FB2020_01, released Feb 12, 2020

Gene: Dmel\AstC-R1

Open Close
General Information
Symbol
Dmel\AstC-R1
Species
D. melanogaster
Name
Allatostatin C receptor 1
Annotation Symbol
CG7285
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036790
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Allatostatin C receptor 1 (AstC-R1) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

star1, Drostar1

Key Links
Genomic Location
Cytogenetic map
75D2-75D2
Sequence location
3L:18,560,258..18,576,326 [+]
Recombination map

3-45

RefSeq locus
NT_037436 REGION:18560258..18576326
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
allatostatin receptor activity
Predictions / Assertions
G protein-coupled receptor activity; neuropeptide receptor activity; peptide binding; somatostatin receptor activity
Summaries
Gene Group (FlyBase)
CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -
The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\AstC-R1 or the JBrowse view of Dmel\AstC-R1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AstC-R1-RA
FBtr0089578
NM_140783
2912
483
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
AstC-R1-PA
FBpp0088997
54.2
483
9.16
NP_649040
AAF49259
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AstC-R1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (10 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
allatostatin receptor activity
inferred from direct assay
(Johnson et al., 2003, Kreienkamp et al., 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
G protein-coupled receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001200938
(assigned by GO_Central )
(Gaudet et al., 2011)
neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
peptide binding
inferred from biological aspect of ancestor with PANTHER:PTN001200938
(assigned by GO_Central )
(Gaudet et al., 2011)
somatostatin receptor activity
inferred from electronic annotation with InterPro:IPR000586
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
neuropeptide signaling pathway
inferred from direct assay
(Johnson et al., 2003, Kreienkamp et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
G protein-coupled receptor signaling pathway
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
integral component of membrane
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
integral component of plasma membrane
inferred by curator from GO:0008261
(Johnson et al., 2003, Kreienkamp et al., 2002)
inferred from biological aspect of ancestor with PANTHER:PTN001200938
(assigned by GO_Central )
(Gaudet et al., 2011)
neuron projection
inferred from biological aspect of ancestor with PANTHER:PTN001200938
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval central nervous system | restricted
(Kreienkamp et al., 2002)
adult stage
lamina & glial cell
(Kreienkamp et al., 2002)
lamina monopolar neuron
(Kreienkamp et al., 2002)
adult pars intercerebralis | restricted
(Kreienkamp et al., 2002)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\AstC-R1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AstC-R1
Transgenic constructs containing regulatory region of AstC-R1
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SSTR2
9 of 15
Yes
Yes
Hsap\SSTR1
7 of 15
No
No
Hsap\SSTR3
7 of 15
No
No
Hsap\SSTR4
7 of 15
No
No
Hsap\SSTR5
7 of 15
No
No
Hsap\MCHR1
3 of 15
No
No
Hsap\NPBWR1
3 of 15
No
Yes
Hsap\OPRD1
3 of 15
No
No
Hsap\OPRM1
3 of 15
No
No
 
