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Gene Dmel\CG7430

General Information
Symbol	Dmel\CG7430	Species	D. melanogaster
Name		Annotation symbol	CG7430
Feature type	protein_coding_gene	FlyBase ID	FBgn0036762
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75A4-75A4	Sequence location	3L:17,840,016..17,842,472 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG7430 (FBgn0036762). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: dihydrolipoyl dehydrogenase activity. Based on sequence similarity, it is predicted to be involved in the biological process: glycine catabolic process; lipoamide metabolic process; tricarboxylic acid cycle. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dihydrolipoamide dehydrogenase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD/NAD-linked reductase, dimerisation; Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain; Pyridine nucleotide-disulphide oxidoreductase, class I, active site; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1641291_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG7430. Gene sequence location is 3L:17840016..17842472.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75A4-75A4   Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG7430 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG7430-RA FBtr0075140  NM_140760   2023   504 CG7430-RB FBtr0331810  NM_001275071   1903   504
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG7430-PA   FBpp0074906   53.1   504   6.87     NP_649017   AAF49294 CG7430-PB   FBpp0304195   53.1   504   6.87     NP_001262000   AGB94693
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain (IPR001327) Pyridine nucleotide-disulphide oxidoreductase, dimerisation (IPR004099) Dihydrolipoamide dehydrogenase (IPR006258) Pyridine nucleotide-disulphide oxidoreductase, class I, active site (IPR012999) FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR013027) Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain (IPR023753) FAD/NAD-linked reductase, dimerisation (IPR016156) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME07430
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246896   AA391530   AA440462   AA536248   AA539361   AA567854   AA696185   AA697377   AA801975   AA951032   AE014296 AAF49294   AE014296 AGB94693   AI063531   AI109472   AI238373   AI260223   AI260896   AI292748   AI294544   AI294700   AI297652   AI387527   AI389431   AI403267   AI405440   AI530897   AI532093   AI534686   AI534753   AI541758   AI541776   AI542674   AQ073127   AQ073840   AW944033   AY058740 AAL13969   BE977389   BF486364   BF486747   BF487479   BF489951   BF496458   BF500857   BF502871   BF504400   BF505538   BG640762   BG641371   BI167996   BI234500   BI352038   BI356627   BI565721   BI566414   BI566858   BI567698   BI568147   BI572121   BI585571   BI586255   BI587075   BI591119   BI591627   BI592301   BI593343   BI606700   BI606728   BI607510   BI608368   BI608532   BI612808   BI613143   BI615051   BI616213   BI617659   BI618472   BI619713   BI620299   BI621090   BI621670   BI622453   BI629300   BI631624   BI634363   BI634718   BI641014   BX028040   BX034708   CA807565   CO153252   CO179743   CO179797   CO185924   CO193743   CO264481   CO280827   CO285388   CO295188   CO300694   EC085303   EC194707   EC199393   EC221291   EC237170   EC238457   EC245836   EC247529   EC265435   EL873579   EL882779   EL882875   EL883048   EL884247   EL886487   ES693398   ES693436   ES693946   EV586989   EV594423   GH805227   GH809132   GH906043
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVL7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) dorsal pharyngeal muscle primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut    1340.9 Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass    1283.525 Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion    1103.7 Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut    1316.6 Adult Malpighian Tubules    1818.3 Adult Fat Body    958.4 Adult Salivary Gland    1326.9 Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass    1533.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (564.175) Larval Midgut  (710.6) Larval Hindgut  (1340.9) Larval Malpighian Tubules  (901.9) Larval Fat Body    425.3 Larval Salivary Gland  (659.5) Larval Trachea  (591.6) Larval Carcass  (1283.525) Adult Head  (801.5) Adult Eye  (796.6) Adult Brain  (846.1) Adult Thoracic-Abdominal Ganglion  (1103.7) Adult Crop  (787.5) Adult Midgut  (649.4) Adult Hindgut  (1316.6) Adult Malpighian Tubules  (1818.3) Adult Fat Body  (958.4) Adult Salivary Gland  (1326.9) Adult Heart  (921.825) Adult VirginFemale Spermatheca  (995.6) Adult InseminatedFemale Spermatheca  (909.5) Adult Ovary    497.5 Adult Testis  (711.2) Adult Male Accessory Gland    363.5 Adult Carcass  (1533.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut  (1340.9) Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass  (1283.525) Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion  (1103.7) Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut  (1316.6) Adult Malpighian Tubules  (1818.3) Adult Fat Body    958.4 Adult Salivary Gland  (1326.9) Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass  (1533.