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Gene Dmel\Adgf-A

General Information
Symbol	Dmel\Adgf-A	Species	D. melanogaster
Name	Adenosine deaminase-related growth factor A	Annotation symbol	CG5992
Feature type	protein_coding_gene	FlyBase ID	FBgn0036752
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75A1-75A1	Sequence location	3L:17,744,831..17,757,258 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adenosine deaminase-related growth factor A is referred to in FlyBase by the symbol Dmel\Adgf-A (CG5992, FBgn0036752). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: growth factor activity; adenosine deaminase activity. There is experimental evidence that it is involved in the biological process: cell proliferation; hemocyte differentiation. 50 alleles are reported. The phenotypes of these alleles are annotated with: sessile hemocyte; embryonic/larval lymph gland; lamellocyte; adult abdomen; embryonic/larval hemocyte; embryonic/larval fat body; melanotic mass; crystal cell; pupal abdomen. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Adenosine deaminase-related growth factor; Adenosine/AMP deaminase N-terminal; Adenosine/AMP deaminase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult hindgut, larval Malpighian tubules, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1624054_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Adgf-A. Gene sequence location is 3L:17744831..17757258.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms cytosol hypoxanthine salvage inosine biosynthetic process adenosine catabolic process
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75A1-75A1   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References 75A-75A     (Maier, 2001.1.18)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Adgf-A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Shares 5' UTR with upstream gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Adgf-A-RA FBtr0075190  NM_079406   2588   553 Adgf-A-RB FBtr0075191  NM_206397   2584   553
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Adgf-A-PA   FBpp0074955   62.8   553   5.37     NP_524130   AAF49306 Adgf-A-PB   FBpp0089360   62.8   553   5.37     NP_996119   AAS64976
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenosine/AMP deaminase domain (IPR001365) Adenosine deaminase-related growth factor (IPR006331) Adenosine/AMP deaminase N-terminal (IPR013659)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49306   AE014296 AAS64976   AF337554 AAL40913   AI109162   AI405819   AI455786   AW943290   AY058655 AAL13884   BE975420   BE975656   BE978519   BI161551   BI161552   BI161646   BI161647   BI168570   BI214024   BI216769   BI481746   BI485535   BI609241   BI632269   BI641075   BP549408   CO153768   CO188472   CO286522   CO309245   CZ477829   CZ487243   CZ487244   EC057786   EC080659   EC199972   EC216078   EC238329   EC260904   EV583781   GH944450   GH945640   GH946034   GH948410   GH949654   GH951015   GH956009   GH956795   GH957352   GH959846   GH964080   GH968512   GH970893   GH971244   GH975187   GH981131   GH981430   GH981848
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVK5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium head mesoderm   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult hindgut, larval Malpighian tubules, adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut    1158.1 Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut  (850.2) Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut  (1158.1) Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut  (1158.1) Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut    1158.1 Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut    1158.1 Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut  (850.2) Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut  (1158.1) Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut  1158.1 Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    122.15 Larval Midgut    850.2 Larval Hindgut    103 Larval Malpighian Tubules    209.7 Larval Fat Body    56 Larval Salivary Gland    27.4 Larval Trachea    20.9 Larval Carcass    43.35 Adult Head    77.8 Adult Eye    4.1 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    5.9 Adult Crop    80.7 Adult Midgut    1158.1 Adult Hindgut    305.8 Adult Malpighian Tubules    38.6 Adult Fat Body    21.7 Adult Salivary Gland    10.3 Adult Heart    198.125 Adult VirginFemale Spermatheca    85.5 Adult InseminatedFemale Spermatheca    85.9 Adult Ovary    76.2 Adult Testis    92.5 Adult Male Accessory Gland    2.8 Adult Carcass    37.