• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\dysb

General Information
Symbol	Dmel\dysb	Species	D. melanogaster
Name	dysbindin	Annotation symbol	CG6856
Feature type	protein_coding_gene	FlyBase ID	FBgn0036819
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75E2-75E2	Sequence location	3L:18,860,877..18,862,319 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dysbindin is referred to in FlyBase by the symbol Dmel\dysb (CG6856, FBgn0036819). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: regulation of synaptic plasticity. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Dysbindin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult spermathecae. Comments on Affy2 ProbeSet: ProbeSet 1637720_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dysb. Gene sequence location is 3L:18860877..18862319.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References FlyBase Curators, 2010-, Gene Ontology (GO) annotation review.
FB2012_01	Sequence features BKN22549 HFA10730
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75E2-75E2   Limits computationally determined from genome sequence between P{lacW}l(3)j14E7j14E7 and P{lacW}l(3)j4E6j4E6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dysb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dysb-RA FBtr0075062  NM_140807   1385   288
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dysb-PA   FBpp0074829   32.4   288   4.90     NP_649064   AAF49223
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dysbindin (IPR007531)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49223   AY071009 AAL48631   BI168435   BI228416   CO344241   CZ478858   CZ478859   EC057938   EC252558   GH748398   GH748641   GH749060   GH751016   GH751173   GH753784   GH755222   GH756349   GH758852   GH761102   GH761166   GH770316   GH771895   GH773662   GH774387   GH775184   GH777040   GH779959   GH780038   GH780599   GH780875   GH781054   GH781780   GH782098   GH782860   GH789259   GH789534   GH791105   GH791347   GH793024   GH794700   GH795820   GH796553   GH797144   GH797488   GH799705   GH802146   GH803363   GH803458   GH804201   GH804897   GH807270   GH808872   GH809964   GH812788   GH812889   GH813220   GH813957   GH815616   GH816770   GH818790   GH820057   GH820845   GH821728   GH825240   GH827260   GH828006   GH829249   GH829378   GH829424   GH830682   GH832300   GH832483   GH834094   GH836907   GH837531   GH838254   GH839024   GH842190   GH842462   GH843007   GH843784   GH843940   GH845962   GH846597   GH846844   GH847115   GH849185   GH851081   GH852284   GH853228   GH853250   GH853644   GH854355   GH855118   GH856013   GH857044   GH858469   GH860517   GH860973   GH861097   GH861417   GH862799   GH866807   GH866903   GH867057   GH868850   GH869393   GH869425   GH870336   GH871034   GH871416   GH873613   GH874436   GH874571   GH875385   GH876366   GH876733   GH876938   GH877025   GH877224   GH877683   GH878104   GH878575   GH878941   GH879302   GH879834   GH880303   GH880773   GH880902   GH881939   GH882164   GH882655   GH882967   GH884894   GH885431   GH885659   GH885757   GH885978   GH886141   GH887347   GH887569   GH887715   GH888652   GH891316   GH891359   GH891663   GH891732   GH892701   GH892717   GH893026   GH893135   GH893269   GH893997   GH896833   GH899184   GH900414   GH900728   GH901803   GH903485   GH904105   GH904863   GH906325   GH906434   GH906689   GH907354   GH909969   GH912232   GH912645   GH913227   GH913363   GH913441   GH913453   GH913642   GH913788   GH913828   GH915251   GH915381   GH916429   GH918185   GH919090   GH919313   GH920264   GH921447   GH921728   GH922307   GH922780   GH923937   GH924667   GH927715   GH928688   GH928927   GH929135   GH929677   GH929720   GH929962   GH931459   GH931737   GH931784   GH931829   GH932458   GH933052   GH934294   GH935054   GH937027   GH938462
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVT5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036819    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036819 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036819 expression level Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (640) embryo 02-04hr  (122) embryo 04-06hr  (187) embryo 06-08hr  (414) embryo 08-10hr  (441) embryo 10-12hr  (592) embryo 12-14hr  (578) embryo 14-16hr  (523) embryo 16-18hr  (497) embryo 18-20hr  (345) embryo 20-22hr  (313) embryo 22-24hr  (386) larva L1  (255) larva L2  (459) larva L3 12hr old  (315) larva L3 puffstage 1-2  (282) larva L3 puffstage 3-6  (324) larva L3 puffstage 7-9  (315) white prepupae new  (326) white prepupae 12hr  (211) white