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Gene Dmel\MED19

General Information
Symbol	Dmel\MED19	Species	D. melanogaster
Name	Mediator complex subunit 19	Annotation symbol	CG5546
Feature type	protein_coding_gene	FlyBase ID	FBgn0036761
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75A4-75A4	Sequence location	3L:17,836,906..17,839,600 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mediator complex subunit 19 is referred to in FlyBase by the symbol Dmel\MED19 (CG5546, FBgn0036761). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: RNA polymerase II transcription cofactor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of transcription from RNA polymerase II promoter. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Mediator complex, subunit Med19, metazoa. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640637_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of MED19. Gene sequence location is 3L:17836906..17839600.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN22921 HFA10516
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75A4-75A4   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MED19 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MED19-RA FBtr0075160  NM_140759   1771   337
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MED19-PA   FBpp0074926   35.4   337   10.64     NP_649016   AAF49295
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med19, metazoa (IPR019403)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49295   AI297702   AI511732   AI512248   AI514871   AI515741   AI519087   AY069647 AAL39792   BI167852   BI243838   BI356603   BI482141   BI579253   BI614597   BI618777   BI622934   BI627157   BI633292   BI633673   BI635126   BI635453   BP547801   BP548726   CO302533   CO335320   CO340475   CZ489901   EC053377   EC068363   EC224328   EC246229   EC253166   EC257047   EC262227   GH753053   GH753679   GH754848   GH757028   GH772975   GH774160   GH778708   GH780692   GH780756   GH783419   GH786752   GH791351   GH795623   GH800594   GH805282   GH808550   GH808778   GH812992   GH815361   GH817813   GH823152   GH826622   GH828339   GH829734   GH832952   GH835776   GH836156   GH844887   GH845152   GH849569   GH850935   GH851112   GH855873   GH857998   GH868211   GH870679   GH874686   GH880688   GH884020   GH886045   GH888653   GH902974   GH911847   GH914072   GH916379   GH917078   GH917682   GH932371   GH934027   GH937494
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVL6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036761    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036761 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036761 expression level Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6780) embryo 02-04hr  (2985) embryo 04-06hr  (5146) embryo 06-08hr  (5559) embryo 08-10hr  (4484) embryo 10-12hr  (4397) embryo 12-14hr  (2583) embryo 14-16hr  (1824) embryo 16-18hr  (1554) embryo 18-20hr  (1603) embryo 20-22hr  (1171) embryo 22-24hr  (1218) larva L1  (1245) larva L2  (937) larva L3 12hr old  (711) larva L3 puffstage 1-2  (1029) larva L3 puffstage 3-6  (1961) larva L3 puffstage 7-9  (4510) white prepupae new  (5781) white prepupae 12hr  (2561) white prepupae 24hr  (2919) pupae 2d postWPP  (2001) pupae 3d postWPP  (1115) pupae 4d postWPP  (1391) adult male 01day  (1119) adult male 05day  (1257) adult male 30day  (1177) adult female 01day  (2064) adult female 05day  (4066) adult female 30day  (4211) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6780) embryo 02-04hr  (2985) embryo 04-06hr  (5146) embryo 06-08hr  (5559) embryo 08-10hr  (4484) embryo 10-12hr  (4397) embryo 12-14hr  (2583) embryo 14-16hr  (1824) embryo 16-18hr  (1554) embryo 18-20hr  (1603) embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6  (1961) larva L3 puffstage 7-9  (4510) white prepupae new  (5781) white prepupae 12hr  (2561) white prepupae 24hr  (2919) pupae 2d postWPP  (2001) pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day  (2064) adult female 05day  (4066) adult female 30day  (4211) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036761 expression level Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6780) embryo 02-04hr  (2985) embryo 04-06hr  (5146) embryo 06-08hr  (5559) embryo 