FB2025_01 , released February 20, 2025
Gene: Dmel\CG7402
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General Information
Symbol
Dmel\CG7402
Species
D. melanogaster
Name
Annotation Symbol
CG7402
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036768
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
75A8-75A8
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17887705..17891404
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (1 term)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables sulfuric ester hydrolase activity
inferred from electronic annotation with InterPro:IPR047115
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P15848
(Gene Ontology Curators, 2002-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
UNCLASSIFIED SULFURIC ESTER HYDROLASES -
This group comprises sulfuric ester hydrolases that do not classify under other groups in FlyBase.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG7402 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VVM4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG7402-RA
FBtr0075143
NM_140766
1894
579
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CG7402-PA
FBpp0074909
65.1
579
6.17
Q9VVM4
NP_649023
AAF49287
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG7402 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.51

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG7402 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG7402
Transgenic constructs containing regulatory region of CG7402
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (17)
Hsap\ARSB
11 of 14
Yes
Yes
1  
Hsap\ARSI
10 of 14
No
No
Hsap\ARSJ
10 of 14
No
Yes
Hsap\ARSA
3 of 14
No
Yes
3  
Hsap\ARSD
3 of 14
No
Yes
Hsap\ARSF
3 of 14
No
Yes
Hsap\ARSG
3 of 14
No
Yes
Hsap\ARSH
3 of 14
No
Yes
Hsap\ARSK
3 of 14
No
Yes
Hsap\ARSL
3 of 14
No
No
Hsap\GALNS
3 of 14
No
Yes
Hsap\GNS
3 of 14
No
No
Hsap\STS
3 of 14
No
Yes
Hsap\SULF1
3 of 14
No
No
Hsap\SULF2
3 of 14
No
No
1  
Hsap\IDS
2 of 14
No
No
1  
Hsap\SGSH
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (13)
Rnor\Arsb
11 of 14
Yes
Yes
Rnor\Arsi
10 of 14
No
No
Rnor\Arsa
3 of 14
No
Yes
Rnor\Arse
3 of 14
No
No
Rnor\Arsk
3 of 14
No
Yes
Rnor\Galns
3 of 14
No
Yes
Rnor\Gns
3 of 14
No
No
Rnor\Sulf1
3 of 14
No
No
Rnor\Sulf2
3 of 14
No
No
Rnor\Arsg
2 of 14
No
Yes
Rnor\Sts
2 of 14
No
Yes
Rnor\Arsj
1 of 14
No
Yes
Rnor\Ids
1 of 14
No
No
Mus musculus (laboratory mouse) (13)
Mmus\Arsb
11 of 14
Yes
Yes
Mmus\Arsi
10 of 14
No
No
Mmus\Arsj
9 of 14
No
Yes
Mmus\Arsa
3 of 14
No
Yes
Mmus\Arsg
3 of 14
No
Yes
Mmus\Arsk
3 of 14
No
Yes
Mmus\Galns
3 of 14
No
Yes
Mmus\Gns
3 of 14
No
No
Mmus\Sulf1
3 of 14
No
No
Mmus\Sulf2
3 of 14
No
No
Mmus\Ids
2 of 14
No
No
Mmus\Sgsh
2 of 14
No
No
Mmus\Sts
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (25)
Xtro\arsi
7 of 13
Yes
No
Xtro\arsj
7 of 13
Yes
Yes
Xtro\pdcd4
5 of 13
No
No
Xtro\arsb
2 of 13
No
Yes
Xtro\foxe3
2 of 13
No
No
Xtro\arsa.1
1 of 13
No
Yes
Xtro\arsa.2
1 of 13
No
No
Xtro\arsg
1 of 13
No
Yes
Xtro\arsh
1 of 13
No
Yes
Xtro\arsk
1 of 13
No
Yes
Xtro\birc7
1 of 13
No
No
Xtro\c4orf47
1 of 13
No
No
Xtro\cd53
1 of 13
No
No
Xtro\clrn2
1 of 13
No
No
Xtro\colec10
1 of 13
No
No
Xtro\exosc7
1 of 13
No
No
Xtro\foxj1.2
1 of 13
No
Yes
Xtro\galns
1 of 13
No
Yes
Xtro\kif11
1 of 13
No
No
Xtro\reep4
1 of 13
No
No
Xtro\smad6
1 of 13
No
No
Xtro\stard4
1 of 13
No
Yes
Xtro\sulf1
1 of 13
No
No
Xtro\sulf2
1 of 13
No
No
Xtro\tlcd3a
1 of 13
No
No
Danio rerio (Zebrafish) (18)
Drer\arsb
10 of 14
Yes
Yes
Drer\arsia
10 of 14
Yes
No
Drer\arsj
10 of 14
Yes
Yes
Drer\si:dkey-174i8.1
10 of 14
Yes
Yes
Drer\arsib
9 of 14
No
No
Drer\arsa
3 of 14
No
Yes
Drer\arsk
3 of 14
No
Yes
Drer\galns
3 of 14
No
Yes
Drer\gnsa
3 of 14
No
No
Drer\sulf1
3 of 14
No
No
Drer\sulf2a
3 of 14
No
No
Drer\sulf2b
3 of 14
No
No
Drer\arsg
2 of 14
No
Yes
Drer\gnsb
2 of 14
No
No
Drer\ids
2 of 14
No
No
Drer\sgsh
2 of 14
No
No
Drer\sts
2 of 14
No
Yes
Drer\arsh
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\sul-3
10 of 14
Yes
Yes
Cele\sul-2
3 of 14
No
Yes
Cele\sul-1
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP011347
10 of 12
Yes
Yes
Agam\AgaP_AGAP011348
10 of 12
Yes
Yes
Agam\AgaP_AGAP012047
6 of 12
No
No
Agam\AgaP_AGAP003374
2 of 12
No
No
Agam\AgaP_AGAP004205
2 of 12
No
No
Agam\AgaP_AGAP004721
2 of 12
No
No
Agam\AgaP_AGAP005778
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBPB10D8.02c
9 of 12
Yes
Yes
Escherichia coli (enterobacterium) (3)
Ecol\ydeN
6 of 11
Yes
Yes
Ecol\aslA
3 of 11
No
No
Ecol\yidJ
2 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CG7402. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
CG7408
11 of 13
CG32191
11 of 13
CG8646
10 of 13
Gns
3 of 13
Ids
3 of 13
Sgsh
3 of 13
Sulf1
3 of 13
CG30059
2 of 13
CG32187
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 4 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARSB; arylsulfatase B
    11 of 14
    611542
     
