plasma membrane transporter of Krebs cycle intermediates - midgut - regulation of lifespan - regulation of mitochondrial function
Please see the JBrowse view of Dmel\Indy for information on other features
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Transposon inserted in intron
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Indy using the Feature Mapper tool.
Comment: maternally deposited
Comment: low expression throughout adult brain
GBrowse - Visual display of RNA-Seq signals
View Dmel\Indy in GBrowse 23-45
3-45
3-42.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Indy CG3979
Source for merge of: Indy BEST:LP01220
Source for merge of: CG3979 anon- EST:fe3A7
Source for merge of: Indy anon-WO0172774.70
Source for merge of CG3979 anon- EST:fe3A7 was sequence comparison ( date:000605 ).
Source for merge of Indy anon-WO0172774.70 was sequence comparison ( date:051113 ).
Indy encodes a transporter that mediates transport of succinate and also citrate across the plasma membrane. The transport of succinate is not cation dependent. The transport of citrate is Na+-independent, but is markedly stimulated at pH6.0 compared to pH7.5.
Area matching Drosophila EST AA441327. This EST has sequence similarity to Rat sodium dependant dicarboxylate transporter, AB001321.
Heterozygous Indy mutants show a near doubling of the average adult life-span without a decline in fertility or physical activity.
The gene is named "I'm not dead yet" based on a quip in the movie "Monty Python and the Holy Grail".