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut    1340.9 Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass    1283.525 Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion    1103.7 Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut    1316.6 Adult Malpighian Tubules    1818.3 Adult Fat Body    958.4 Adult Salivary Gland    1326.9 Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass    1533.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut    1340.9 Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass    1283.525 Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion    1103.7 Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut    1316.6 Adult Malpighian Tubules    1818.3 Adult Fat Body    958.4 Adult Salivary Gland    1326.9 Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass    1533.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  564.175 Larval Midgut  710.6 Larval Hindgut  (1340.9) Larval Malpighian Tubules  (901.9) Larval Fat Body    425.3 Larval Salivary Gland  659.5 Larval Trachea  591.6 Larval Carcass  (1283.525) Adult Head  801.5 Adult Eye  796.6 Adult Brain  (846.1) Adult Thoracic-Abdominal Ganglion  (1103.7) Adult Crop  787.5 Adult Midgut  649.4 Adult Hindgut  (1316.6) Adult Malpighian Tubules  (1818.3) Adult Fat Body  (958.4) Adult Salivary Gland  (1326.9) Adult Heart  (921.825) Adult VirginFemale Spermatheca  (995.6) Adult InseminatedFemale Spermatheca  (909.5) Adult Ovary    497.5 Adult Testis  711.2 Adult Male Accessory Gland    363.5 Adult Carcass  (1533.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut  1340.9 Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass  1283.525 Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion  1103.7 Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut  1316.6 Adult Malpighian Tubules  (1818.3) Adult Fat Body    958.4 Adult Salivary Gland  1326.9 Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass  1533.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    564.175 Larval Midgut    710.6 Larval Hindgut    1340.9 Larval Malpighian Tubules    901.9 Larval Fat Body    425.3 Larval Salivary Gland    659.5 Larval Trachea    591.6 Larval Carcass    1283.525 Adult Head    801.5 Adult Eye    796.6 Adult Brain    846.1 Adult Thoracic-Abdominal Ganglion    1103.7 Adult Crop    787.5 Adult Midgut    649.4 Adult Hindgut    1316.6 Adult Malpighian Tubules    1818.3 Adult Fat Body    958.4 Adult Salivary Gland    1326.9 Adult Heart    921.825 Adult VirginFemale Spermatheca    995.6 Adult InseminatedFemale Spermatheca    909.5 Adult Ovary    497.5 Adult Testis    711.2 Adult Male Accessory Gland    363.5 Adult Carcass    1533.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    801.5   NA  Eye    796.6   NA  Brain    846.1   564.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1103.7   NA  Crop    787.5   710.6  Midgut    649.4   1340.9  Hindgut    1316.6   901.9  Malpighian Tubules    1818.3   425.3  Fat Body    958.4   659.5  Salivary Gland    1326.9   NA  Heart    921.825   591.6  Trachea    NA   NA  VirginFemale Spermatheca    995.6   NA  InseminatedFemale Spermatheca    909.5   NA  Ovary    497.5   NA  Testis    711.2   NA  Male Accessory Gland    363.5   1283.525  Carcass    1533.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female    136 head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female    102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male    159 head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult    293 carcass, 4-day adult    109 carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male    202 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (92) central nervous system, larvae L3  (47) central nervous system, pupae P8  (51) head, virgin 1-day female  (136) head, virgin 4-day female  (71) head, virgin 20-day female  (62) head, mated 1-day female  (102) head, mated 4-day female  (67) head, mated 20-day female  (55) head, mated 1-day male  (159) head, mated 4-day male  (99) head, mated 20-day male  (89) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult  (87) digestive system, 4-day adult  (74) digestive system, 20-day adult  (74) fat body, larvae L3 wandering  (27) fat body, white prepupae  (27) fat body, pupae P8  (48) carcass, larvae L3 wandering  (48) carcass, 1-day adult  (293) carcass, 4-day adult  (109) carcass, 20-day adult  (70) ovary, virgin 4-day female  (63) ovary, mated 4-day female  (59) testis, mated 4-day male  (202) accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female  (136) head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female  102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male  (159) head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult  (293) carcass, 4-day adult  (109) carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male  (202) accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female    136 head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female    102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male    159 head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult    293 carcass, 4-day adult    109 carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male    202 accessory gland, mated 4-day male    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female    136 head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female    102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male    159 head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult    293 carcass, 4-day adult    109 carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male    202 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (92) central nervous system, larvae L3  (47) central nervous system, pupae P8  (51) head, virgin 1-day female  (136) head, virgin 4-day female  (71) head, virgin 20-day female  (62) head, mated 1-day female  (102) head, mated 4-day female  (67) head, mated 20-day female  (55) head, mated 1-day male  (159) head, mated 4-day male  (99) head, mated 20-day male  (89) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering  (33) digestive system, 1-day adult  (87) digestive system, 4-day adult  (74) digestive system, 20-day adult  (74) fat body, larvae L3 wandering  27 fat body, white prepupae  27 fat body, pupae P8  (48) carcass, larvae L3 wandering  (48) carcass, 1-day adult  (293) carcass, 4-day adult  (109) carcass, 20-day adult  (70) ovary, virgin 4-day female  (63) ovary, mated 4-day female  (59) testis, mated 4-day male  (202) accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female  136 head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female  102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male  (159) head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult  (293) carcass, 4-day adult  109 carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male  (202) accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    92 central nervous system, larvae L3    47 central nervous system, pupae P8    51 head, virgin 1-day female    136 head, virgin 4-day female    71 head, virgin 20-day female    62 head, mated 1-day female    102 head, mated 4-day female    67 head, mated 20-day female    55 head, mated 1-day male    159 head, mated 4-day male    99 head, mated 20-day male    89 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    33 digestive system, 1-day adult    87 digestive system, 4-day adult    74 digestive system, 20-day adult    74 fat body, larvae L3 wandering    27 fat body, white prepupae    27 fat body, pupae P8    48 carcass, larvae L3 wandering    48 carcass, 1-day adult    293 carcass, 4-day adult    109 carcass, 20-day adult    70 ovary, virgin 4-day female    63 ovary, mated 4-day female    59 testis, mated 4-day male    202 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    116 embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr    166 embryo 12-14hr    99 embryo 14-16hr    171 embryo 16-18hr    162 embryo 18-20hr    192 embryo 20-22hr    229 embryo 22-24hr    191 larva L1    307 larva L2    263 larva L3 12hr old    297 larva L3 puffstage 1-2    126 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP    120 pupae 3d postWPP    307 pupae 4d postWPP    544 adult male 01day    469 adult male 05day    331 adult male 30day    203 adult female 01day    448 adult female 05day    156 adult female 30day    138 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (116) embryo 02-04hr  (90) embryo 04-06hr  (41) embryo 06-08hr  (58) embryo 08-10hr  (82) embryo 10-12hr  (166) embryo 12-14hr  (99) embryo 14-16hr  (171) embryo 16-18hr  (162) embryo 18-20hr  (192) embryo 20-22hr  (229) embryo 22-24hr  (191) larva L1  (307) larva L2  (263) larva L3 12hr old  (297) larva L3 puffstage 1-2  (126) larva L3 puffstage 3-6  (91) larva L3 puffstage 7-9  (65) white prepupae new  (58) white prepupae 12hr  (64) white prepupae 24hr  (77) pupae 2d postWPP  (120) pupae 3d postWPP  (307) pupae 4d postWPP  (544) adult male 01day  (469) adult male 05day  (331) adult male 30day  (203) adult female 01day  (448) adult female 05day  (156) adult female 30day  (138) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (116) embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr  (166) embryo 12-14hr    99 embryo 14-16hr  (171) embryo 16-18hr  (162) embryo 18-20hr  (192) embryo 20-22hr  (229) embryo 22-24hr  (191) larva L1  (307) larva L2  (263) larva L3 12hr old  (297) larva L3 puffstage 1-2  (126) larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP  (120) pupae 3d postWPP  (307) pupae 4d postWPP  (544) adult male 01day  (469) adult male 05day  (331) adult male 30day  (203) adult female 01day  (448) adult female 05day  (156) adult female 30day  (138) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    116 embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr    166 embryo 12-14hr    99 embryo 14-16hr    171 embryo 16-18hr    162 embryo 18-20hr    192 embryo 20-22hr    229 embryo 22-24hr    191 larva L1    307 larva L2    263 larva L3 12hr old    297 larva L3 puffstage 1-2    126 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP    120 pupae 3d postWPP    307 pupae 4d postWPP    544 adult male 01day    469 adult male 05day    331 adult male 30day    203 adult female 01day    448 adult female 05day    156 adult female 30day    138 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    116 embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr    166 embryo 12-14hr    99 embryo 14-16hr    171 embryo 16-18hr    162 embryo 18-20hr    192 embryo 20-22hr    229 embryo 22-24hr    191 larva L1    307 larva L2    263 larva L3 12hr old    297 larva L3 puffstage 1-2    126 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP    120 pupae 3d postWPP    307 pupae 4d postWPP    544 adult male 01day    469 adult male 05day    331 adult male 30day    203 adult female 01day    448 adult female 05day    156 adult female 30day    138 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (116) embryo 02-04hr  (90) embryo 04-06hr  (41) embryo 06-08hr  (58) embryo 08-10hr  (82) embryo 10-12hr  (166) embryo 12-14hr  (99) embryo 14-16hr  (171) embryo 16-18hr  (162) embryo 18-20hr  (192) embryo 20-22hr  (229) embryo 22-24hr  (191) larva L1  (307) larva L2  (263) larva L3 12hr old  (297) larva L3 puffstage 1-2  (126) larva L3 puffstage 3-6  (91) larva L3 puffstage 7-9  (65) white prepupae new  (58) white prepupae 12hr  (64) white prepupae 24hr  (77) pupae 2d postWPP  (120) pupae 3d postWPP  (307) pupae 4d postWPP  (544) adult male 01day  (469) adult male 05day  (331) adult male 30day  (203) adult female 01day  (448) adult female 05day  (156) adult female 30day  (138) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  116 embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr  (166) embryo 12-14hr    99 embryo 14-16hr  (171) embryo 16-18hr  (162) embryo 18-20hr  (192) embryo 20-22hr  (229) embryo 22-24hr  (191) larva L1  (307) larva L2  (263) larva L3 12hr old  (297) larva L3 puffstage 1-2  126 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP  120 pupae 3d postWPP  (307) pupae 4d postWPP  (544) adult male 01day  (469) adult male 05day  (331) adult male 30day  (203) adult female 01day  (448) adult female 05day  (156) adult female 30day  138 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    116 embryo 02-04hr    90 embryo 04-06hr    41 embryo 06-08hr    58 embryo 08-10hr    82 embryo 10-12hr    166 embryo 12-14hr    99 embryo 14-16hr    171 embryo 16-18hr    162 embryo 18-20hr    192 embryo 20-22hr    229 embryo 22-24hr    191 larva L1    307 larva L2    263 larva L3 12hr old    297 larva L3 puffstage 1-2    126 larva L3 puffstage 3-6    91 larva L3 puffstage 7-9    65 white prepupae new    58 white prepupae 12hr    64 white prepupae 24hr    77 pupae 2d postWPP    120 pupae 3d postWPP    307 pupae 4d postWPP    544 adult male 01day    469 adult male 05day    331 adult male 30day    203 adult female 01day    448 adult female 05day    156 adult female 30day    138 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    199 embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1    168 wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9    126 wing disc ML-DmD16-c3    83 wing disc ML-DmD21    141 wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11    157 antennal disc ML-DmD20-c5    101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  (199) embryonic 1182-4H  (75) embryonic GM2  (88) embryonic Kc167  (60) embryonic S1  (94) embryonic S3  (96) leg disc CME L1  (168) wing disc CME-W2  (77) wing disc ML-DmD8  (80) wing disc ML-DmD9  (126) wing disc ML-DmD16-c3  (83) wing disc ML-DmD21  (141) wing disc ML-DmD32  (79) haltere disc ML-DmD17-c3  (85) eye-antennal disc ML-DmD11  (157) antennal disc ML-DmD20-c5  (101) mixed discs ML-DmD4-c1  (94) CNS ML-DmBG1-c1  (95) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (65) ovary fGS/OSS  (42) ovary OSC  (36) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  (199) embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1  (168) wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9  (126) wing disc ML-DmD16-c3    83 wing disc ML-DmD21  (141) wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11  (157) antennal disc ML-DmD20-c5  101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    199 embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1    168 wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9    126 wing disc ML-DmD16-c3    83 wing disc ML-DmD21    141 wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11    157 antennal disc ML-DmD20-c5    101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    199 embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1    168 wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9    126 wing disc ML-DmD16-c3    83 wing disc