    ARSI; arylsulfatase family member I
    10 of 14
    610009
        ARSJ; arylsulfatase family member J
        10 of 14
        610010
            ARSA; arylsulfatase A
            3 of 14
            607574
             
            ARSD; arylsulfatase D
            3 of 14
            300002
                ARSF; arylsulfatase F
                3 of 14
                300003
                    ARSG; arylsulfatase G
                    3 of 14
                    610008
                      ARSH; arylsulfatase family member H
                      3 of 14
                      300586
                          ARSK; arylsulfatase family member K
                          3 of 14
                          610011
                            ARSL; arylsulfatase L
                            3 of 14
                            300180
                            GALNS; galactosamine (N-acetyl)-6-sulfatase
                            3 of 14
                            612222
                            GNS; glucosamine (N-acetyl)-6-sulfatase
                            3 of 14
                            607664
                            STS; steroid sulfatase
                            3 of 14
                            300747
                            SULF1; sulfatase 1
                            3 of 14
                            610012
                                SULF2; sulfatase 2
                                3 of 14
                                610013
                                     
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Other Interaction Browsers
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Other Interaction Browsers
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    External Data
                                    Linkouts
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3L
                                    Recombination map
                                    3-45
                                    Cytogenetic map
                                    75A8-75A8
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    75A8-75A8
                                    Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Determined by segmental aneuploidy (aberrations not specified).
                                    (MacIntyre, 1974)
                                    74A-79D
                                    (MacIntyre, 1974)
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-45

                                    (FlyBase, 2016)

                                    3-41.2

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (5)
                                    Genomic Clones (16)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (30)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                        Other clones
                                        RNAi and Array Information
                                        Linkouts
                                        DRSC - Results frm RNAi screens
                                        Antibody Information
                                        Laboratory Generated Antibodies
                                         
                                        Commercially Available Antibodies
                                         
                                        Cell Line Information
                                        Publicly Available Cell Lines
                                         
                                          Other Stable Cell Lines
                                           
                                            Other Comments

                                            Two independently regulated aryl sulfatase activities are shown to be present in Drosophila and are referred to as Type I and Type II. The peak of enzyme activity coincides with the time of hatching from embryo to larva.

                                            (Pelliccia et al., 1987)
                                            Relationship to Other Genes
                                            Source for database merge of
                                            Additional comments

                                            The non-sequence localized gene 'Ars/Arylsulfatase' (FBgn0000122) was characterized as encoding an arylsulfatase in FBrf0045645 and mapped to 74A-79D in FBrf0063659. There are three candidate genes in that region that have been annotated with a relevant GO term ('sulfuric ester hydrolase activity') and have the InterPro signature 'Arylsulfatase B": CG7402, CG7408, CG32191. Therefore, the 'Ars' gene record has been obsoleted and the associated information and papers transferred to the three candidate genes.

                                            (FlyBase, 1996-)
                                            Nomenclature History
                                            Source for database identify of
                                            Nomenclature comments
                                            Etymology
                                            Synonyms and Secondary IDs (5)
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            Study result (0)
                                            Result
                                            Result Type
                                            Title
                                            External Crossreferences and Linkouts ( 30 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                            Other crossreferences
                                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            MARRVEL_MODEL - MARRVEL (model organism gene)
                                            Linkouts
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                            References (34)