FB2020_06, released Dec 22, 2020

Gene: Dmel\Indy

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General Information
Symbol
Dmel\Indy
Species
D. melanogaster
Name
I'm not dead yet
Annotation Symbol
CG3979
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036816
Gene Model Status
Current
Stock Availability
31 publicly available
Gene Snapshot
I'm not dead yet (Indy) encodes a plasma membrane transporter of Krebs cycle intermediates (citrate, succinate, fumarate, alpha-ketoglutarate) of the SLC13A family that is important in organismal intermediary metabolism. Mutations in Indy create a favorable metabolic state, similar to calorie restriction, and extend life span. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
75E1-75E2
Sequence location
3L:18,828,632..18,846,267 [-]
Recombination map

3-45

RefSeq locus
NT_037436 REGION:18828632..18846267
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables citrate transmembrane transporter activity
inferred from direct assay
(Inoue et al., 2002, Knauf et al., 2002)
enables pyruvate transmembrane transporter activity
inferred from direct assay
(assigned by UniProt )
(Inoue et al., 2002)
enables succinate transmembrane transporter activity
inferred from direct assay
(Inoue et al., 2002, Knauf et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables citrate transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000031937
(assigned by GO_Central )
(Gaudet et al., 2011)
enables succinate transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000031937
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in citrate transport
inferred from direct assay
(assigned by UniProt )
(Inoue et al., 2002, Knauf et al., 2002)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Toivonen et al., 2007, Rogina et al., 2000)
inferred from direct assay
(Wang et al., 2009)
involved_in pyruvate transport
inferred from direct assay
(assigned by UniProt )
(Inoue et al., 2002)
involved_in regulation of sequestering of triglyceride
inferred from direct assay
(Wang et al., 2009)
involved_in succinate transport
inferred from direct assay
(assigned by UniProt )
(Inoue et al., 2002, Knauf et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in anion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000031793
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in citrate transport
inferred from biological aspect of ancestor with PANTHER:PTN000031937
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sodium ion transport
inferred from electronic annotation with InterPro:IPR001898
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(assigned by UniProt )
(Knauf et al., 2002)
located_in plasma membrane
inferred from direct assay
(Knauf et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000031793
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. (Q9VVT2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC13 FAMILY OF DICARBOXYLATE/CITRATE TRANSPORTERS -
Solute carrier family 13 (SLC13) transmembrane transporters mediate the flux of dicarboxylate and citrate across the plasma membrane. These proteins are responsible for the transport of di- and tricarboxylic acid Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate. (Adapted from FBrf0156036 and FBrf0132448).
Protein Function (UniProtKB)
Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.
(UniProt, Q9VVT2)
Summary (Interactive Fly)

plasma membrane transporter of Krebs cycle intermediates - midgut - regulation of lifespan - regulation of mitochondrial function

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Indy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Transposon inserted in intron

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Indy-RA
FBtr0075083
NM_079426
2484
572
Indy-RB
FBtr0075081
NM_168778
2572
590
Indy-RC
FBtr0075082
NM_168779
2600
572
Indy-RD
FBtr0301857
NM_001169994
2581
572
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Indy-PA
FBpp0074850
63.6
572
8.55
NP_524150
AAF49226
Indy-PB
FBpp0074848
65.6
590
8.55
NP_730363
AAF49227
Indy-PC
FBpp0074849
63.6
572
8.55
NP_730364
AAN11670
Indy-PD
FBpp0291071
63.6
572
8.55
NP_001163465
ACZ94736
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