Hsap\MCHR2
2 of 15
No
No
Hsap\NPBWR2
2 of 15
No
No
Hsap\OPRK1
2 of 15
No
No
Hsap\OPRL1
2 of 15
No
No
Hsap\CYSLTR1
1 of 15
No
Yes
Hsap\F2RL1
1 of 15
No
Yes
Hsap\F2RL2
1 of 15
No
Yes
Hsap\GPR1
1 of 15
No
No
Hsap\GPR4
1 of 15
No
Yes
Hsap\GPR17
1 of 15
No
Yes
Hsap\GPR34
1 of 15
No
Yes
Hsap\GPR82
1 of 15
No
Yes
Hsap\GPR87
1 of 15
No
Yes
Hsap\GPR149
1 of 15
No
Yes
Hsap\GPR171
1 of 15
No
Yes
Hsap\GPR183
1 of 15
No
Yes
Hsap\HCAR3
1 of 15
No
Yes
Hsap\OXGR1
1 of 15
No
Yes
Hsap\P2RY1
1 of 15
No
Yes
Hsap\P2RY2
1 of 15
No
Yes
Hsap\P2RY4
1 of 15
No
Yes
Hsap\P2RY12
1 of 15
No
Yes
Hsap\P2RY14
1 of 15
No
Yes
Hsap\PTGDR2
1 of 15
No
No
Hsap\SUCNR1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Sstr2
9 of 15
Yes
Yes
Mmus\Sstr1
7 of 15
No
No
Mmus\Sstr4
7 of 15
No
No
Mmus\Sstr5
7 of 15
No
No
Mmus\Sstr3
6 of 15
No
No
Mmus\Oprd1
4 of 15
No
Yes
Mmus\Mchr1
3 of 15
No
No
Mmus\Oprm1
3 of 15
No
Yes
Mmus\Npbwr1
2 of 15
No
No
Mmus\Oprk1
2 of 15
No
No
Mmus\Oprl1
2 of 15
No
No
Mmus\Cysltr1
1 of 15
No
Yes
Mmus\Cysltr2
1 of 15
No
Yes
Mmus\F2rl1
1 of 15
No
Yes
Mmus\F2rl2
1 of 15
No
Yes
Mmus\Gpr1
1 of 15
No
No
Mmus\Gpr4
1 of 15
No
Yes
Mmus\Gpr17
1 of 15
No
Yes
Mmus\Gpr31b
1 of 15
No
Yes
Mmus\Gpr34
1 of 15
No
Yes
Mmus\Gpr82
1 of 15
No
Yes
Mmus\Gpr87
1 of 15
No
Yes
Mmus\Gpr149
1 of 15
No
Yes
Mmus\Gpr171
1 of 15
No
Yes
Mmus\Hcar2
1 of 15
No
Yes
Mmus\Oxgr1
1 of 15
No
Yes
Mmus\P2ry1
1 of 15
No
Yes
Mmus\P2ry2
1 of 15
No
Yes
Mmus\P2ry4
1 of 15
No
Yes
Mmus\P2ry10b
1 of 15
No
Yes
Mmus\P2ry10
1 of 15
No
Yes
Mmus\P2ry13
1 of 15
No
Yes
Mmus\P2ry14
1 of 15
No
Yes
Mmus\Ptgdr2
1 of 15
No
No
Rattus norvegicus (Norway rat) (33)
Rnor\Sstr2
8 of 13
Yes
Yes
Rnor\Sstr1
6 of 13
No
No
Rnor\Sstr3
6 of 13
No
No
Rnor\Sstr4
6 of 13
No
No
Rnor\Sstr5
6 of 13
No
No
Rnor\Mchr1
3 of 13
No
No
Rnor\Oprd1
3 of 13
No
No
Rnor\Oprm1
3 of 13
No
No
Rnor\Npbwr1
2 of 13
No
No
Rnor\Oprk1
2 of 13
No
No
Rnor\Oprl1
2 of 13
No
No
Rnor\Cysltr1
1 of 13
No
Yes
Rnor\Cysltr2
1 of 13
No
Yes
Rnor\F2rl2
1 of 13
No
Yes
Rnor\Gpr1
1 of 13
No
No
Rnor\Gpr4
1 of 13
No
Yes
Rnor\Gpr17
1 of 13
No
Yes
Rnor\Gpr31
1 of 13
No
Yes
Rnor\Gpr34
1 of 13
No
Yes
Rnor\Gpr82
1 of 13
No
Yes
Rnor\Gpr87
1 of 13
No
Yes
Rnor\Gpr149
1 of 13
No
Yes
Rnor\Gpr171
1 of 13
No
Yes
Rnor\Gpr183
1 of 13
No
Yes
Rnor\Niacr1
1 of 13
No
Yes
Rnor\Oxgr1
1 of 13
No
Yes
Rnor\P2ry1
1 of 13
No
Yes
Rnor\P2ry2
1 of 13
No
Yes
Rnor\P2ry4
1 of 13
No
Yes
Rnor\P2ry13
1 of 13
No
Yes
Rnor\P2ry14
1 of 13
No
Yes
Rnor\Ptgdr2
1 of 13
No
No
Rnor\RGD1560455
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (22)
Xtro\sstr2
7 of 12
Yes
Yes
Xtro\sstr3
3 of 12
No
Yes
Xtro\sstr5
3 of 12
No
Yes
Xtro\mchr1.1
2 of 12
No
Yes
Xtro\oprm1
2 of 12
No
Yes
Xtro\ackr4
1 of 12
No
Yes
Xtro\cxcr6
1 of 12
No
Yes
Xtro\cysltr1
1 of 12
No
Yes
Xtro\f2rl2
1 of 12
No
Yes
Xtro\f2rl3
1 of 12
No
Yes
Xtro\gpr174
1 of 12
No
Yes
Xtro\LOC100487226
1 of 12
No
No
Xtro\LOC101730640
1 of 12
No
Yes
Xtro\npbwr1
1 of 12
No
Yes
Xtro\oprd1
1 of 12
No
Yes
Xtro\oprk1
1 of 12
No
Yes
Xtro\p2ry1
1 of 12
No
Yes
Xtro\p2ry2
1 of 12
No
Yes
Xtro\p2ry4
1 of 12
No
Yes
Xtro\p2ry10
1 of 12
No
Yes
Xtro\sstr1
1 of 12
No
Yes
Xtro\sstr4
1 of 12
No
No
Danio rerio (Zebrafish) (54)