prepupae 24hr  (197) pupae 2d postWPP  (327) pupae 3d postWPP  (279) pupae 4d postWPP  (205) adult male 01day  (292) adult male 05day  (227) adult male 30day  (202) adult female 01day  (294) adult female 05day  (523) adult female 30day  (549) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036819 expression level Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (640) embryo 02-04hr  122 embryo 04-06hr  (187) embryo 06-08hr  (414) embryo 08-10hr  (441) embryo 10-12hr  (592) embryo 12-14hr  (578) embryo 14-16hr  (523) embryo 16-18hr  (497) embryo 18-20hr  (345) embryo 20-22hr  (313) embryo 22-24hr  (386) larva L1  (255) larva L2  (459) larva L3 12hr old  (315) larva L3 puffstage 1-2  (282) larva L3 puffstage 3-6  (324) larva L3 puffstage 7-9  (315) white prepupae new  (326) white prepupae 12hr  (211) white prepupae 24hr  (197) pupae 2d postWPP  (327) pupae 3d postWPP  (279) pupae 4d postWPP  (205) adult male 01day  (292) adult male 05day  (227) adult male 30day  (202) adult female 01day  (294) adult female 05day  (523) adult female 30day  (549) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    640 embryo 02-04hr    122 embryo 04-06hr    187 embryo 06-08hr    414 embryo 08-10hr    441 embryo 10-12hr    592 embryo 12-14hr    578 embryo 14-16hr    523 embryo 16-18hr    497 embryo 18-20hr    345 embryo 20-22hr    313 embryo 22-24hr    386 larva L1    255 larva L2    459 larva L3 12hr old    315 larva L3 puffstage 1-2    282 larva L3 puffstage 3-6    324 larva L3 puffstage 7-9    315 white prepupae new    326 white prepupae 12hr    211 white prepupae 24hr    197 pupae 2d postWPP    327 pupae 3d postWPP    279 pupae 4d postWPP    205 adult male 01day    292 adult male 05day    227 adult male 30day    202 adult female 01day    294 adult female 05day    523 adult female 30day    549 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036819    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036819 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult salivary gland, adult spermathecae. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036819 expression level Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036819 expression level Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    20.125 Larval Midgut    57 Larval Hindgut    76 Larval Malpighian Tubules    66.8 Larval Fat Body    45.4 Larval Salivary Gland    236.1 Larval Trachea    19.35 Larval Carcass    41.75 Adult Head    30.7 Adult Eye    31.725 Adult Brain    18.6 Adult Thoracic-Abdominal Ganglion    25 Adult Crop    47.1 Adult Midgut no informative data Adult Hindgut    47.7 Adult Malpighian Tubules    60.9 Adult Fat Body    72.8 Adult Salivary Gland    122.9 Adult Heart    48.225 Adult VirginFemale Spermatheca    106.9 Adult InseminatedFemale Spermatheca    137 Adult Ovary    70.8 Adult Testis    8.5 Adult Male Accessory Gland    79 Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30.7   NA  Eye    31.725   NA  Brain    18.6   20.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25   NA  Crop    47.1   57  Midgut    no informative data   76  Hindgut    47.7   66.8  Malpighian Tubules    60.9   45.4  Fat Body    72.8   236.1  Salivary Gland    122.9   NA  Heart    48.225   19.35  Trachea    NA   NA  VirginFemale Spermatheca    106.9   NA  InseminatedFemale Spermatheca    137   NA  Ovary    70.8   NA  Testis    8.5   NA  Male Accessory Gland    79   41.75  Carcass    39.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036819 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6856-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dysb Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 dysbGD10754 Other Phenotypes Allele eye color defective, with Scer\GAL4GMR.PF dysbGD10754 neurophysiology defective, with Scer\GAL4elav-C155 dysbScer\UAS.cDa neurophysiology defective (with Df(3L)BSC416) dysbe01028 neurophysiology defective | recessive dysbe01028 visible, with Scer\GAL4pnr-MD237 dysbGD10754 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 dysbGD10754
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of dysb Class Mutagen Stocks Known lesion dysbe01028 loss of function allele piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dysb Class Mutagen Stocks Known lesion dysbGD10754 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dysbKK102468 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dysbScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes dysbScer\UAS.T:Avic\GFP-YFP.Venus in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-dysb.D} NA P{UAS-dysb.ven} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}dysbe01028 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with blos4 (Cheli et al., 2010) inferred from physical interaction with snapin (Cheli et al., 2010)