08-10hr  (4484) embryo 10-12hr  (4397) embryo 12-14hr  (2583) embryo 14-16hr  (1824) embryo 16-18hr  (1554) embryo 18-20hr  (1603) embryo 20-22hr  (1171) embryo 22-24hr  (1218) larva L1  (1245) larva L2  (937) larva L3 12hr old  (711) larva L3 puffstage 1-2  (1029) larva L3 puffstage 3-6  (1961) larva L3 puffstage 7-9  (4510) white prepupae new  (5781) white prepupae 12hr  (2561) white prepupae 24hr  (2919) pupae 2d postWPP  (2001) pupae 3d postWPP  (1115) pupae 4d postWPP  (1391) adult male 01day  (1119) adult male 05day  (1257) adult male 30day  (1177) adult female 01day  (2064) adult female 05day  (4066) adult female 30day  (4211) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6780) embryo 02-04hr  (2985) embryo 04-06hr  (5146) embryo 06-08hr  (5559) embryo 08-10hr  (4484) embryo 10-12hr  (4397) embryo 12-14hr  (2583) embryo 14-16hr  1824 embryo 16-18hr  1554 embryo 18-20hr  1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6  1961 larva L3 puffstage 7-9  (4510) white prepupae new  (5781) white prepupae 12hr  (2561) white prepupae 24hr  (2919) pupae 2d postWPP  2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day  2064 adult female 05day  (4066) adult female 30day  (4211) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6780 embryo 02-04hr    2985 embryo 04-06hr    5146 embryo 06-08hr    5559 embryo 08-10hr    4484 embryo 10-12hr    4397 embryo 12-14hr    2583 embryo 14-16hr    1824 embryo 16-18hr    1554 embryo 18-20hr    1603 embryo 20-22hr    1171 embryo 22-24hr    1218 larva L1    1245 larva L2    937 larva L3 12hr old    711 larva L3 puffstage 1-2    1029 larva L3 puffstage 3-6    1961 larva L3 puffstage 7-9    4510 white prepupae new    5781 white prepupae 12hr    2561 white prepupae 24hr    2919 pupae 2d postWPP    2001 pupae 3d postWPP    1115 pupae 4d postWPP    1391 adult male 01day    1119 adult male 05day    1257 adult male 30day    1177 adult female 01day    2064 adult female 05day    4066 adult female 30day    4211 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036761    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036761 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036761 expression level Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036761 expression level Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    228.175 Larval Midgut    81 Larval Hindgut    97.2 Larval Malpighian Tubules    105.7 Larval Fat Body    98.6 Larval Salivary Gland    141.8 Larval Trachea    112.45 Larval Carcass    173.275 Adult Head    70.9 Adult Eye    66.575 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    144.1 Adult Crop    92.1 Adult Midgut    69.1 Adult Hindgut    79.4 Adult Malpighian Tubules    94.2 Adult Fat Body    60.3 Adult Salivary Gland    124.2 Adult Heart    57.325 Adult VirginFemale Spermatheca    63 Adult InseminatedFemale Spermatheca    56.9 Adult Ovary    373.7 Adult Testis    160.9 Adult Male Accessory Gland    79.5 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    70.9   NA  Eye    66.575   NA  Brain    164.2   228.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    144.1   NA  Crop    92.1   81  Midgut    69.1   97.2  Hindgut    79.4   105.7  Malpighian Tubules    94.2   98.6  Fat Body    60.3   141.8  Salivary Gland    124.2   NA  Heart    57.325   112.45  Trachea    NA   NA  VirginFemale Spermatheca    63   NA  InseminatedFemale Spermatheca    56.9   NA  Ovary    373.7   NA  Testis    160.9   NA  Male Accessory Gland    79.5   173.275  Carcass    73.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5546-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 MED19GD11688 viable MED19f07123 Sterility Allele fertile MED19f07123 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of MED19 Class Mutagen Stocks Known lesion MED19f07123 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MED19 Class Mutagen Stocks Known lesion MED19GD11688 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED19HMS00588 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED19JF02713 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED19KK102825 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MED19dsRNA.cMa in vitro construct - RNAi 0 --