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    77.8   NA  Eye    4.1   NA  Brain    8.7   122.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.9   NA  Crop    80.7   850.2  Midgut    1158.1   103  Hindgut    305.8   209.7  Malpighian Tubules    38.6   56  Fat Body    no informative data   27.4  Salivary Gland    no informative data   NA  Heart    198.125   20.9  Trachea    NA   NA  VirginFemale Spermatheca    85.5   NA  InseminatedFemale Spermatheca    85.9   NA  Ovary    76.2   NA  Testis    92.5   NA  Male Accessory Gland    2.8   43.35  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (39) digestive system, 1-day adult  (93) digestive system, 4-day adult  (92) digestive system, 20-day adult  (72) fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (39) digestive system, 1-day adult  (93) digestive system, 4-day adult  (92) digestive system, 20-day adult  (72) fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    9 central nervous system, pupae P8    2 head, virgin 1-day female    10 head, virgin 4-day female    5 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    4 head, mated 20-day female    7 head, mated 1-day male    12 head, mated 4-day male    7 head, mated 20-day male    15 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    39 digestive system, 1-day adult    93 digestive system, 4-day adult    92 digestive system, 20-day adult    72 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    25 carcass, larvae L3 wandering    3 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr  (27) embryo 08-10hr  (56) embryo 10-12hr  (90) embryo 12-14hr  (81) embryo 14-16hr  (29) embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1  (43) larva L2  (45) larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr  27 embryo 08-10hr  (56) embryo 10-12hr  (90) embryo 12-14hr  (81) embryo 14-16hr  29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1  (43) larva L2  (45) larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    6 embryo 06-08hr    27 embryo 08-10hr    56 embryo 10-12hr    90 embryo 12-14hr    81 embryo 14-16hr    29 embryo 16-18hr    19 embryo 18-20hr    17 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    43 larva L2    45 larva L3 12hr old    20 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    12 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    23 pupae 2d postWPP    8 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    14 adult male 05day    12 adult male 30day    10 adult female 01day    21 adult female 05day    16 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    117 embryonic 1182-4H    3 embryonic GM2    130 embryonic Kc167    89 embryonic S1    231 embryonic S3    17 leg disc CME L1    115 wing disc CME-W2    101 wing disc ML-DmD8    117 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    181 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    143 tumorous blood cells mbn2    119 ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  (117) embryonic 1182-4H    3 embryonic GM2  (130) embryonic Kc167  (89) embryonic S1  (231) embryonic S3    17 leg disc CME L1  (115) wing disc CME-W2  (101) wing disc ML-DmD8  (117) wing disc ML-DmD9    5 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (43) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  (181) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (97) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (143) tumorous blood cells mbn2  (119) ovary fGS/OSS  (74) ovary OSC    4 ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4  (117) embryonic 1182-4H    3 embryonic GM2  (130) embryonic Kc167    89 embryonic S1  (231) embryonic S3    17 leg disc CME L1  (115) wing disc CME-W2  101 wing disc ML-DmD8  (117) wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  (181) antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (143) tumorous blood cells mbn2  (119) ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    117 embryonic 1182-4H    3 embryonic GM2    130 embryonic Kc167    89 embryonic S1    231 embryonic S3    17 leg disc CME L1    115 wing disc CME-W2    101 wing disc ML-DmD8    117 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    181 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    143 tumorous blood cells mbn2    119 ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    117 embryonic 1182-4H    3 embryonic GM2    130 embryonic Kc167    89 embryonic S1    231 embryonic S3    17 leg disc CME L1    115 wing disc CME-W2    101 wing disc ML-DmD8    117 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    181 