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Gene Dmel\CG6841

General Information
Symbol	Dmel\CG6841	Species	D. melanogaster
Name		Annotation symbol	CG6841
Feature type	protein_coding_gene	FlyBase ID	FBgn0036828
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75E4-75E5	Sequence location	3L:18,898,474..18,902,074 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6841 (FBgn0036828). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: regulation of alternative nuclear mRNA splicing, via spliceosome; neurogenesis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: PRP1 splicing factor, N-terminal; RNA-processing protein, HAT helix; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1628665_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6841. Gene sequence location is 3L:18898474..18902074.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN20947 HFA10724
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75E4-75E5   Limits computationally determined from genome sequence between P{lacW}l(3)j4E6j4E6 and P{EP}MESR6EP3142
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6841 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6841-RA FBtr0075068  NM_140816   3380   931
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6841-PA   FBpp0074835   105.2   931   7.48     NP_649073   AAF49211
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA-processing protein, HAT helix (IPR003107) PRP1 splicing factor, N-terminal (IPR010491) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540036   AE014296 AAF49211   AI295364   AI511764   AW943652   AY094835 AAM11188   BI163637   BI212195   BI229552   BI230831   BI632393   BI640073   BT021415 AAX33563   CL528030   CO262234   CO262828   CO264425   CO285198   CO285372   EC059170   EC062361   EC070509   EC196730   EC214604   EC232906   GH752041   GH752280   GH753934   GH755373   GH758191   GH758367   GH760575   GH773323   GH773874   GH775028   GH775140   GH783639   GH783669   GH792451   GH799924   GH810160   GH810537   GH812405   GH815564   GH826720   GH827988   GH831820   GH844187   GH852220   GH853694   GH853721   GH857357   GH859027   GH860503   GH860758   GH862172   GH872581   GH879772   GH882093   GH882583   GH889390   GH895948   GH897806   GH903399   GH904203   GH904711   GH905787   GH907720   GH916137   GH919121   GH925864   GH928265   GH931165   GH931343   GH931554   GH934786   GH935621   GH938332
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SX58 Q9VVU6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036828    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036828 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036828 expression level Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2244) embryo 02-04hr  (1572) embryo 04-06hr  (2131) embryo 06-08hr  (1869) embryo 08-10hr  (1429) embryo 10-12hr  (1361) embryo 12-14hr  (938) embryo 14-16hr  (638) embryo 16-18hr  (469) embryo 18-20hr  (340) embryo 20-22hr  (377) embryo 22-24hr  (393) larva L1  (541) larva L2  (555) larva L3 12hr old  (411) larva L3 puffstage 1-2  (356) larva L3 puffstage 3-6  (514) larva L3 puffstage 7-9  (624) white prepupae new  (637) white prepupae 12hr  (706) white prepupae 24hr  (856) pupae 2d postWPP  (639) pupae 3d postWPP  (364) pupae 4d postWPP  (217) adult male 01day  (399) adult male 05day  (478) adult male 30day  (435) adult female 01day  (663) adult female 05day  (1281) adult female 30day  (1351) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2244) embryo 02-04hr  (1572) embryo 04-06hr  (2131) embryo 06-08hr  (1869) embryo 08-10hr  1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036828 expression level Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2244) embryo 02-04hr  (1572) embryo 04-06hr  (2131) embryo 06-08hr  (1869) embryo 08-10hr  (1429) embryo 10-12hr  (1361) embryo 12-14hr  (938) embryo 14-16hr  (638) embryo 16-18hr  (469) embryo 18-20hr  (340) embryo 20-22hr  (377) embryo 22-24hr  (393) larva L1  (541) larva L2  (555) larva L3 12hr old  (411) larva L3 puffstage 1-2  (356) larva L3 puffstage 3-6  (514) larva L3 puffstage 7-9  (624) white prepupae new  (637) white prepupae 12hr  (706) white prepupae 24hr  (856) pupae 2d postWPP  (639) pupae 3d postWPP  (364) pupae 4d postWPP  (217) adult male 01day  (399) adult male 05day  (478) adult male 30day  (435) adult female 01day  (663) adult female 05day  (1281) adult female 30day  (1351) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2244 embryo 02-04hr  1572 embryo 04-06hr  2131 embryo 06-08hr  1869 embryo 08-10hr  1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2244 embryo 02-04hr    1572 embryo 04-06hr    2131 embryo 06-08hr    1869 embryo 08-10hr    1429 embryo 10-12hr    1361 embryo 12-14hr    938 embryo 14-16hr    638 embryo 16-18hr    469 embryo 18-20hr    340 embryo 20-22hr    377 embryo 22-24hr    393 larva L1    541 larva L2    555 larva L3 12hr old    411 larva L3 puffstage 1-2    356 larva L3 puffstage 3-6    514 larva L3 puffstage 7-9    624 white prepupae new    637 white prepupae 12hr    706 white prepupae 24hr    856 pupae 2d postWPP    639 pupae 3d postWPP    364 pupae 4d postWPP    217 adult male 01day    399 adult male 05day    478 adult male 30day    435 adult female 01day    663 adult female 05day    1281 adult female 30day    1351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036828    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036828 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036828 expression level Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036828 expression level Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    193.65 Larval Midgut    51 Larval Hindgut    70.9 Larval Malpighian Tubules    66.2 Larval Fat Body    51.9 Larval Salivary Gland    88.7 Larval Trachea    84.1 Larval Carcass    63.475 Adult Head    63.6 Adult Eye    73.55 Adult Brain    113.2 Adult Thoracic-Abdominal Ganglion    80.7 Adult Crop    59.3 Adult Midgut    44.6 Adult Hindgut    57 Adult Malpighian Tubules    51 Adult Fat Body    59.1 Adult Salivary Gland    89.8 Adult Heart    48.175 Adult VirginFemale Spermatheca    78.3 Adult InseminatedFemale Spermatheca    82 Adult Ovary    190.2 Adult Testis    38.5 Adult Male Accessory Gland    66.3 Adult Carcass    43.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.6   NA  Eye    73.55   NA  Brain    113.2   193.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    80.7   NA  Crop    59.3   51  Midgut    44.6   70.9  Hindgut    57   66.2  Malpighian Tubules    51   51.9  Fat Body    59.1   88.7  Salivary Gland    89.8   NA  Heart    48.175   84.1  Trachea    NA   NA  VirginFemale Spermatheca    78.3   NA  InseminatedFemale Spermatheca    82   NA  Ovary    190.2   NA  Testis    38.5   NA  Male Accessory Gland    66.3   63.475  Carcass    43.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036828 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6841-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG6841 Stages(s) 1-3 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG6841GD10654 lethal, with Scer\GAL4pnr-MD237 CG6841GD10654 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG6841GD10654 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG6841GD10654 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CG6841GD10654 ganglion mother cell | larval stage, with Scer\GAL41407 CG6841GD10654
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG6841 Class Mutagen Stocks Known lesion CG6841c02256 1 -- CG6841EY07495 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6841 Class Mutagen Stocks Known lesion CG6841GD10654 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10654} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG6841EY07495 NA miscellaneous insertions PBac{PB}CG6841c02256 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of alternative nuclear mRNA splicing, via spliceosome inferred from mutant phenotype (Park et al., 2004)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity with Saccharomyces PRP6 (FlyBase, 1992-) inferred from sequence or structural similarity with Saccharomyces PRP6 AND inferred from sequence or structural similarity with NCBI:BAA37140 (Mount and Salz, 2000)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0000381 (Park et al., 2004) small nuclear ribonucleoprotein complex inferred from sequence or structural similarity with Saccharomyces PRP6 AND inferred from sequence or structural similarity with NCBI:BAA37140 (Mount and Salz, 2000) U2-type spliceosomal complex inferred from sequence or structural similarity with Saccharomyces PRP6 (FlyBase, 1992-) U5 snRNP inferred from sequence or structural similarity with NCBI:BAA37140 (Mount and Salz, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6841 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65344 DroID - A comprehensive database of gene and protein interactions. • FBgn0036828 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40064
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23653 Dere\GG16015 Dgri\GH23803 Dmoj\GI13491 Dper\GL21701 Dpse\GA19898 Dsec\GM15004 Dsim\GD14782 Dvir\GJ11852 Dwil\GK10384 Dyak\GE19580
Curated drosophilid orthologs	Dmir\CG6841 (Thornton, 2005.12.20) Dpse\GA19898
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010387-PA Aedes aegypti (mosquito) AGAP005640-PA Anopheles gambiae (mosquito) XP_623891.2 Apis mellifera (honey bee) XP_001951091.1 Acyrthosiphon pisum (pea aphid) At4g03430.1 Arabidopsis thaliana (wall cress) 29905 Batrachochytrium dendrobatidis (chytrid fungus) 120892 Branchiostoma floridae (lancelet) 125463 Branchiostoma floridae (lancelet) XP_001891604.1 Brugia malayi (roundworm nematode) BGIBMGA008911-PA Bombyx mori (silk worm) ENSBTAP00000015480 Bos taurus (bovine) CAL0001343 Candida albicans (a form of yeast) CN22931 Caenorhabditis brenneri (small nematode) CBP01451 Caenorhabditis briggsae (nematode) CE28858 Caenorhabditis elegans (worm) ENSCAFP00000019418 Canis familiaris (dog) CAGL0H10098g Candida glabrata (haploid yeast) Chro.50295 Cryptosporidium hominis (obligate parasite) ENSCINP00000017949 Ciona intestinalis (sea squirt) JA10899 Caenorhabditis japonica (nematode) cn01073 Cryptococcus neoformans (yeast-like fungus) cgd5_920 Cryptosporidium parvum (protozoan parasite) CPIJ016885 Culex pipens (mosquito) ENSCPOP00000006785 Cavia porcellus (guinea pig) 129783 Chlamidomonas reinhardtii (green alga) RP41650 Caenorhabditis remanei (nematode) ENSCSAVP00000016151 Ciona savignyi (sedentary tunicate) 223651 Capitella spl (polychaete worm) DDB0233221 Dictyostelium discoideum (amoeba) DEHA2D05104g Debaryomyces Hansenii (yeast) 303888 Daphnia pulex (daphnia) ENSDARP00000011609 Danio rerio (zebra fish) ENSECAP00000012194 Equus caballus (horse) XP_657274 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003409 Gymnopilus aculeatus (mushroom) ENSGALP00000009642 Gallus gallus (chicken) 77344 Hypsipyla robusta (cedar shoot borer) ENSP00000266079 Homo sapiens (human) ISCW022841-PA Ixodes scapularis (deer tick) KLLA0F04191g Kluyveromyces lactis (yeast) 141173 Lottia gigantea (owl limpet) LmjF32.2490 Leishmania major (virus) 14895 Monocosta brevicollis (choanoflagellate) ENSMODP00000021275 Monodelphis domestica (gray opossum) ENSMMUP00000020409 Macaca mulatta (rhesus monkey) ENSMUSP00000002529 Mus musculus (house mouse) 130381 Nematostella vectensis (starlet anemone) XP_001604212.1 Nasonia vitripennis (wasp) ENSOANP00000007797 Ornithorynchus anatinus (platypus) ENSORLP00000012022 Oryzias latipes (japanese killifish) LOC_Os10g35550.1 Oryza sativa (asian rice) 9042 Ostreococcus tauri (green alga) PF11_0108 Plasmodium falciparum (protozoal parasite) PHUM003672-PA Pediculus humanus (human body louse) PP25571 Pristionchus pacificus (nematode) 203777 Physcomitrella patens (moss) 221366 Physcomitrella patens (moss) ENSPPYP00000012574 Pongo pygmaeus (orangutan) 76913 Phytophthora ramorum (sudden oak death pathogen) 108589 Phytophthora sojae (root rot pathogen) 730490 Populus trichocarpa (black cottonwood) ENSPTRP00000023718 Pan troglodytes (chimpanzee) ENSRNOP00000021723 Rattus norvegicus (norway rat) 4892795 Sorghum bicolor (sorghum) YBR055C Saccharomyces cerevisiae (budding yeast) SPBC6B1.07 Schizosaccharomyces pombe (fission yeast) 51004 Trichoplax adhaerens (metazoa) TA05710 Theileria annulata (apicomplexan parasite) XP_971592.1 Tribolium castaneum (red flour beetle) Tc00.1047053507041.