Drer\sstr2a
9 of 15
Yes
Yes
Drer\sstr1b
8 of 15
No
No
Drer\sstr2b
8 of 15
No
No
Drer\sstr1a
7 of 15
No
No
Drer\sstr3
7 of 15
No
Yes
Drer\sstr5
4 of 15
No
Yes
Drer\LOC100333697
3 of 15
No
Yes
Drer\mchr1b
3 of 15
No
No
Drer\oprd1a
3 of 15
No
Yes
Drer\oprd1b
3 of 15
No
No
Drer\oprk1
3 of 15
No
No
Drer\oprm1
3 of 15
No
No
Drer\si:zfos-169g10.2
3 of 15
No
No
Drer\LOC556532
2 of 15
No
Yes
Drer\LOC558520
2 of 15
No
No
Drer\LOC571123
2 of 15
No
No
Drer\LOC100535160
2 of 15
No
Yes
Drer\mchr1a
2 of 15
No
No
Drer\oprl1
2 of 15
No
No
Drer\si:dkey-165n16.5
2 of 15
No
Yes
Drer\bdkrb1
1 of 15
No
Yes
Drer\cxcr3.2
1 of 15
No
Yes
Drer\cysltr1
1 of 15
No
Yes
Drer\cysltr2a
1 of 15
No
Yes
Drer\f2r
1 of 15
No
Yes
Drer\f2rl1.1
1 of 15
No
Yes
Drer\f2rl1.2
1 of 15
No
Yes
Drer\gpr1
1 of 15
No
No
Drer\gpr4
1 of 15
No
Yes
Drer\gpr17
1 of 15
No
Yes
Drer\gpr20
1 of 15
No
Yes
Drer\gpr34a
1 of 15
No
Yes
Drer\gpr34b
1 of 15
No
Yes
Drer\gpr174
1 of 15
No
Yes
Drer\gpr183a
1 of 15
No
Yes
Drer\gpr183b
1 of 15
No
Yes
Drer\hcar1-1
1 of 15
No
Yes
Drer\hcar1-2
1 of 15
No
Yes
Drer\LOC556532
1 of 15
No
Yes
Drer\LOC564730
1 of 15
No
Yes
Drer\LOC100005512
1 of 15
No
No
Drer\LOC100334739
1 of 15
No
Yes
Drer\lpar5a
1 of 15
No
Yes
Drer\oxgr1a.2
1 of 15
No
Yes
Drer\p2ry1
1 of 15
No
Yes
Drer\p2ry2.1
1 of 15
No
Yes
Drer\p2ry2.2
1 of 15
No
Yes
Drer\p2ry4
1 of 15
No
Yes
Drer\si:ch211-184m13.4
1 of 15
No
Yes
Drer\si:dkey-42l23.2
1 of 15
No
No
Drer\si:dkey-96n2.3
1 of 15
No
Yes
Drer\si:dkey-216e24.9
1 of 15
No
Yes
Drer\taar10
1 of 15
No
Yes
Drer\zgc:194202
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\npr-24
10 of 15
Yes
Yes
Cele\npr-16
3 of 15
No
No
Cele\npr-20
2 of 15
No
No
Cele\F36D4.4
1 of 15
No
Yes
Cele\npr-3
1 of 15
No
Yes
Cele\npr-17
1 of 15
No
No
Cele\npr-18
1 of 15
No
No
Cele\npr-21
1 of 15
No
No
Cele\npr-26
1 of 15
No
Yes
Cele\npr-28
1 of 15
No
Yes
Cele\npr-30
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908PY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\AstC-R1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011268
Drosophila simulans
Dsim\GD14751
Drosophila sechellia
Dsec\GM14973
Drosophila erecta
Dere\GG13659
Drosophila yakuba
Dyak\GE19956
Drosophila ananassae
Dana\GF23626
Drosophila pseudoobscura pseudoobscura
Dpse\GA23907
Drosophila persimilis
Dper\GL22877
Drosophila persimilis
Dper\GL15778
Drosophila willistoni
Dwil\GK11187
Drosophila virilis
Dvir\GJ13930
Drosophila mojavensis
Dmoj\GI13590
Drosophila grimshawi
Dgri\GH14454
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915079S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025001
Musca domestica
House fly
Mdoa\17025000
Glossina morsitans
Tsetse fly
Gmor\GMOY012068
Glossina morsitans
Tsetse fly
Gmor\GMOY002651
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05703
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05701
Mayetiola destructor
Hessian fly
Mdes\Mdes005835
Mayetiola destructor
Hessian fly
Mdes\Mdes010813
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRSMS
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRALS3
Anopheles darlingi
American malaria mosquito
Adar\ADAC002193
Anopheles darlingi