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    143 tumorous blood cells mbn2    119 ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4  (117) embryonic 1182-4H    3 embryonic GM2  (130) embryonic Kc167  (89) embryonic S1  (231) embryonic S3    17 leg disc CME L1  (115) wing disc CME-W2  (101) wing disc ML-DmD8  (117) wing disc ML-DmD9    5 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (43) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  (181) antennal disc ML-DmD20-c5  (35) mixed discs ML-DmD4-c1  (97) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (143) tumorous blood cells mbn2  (119) ovary fGS/OSS  (74) ovary OSC    4 ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4  117 embryonic 1182-4H    3 embryonic GM2  130 embryonic Kc167    89 embryonic S1  (231) embryonic S3    17 leg disc CME L1  115 wing disc CME-W2  101 wing disc ML-DmD8  117 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11  (181) antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  143 tumorous blood cells mbn2  119 ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    117 embryonic 1182-4H    3 embryonic GM2    130 embryonic Kc167    89 embryonic S1    231 embryonic S3    17 leg disc CME L1    115 wing disc CME-W2    101 wing disc ML-DmD8    117 wing disc ML-DmD9    5 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    43 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    181 antennal disc ML-DmD20-c5    35 mixed discs ML-DmD4-c1    97 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    143 tumorous blood cells mbn2    119 ovary fGS/OSS    74 ovary OSC    4 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  (28) Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3  28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    14 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD35474 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036752 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5992-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Adgf-A Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Adgf-AKarel.3') Adgf-AKarel.5' lethal (with Adgf-AKarel.5') Adgf-AKarel.3' lethal | larval stage (with Adgf-AGerda.3') Adgf-AGerda.5' lethal | larval stage (with Adgf-AGerda.5') Adgf-AGerda.3' lethal | larval stage (with Adgf-AKarel.3') Adgf-AKarel.5' lethal | larval stage (with Adgf-AKarel.5') Adgf-AKarel.3' viable Adgf-Ad11616 viable, with Scer\GAL4pnr-MD237 Adgf-AGD6156 Adgf-AGD17237 Sterility Allele fertile Adgf-Ad11616 Other Phenotypes Allele developmental rate defective (with Adgf-AKarel.3') Adgf-AKarel.5' developmental rate defective (with Adgf-AKarel.5') Adgf-AKarel.3' melanotic mass phenotype Adgf-AAGFP melanotic mass phenotype (with Adgf-AGerda.3') Adgf-AGerda.5' melanotic mass phenotype (with Adgf-AGerda.5') Adgf-AGerda.3' melanotic mass phenotype (with Adgf-AKarel.3') Adgf-AKarel.5' melanotic mass phenotype (with Adgf-AKarel.5') Adgf-AKarel.3' Phenotype manifest in Allele adult abdomen (with Adgf-AKarel.3') Adgf-AKarel.5' adult abdomen (with Adgf-AKarel.5') Adgf-AKarel.3' crystal cell (with Adgf-AKarel.3') Adgf-AKarel.5' crystal cell (with Adgf-AKarel.5') Adgf-AKarel.3' embryonic/larval fat body (with Adgf-AGerda.3') Adgf-AGerda.5' embryonic/larval fat body (with Adgf-AGerda.5') Adgf-AGerda.3' embryonic/larval fat body (with Adgf-AKarel.3') Adgf-AKarel.5' embryonic/larval fat body (with Adgf-AKarel.5') Adgf-AKarel.3' embryonic/larval hemocyte (with Adgf-AKarel.3') Adgf-AKarel.5' embryonic/larval hemocyte (with Adgf-AKarel.5') Adgf-AKarel.3' embryonic/larval lymph gland (with Adgf-AKarel.3') Adgf-AKarel.5' embryonic/larval lymph gland (with Adgf-AKarel.5') Adgf-AKarel.3' lamellocyte (with Adgf-AKarel.3') Adgf-AKarel.5' lamellocyte (with Adgf-AKarel.5') Adgf-AKarel.3' melanotic mass Adgf-AAGFP melanotic mass (with Adgf-AGerda.3') Adgf-AGerda.5' melanotic mass (with Adgf-AGerda.5') Adgf-AGerda.3' melanotic mass (with Adgf-AKarel.3') Adgf-AKarel.5' melanotic mass (with Adgf-AKarel.5') Adgf-AKarel.3' pupal abdomen (with Adgf-AKarel.3') Adgf-AKarel.5' pupal abdomen (with Adgf-AKarel.5') Adgf-AKarel.3' sessile hemocyte (with Adgf-AKarel.3') Adgf-AKarel.5' sessile hemocyte (with Adgf-AKarel.5') Adgf-AKarel.3'
Classical Alleles ( 43 )
For All Classical Alleles Show