Biological Process
CV term Evidence References
regulation of synaptic plasticity inferred from mutant phenotype (Dickman and Davis, 2009)
Cellular Component
CV term Evidence References
synaptic vesicle inferred from direct assay (Dickman and Davis, 2009)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
BLOC-1 complex inferred from sequence or structural similarity with human DTNBP1 (Cheli et al., 2010)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dysb allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65333 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036819 DroID - A comprehensive database of gene and protein interactions. • FBgn0036819 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40052
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23643 Dere\GG16007 Dgri\GH14378 Dmoj\GI11321 Dper\GL21438 Dpse\GA19908 Dsec\GM14997 Dsim\GD14774 Dvir\GJ11577 Dwil\GK20446 Dyak\GE19569
Curated drosophilid orthologs	Dpse\GA19908
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_624364.1 Apis mellifera (honey bee) XP_001952369.1 Acyrthosiphon pisum (pea aphid) 223800 Branchiostoma floridae (lancelet) BGIBMGA004333-PA Bombyx mori (silk worm) ENSBTAP00000017191 Bos taurus (bovine) ENSCAFP00000014562 Canis familiaris (dog) ENSCPOP00000008463 Cavia porcellus (guinea pig) 204927 Capitella spl (polychaete worm) 313831 Daphnia pulex (daphnia) ENSDARP00000071887 Danio rerio (zebra fish) ENSECAP00000010476 Equus caballus (horse) ENSGACP00000005239 Gymnopilus aculeatus (mushroom) ENSGALP00000020712 Gallus gallus (chicken) ENSP00000348183 Homo sapiens (human) ENSMODP00000013484 Monodelphis domestica (gray opossum) ENSMMUP00000020145 Macaca mulatta (rhesus monkey) ENSMUSP00000072170 Mus musculus (house mouse) XP_001603914.1 Nasonia vitripennis (wasp) ENSOANP00000018810 Ornithorynchus anatinus (platypus) ENSORLP00000004644 Oryzias latipes (japanese killifish) PHUM010879-PA Pediculus humanus (human body louse) ENSPPYP00000018174 Pongo pygmaeus (orangutan) ENSPTRP00000030301 Pan troglodytes (chimpanzee) 63864 Trichoplax adhaerens (metazoa) XP_976168.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014618 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008816 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033675 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23674 NV21542 NV10076 LH11717 FBgn0240286 FBgn0236909 FBgn0222443 FBgn0198835 FBgn0186447 FBgn0169917 JGI_V11_313831 FBgn0079904 FBgn0159031 FBgn0134082 FBgn0121854 FBgn0108242 FBgn0100637 BGIBMGA004333 ACYPI008236 GB16781 PHUM549410 GLEAN_09517
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	17918 w1118; PBac{RB}dysbe01028/TM6B, Tb1
VDRC	v106957 P{KK102468}VIE-260B v34354 w1118; P{GD10754}v34354 v34355 w1118; P{GD10754}v34355
Genomic Clones ( 1 )
	BACR48N04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 202 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE09163
Other clones	DPiM_RE09163
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE25956
Other clones	214247.47 CK01.56C.F9 EP18921 RP003003052 RP003009034 RP003011292 RP003017594 RP003018554 RP003025389 RP003027051 RP003030430 RP003031625 RP003034776 RP003038517 RP003039921 RP003044592 RP003046672 RP003060497 RP003062528 RP003068761 RP003069533 RP003073026 RP003078741 RP003082036 RP003088916 RP003091239 RP003102076 RP003103004 RP003104750 RP003105681 RP003113325 RP003113419 RP003114586 RP003117224 RP003119425 RP003119493 RP003128104 RP003128719 RP003129245 RP003130964 RP003142979 RP003153717 RP003153878 RP003156241 RP003157708 RP003161092 RP003162107 RP003171895 RP003173736 RP003177111 RP003192480 RP003196963 RP003204726 RP003204951 RP003205721 RP003213523 RP003214427 RP003214471 RP003215138 RP003217139 RP003217266 RP003217780 RP003220111 RP003222665 RP003223082 RP003224719 RP003231770 RP003233224 RP003235655 RP003241279 RP003244908 RP003245714 RP003248944 RP003249040 RP003249682 RP003254952 RP003257820 RP003262252 RP003266114 RP003274506 RP003275319 RP003282007 RP003282215 RP003283416 RP003285210 RP003286442 RP003289605 RP003294111 RP003296016 RP003306007 RP003309597 RP003311062 RP003314981 RP003316285 RP003319358 RP003322412 RP003325648 RP003327372 RP003328360 RP003328456 RP003330476 RP003332746 RP003334352 RP003339800 RP003342573 RP003342745 RP003343139 RP003346200 RP003352274 RP003353151 RP003354116 RP003354411 RP003358475 RP003360244 RP003369569 RP003371261 RP003379815 RP003379895 RP003383688 