ML-DmD21    141 wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11    157 antennal disc ML-DmD20-c5    101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (113) Schneider line 2 Sg4  (199) embryonic 1182-4H  (75) embryonic GM2  (88) embryonic Kc167  (60) embryonic S1  (94) embryonic S3  (96) leg disc CME L1  (168) wing disc CME-W2  (77) wing disc ML-DmD8  (80) wing disc ML-DmD9  (126) wing disc ML-DmD16-c3  (83) wing disc ML-DmD21  (141) wing disc ML-DmD32  (79) haltere disc ML-DmD17-c3  (85) eye-antennal disc ML-DmD11  (157) antennal disc ML-DmD20-c5  (101) mixed discs ML-DmD4-c1  (94) CNS ML-DmBG1-c1  (95) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (65) ovary fGS/OSS  (42) ovary OSC  (36) ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  113 Schneider line 2 Sg4  (199) embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1  (168) wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9  126 wing disc ML-DmD16-c3    83 wing disc ML-DmD21  141 wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11  (157) antennal disc ML-DmD20-c5  101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    113 Schneider line 2 Sg4    199 embryonic 1182-4H    75 embryonic GM2    88 embryonic Kc167    60 embryonic S1    94 embryonic S3    96 leg disc CME L1    168 wing disc CME-W2    77 wing disc ML-DmD8    80 wing disc ML-DmD9    126 wing disc ML-DmD16-c3    83 wing disc ML-DmD21    141 wing disc ML-DmD32    79 haltere disc ML-DmD17-c3    85 eye-antennal disc ML-DmD11    157 antennal disc ML-DmD20-c5    101 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    95 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    65 ovary fGS/OSS    42 ovary OSC    36 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    138 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    118 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3    111 Ethanol 5% 3 hrs, larvae L3    110 Ethanol 10% 3 hrs, larvae L3    147 Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult    132 Rotenone 2 μg 12 hrs, larvae L3    107 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (51) cold shock, 4-day adult  (44) heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (138) Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult  (118) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3  (68) Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (52) Ethanol 2.5% 3 hrs, larvae L3  (111) Ethanol 5% 3 hrs, larvae L3  (110) Ethanol 10% 3 hrs, larvae L3  (147) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (86) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (58) Caffeine 25 mg/ml 48 hrs, 4-day adult  (46) Paraquat 5 mM 48 hrs, 4-day adult  (97) Paraquat 10 mM 48 hrs, 4-day adult  (132) Rotenone 2 μg 12 hrs, larvae L3  (107) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (138) Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult  (118) Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3  (111) Ethanol 5% 3 hrs, larvae L3  (110) Ethanol 10% 3 hrs, larvae L3  (147) Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult  (132) Rotenone 2 μg 12 hrs, larvae L3  107 Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    138 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    118 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3    111 Ethanol 5% 3 hrs, larvae L3    110 Ethanol 10% 3 hrs, larvae L3    147 Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult    132 Rotenone 2 μg 12 hrs, larvae L3    107 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    138 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    118 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3    111 Ethanol 5% 3 hrs, larvae L3    110 Ethanol 10% 3 hrs, larvae L3    147 Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult    132 Rotenone 2 μg 12 hrs, larvae L3    107 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (51) cold shock, 4-day adult  (44) heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (138) Cadmium 50 mM 12 hrs, larvae L3  (45) Cadmium 50 mM 48 hrs, 4-day adult  (118) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3  (68) Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (52) Ethanol 2.5% 3 hrs, larvae L3  (111) Ethanol 5% 3 hrs, larvae L3  (110) Ethanol 10% 3 hrs, larvae L3  (147) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (86) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (58) Caffeine 25 mg/ml 48 hrs, 4-day adult  (46) Paraquat 5 mM 48 hrs, 4-day adult  (97) Paraquat 10 mM 48 hrs, 4-day adult  (132) Rotenone 2 μg 12 hrs, larvae L3  (107) Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult  130 Cadmium 50 mM 6 hrs, larvae L3  138 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult  118 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3  111 Ethanol 5% 3 hrs, larvae L3  110 Ethanol 10% 3 hrs, larvae L3  (147) Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult  132 Rotenone 2 μg 12 hrs, larvae L3  107 Rotenone 8 μg 12 hrs, larvae L3  (162) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    44 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    138 Cadmium 50 mM 12 hrs, larvae L3    45 Cadmium 50 mM 48 hrs, 4-day adult    118 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    52 Ethanol 2.5% 3 hrs, larvae L3    111 Ethanol 5% 3 hrs, larvae L3    110 Ethanol 10% 3 hrs, larvae L3    147 Caffeine 1.5 mg/ml 4 hrs, larvae L3    86 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    58 Caffeine 25 mg/ml 48 hrs, 4-day adult    46 Paraquat 5 mM 48 hrs, 4-day adult    97 Paraquat 10 mM 48 hrs, 4-day adult    132 Rotenone 2 μg 12 hrs, larvae L3    107 Rotenone 8 μg 12 hrs, larvae L3    162 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LP04889 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036762 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7430-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG7430 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG7430GD12237 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG7430 Class Mutagen Stocks Known lesion CG7430EP3698 P-element activity 1 -- CG7430EP3231 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG7430 Class Mutagen Stocks Known lesion CG7430GD12237 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG7430KK102614 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12237} NA P{KK102614} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG7430EP3231 NA P{EP}CG7430EP3698 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
dihydrolipoyl dehydrogenase activity inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11) flavin adenine dinucleotide binding inferred from electronic annotation with InterPro:IPR001327, InterPro:IPR004099, InterPro:IPR006258, InterPro:IPR016156 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell redox homeostasis inferred from electronic annotation with InterPro:IPR004099 (FlyBase Curators et al., 2004-) glycine catabolic process inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11) lipoamide metabolic process inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11) tricarboxylic acid cycle inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
glycine cleavage complex inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11) mitochondrial alpha-ketoglutarate dehydrogenase complex inferred from sequence or structural similarity with UniProtKB:P09622 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG7430 - Atu anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG7430 - CG10638 experimental knowledge based (Guruharsha et al., 2011) CG7430 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG31546 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG3568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG5261 experimental knowledge based (Guruharsha et al., 2011) CG7430 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - Inos experimental knowledge based (Guruharsha et al., 2011) CG7430 - Kdm4A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - Pgk experimental knowledge based (Guruharsha et al., 2011) CG7430 - Snx3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - Uch experimental knowledge based (Guruharsha et al., 2011) CG7430 - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - awd experimental knowledge based (Guruharsha et al., 2011) CG7430 - pdgy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7430 - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG7430 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65273 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036762 DroID - A comprehensive database of gene and protein interactions. • FBgn0036762 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39988
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG605SKS Dipteran inclusive ortholog search EOG65496X Insect inclusive ortholog search EOG62JMMT Arthropod inclusive ortholog search EOG6BVQ92 Metazoa inclusive ortholog search EOG69SK0R
Orthologs in Drosophila Species (EOG605SKS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG7430     Drosophila simulans   Dsim\GD14729 Y   Drosophila sechellia   Dsec\GM25722 Y   Drosophila erecta   Dere\GG13635 Y   Drosophila yakuba   Dyak\GE19931 Y   Drosophila ananassae   Dana\GF24574 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20345 Y   Drosophila persimilis   Dper\GL22852 Y   Drosophila willistoni   Dwil\GK12667 Y   Drosophila virilis   Dvir\GJ11371 Y   Drosophila mojavensis   Dmoj\GI11696 Y   Drosophila grimshawi   Dgri\GH17093 Y
Orthologs in non-Drosophila Dipterans (EOG65496X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006928   Anopheles gambiae Malaria mosquito  Agam\AGAP011629   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019726