572 aa isoforms: Indy-PA, Indy-PC, Indy-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Indy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from direct assay
(assigned by UniProt )
(Knauf et al., 2002)
located_in plasma membrane
inferred from direct assay
(Knauf et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Indy in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 51 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Indy
Transgenic constructs containing regulatory region of Indy
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC13A2
13 of 15
Yes
Yes
Hsap\SLC13A5
12 of 15
No
Yes
Hsap\SLC13A1
11 of 15
No
Yes
Hsap\SLC13A3
11 of 15
No
Yes
Hsap\SLC13A4
11 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc13a2
13 of 15
Yes
Yes
Mmus\Slc13a5
12 of 15
No
Yes
Mmus\Slc13a1
11 of 15
No
Yes
Mmus\Slc13a3
9 of 15
No
Yes
Mmus\Slc13a4
9 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Slc13a2
12 of 13
Yes
Yes
Rnor\Slc13a1
11 of 13
No
Yes
Rnor\Slc13a5
11 of 13
No
Yes
Rnor\Slc13a4
10 of 13
No
Yes
Rnor\Slc13a3
9 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\slc13a2
12 of 12
Yes
Yes
Xtro\slc13a3
7 of 12
No
Yes
Xtro\slc13a5
7 of 12
No
Yes
Xtro\slc13a1
6 of 12
No
Yes
Xtro\slc13a4
6 of 12
No
Yes
Xtro\slc13a4
2 of 12
No
Yes
Danio rerio (Zebrafish) (6)
Drer\slc13a1
11 of 15
Yes
Yes
Drer\slc13a5a
11 of 15
Yes
Yes
Drer\slc13a5b
10 of 15
No
Yes
Drer\slc13a3
9 of 15
No
Yes
Drer\slc13a2
8 of 15
No
Yes
Drer\slc13a4
8 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\nac-1
12 of 15
Yes
Yes
Cele\nac-3
12 of 15
Yes
Yes
Cele\B0285.6
8 of 15
No
Yes
Cele\nac-2
6 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\TDT
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PHO90
8 of 15
Yes
Yes
Scer\PHO91
8 of 15
Yes
Yes
Scer\PHO87
7 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC3B8.04c
6 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905VY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00011805
Drosophila simulans
Dsim\GD12325
Drosophila sechellia
Dsec\GM14919
Drosophila erecta
Dere\GG15722
Drosophila yakuba
Dyak\GE22053
Drosophila ananassae
Dana\GF10804
Drosophila pseudoobscura pseudoobscura
Dpse\GA23740
Drosophila persimilis
Dper\GL25253
Drosophila willistoni
Dwil\GK20442
Drosophila virilis
Dvir\GJ13740
Drosophila mojavensis
Dmoj\GI13959
Drosophila grimshawi
Dgri\GH17192
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915033N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023656
Glossina morsitans
Tsetse fly
Gmor\GMOY012143
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03468
Mayetiola destructor
Hessian fly
Mdes\Mdes005608
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009856
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009863
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009855
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009860
Anopheles darlingi
American malaria mosquito
Adar\ADAC008634
Anopheles darlingi
American malaria mosquito
Adar\ADAC008635
Anopheles gambiae
Malaria mosquito
Agam\AGAP007055
Anopheles gambiae
Malaria mosquito
Agam\AGAP007054
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004954
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004955
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09U0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007274
Bombyx mori
Silkmoth
Bmor\BGIBMGA012800
Bombyx mori
Silkmoth
Bmor\BGIBMGA007283
Danaus plexippus
Monarch butterfly
Dple\DPOGS203617-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206847-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS203616-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017321
Heliconius melpomene
Postman butterfly
Hmel\HMEL009312
Apis florea
Little honeybee
Aflo\4791999780
Apis florea
Little honeybee
Aflo\2215876836
Apis mellifera
Western honey bee
Amel\GB40386
Apis mellifera
Western honey bee
Amel\GB40381
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24052
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24048
Bombus terrestris
Buff-tailed bumblebee
Bter\15208316
Bombus terrestris
Buff-tailed bumblebee
Bter\15209327
Linepithema humile
Argentine ant
Lhum\LH11966
Linepithema humile
Argentine ant
Lhum\LH11965
Linepithema humile
Argentine ant
Lhum\LH19337
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000952
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000945
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007271
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013454
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02928
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15326
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15325
Tribolium castaneum
Red flour beetle
Tcas\TC015404
Pediculus humanus
Human body louse
Phum\PHUM047000
Cimex lectularius
Bed bug
Clec\CLEC010269
Cimex lectularius
Bed bug
Clec\CLEC010357
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI087571
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13834
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0580 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW000455
Ixodes scapularis
Black-legged tick
Isca\ISCW000567
Ixodes scapularis
Black-legged tick
Isca\ISCW003456
Ixodes scapularis
Black-legged tick
Isca\ISCW007956
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81665.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67628.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81666.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73351.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_226776
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G092X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a2_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a3_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc13a2
Ciona intestinalis
Vase tunicate
Cint\LOC100175240
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008631
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020016
Ciona intestinalis
Vase tunicate
Cint\LOC101242602
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020543
Ciona intestinalis
Vase tunicate
Cint\LOC100184727
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003703
Gallus gallus
Domestic chicken
Ggal\SLC13A3
Gallus gallus
Domestic chicken
Ggal\SLC13A4
Gallus gallus
Domestic chicken
Ggal\SLC13A1
Gallus gallus
Domestic chicken
Ggal\SLC13A5
Gallus gallus
Domestic chicken
Ggal\SLC13A2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7309
7 of 10
Indy-2
6 of 10
CG33934
5 of 10
CG11262
1 of 10
CG13801
1 of 10
CG31693
1 of 10
hoe1
1 of 10
hoe2
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC13A2; solute carrier family 13 member 2
    13 of 15
    604148
        SLC13A5; solute carrier family 13 member 5
        12 of 15
        608305
        SLC13A1; solute carrier family 13 member 1
        11 of 15
        606193
            SLC13A3; solute carrier family 13 member 3
            11 of 15
            606411
              SLC13A4; solute carrier family 13 member 4
              11 of 15
              604309
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Interactions Browser
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  External Data
                  Linkouts
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  3L
                  Recombination map