American malaria mosquito
Adar\ADAC001322
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011191
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010469
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W048G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BNGR-A1
Danaus plexippus
Monarch butterfly
Dple\DPOGS213889-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010877
Apis florea
Little honeybee
Aflo\2261015956
Apis mellifera
Western honey bee
Amel\LOC412883
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11219
Bombus terrestris
Buff-tailed bumblebee
Bter\15215389
Linepithema humile
Argentine ant
Lhum\LH24824
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00231e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012608
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04364
Tribolium castaneum
Red flour beetle
Tcas\TC012842
Pediculus humanus
Human body louse
Phum\PHUM101310
Rhodnius prolixus
Kissing bug
Rpro\RPRC013486
Cimex lectularius
Bed bug
Clec\CLEC004005
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002528
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17322
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X044W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW007666
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59525.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74632.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g16794
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_12571
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_12576
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0D8Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gpr54_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_026973gn
Ciona intestinalis
Vase tunicate
Cint\LOC100181055
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000406
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019761
Ciona intestinalis
Vase tunicate
Cint\LOC101242898
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
AstC-R2
6 of 10
AstA-R1
1 of 10
Rh7
1 of 10
TrissinR
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SSTR2; somatostatin receptor 2
    9 of 15
    182452
        SSTR1; somatostatin receptor 1
        7 of 15
        182451
            SSTR3; somatostatin receptor 3
            7 of 15
            182453
                SSTR4; somatostatin receptor 4
                7 of 15
                182454
                    SSTR5; somatostatin receptor 5
                    7 of 15
                    182455
                        MCHR1; melanin concentrating hormone receptor 1
                        3 of 15
                        601751
                            NPBWR1; neuropeptides B and W receptor 1
                            3 of 15
                            600730
                                OPRD1; opioid receptor delta 1
                                3 of 15
                                165195
                                    OPRM1; opioid receptor mu 1
                                    3 of 15
                                    600018
                                         
