General Information Symbol Dmel\ CG5567Species D. melanogaster Name Annotation symbol CG5567 Feature type protein_coding_gene FlyBase ID FBgn0036760 Gene Model Status Current Stock availability 8 publicly
available Genomic Location Chromosome (arm) 3L Recombination map Cytogenetic map 75A4-75A4 Sequence location 3L:17,834,640..17,836,644 [-]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG5567 (FBgn0036760). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : 4-nitrophenylphosphatase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : metabolic process.
7 alleles are reported . No phenotypic data is available. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: 2-phosphoglycolate phosphatase, eukaryotic; HAD-like domain; HAD-superfamily hydrolase, subfamily IIA; Nitrophenylphosphatase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult Malpighian tubules, adult heart, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637298_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5567. Gene sequence location is
3L:17834640..17836644 .
User Contributed Data
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.45
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
(609.4)
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
(993.3)
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
(588.625)
Adult VirginFemale Spermatheca
(549.4)
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
(993.3)
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
198.9
Larval Midgut
138.1
Larval Hindgut
171.4
Larval Malpighian Tubules
243.1
Larval Fat Body
106.5
Larval Salivary Gland
76.2
Larval Trachea
153.375
Larval Carcass
247.7
Adult Head
260.7
Adult Eye
223.55
Adult Brain
217.6
Adult Thoracic-Abdominal Ganglion
209.7
Adult Crop
609.4
Adult Midgut
528.1
Adult Hindgut
419.7
Adult Malpighian Tubules
993.3
Adult Fat Body
404.6
Adult Salivary Gland
306.3
Adult Heart
588.625
Adult VirginFemale Spermatheca
549.4
Adult InseminatedFemale Spermatheca
447.5
Adult Ovary
335.2
Adult Testis
167.8
Adult Male Accessory Gland
94.7
Adult Carcass
381.9
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
260.7
NA
Eye
223.55
NA
Brain
217.6
198.9
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
209.7
NA
Crop
609.4
138.1
Midgut
528.1
171.4
Hindgut
419.7
243.1
Malpighian Tubules
993.3
106.5
Fat Body
404.6
76.2
Salivary Gland
306.3
NA
Heart
588.625
153.375
Trachea
NA
NA
VirginFemale Spermatheca
549.4
NA
InseminatedFemale Spermatheca
447.5
NA
Ovary
335.2
NA
Testis
167.8
NA
Male Accessory Gland
94.7
247.7
Carcass
381.9
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
(33)
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
(31)
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
(39)
ovary, mated 4-day female
(27)
testis, mated 4-day male
(39)
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
(33)
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
(39)
ovary, mated 4-day female
27
testis, mated 4-day male
(39)
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
12
central nervous system, larvae L3
5
central nervous system, pupae P8
5
head, virgin 1-day female
20
head, virgin 4-day female
19
head, virgin 20-day female
22
head, mated 1-day female
13
head, mated 4-day female
16
head, mated 20-day female
17
head, mated 1-day male
17
head, mated 4-day male
21
head, mated 20-day male
33
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
3
digestive system, larvae L3 wandering
9
digestive system, 1-day adult
31
digestive system, 4-day adult
20
digestive system, 20-day adult
24
fat body, larvae L3 wandering
2
fat body, white prepupae
6
fat body, pupae P8
10
carcass, larvae L3 wandering
7
carcass, 1-day adult
15
carcass, 4-day adult
18
carcass, 20-day adult
22
ovary, virgin 4-day female
39
ovary, mated 4-day female
27
testis, mated 4-day male
39
accessory gland, mated 4-day male
7
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(41)
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
(30)
embryo 18-20hr
(62)
embryo 20-22hr
(93)
embryo 22-24hr
(102)
larva L1
(56)
larva L2
(59)
larva L3 12hr old
(43)
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
(41)
adult male 05day
(36)
adult male 30day
(29)
adult female 01day
(28)
adult female 05day
(36)
adult female 30day
(37)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(41)
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
(62)
embryo 20-22hr
(93)
embryo 22-24hr
(102)
larva L1
(56)
larva L2
(59)
larva L3 12hr old
(43)
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
(41)
adult male 05day
(36)
adult male 30day
29
adult female 01day
28
adult female 05day
(36)
adult female 30day
(37)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
41
embryo 02-04hr
10
embryo 04-06hr
2
embryo 06-08hr
2
embryo 08-10hr
4
embryo 10-12hr
11
embryo 12-14hr
14
embryo 14-16hr
13
embryo 16-18hr
30
embryo 18-20hr
62
embryo 20-22hr
93
embryo 22-24hr
102
larva L1
56