                  3-45

                  Cytogenetic map
                  75E1-75E2
                  Sequence location
                  3L:18,828,632..18,846,267 [-]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  75E1-75E2
                  Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  3-45

                  (FlyBase, 2016)

                  3-42.0

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (31)
                  Genomic Clones (20)
                  cDNA Clones (237)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: Indy CG3979

                    (Rogina et al., 2000)
                    Source for database merge of

                    Source for merge of: Indy BEST:LP01220

                    (Rana, 2004.7.8)

                    Source for merge of: CG3979 anon- EST:fe3A7

                    (FlyBase, 1996-)

                    Source for merge of: Indy anon-WO0172774.70

                    (FlyBase, 1996-)
                    Additional comments

                    Source for merge of CG3979 anon- EST:fe3A7 was sequence comparison ( date:000605 ).

                    (FlyBase, 1996-)

                    Source for merge of Indy anon-WO0172774.70 was sequence comparison ( date:051113 ).

                    (FlyBase, 1996-)
                    Other Comments

                    Indy encodes a transporter that mediates transport of succinate and also citrate across the plasma membrane. The transport of succinate is not cation dependent. The transport of citrate is Na+-independent, but is markedly stimulated at pH6.0 compared to pH7.5.

                    (Knauf et al., 2002)

                    Area matching Drosophila EST AA441327. This EST has sequence similarity to Rat sodium dependant dicarboxylate transporter, AB001321.

                    (Davies, 2001.3.15)

                    Heterozygous Indy mutants show a near doubling of the average adult life-span without a decline in fertility or physical activity.

                    (Rogina et al., 2000)
                    Origin and Etymology
                    Discoverer
                    Etymology

                    The gene is named "I'm not dead yet" based on a quip in the movie "Monty Python and the Holy Grail".

                    (Pennisi, 2000)
                    Identification
                    External Crossreferences and Linkouts ( 74 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (12)
                    Reported As
                    Symbol Synonym
                    BEST:LP01220
                    CG3979
                    (Christis and Munro, 2012, Cammarato et al., 2011, Desalvo et al., 2011, Khanna et al., 2010, Fujikawa et al., 2009, Quinones-Coello, 2007, Hollien and Weissman, 2006)
                    INDY
                    (Staats et al., 2018, Carlson and Derr, 2007)
                    Indy
                    (Brunet Avalos et al., 2019, Huang et al., 2019, Hudry et al., 2019, Krittika and Yadav, 2019, Yan et al., 2019, Croset et al., 2018, Staats et al., 2018, Sui et al., 2018, Velentzas et al., 2018, Willmes et al., 2018, Maistrenko et al., 2016, Aradska et al., 2015, Bradley et al., 2015, Briga and Verhulst, 2015, Gene Disruption Project members, 2015-, Rogers and Rogina, 2015, Van Bortle et al., 2015, DeSalvo et al., 2014, Rogers and Rogina, 2014, Coelho et al., 2013, Levis et al., 2013-, Rogina and Helfand, 2013, Sen et al., 2013, Eleftherianos and Castillo, 2012, Iliadi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Cho et al., 2011, Jones and Grotewiel, 2011, Kanda et al., 2011, Tatar, 2011, Bauer et al., 2010, Cook et al., 2010.2.12, Chittaranjan et al., 2009, Fujikawa et al., 2009, Neretti et al., 2009, Toivonen et al., 2009, Wang et al., 2009, Buszczak et al., 2007, Lai et al., 2007, Leandro et al., 2007, Quinones-Coello, 2007, Quinones-Coello et al., 2007, Toivonen et al., 2007, Zhan et al., 2007, Zhang et al., 2007, Hollien and Weissman, 2006, Hollien and Weissman, 2006, Bulgakova et al., 2004, Bulgakova et al., 2002)
                    anon-EST:fe3A7
                    anon-WO0172774.70
                    drIndy
                    (Inoue et al., 2002)
                    indy
                    (Burke et al., 2014, Coelho et al., 2013, Kenyon C., 2005, Boulianne, 2001)
                    Name Synonyms
                    I am not dead yet
                    (Aigaki et al., 2002)
                    I'm Not Dead Yet
                    (Staats et al., 2018)
                    I'm not dead yet
                    (Willmes et al., 2018, Maistrenko et al., 2016, Cammarato et al., 2011, Khanna et al., 2010, Carlson and Derr, 2007, Lai et al., 2007, Quinones-Coello et al., 2007, Zhan et al., 2007, Rogina et al., 2000)
                    anon-fast-evolving-3A7
                    Secondary FlyBase IDs
                    • FBgn0025199
                    • FBgn0045781
                    • FBgn0046362
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (124)