                                        Functional Complementation Data
                                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                        Interactions
                                        Summary of Physical Interactions
                                        esyN Network Diagram
                                        Interactions Browser
                                        Summary of Genetic Interactions
                                        esyN Network Diagram
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        Starting gene(s)
                                        Interaction type
                                        Interacting gene(s)
                                        Reference
                                        External Data
                                        Linkouts
                                        BioGRID - A database of protein and genetic interactions.
                                        DroID - A comprehensive database of gene and protein interactions.
                                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        Pathways
                                        Signaling Pathways (FlyBase)
                                        Metabolic Pathways
                                        External Data
                                        Linkouts
                                        Genomic Location and Detailed Mapping Data
                                        Chromosome (arm)
                                        3L
                                        Recombination map

                                        3-45

                                        Cytogenetic map
                                        75D2-75D2
                                        Sequence location
                                        3L:18,560,258..18,576,326 [+]
                                        FlyBase Computed Cytological Location
                                        Cytogenetic map
                                        Evidence for location
                                        75D2-75D2
                                        Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
                                        Experimentally Determined Cytological Location
                                        Cytogenetic map
                                        Notes
                                        References
                                        75D1-75D1
                                        (Larusson, 2001.1.9)
                                        Experimentally Determined Recombination Data
                                        Location

                                        3-45

                                        (FlyBase, 2016)

                                        3-41.8

                                        (Comeron et al., 2012)
                                        Left of (cM)
                                        Right of (cM)
                                        Notes
                                        Stocks and Reagents
                                        Stocks (11)
                                        Genomic Clones (29)
                                        cDNA Clones (2)
                                         

                                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                        cDNA clones, fully sequences
                                        BDGP DGC clones
                                          Other clones
                                            Drosophila Genomics Resource Center cDNA clones

                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                            cDNA Clones, End Sequenced (ESTs)
                                            BDGP DGC clones
                                              Other clones
                                                RNAi and Array Information
                                                Linkouts
                                                DRSC - Results frm RNAi screens
                                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                Antibody Information
                                                Laboratory Generated Antibodies
                                                 
                                                Commercially Available Antibodies
                                                 
                                                Other Information
                                                Relationship to Other Genes
                                                Source for database identify of

                                                Source for identity of: Drostar1 CG7285

                                                (FlyBase, 1996-)

                                                Source for identity of: AstC-R1 star1

                                                (FlyBase, 2009-)
                                                Source for database merge of

                                                Source for merge of: star1 anon-WO0131005.19 anon-WO0170980.79 anon-WO0170980.80

                                                (FlyBase, 1996-)
                                                Additional comments

                                                Symbol changed from 'star1' to 'AstC-R1' to provide consistent format across all Allatostatin Receptor-encoding genes, and to match the nomenclature of the respective ligands. (Also see FBrf0211443.)

                                                (FlyBase, 2009-)

                                                Source for identity of Drostar1 CG7285 was sequence comparison ( date:021108 ).

                                                (FlyBase, 1996-)

                                                Source for merge of star1 anon-WO0131005.19 anon-WO0170980.79 anon-WO0170980.80 was sequence comparison ( date:051113 ).

                                                (FlyBase, 1996-)
                                                Other Comments
                                                Origin and Etymology
                                                Discoverer
                                                Etymology
                                                Identification
                                                External Crossreferences and Linkouts ( 34 )
                                                Sequence Crossreferences
                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                Other crossreferences
                                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                Flygut - An atlas of the Drosophila adult midgut
                                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                InterPro - A database of protein families, domains and functional sites
                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                modMine - A data warehouse for the modENCODE project
                                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                Linkouts
                                                BioGRID - A database of protein and genetic interactions.
                                                DroID - A comprehensive database of gene and protein interactions.
                                                DRSC - Results frm RNAi screens
                                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                FlyMine - An integrated database for Drosophila genomics
                                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                Synonyms and Secondary IDs (14)
                                                Datasets (0)
                                                Study focus (0)
                                                Experimental Role
                                                Project
                                                Project Type
                                                Title
                                                References (63)