Allele of Adgf-A Class Mutagen Stocks Known lesion Adgf-Ad11616 P-element activity 2 -- Adgf-Af04691 piggyBac transposase 1 -- Adgf-AMB11970 1 -- Adgf-AAGFP ends-in gene targeting 0 Yes Adgf-AAlbert.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AAlbert.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AAm3 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AAm7 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AAmalie.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AAmalie.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ABerta.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ABerta.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ABerta.mid recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ADrahomira.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ADrahomira.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AFerda.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AFerda.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AFr1 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr21 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr24 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr2 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr3 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr6 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFr7 I-CreI endonuclease ends-in gene targeting 0 Yes Adgf-AFranta.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AFranta.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AGerda.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AGerda.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AHermina.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AHermina.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AHubert.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AHubert.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AHubert.mid recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AKarel.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AKarel.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AMojmir.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AMojmir.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ARudolf.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ARudolf.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ATeodor.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-ATeodor.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AViktor.3' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes Adgf-AViktor.5' recombination SCEI endonuclease FLPase ends-in gene targeting 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Adgf-A Class Mutagen Stocks Known lesion Adgf-AGD17237 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Adgf-AGD6156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Adgf-AHR.cDa in vitro construct 0 Yes Adgf-Ahs.PD in vitro construct - regulatory fusion 0 Yes Adgf-AKK102041 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Adgf-Amut.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Adgf-AScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel9005 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6156} NA P{GD17237} NA P{KK102041} NA P{UAS-Adgf-A.mut.myc} NA P{UAS-Adgf-A.myc} NA heat-shock construct P{hs-Adgf-A.D} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}Adgf-Ad11616 NA miscellaneous insertions PBac{WH}Adgf-Af04691 NA insertion of enhancer trap binary system Mi{ET1}Adgf-AMB11970 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
adenosine deaminase activity inferred from direct assay (Zurovec et al., 2001, Zurovec et al., 2002) growth factor activity inferred from direct assay (Zurovec et al., 2001, Zurovec et al., 2002)
Biological Process
CV term Evidence References
cell proliferation inferred from direct assay (Zurovec et al., 2002) hemocyte differentiation inferred from mutant phenotype (Dolezal et al., 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
adenosine catabolic process inferred from biological aspect of ancestor with PANTHER:PTN000150817 (assigned by RefGenome) (Gaudet et al., 2010) hypoxanthine salvage inferred from biological aspect of ancestor with PANTHER:PTN000150817 (assigned by RefGenome) (Gaudet et al., 2010) inosine biosynthetic process inferred from biological aspect of ancestor with PANTHER:PTN000150817 (assigned by RefGenome) (Gaudet et al., 2010) purine ribonucleoside monophosphate biosynthetic process inferred from electronic annotation with InterPro:IPR001365 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
NOT cytosol inferred from rapid divergence with PANTHER:PTN000150872 (assigned by RefGenome) (Gaudet et al., 2010) extracellular space inferred from biological aspect of ancestor with PANTHER:PTN000150875 (assigned by RefGenome) (Gaudet et al., 2010) non-traceable author statement (Zurovec et al., 2002)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_primary_transcript (FlyBase Genome Annotators, 2006) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Adgf-A allele Gene References unspecified AdoR (Dolezal et al., 2005) cact (Dolezal et al., 2005) crq (Dolezal et al., 2005) l(3)hem (Dolezal et al., 2005)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036752