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508273.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021032 Tetraodon nigroviridis (green spotted pufferfish) TP01_0797 Theileria parva (parasitic protozoan) 41117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000006811 Takifugu rubripes (pufferfish Takifugu) 3750.m00279 Tetrahymena thermophila (ciliate protozoa) 80452.m00071 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026326 Xenopus tropicalis (frog) YALI0C19426g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15518 NV16313 LH11664 ISCW022841 FBgn0236919 FBgn0212399 FBgn0199106 FBgn0186455 FBgn0169924 JGI_V11_303888 FBgn0079894 FBgn0159294 FBgn0136247 FBgn0131260 FBgn0108250 FBgn0100647 CPIJ016885 BGIBMGA008911 ACYPI002837 GB14450 AGAP005640 AAEL010387 PHUM376530 GLEAN_05794
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	16834 y1 w67c23; P{EPgy2}CG6841EY07495/TM3, Sb1 Ser1
Harvard	- PBac{PB}CG6841c02256
VDRC	v34254 w1118 P{GD10654}v34254 v34253 w1118; P{GD10654}v34253/CyO
Genomic Clones ( 1 )
	BACR09M20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 73 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD04472 LD43276
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD19366 LP08968 RE03081 RE15278 RE17237 RE27357 SD22849 SD26162
Other clones	29751 52691 125560 CK01.100A.G8 CK01.102D.E6 EK084743 EK086451 EK139164 EK168504 EK168846 RP003018427 RP003045241 RP003051229 RP003068026 RP003081340 RP003085429 RP003091395 RP003093454 RP003093552 RP003100765 RP003102245 RP003118199 RP003119470 RP003123025 RP003127215 RP003133698 RP003142954 RP003148481 RP003149805 RP003151217 RP003163684 RP003169547 RP003180370 RP003199346 RP003242223 RP003281795 RP003285779 RP003289940 RP003299439 RP003302403 RP003307547 RP003330004 RP003351671 RP003358712 RP003359122 RP003372578 RP003378002 RP003409604 RP003422333 RP003447152 RP003466119 RP003466524 RP003467665 RP003480658 RP003513812 RP003522049 RP003533855 RP003562038 RP003574128 RP003590411 RP003622346 RP003645598 RP003682762
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036828 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40064
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6841 BcDNA:LD43276 (FlyBase, 1996-)
Additional comments	Source for merge of CG6841 BcDNA:LD43276 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140816 RefSeq (Proteins) • NP_649073 DDBJ / EMBL / GenBank • AAF49211 AAM11188 AAX33563 AI511764 AW943652 AY094835 BT021415 CL528030 Entrez Gene - A searchable database of RefSeq genes. • 40064 UniProtKB/TrEMBL • Q8SX58 Q9VVU6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA-processing protein, HAT helix (IPR003107) PRP1 splicing factor, N-terminal (IPR010491) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65344 DroID - A comprehensive database of gene and protein interactions. • FBgn0036828 DRSC - Results from RNAi screens. • FBgn0036828 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036828 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6841-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036828 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40064 InParanoid A subset of ortholog calls from InParanoid. • AAEL010387-PA Aedes aegypti (mosquito) AGAP005640-PA Anopheles gambiae (mosquito) XP_623891.2 Apis mellifera (honey bee) XP_001951091.1 Acyrthosiphon pisum (pea aphid) At4g03430.1 Arabidopsis thaliana (wall cress) 29905 Batrachochytrium dendrobatidis (chytrid fungus) 120892 Branchiostoma floridae (lancelet) 125463 Branchiostoma floridae (lancelet) XP_001891604.1 Brugia malayi (roundworm nematode) BGIBMGA008911-PA Bombyx mori (silk worm) ENSBTAP00000015480 Bos taurus (bovine) CAL0001343 Candida albicans (a form of yeast) CN22931 Caenorhabditis brenneri (small nematode) CBP01451 Caenorhabditis briggsae (nematode) CE28858 Caenorhabditis elegans (worm) ENSCAFP00000019418 Canis familiaris (dog) CAGL0H10098g Candida glabrata (haploid yeast) Chro.50295 Cryptosporidium hominis (obligate parasite) ENSCINP00000017949 Ciona intestinalis (sea squirt) JA10899 Caenorhabditis japonica (nematode) cn01073 