosine deaminase
          (Zuberova and Dolezal, 2008)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 56 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
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