RP003383750 RP003388833 RP003394512 RP003396519 RP003403911 RP003406599 RP003417054 RP003418745 RP003418777 RP003425062 RP003434562 RP003437085 RP003441021 RP003442950 RP003445531 RP003449215 RP003449906 RP003450412 RP003453486 RP003453804 RP003467825 RP003470124 RP003471566 RP003473221 RP003474968 RP003476466 RP003477302 RP003488294 RP003488932 RP003492566 RP003493524 RP003493715 RP003496819 RP003500982 RP003501847 RP003501891 RP003504125 RP003505375 RP003506307 RP003506719 RP003515344 RP003528278 RP003530250 RP003531542 RP003547002 RP003552562 RP003553161 RP003559473 RP003562339 RP003567487 RP003569700 RP003572605 RP003574799 RP003581340 RP003581536 RP003581838 RP003586898 RP003588060 RP003588800 RP003590484 RP003595031 RP003600094 RP003603428 RP003605179 RP003605912 RP003606506 RP003609008 RP003610706 RP003621935 RP003625723 RP003628245 RP003628689 RP003634386 RP003646855 RP003651179 RP003653980 RP003655631 RP003662291 RP003670763 RP003678196
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036819 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40052
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dysb CG6856 (Dickman and Davis, 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140807 RefSeq (Proteins) • NP_649064 DDBJ / EMBL / GenBank • AAF49223 AAL48631 AY071009 BI168435 CZ478858 CZ478859 Entrez Gene - A searchable database of RefSeq genes. • 40052 UniProtKB/TrEMBL • Q9VVT5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dysbindin (IPR007531)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65333 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036819 DroID - A comprehensive database of gene and protein interactions. • FBgn0036819 DRSC - Results from RNAi screens. • FBgn0036819 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036819 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6856-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036819 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40052 InParanoid A subset of ortholog calls from InParanoid. • XP_624364.1 Apis mellifera (honey bee) XP_001952369.1 Acyrthosiphon pisum (pea aphid) 223800 Branchiostoma floridae (lancelet) BGIBMGA004333-PA Bombyx mori (silk worm) ENSBTAP00000017191 Bos taurus (bovine) ENSCAFP00000014562 Canis familiaris (dog) ENSCPOP00000008463 Cavia porcellus (guinea pig) 204927 Capitella spl (polychaete worm) 313831 Daphnia pulex (daphnia) ENSDARP00000071887 Danio rerio (zebra fish) ENSECAP00000010476 Equus caballus (horse) ENSGACP00000005239 Gymnopilus aculeatus (mushroom) ENSGALP00000020712 Gallus gallus (chicken) ENSP00000348183 Homo sapiens (human) ENSMODP00000013484 Monodelphis domestica (gray opossum) ENSMMUP00000020145 Macaca mulatta (rhesus monkey) ENSMUSP00000072170 Mus musculus (house mouse) XP_001603914.1 Nasonia vitripennis (wasp) ENSOANP00000018810 Ornithorynchus anatinus (platypus) ENSORLP00000004644 Oryzias latipes (japanese killifish) PHUM010879-PA Pediculus humanus (human body louse) ENSPPYP00000018174 Pongo pygmaeus (orangutan) ENSPTRP00000030301 Pan troglodytes (chimpanzee) 63864 Trichoplax adhaerens (metazoa) XP_976168.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014618 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008816 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000033675 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40052 modMine - Data generated by the modENCODE project. • FBgn0036819 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV23674 NV21542 NV10076 LH11717 FBgn0240286 FBgn0236909 FBgn0222443 FBgn0198835 FBgn0186447 FBgn0169917 JGI_V11_313831 FBgn0079904 FBgn0159031 FBgn0134082 FBgn0121854 FBgn0108242 FBgn0100637 BGIBMGA004333 ACYPI008236 GB16781 PHUM549410 GLEAN_09517
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG6856 (Falcon-Perez et al., 2007, Keleman et al., 2009.8.5, Cheli et al., 2010) dysb (Dickman and Davis, 2009, )
Name Synonym	dysbindin (Dickman and Davis, 2009, Cheli et al., 2010, Cheli et al., 2010)
Secondary FlyBase IDs
References ( 16 )
Research paper	Cheli et al., 2010, Hum. Mol. Genet. 19(5): 861--878 Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. [FBrf0209903] Dickman and Davis, 2009, Science 326(5956): 1127--1130 The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. [FBrf0209454] Falcon-Perez et al., 2007, Traffic 8(2): 154--168 The Drosophila Pigmentation Gene pink (p) Encodes a Homologue of Human Hermansky-Pudlak Syndrome 5 (HPS5). [FBrf0192474]
Supplementary material	Cheli et al., 2010, Hum. Mol. Genet. 19(5): Supplementary Data. [FBrf0210495] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]