Orthologs
OrthoDB Orthologs (68) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG698VKC Dipteran inclusive ortholog search EOG6Q2DQ7 Insect inclusive ortholog search EOG6P2NXZ Arthropod inclusive ortholog search EOG6B8GVQ Metazoa inclusive ortholog search EOG6V4G1V
Orthologs in Drosophila Species (EOG698VKC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Adgf-A     Drosophila simulans   Dsim\GD12381 Y   Drosophila sechellia   Dsec\GM24311 Y   Drosophila erecta   Dere\GG15787 Y   Drosophila yakuba   Dyak\GE22124 Y   Drosophila ananassae   Dana\GF23892 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19282 Y   Drosophila persimilis   Dper\GL18074 Y   Drosophila willistoni   Dwil\GK12327 Y   Drosophila virilis   Dvir\GJ13087 Y   Drosophila mojavensis   Dmoj\GI12945 Y   Drosophila grimshawi   Dgri\GH18002     Drosophila grimshawi   Dgri\GH15340 Y
Orthologs in non-Drosophila Dipterans (EOG6Q2DQ7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005676 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005672 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006907 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006906 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010860 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010861 Y
Orthologs in non-Dipteran Insects (EOG6P2NXZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53847 Y Apis mellifera Western honey bee  Amel\GB53848 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000059 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000060 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000062 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000058 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000061 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25641 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25640 Y Atta cephalotes Leafcutter ant  Acep\ACEP13084 Y Atta cephalotes Leafcutter ant  Acep\ACEP13067 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16463 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16462 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16433 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16434 Y Linepithema humile Argentine ant  Lhum\LH22124 Y Linepithema humile Argentine ant  Lhum\LH22122 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14118 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB14115 Y Solenopsis invicta Red fire ant  Sinv\SINV14149 Y Solenopsis invicta Red fire ant  Sinv\SINV14160 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006179 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006167 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012895 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012939 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012938 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012894 Y Pediculus humanus Human body louse  Phum\PHUM458210 Y Tribolium castaneum Red flour beetle  Tcas\TC003178 Y Tribolium castaneum Red flour beetle  Tcas\TC003279 Y Tribolium castaneum Red flour beetle  Tcas\TC009769 Y
Orthologs in non-Insect Arthropods (EOG6B8GVQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_305023 Y Daphnia pulex Water flea  Dpux\cad Y
Orthologs in non-Arthropod Metazoa (EOG6V4G1V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017738gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020443gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011143gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019667gn Y Danio rerio Zebrafish  Drer\abhd2b Y Danio rerio Zebrafish  Drer\cecr1a Y Danio rerio Zebrafish  Drer\cecr1b Y Danio rerio Zebrafish  Drer\abhd2a Y Xenopus tropicalis Western clawed frog  Xtro\cecr1 Y Xenopus tropicalis Western clawed frog  Xtro\abhd2 Y Gallus gallus Domestic chicken  Ggal\CECR1 Y Gallus gallus Domestic chicken  Ggal\ABHD2 Y Mus musculus House mouse  Mmus\Abhd2 Y Rattus norvegicus Norway rat  Rnor\Abhd2 Y Homo sapiens Human  Hsap\ABHD2 Y Homo sapiens Human  Hsap\CECR1 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\ABHD2     Hsap\CECR1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12381 Drosophila sechellia Dsec\GM24311 Drosophila erecta Dere\GG15787 Drosophila yakuba Dyak\GE22124 Drosophila ananassae Dana\GF23892 Drosophila pseudoobscura pseudoobscura Dpse\GA19282 Drosophila persimilis Dper\GL18074 Drosophila willistoni Dwil\GK12327 Drosophila virilis Dvir\GJ13087 Drosophila mojavensis Dmoj\GI12945 Drosophila grimshawi Dgri\GH15340