larva L2
59
larva L3 12hr old
43
larva L3 puffstage 1-2
21
larva L3 puffstage 3-6
15
larva L3 puffstage 7-9
15
white prepupae new
13
white prepupae 12hr
14
white prepupae 24hr
13
pupae 2d postWPP
14
pupae 3d postWPP
22
pupae 4d postWPP
23
adult male 01day
41
adult male 05day
36
adult male 30day
29
adult female 01day
28
adult female 05day
36
adult female 30day
37
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
(37)
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
(37)
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
19
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
37
embryonic Kc167
22
embryonic S1
15
embryonic S3
13
leg disc CME L1
21
wing disc CME-W2
12
wing disc ML-DmD8
11
wing disc ML-DmD9
12
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
15
wing disc ML-DmD32
8
haltere disc ML-DmD17-c3
12
eye-antennal disc ML-DmD11
20
antennal disc ML-DmD20-c5
8
mixed discs ML-DmD4-c1
11
CNS ML-DmBG1-c1
12
CNS ML-DmBG2-c2
14
tumorous blood cells mbn2
13
ovary fGS/OSS
5
ovary OSC
9
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
(30)
Ethanol 5% 3 hrs, larvae L3
(33)
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(29)
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
(33)
Rotenone 2 μg 12 hrs, larvae L3
(29)
Rotenone 8 μg 12 hrs, larvae L3
(30)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
(33)
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
(33)
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
19
Cadmium 50 mM 6 hrs, larvae L3
20
Cadmium 50 mM 12 hrs, larvae L3
17
Cadmium 50 mM 48 hrs, 4-day adult
22
Cadmium 100 mM 48 hrs, 4-day adult
25
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
11
Zinc 5 mM 12 hrs, larvae L3
8
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
30
Ethanol 5% 3 hrs, larvae L3
33
Ethanol 10% 3 hrs, larvae L3
22
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
29
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
23
Paraquat 10 mM 48 hrs, 4-day adult
33
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
30
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 3 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 4 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 2 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 2 terms ) Molecular Function Biological Process Cellular Component ( 0 terms) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (51)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6CC4MH )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6J6S0R )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6FJ75K )
Apis mellifera
Western honey bee
Amel\GB40767
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012065
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012066
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010829
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH16497
Atta cephalotes
Leafcutter ant
Acep\ACEP25349
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO12675
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL14856
Linepithema humile
Argentine ant
Lhum\LH24544
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB13671
Solenopsis invicta
Red fire ant
Sinv\SINV10435
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG66M91D )
Daphnia pulex
Water flea
Y
Ixodes scapularis
Deer tick
Y
Orthologs in non-Arthropod Metazoa
(EOG6Z99QG )
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Gallus gallus
Domestic chicken
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (2)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 8 )Bloomington Harvard VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 129 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 2 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 20 )Research paper Cao et al., 2009, Biochem. Biophys. Res. Commun. 380(1): 188--192An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. [FBrf0206788] Buffin et al., 2007, Nat. Cell Biol. 9(5): 565--572Flies without a spindle checkpoint. [FBrf0200956] Pile et al., 2003, J. Biol. Chem. 278(39): 37840--37848The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism. [FBrf0162185] Supplementary material Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Personal communication to FlyBase Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Perkins et al., 2009, Update to TRiP stock collection.Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file)Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file)(Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] FlyBase analysis FlyBase, 1992-, FlyBase curation.FlyBase curation. [FBrf0105495] Stock list Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.RNAi stocks available from NIG-FLY. [FBrf0218457] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073] Curated genome annotation Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.][Annotations performed at the Celera Jamboreee.] [FBrf0126704]