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11688} NA P{KK102825} NA P{TRiP.HMS00588} NA P{TRiP.JF02713} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}MED19f07123 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
RNA polymerase II transcription cofactor activity inferred from electronic annotation with InterPro:IPR019403 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter inferred from electronic annotation with InterPro:IPR019403 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mediator complex inferred from electronic annotation with InterPro:IPR019403 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Bourbon et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MED19 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65272 DroID - A comprehensive database of gene and protein interactions. • FBgn0036761 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39987
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25231 Dere\GG15773 Dgri\GH14462 Dmoj\GI13607 Dper\GL22742 Dpse\GA18960 Dsec\GM24298 Dsim\GD12367 Dvir\GJ13943 Dwil\GK21178 Dyak\GE22108
Curated drosophilid orthologs	Dpse\GA18960
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006934-PA Aedes aegypti (mosquito) AGAP011626-PA Anopheles gambiae (mosquito) XP_395809.2 Apis mellifera (honey bee) XP_001948446.1 Acyrthosiphon pisum (pea aphid) 100644 Branchiostoma floridae (lancelet) 86022 Branchiostoma floridae (lancelet) XP_001899665.1 Brugia malayi (roundworm nematode) BGIBMGA002887-PA Bombyx mori (silk worm) ENSBTAP00000003099 Bos taurus (bovine) CN22197 Caenorhabditis brenneri (small nematode) CE22945 Caenorhabditis elegans (worm) ENSCAFP00000011527 Canis familiaris (dog) JA16505 Caenorhabditis japonica (nematode) CPIJ013981 Culex pipens (mosquito) RP26754 Caenorhabditis remanei (nematode) 157326 Capitella spl (polychaete worm) ENSDARP00000054409 Danio rerio (zebra fish) ENSECAP00000011770 Equus caballus (horse) ENSGACP00000023546 Gymnopilus aculeatus (mushroom) ENSGALP00000011863 Gallus gallus (chicken) 188804 Hypsipyla robusta (cedar shoot borer) ENSP00000337340 Homo sapiens (human) ISCW016111-PA Ixodes scapularis (deer tick) 142396 Lottia gigantea (owl limpet) ENSMODP00000025130 Monodelphis domestica (gray opossum) ENSMMUP00000003444 Macaca mulatta (rhesus monkey) ENSMUSP00000099705 Mus musculus (house mouse) 239233 Nematostella vectensis (starlet anemone) XP_001607619.1 Nasonia vitripennis (wasp) ENSORLP00000004464 Oryzias latipes (japanese killifish) ENSPPYP00000003751 Pongo pygmaeus (orangutan) ENSPTRP00000006332 Pan troglodytes (chimpanzee) ENSRNOP00000008911 Rattus norvegicus (norway rat) Smp_061570 Schistosoma mansoni (trematode parasite) XP_793184.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970402.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016111 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032662 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15699 LH17613 ISCW016111 FBgn0239338 FBgn0223170 FBgn0201161 FBgn0184099 FBgn0179162 JGI_V11_27461 FBgn0078959 FBgn0160333 FBgn0136362 FBgn0121938 FBgn0108014 FBgn0102223 CPIJ013981 BGIBMGA002887 ACYPI003764 GB11921 AGAP011626 MED19_AEDAE PB20225 PHUM250710 GLEAN_11979
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	19047 w1118; PBac{WH}MED19f07123 27559 y1 v1; P{TRiP.JF02713}attP2 33710 y1 sc* v1; P{TRiP.HMS00588}attP2
Harvard	- PBac{WH}MED19f07123
VDRC	v103926 P{KK102825}VIE-260B v27457 w1118; P{GD11688}v27457/TM3
Genomic Clones ( 1 )
	BACR17C17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 81 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD41395
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD38373 LD41305 LD43231 LD44024 LP12065 RE08336 RE41623 RE42786 RE64793 RE73251 RH44010 RH49683 RH54976 RH68387 SD16370 SD16817 SD27347 SD27820
Other clones	59556 74519 214245.60 214475.54 533999 CK01.1B.F7 EC053377 EK184351 EN10018 EP10725 FGH120H01 FGM001D12 RP003008675 RP003062834 RP003069413 RP003069681 RP003072730 RP003077760 RP003086211 RP003116579 RP003127003 RP003131586 RP003159309 RP003171095 RP003181614 RP003186606 RP003195681 RP003196309 RP003218439 RP003241660 RP003246108 RP003246200 RP003256394 RP003258730 RP003264265 RP003264537 RP003264836 RP003279459 RP003281161 RP003309508 RP003321024 RP003331382 RP003340038 RP003340799 RP003422791 RP003422917 RP003426467 RP003443553 RP003448768 RP003469090 RP003477082 RP003479853 RP003493571 RP003507367 RP003508280 RP003553172 RP003559013 RP003570100 RP003585599 RP003592089 RP003640263 RP003663210