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	19354 w1118; P{XP}Adgf-Ad11616 29268 w1118; Mi{ET1}Adgf-AMB11970 MsiMB11970 CG32181MB11970
Harvard	- P{XP}Adgf-Ad11616 - PBac{WH}Adgf-Af04691
VDRC	v16456 w1118; P{GD6156}v16456 v50426 w1118; P{GD17237}v50426 v50427 w1118; P{GD17237}v50427
Genomic Clones ( 1 )
	BACR44L18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35474
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08276 GH25955 RE09361 RE19712 RE24044 RE64347 RE68882 RH13996 SD24192 SD26005
Other clones	54198 157978 180894 522784 bs43b09 bs45a03 bs78g12 CK01.50A.H8 Dmel_dig_011230_0636_2900 EK040364 EK063046 EK260824 EN02761 FGM101D02 RE01043 RE01102 RP004060595 RP004071245 RP004086522 RP004162604 RP004180321 RP004199378 RP004225327 RP004226366 RP004229057 RP004231372 RP004235625 RP004240657 RP004348698 RP004415435 RP004420598 RP004454152 RP004507038 RP004551952
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036752 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39976
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Adgf-A CG5992 (Zurovec, 2001.3.14)
Source for database merge of
Additional comments	One or more of the processed transcripts for this gene share(s) untranslated sequences with a transcript of an adjacent gene, but encode(s) a single open reading frame (ORF). The non-overlapping ORFs that share untranslated sequences are represented by Msi and Adgf-A. (FlyBase Genome Annotators, 2006)
Other Comments
	Loss of Adgf-A function results in abnormal hemocyte development, leading to melanotic tumour formation, as well as fat body disintegration associated with death during the larval stage or delayed transition to the pupal stage of development. (Dolezal et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079406 NM_206397 RefSeq (Proteins) • NP_524130 NP_996119 DDBJ / EMBL / GenBank • AAF49306 AAL13884 AAL40913 AAS64976 AF337554 AI109162 AI455786 AW943290 AY058655 CZ477829 CZ487243 CZ487244 Entrez Gene - A searchable database of RefSeq genes. • 39976 UniProtKB/TrEMBL • Q9VVK5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenosine/AMP deaminase domain (IPR001365) Adenosine deaminase-related growth factor (IPR006331) Adenosine/AMP deaminase N-terminal (IPR013659) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD35474
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036752 DRSC - Results from RNAi screens. • FBgn0036752 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036752 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5992-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036752 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39976 modMine - Data generated by the modENCODE project. • FBgn0036752
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	ADGDF-A (Zurovec et al., 2002) ADGF-A (Dolezal et al., 2003, Maier et al., 2001, Zurovec, 2001.3.14, Fenckova and Dolezal, 2007, Wu and Silverman, 2007, Dolezelova et al., 2005, Novakova and Dolezal, 2011) adgfa (Maier, 2001.1.18) Adgf-A (Fenckova and Dolezal, 2007, Fenckova and Dolezal, 2007, Rehwinkel et al., 2004) adgf-a (Zuberova and Dolezal, 2007, Dolezal et al., 2008, Zuberova and Dolezal, 2008) Adgf-a (Wertheim et al., 2011) CG5992 (Zurovec et al., 2002, Charlab et al., 2001, Mosallanejad et al., 2010, Toledano-Katchalski et al., 2007, Piacentini et al., 2009, Novakova and Dolezal, 2011, Keleman et al., 2009.8.5, Cammarato et al., 2011)
Name Synonym	adenosine deaminase (Zuberova and Dolezal, 2008) Adenosine deaminase-related growth factor A (Zurovec et al., 2001, Wertheim et al., 2011, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 16 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 9 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Tan et al., 2012, G3 (Bethesda) 2(3): 393--405 Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila. [FBrf0217733] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Mondal et al., 2011, Cell 147(7): 1589--1600 Interaction between Differentiating Cell- and Niche-Derived Signals in Hematopoietic Progenitor Maintenance. [FBrf0217084] Novakova and Dolezal, 2011, PLoS ONE 6(3): e17741 Expression of Drosophila Adenosine Deaminase in Immune Cells during Inflammatory Response. [FBrf0213278] Wertheim et al., 2011, Mol. Ecol. 20(5): 932--949 Functional genomics of the evolution of increased resistance to parasitism in Drosophila. [FBrf0213049] Show all research papers ...