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Gene Dmel\HipHop

General Information
Symbol	Dmel\HipHop	Species	D. melanogaster
Name	HP1-HOAP-interacting protein	Annotation symbol	CG6874
Feature type	protein_coding_gene	FlyBase ID	FBgn0036815
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	l(3)neo26
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75E1-75E1	Sequence location	3L:18,814,271..18,815,453 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene HP1-HOAP-interacting protein is referred to in FlyBase by the symbol Dmel\HipHop (CG6874, FBgn0036815). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neurogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1625792_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of HipHop. Gene sequence location is 3L:18814271..18815453.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75E1-75E1   Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 75C1-75C7   (determined by in situ hybridisation)   (Spradling et al., 1999) 75C1-75C7     (BDGP Project Members, 1994-1999) 75C-75C   (determined by in situ hybridisation)   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\HipHop for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) HipHop-RA FBtr0075056  NM_140804   1124   221 HipHop-RB FBtr0075057  NM_168777   1183   221
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein HipHop-PA   FBpp0074823   24.4   221   9.27     NP_649061   AAN11669 HipHop-PB   FBpp0074824   24.4   221   9.27     NP_730362   AAF49229
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA802617   AE014296 AAF49229   AE014296 AAN11669   AQ026340   AW941953   AY060915 AAL28463   AY113402 AAM29407   BI169297   BI169397   BI213209   BI235101   BI353458   BI362244   BI638574   BP547014   CL526161   CO188944   CO264394   CO264743   CO273821   CO298291   EC072459   EC083824   EC208521   EC216057   EC220885   EC227835   EC252456   EV583249   GH748064   GH748366   GH749904   GH750764   GH751041   GH756480   GH757343   GH759260   GH761022   GH761211   GH771476   GH774631   GH775052   GH775274   GH775511   GH775666   GH775850   GH776052   GH778441   GH782093   GH783100   GH783333   GH785484   GH787324   GH788900   GH792547   GH797268   GH797495   GH798452   GH801086   GH805045   GH805585   GH806645   GH808080   GH808983   GH809849   GH810426   GH813775   GH815751   GH818739   GH820056   GH820977   GH821641   GH824611   GH826758   GH827493   GH829974   GH834033   GH836337   GH837129   GH837877   GH838733   GH840761   GH840935   GH843761   GH844862   GH844981   GH846608   GH851260   GH852438   GH853425   GH857811   GH858871   GH859063   GH860545   GH862934   GH863360   GH864181   GH865917   GH868178   GH869741   GH870565   GH871727   GH873318   GH881122   GH886320   GH886422   GH888466   GH888762   GH890915   GH892796   GH893236   GH894483   GH894498   GH895080   GH897965   GH899699   GH901922   GH903286   GH903721   GH903906   GH904387   GH906055   GH906794   GH911520   GH911587   GH916441   GH916683   GH917000   GH918546   GH919268   GH920098   GH920829   GH920966   GH922526   GH923349   GH923611   GH924685   GH925830   GH926196   GH926359   GH926530   GH927440   GH928396   GH935618   GH935729   GH937483   GH940134
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7JWP6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
chromosome, telomeric region inferred from direct assay (Gao et al., 2010, Dubruille et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary  (602.3) Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary  602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    295.325 Larval Midgut    9.7 Larval Hindgut    18.9 Larval Malpighian Tubules    14.3 Larval Fat Body    24.3 Larval Salivary Gland    19.7 Larval Trachea    77.3 Larval Carcass    29.35 Adult Head    22 Adult Eye    43.75 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    30.1 Adult Crop    28.6 Adult Midgut    9.8 Adult Hindgut    16.6 Adult Malpighian Tubules    17.6 Adult Fat Body    83.2 Adult Salivary Gland    12.1 Adult Heart    94.925 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    24.7 Adult Ovary    602.3 Adult Testis    17.9 Adult Male Accessory Gland    15.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    22   NA  Eye    43.75   NA  Brain    21.9   295.