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39987
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MED19 CG5546 (Bourbon et al., 2004)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140759 RefSeq (Proteins) • NP_649016 DDBJ / EMBL / GenBank • AAF49295 AAL39792 AI515741 AY069647 CZ489901 Entrez Gene - A searchable database of RefSeq genes. • 39987 UniProtKB/TrEMBL • Q9VVL6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med19, metazoa (IPR019403)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65272 DroID - A comprehensive database of gene and protein interactions. • FBgn0036761 DRSC - Results from RNAi screens. • FBgn0036761 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036761 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5546-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036761 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39987 InParanoid A subset of ortholog calls from InParanoid. • AAEL006934-PA Aedes aegypti (mosquito) AGAP011626-PA Anopheles gambiae (mosquito) XP_395809.2 Apis mellifera (honey bee) XP_001948446.1 Acyrthosiphon pisum (pea aphid) 100644 Branchiostoma floridae (lancelet) 86022 Branchiostoma floridae (lancelet) XP_001899665.1 Brugia malayi (roundworm nematode) BGIBMGA002887-PA Bombyx mori (silk worm) ENSBTAP00000003099 Bos taurus (bovine) CN22197 Caenorhabditis brenneri (small nematode) CE22945 Caenorhabditis elegans (worm) ENSCAFP00000011527 Canis familiaris (dog) JA16505 Caenorhabditis japonica (nematode) CPIJ013981 Culex pipens (mosquito) RP26754 Caenorhabditis remanei (nematode) 157326 Capitella spl (polychaete worm) ENSDARP00000054409 Danio rerio (zebra fish) ENSECAP00000011770 Equus caballus (horse) ENSGACP00000023546 Gymnopilus aculeatus (mushroom) ENSGALP00000011863 Gallus gallus (chicken) 188804 Hypsipyla robusta (cedar shoot borer) ENSP00000337340 Homo sapiens (human) ISCW016111-PA Ixodes scapularis (deer tick) 142396 Lottia gigantea (owl limpet) ENSMODP00000025130 Monodelphis domestica (gray opossum) ENSMMUP00000003444 Macaca mulatta (rhesus monkey) ENSMUSP00000099705 Mus musculus (house mouse) 239233 Nematostella vectensis (starlet anemone) XP_001607619.1 Nasonia vitripennis (wasp) ENSORLP00000004464 Oryzias latipes (japanese killifish) ENSPPYP00000003751 Pongo pygmaeus (orangutan) ENSPTRP00000006332 Pan troglodytes (chimpanzee) ENSRNOP00000008911 Rattus norvegicus (norway rat) Smp_061570 Schistosoma mansoni (trematode parasite) XP_793184.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970402.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016111 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032662 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39987 modMine - Data generated by the modENCODE project. • FBgn0036761 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15699 LH17613 ISCW016111 FBgn0239338 FBgn0223170 FBgn0201161 FBgn0184099 FBgn0179162 JGI_V11_27461 FBgn0078959 FBgn0160333 FBgn0136362 FBgn0121938 FBgn0108014 FBgn0102223 CPIJ013981 BGIBMGA002887 ACYPI003764 GB11921 AGAP011626 MED19_AEDAE PB20225 PHUM250710 GLEAN_11979
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG5546 (Bourbon et al., 2004, Guglielmi et al., 2004, Baeg et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) MED19 (Ma et al., 2006)
Name Synonym	Mediator complex subunit 19 (Bourbon et al., 2004)
Secondary FlyBase IDs
References ( 17 )
Research paper	Ma et al., 2006, Nature 443(7109): 359--363 Prevalence of off-target effects in Drosophila RNA interference screens. [FBrf0194302] Guglielmi et al., 2004, Nucleic Acids Res. 32(18): 5379--5391 A high resolution protein interaction map of the yeast Mediator complex. [FBrf0180597]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Erratum	Baeg et al., 2007, Genes Dev. 21(7): 875--877 Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. [FBrf0201371]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Letter	Bourbon et al., 2004, Molec. Cell 14(5): 553--557 A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II. [FBrf0179142]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]