Cryptococcus neoformans (yeast-like fungus) cgd5_920 Cryptosporidium parvum (protozoan parasite) CPIJ016885 Culex pipens (mosquito) ENSCPOP00000006785 Cavia porcellus (guinea pig) 129783 Chlamidomonas reinhardtii (green alga) RP41650 Caenorhabditis remanei (nematode) ENSCSAVP00000016151 Ciona savignyi (sedentary tunicate) 223651 Capitella spl (polychaete worm) DDB0233221 Dictyostelium discoideum (amoeba) DEHA2D05104g Debaryomyces Hansenii (yeast) 303888 Daphnia pulex (daphnia) ENSDARP00000011609 Danio rerio (zebra fish) ENSECAP00000012194 Equus caballus (horse) XP_657274 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003409 Gymnopilus aculeatus (mushroom) ENSGALP00000009642 Gallus gallus (chicken) 77344 Hypsipyla robusta (cedar shoot borer) ENSP00000266079 Homo sapiens (human) ISCW022841-PA Ixodes scapularis (deer tick) KLLA0F04191g Kluyveromyces lactis (yeast) 141173 Lottia gigantea (owl limpet) LmjF32.2490 Leishmania major (virus) 14895 Monocosta brevicollis (choanoflagellate) ENSMODP00000021275 Monodelphis domestica (gray opossum) ENSMMUP00000020409 Macaca mulatta (rhesus monkey) ENSMUSP00000002529 Mus musculus (house mouse) 130381 Nematostella vectensis (starlet anemone) XP_001604212.1 Nasonia vitripennis (wasp) ENSOANP00000007797 Ornithorynchus anatinus (platypus) ENSORLP00000012022 Oryzias latipes (japanese killifish) LOC_Os10g35550.1 Oryza sativa (asian rice) 9042 Ostreococcus tauri (green alga) PF11_0108 Plasmodium falciparum (protozoal parasite) PHUM003672-PA Pediculus humanus (human body louse) PP25571 Pristionchus pacificus (nematode) 203777 Physcomitrella patens (moss) 221366 Physcomitrella patens (moss) ENSPPYP00000012574 Pongo pygmaeus (orangutan) 76913 Phytophthora ramorum (sudden oak death pathogen) 108589 Phytophthora sojae (root rot pathogen) 730490 Populus trichocarpa (black cottonwood) ENSPTRP00000023718 Pan troglodytes (chimpanzee) ENSRNOP00000021723 Rattus norvegicus (norway rat) 4892795 Sorghum bicolor (sorghum) YBR055C Saccharomyces cerevisiae (budding yeast) SPBC6B1.07 Schizosaccharomyces pombe (fission yeast) 51004 Trichoplax adhaerens (metazoa) TA05710 Theileria annulata (apicomplexan parasite) XP_971592.1 Tribolium castaneum (red flour beetle) Tc00.1047053507041.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508273.60 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021032 Tetraodon nigroviridis (green spotted pufferfish) TP01_0797 Theileria parva (parasitic protozoan) 41117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000006811 Takifugu rubripes (pufferfish Takifugu) 3750.m00279 Tetrahymena thermophila (ciliate protozoa) 80452.m00071 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026326 Xenopus tropicalis (frog) YALI0C19426g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40064 modMine - Data generated by the modENCODE project. • FBgn0036828 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15518 NV16313 LH11664 ISCW022841 FBgn0236919 FBgn0212399 FBgn0199106 FBgn0186455 FBgn0169924 JGI_V11_303888 FBgn0079894 FBgn0159294 FBgn0136247 FBgn0131260 FBgn0108250 FBgn0100647 CPIJ016885 BGIBMGA008911 ACYPI002837 GB14450 AGAP005640 AAEL010387 PHUM376530 GLEAN_05794
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:LD43276   CG6841 (Herold et al., 2009, McIntyre et al., 2006, Neumüller et al., 2011) Prp6 (Park et al., 2004)
Name Synonym
Secondary FlyBase IDs
References ( 18 )
Research paper	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] McIntyre et al., 2006, GenomeBiol. 7(8): Sex-specific expression of alternative transcripts in Drosophila. [FBrf0192874] Park et al., 2004, Proc. Natl. Acad. Sci. USA 101(45): 15974--15979 Identification of alternative splicing regulators by RNA interference in Drosophila. [FBrf0180650] Mount and Salz, 2000, J. Cell Biol. 150(2): F37--F43 Pre-messenger RNA processing factors in the Drosophila genome. [FBrf0129982]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
DNA/RNA sequence record	Thornton, 2005.12.20, GenBank/EMBL/DDBJ: DQ334197 Drosophila miranda CG6841 gene, partial cds. [FBrf0197805]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]