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    30.1   NA  Crop    28.6   9.7  Midgut    9.8   18.9  Hindgut    no informative data   14.3  Malpighian Tubules    no informative data   24.3  Fat Body    83.2   19.7  Salivary Gland    no informative data   NA  Heart    94.925   77.3  Trachea    NA   NA  VirginFemale Spermatheca    33.9   NA  InseminatedFemale Spermatheca    24.7   NA  Ovary    602.3   NA  Testis    17.9   NA  Male Accessory Gland    no informative data   29.35  Carcass    42.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    173 ovary, mated 4-day female    124 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  (27) central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (173) ovary, mated 4-day female  (124) testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (173) ovary, mated 4-day female  (124) testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    173 ovary, mated 4-day female    124 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    173 ovary, mated 4-day female    124 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3  27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (173) ovary, mated 4-day female  (124) testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female  (173) ovary, mated 4-day female  124 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    27 central nervous system, pupae P8    3 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    4 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    2 head, mated 20-day male    5 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    2 digestive system, 4-day adult    6 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    1 carcass, larvae L3 wandering    15 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    9 ovary, virgin 4-day female    173 ovary, mated 4-day female    124 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    128 embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (128) embryo 02-04hr  (34) embryo 04-06hr  (71) embryo 06-08hr  (60) embryo 08-10hr  (40) embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day  (29) adult female 05day  (60) adult female 30day  (63) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (128) embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    128 embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    128 embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (128) embryo 02-04hr  (34) embryo 04-06hr  (71) embryo 06-08hr  (60) embryo 08-10hr  (40) embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day  29 adult female 05day  (60) adult female 30day  (63) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  128 embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    128 embryo 02-04hr    34 embryo 04-06hr    71 embryo 06-08hr    60 embryo 08-10hr    40 embryo 10-12hr    21 embryo 12-14hr    9 embryo 14-16hr    6 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    5 larva L2    4 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    14 white prepupae 24hr    11 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    4 adult male 01day    3 adult male 05day    5 adult male 30day    5 adult female 01day    29 adult female 05day    60 adult female 30day    63 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (79) embryonic 1182-4H  (47) embryonic GM2  (57) embryonic Kc167  (55) embryonic S1  (43) embryonic S3  (54) leg disc CME L1  (70) wing disc CME-W2  (32) wing disc ML-DmD8  (43) wing disc ML-DmD9  (48) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (94) wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  (32) tumorous blood cells mbn2  (34) ovary fGS/OSS  (81) ovary OSC  26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (79) embryonic 1182-4H  (47) embryonic GM2  (57) embryonic Kc167  (55) embryonic S1  (43) embryonic S3  (54) leg disc CME L1  (70) wing disc CME-W2  32 wing disc ML-DmD8  (43) wing disc ML-DmD9  (48) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21  (94) wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (65) eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  32 tumorous blood cells mbn2  (34) ovary fGS/OSS  (81) ovary OSC  26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    79 embryonic 1182-4H    47 embryonic GM2    57 embryonic Kc167    55 embryonic S1    43 embryonic S3    54 leg disc CME L1    70 wing disc CME-W2    32 wing disc ML-DmD8    43 wing disc ML-DmD9    48 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    94 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    65 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    34 ovary fGS/OSS    81 ovary OSC    26 ovary OSS    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (98) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult  (28) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (107) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (97) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (98) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult  28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (107) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (97) Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult  (76) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    13 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    98 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    107 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    97 Caffeine 25 mg/ml 48 hrs, 4-day adult    23 Paraquat 5 mM 48 hrs, 4-day adult    76 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036815 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6874-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal HipHopGD10755 lethal | first instar larval stage (with HipHop1) HipHopEY07584 lethal | first instar larval stage (with HipHopEY07584) HipHop1 lethal | first instar larval stage | recessive HipHopunspecified lethal | recessive HipHop1 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 HipHopGD10755 Other Phenotypes Allele neuroanatomy defective | larval stage HipHopGD10755 visible, with Scer\GAL4pnr-MD237 HipHopGD10755 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage HipHopGD10755 ganglion mother cell | larval stage HipHopGD10755 mesothoracic tergum, with Scer\GAL4pnr-MD237 HipHopGD10755 trichogen cell, with Scer\GAL4pnr-MD237 HipHopGD10755
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of HipHop Class Mutagen Stocks Known lesion HipHop1 P-element activity 1 -- HipHop5-HA-5083 1 -- HipHopB408 1 -- HipHopEY09894 P-element activity 1 -- HipHopEY07584 P-element activity 0 Yes HipHopL14 P-element activity 0 Yes HipHopL32 P-element activity 0 Yes HipHopL35-2 P-element activity 0 Yes HipHopL41 P-element activity 0 Yes HipHopunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of HipHop Class Mutagen Stocks Known lesion HipHopGD10755 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HipHopKK111545 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HipHopms(3)K81.PG in vitro construct - regulatory fusion 0 Yes HipHopms(3)K81.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HipHopms(3)K81.T:Disc\RFP-mCherry in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes HipHopT:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes HipHopT:Disc\RFP-mCherry in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)W4 (BDGP Project Members, 1994-1999) Df(3L)W10 (BDGP Project Members, 1994-1999)
Disrupted in	Df(3L)BSC776 (Christensen et al., 2009.5.6)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{HipHop.mCherry} NA P{HipHop-GFP.HipHop} NA P{ms(3)K81-HipHop::ms(3)K81.GFP.aHbHcK} NA P{ms(3)K81-HipHop::ms(3)K81.GFP.aHbKcK} NA P{ms(3)K81-HipHop::ms(3)K81.GFP.aKbHcK} NA P{ms(3)K81-HipHop::ms(3)K81.GFP.aKbKcH} NA P{ms(3)K81-HipHop.G} NA P{ms(3)K81-HipHop.GFP} NA P{ms(3)K81-HipHop.mCherry} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsneo}HipHop1 NA P{RS5}HipHop5-HA-5083 NA PBac{5HPw+}HipHopB408 NA insertion of mobile activating element P{EPgy2}HipHopEY07584 NA P{EPgy2}HipHopEY09894 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
chromosome, telomeric region inferred from direct assay (Gao et al., 2010, Dubruille et al., 2010)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
HipHop - Su(var)205 anti bait coimmunoprecipitation, western blot, pull down (Gao et al., 2010) HipHop - cav pull down, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, anti bait coimmunoprecipitation (Gao et al., 2010)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions HipHop allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65328 DroID - A comprehensive database of gene and protein interactions. • FBgn0036815 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40047
Orthologs
OrthoDB Orthologs (5) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6R7VX5 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6R7VX5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\HipHop     Drosophila simulans   Dsim\GD14769 Y   Drosophila sechellia   Dsec\GM14992 Y   Drosophila erecta   Dere\GG13678 Y   Drosophila yakuba   Dyak\GE19974 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14769 Drosophila sechellia Dsec\GM14992 Drosophila erecta Dere\GG13678 Drosophila yakuba Dyak\GE19974 Drosophila pseudoobscura pseudoobscura Dpse\GA19922 Drosophila persimilis Dper\GL24882 Drosophila willistoni Dwil\hiphop