Orthologs in non-Dipteran Insects (EOG62JMMT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551039   Apis mellifera Western honey bee  Amel\Ame.16077   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016021   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18646   Atta cephalotes Leafcutter ant  Acep\ACEP21154   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15827   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17597   Linepithema humile Argentine ant  Lhum\LH12837   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23787   Solenopsis invicta Red fire ant  Sinv\SINV11663   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003581   Bombyx mori Silkmoth  Bmor\BGIBMGA000292   Pediculus humanus Human body louse  Phum\PHUM336850   Tribolium castaneum Red flour beetle  Tcas\TC006823
Orthologs in non-Insect Arthropods (EOG6BVQ92)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_197043   Ixodes scapularis Deer tick  Isca\ISCW016077
Orthologs in non-Arthropod Metazoa (EOG69SK0R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\LLC1.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028728gn   Danio rerio Zebrafish  Drer\dldh   Xenopus tropicalis Western clawed frog  Xtro\dld   Gallus gallus Domestic chicken  Ggal\DLD   Mus musculus House mouse  Mmus\Dld   Rattus norvegicus Norway rat  Rnor\Dld   Homo sapiens Human  Hsap\DLD
Human Orthologs (1)
Gene OMIM HGNC Hsap\DLD
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14729 Drosophila sechellia Dsec\GM25722 Drosophila erecta Dere\GG13635 Drosophila yakuba Dyak\GE19931 Drosophila ananassae Dana\GF24574 Drosophila pseudoobscura pseudoobscura Dpse\GA20345 Drosophila persimilis Dper\GL22852 Drosophila willistoni Dwil\GK12667 Drosophila virilis Dvir\GJ11371 Drosophila mojavensis Dmoj\GI11696 Drosophila grimshawi Dgri\GH17093
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	17275 w1118; P{EP}CG7430EP3698/TM6B, Tb1
VDRC	v106126 P{KK102614}VIE-260B v28011 w1118; P{GD12237}v28011/CyO
Genomic Clones ( 1 )
	BACR17C17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP04889
Other clones	DPiM_LP04889
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05754 AT07782 AT10375 AT16008 AT18714 AT20642 AT21263 AT22284 AT26196 GH03395 GH08686 GH14407 GH15723 GH18078 GH20603 GH22670 GH25445 GM03663 GM05238 GM17316 HL01891 HL02361 LD05905 LD10188 LD15314 LD16740 LD17460 LD31301 LP03939 LP07943 LP08131 LP12001 RE08525 RE30209 RE42816 RH04837 RH06378 RH07467 RH09949 RH11353 RH12780 RH13095 RH25179 RH26129 RH27343 RH35653 RH36627 RH38253 RH38407 RH38931 RH39532 RH41781 RH42233 RH44570 RH46106 RH48060 RH49319 RH50806 RH51387 RH52382 RH53053 RH54331 RH58144 RH61239 RH63535 RH73334 RH73503 RH74589 SD01664 SD03460 SD06905 SD06935 SD07664 SD07759 SD09112 SD11908 SD12693 SD24073
Other clones	30432 41717 52847 54258 79230 106884 160573 522217 bs63b12 CK01.13C.E10 Dmel_neb_011470_0186_1564 Dmel_neb_016037_0613_1709 EC00123 EC00223 EC36724 EK014449 EK139351 EK154957 EK168864 EK179150 EK208844 EN01560 ESG018c.E21.1_B09 IP12560 IP12760 IP13652 IP15579 IP17758 RP003002302 RP003078587 RP003104041
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036762 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39988
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140760 NM_001275071 RefSeq (Proteins) • NP_649017 NP_001262000 DDBJ / EMBL / GenBank • AAF49294 AAL13969 AGB94693 AI260896 AQ073127 AQ073840 AW944033 AY058740 Entrez Gene - A searchable database of RefSeq genes. • 39988 UniProtKB/TrEMBL • Q9VVL7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain (IPR001327) Pyridine nucleotide-disulphide oxidoreductase, dimerisation (IPR004099) Dihydrolipoamide dehydrogenase (IPR006258) Pyridine nucleotide-disulphide oxidoreductase, class I, active site (IPR012999) FAD-dependent pyridine nucleotide-disulphide oxidoreductase (IPR013027) Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain (IPR023753) FAD/NAD-linked reductase, dimerisation (IPR016156) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME07430 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP04889
Linkouts
	BioGRID - A database of protein and genetic interactions • 65273 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036762 DroID - A comprehensive database of gene and protein interactions. • FBgn0036762 DRSC - Results from RNAi screens. • FBgn0036762 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036762 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7430-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036762 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39988 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39988 modMine - Data generated by the modENCODE project. • FBgn0036762
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG7430 (Beller et al., 2006, Beller et al., 2006, Metta et al., 2006, Stuart et al., 2007, Arancio et al., 2010, Dorus et al., 2006, Zhou et al., 2008, O'Keefe et al., 2011, Lebo et al., 2009, Andersen and Tapon, 2008, Keleman et al., 2009.8.5, Chen et al., 2008, Wasbrough et al., 2010, Cammarato et al., 2011) E3 (Chen et al., 2008)
Name Synonym	Pyruvate dehydrogenase E3 subunit (Chen et al., 2008) α-ketoglutarate dehydrogenase E3 subunit (Chen et al., 2008)
Secondary FlyBase IDs
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...