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	17618 y1 w67c23; P{EPgy2}HipHopEY09894/TM3, Sb1 Ser1 16215 y1 w1118; PBac{5HPw+}HipHopB408/TM3, Sb1 Ser1 10264 mwh1 P{hsneo}HipHop1 red1 e1/TM3, ryRK Sb1 Ser1
Kyoto	125820 w1118; P{RS5}HipHop5-HA-5083
VDRC	v107516 P{KK111545}VIE-260B v34358 w1118; P{GD10755}v34358 v34359 w1118; P{GD10755}v34359
Genomic Clones ( 1 )
	BACR48N04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 140 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM06015 RE10558
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM23711 RE10433 RE18564 RE30910 RE46756 SD20902
Other clones	11808 30045 31303 179882 191410 214441.7 CK01.119A.D2 Dmel_dig_020051_0690_0940 EK042520 EK112340 EK138943 EK140229 EK172707 FGH112E05 RP003003685 RP003013030 RP003016803 RP003017736 RP003023113 RP003029236 RP003033160 RP003043802 RP003058403 RP003071058 RP003072497 RP003075066 RP003076491 RP003076574 RP003086785 RP003093711 RP003098903 RP003101894 RP003103135 RP003104889 RP003112316 RP003117075 RP003118304 RP003121224 RP003127505 RP003137313 RP003139367 RP003141027 RP003147692 RP003158183 RP003162161 RP003166423 RP003166648 RP003169328 RP003172399 RP003181770 RP003183337 RP003185488 RP003185828 RP003200686 RP003207671 RP003224264 RP003224712 RP003231986 RP003233979 RP003234020 RP003240296 RP003246302 RP003249148 RP003250912 RP003252670 RP003257093 RP003269693 RP003272287 RP003274092 RP003279629 RP003280934 RP003290486 RP003292082 RP003304943 RP003307136 RP003311457 RP003312936 RP003313126 RP003317092 RP003318773 RP003322769 RP003326638 RP003331139 RP003338566 RP003339701 RP003345077 RP003348232 RP003350634 RP003358646 RP003380247 RP003381141 RP003381279 RP003383853 RP003385324 RP003390663 RP003396765 RP003408581 RP003420719 RP003421248 RP003427031 RP003430295 RP003457929 RP003473994 RP003484471 RP003498047 RP003509632 RP003516902 RP003517210 RP003521991 RP003533138 RP003534041 RP003537066 RP003537908 RP003543993 RP003549872 RP003575909 RP003579443 RP003583233 RP003585344 RP003592804 RP003598814 RP003599029 RP003600593 RP003611503 RP003615953 RP003616341 RP003624111 RP003626640 RP003630661 RP003635238 RP003639020 RP003641449
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036815 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40047
Antibody Information
	polyclonal (Gao et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6874 BcDNA:RE10558 (FlyBase, 1996-)
Additional comments	Source for merge of CG6874 BcDNA:RE10558 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140804 NM_168777 RefSeq (Proteins) • NP_649061 NP_730362 DDBJ / EMBL / GenBank • AA802617 AAF49229 AAL28463 AAM29407 AAN11669 AQ026340 AW941953 AY060915 AY113402 BI169397 CL526161 Entrez Gene - A searchable database of RefSeq genes. • 40047 UniProtKB/TrEMBL • Q7JWP6
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 65328 DroID - A comprehensive database of gene and protein interactions. • FBgn0036815 DRSC - Results from RNAi screens. • FBgn0036815 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036815 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6874-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036815 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40047 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40047 modMine - Data generated by the modENCODE project. • FBgn0036815
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BcDNA:RE10558   CG6874 (Khokhar et al., 2008, Loppin et al., 2005, Dimova et al., 2003, Giot et al., 2003, Proschel et al., 2006, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Gao et al., 2010) hiphop (Gao et al., 2011, Gao et al., 2010, Dubruille et al., 2010) HipHop (Raffa et al., 2011, Gao et al., 2010, Dubruille et al., 2010) l(3)neo26 (Gao et al., 2010, Khokhar et al., 2008, Christensen et al., 2009.5.6)
Name Synonym	HP1 and HOAP-interacting protein (Gao et al., 2011) HP1-HOAP-interacting protein (Gao et al., 2010) lethal (3) neo26
Secondary FlyBase IDs
	FBgn0011460 FBgn0063064
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 )
Recent research papers ( 2 )
	Gao et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(12): 4932--4937 Paternal imprint essential for the inheritance of telomere identity in Drosophila. [FBrf0213318] Raffa et al., 2011, Nucleus 2(5): 383--391 Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres. [FBrf0216520] Show all research papers ...