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Gene Dmel\Ir75d

General Information
Symbol	Dmel\Ir75d	Species	D. melanogaster
Name	Ionotropic receptor 75d	Annotation symbol	CG14076
Feature type	protein_coding_gene	FlyBase ID	FBgn0036829
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75E5-75E5	Sequence location	3L:18,901,360..18,904,282 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ionotropic receptor 75d is referred to in FlyBase by the symbol Dmel\Ir75d (CG14076, FBgn0036829). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: extracellular-glutamate-gated ion channel activity; ligand-gated ion channel activity. There is experimental evidence that it is involved in the biological process: detection of chemical stimulus involved in sensory perception. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ionotropic glutamate receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1626540_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of Ir75d expression signal. See the GBrowse view of Ir75d to determine the overlapping gene(s). Gene sequence location is 3L:18901360..18904282.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms Johnston organ
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75E5-75E5   Limits computationally determined from genome sequence between P{lacW}l(3)j4E6j4E6 and P{EP}MESR6EP3142
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ir75d for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.46 Transcripts exist which overlap both CG14077 and CG14076 (Ir75d). They include the CG14077 CDS and most of the CG14076 transcript but do not encode the entire CG14076 CDS, and thus are not dicistronic.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ir75d-RC FBtr0309798  NM_140817   2312   675
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ir75d-PC   FBpp0301551   78.1   675   7.37     NP_649074   AAF49210
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49210   EL879382   EL883141
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVU7 Q4V504
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   Johnston organ   (Senthilan et al., 2012) neuron of antennal coeloconic sensillum ac1   (Benton et al., 2009) neuron of antennal coeloconic sensillum ac2   (Benton et al., 2009) neuron of antennal coeloconic sensillum ac4   (Benton et al., 2009) RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage   antenna   (Croset et al., 2010)
Additional Descriptive Data
	Ir75d transcript is observed in the neurons of the antennal coeloconic sensilla ac1, ac2 and ac4. In sensillum ac1 it is co-expressed with Ir31a, Ir92a and Ir76b. In sensillum ac2 it is co-expressed with Ir75a and Ir76b. In sensillum ac4 it is co-expressed with Ir76a, Ir76b and Ir84a. (Benton et al., 2009)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    9.375 Larval Midgut    4.6 Larval Hindgut    5.6 Larval Malpighian Tubules    12.3 Larval Fat Body    28.4 Larval Salivary Gland    10.8 Larval Trachea    8.4 Larval Carcass    4.125 Adult Head    12.8 Adult Eye    3.55 Adult Brain    5.2 Adult Thoracic-Abdominal Ganglion    9.6 Adult Crop    8.5 Adult Midgut    8.4 Adult Hindgut    5.3 Adult Malpighian Tubules    5.4 Adult Fat Body    8.7 Adult Salivary Gland    14.2 Adult Heart    4.325 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    7.7 Adult Ovary    10.2 Adult Testis    405.2 Adult Male Accessory Gland    9.6 Adult Carcass    9.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    12.8   NA  Eye    3.55   NA  Brain    5.2   9.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    9.6   NA  Crop    8.5   4.6  Midgut    8.4   5.6  Hindgut    5.3   no informative data  Malpighian Tubules    5.4   no informative data  Fat Body    8.7   no informative data  Salivary Gland    no informative data   NA  Heart    4.325   8.4  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    7.7   NA  Ovary    no informative data   NA  Testis    405.2   NA  Male Accessory Gland    9.6   4.125  Carcass    9.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_28 mE1_20_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14076-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Ir75dGD2714 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW Ir75dGD2714 Ir75dKK105293 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ir75d Class Mutagen Stocks Known lesion Ir75dMB04616 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ir75d Class Mutagen Stocks Known lesion Ir75dGD2714 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ir75dKK105293 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ir75dScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK105293} NA P{UAS-Ir75d.B} NA GAL4 construct P{Ir75d-GAL4.1995} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Ir75dMB04616 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
detection of chemical stimulus involved in sensory perception inferred from expression pattern (Benton et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ionotropic glutamate receptor activity inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-) ligand-gated ion channel activity inferred from sequence model (Benton et al., 2009)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence model (Benton et al., 2009) membrane inferred from electronic annotation with InterPro:IPR001320 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ir75d allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036829
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62FT31 Dipteran inclusive ortholog search EOG6J3WR5 Insect inclusive ortholog search EOG66T1WH Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG62FT31)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ir75d     Drosophila simulans   Dsim\GD12319 Y   Drosophila sechellia   Dsec\GM14912 Y   Drosophila erecta   Dere\GG13443 Y   Drosophila yakuba   Dyak\GE22799     Drosophila yakuba   Dyak\GE22541 Y   Drosophila ananassae   Dana\GF10798 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12748 Y   Drosophila persimilis   Dper\GL22050 Y   Drosophila willistoni   Dwil\GK12623 Y   Drosophila virilis   Dvir\GJ13526 Y   Drosophila mojavensis   Dmoj\GI11826     Drosophila mojavensis   Dmoj\GI11825     Drosophila grimshawi   Dgri\GH23804 Y
Orthologs in non-Drosophila Dipterans (EOG6J3WR5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009696   Anopheles gambiae Malaria mosquito  Agam\AGAP004969   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010900
Orthologs in non-Dipteran Insects (EOG66T1WH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI004474   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002614   Bombyx mori Silkmoth  Bmor\BGIBMGA005863   Pediculus humanus Human body louse  Phum\PHUM063490
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12319 Drosophila sechellia Dsec\GM14912 Drosophila erecta Dere\GG13443 Drosophila yakuba Dyak\GE22541 Drosophila ananassae Dana\GF10798 Drosophila pseudoobscura pseudoobscura Dpse\GA12748 Drosophila persimilis Dper\GL22050 Drosophila willistoni Dwil\GK12623 Drosophila virilis Dvir\GJ13526 Drosophila grimshawi Dgri\GH23804
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24205 w1118; Mi{ET1}Ir75dMB04616
VDRC	v106286 P{KK105293}VIE-260B v7499 w1118 P{GD2714}v7499 v7500 w1118; P{GD2714}v7500
Genomic Clones ( 1 )
	BACR09M20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	IP09369 IP12861
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40065
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ir75d CG14076 (Benton et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140817 RefSeq (Proteins) • NP_649074 DDBJ / EMBL / GenBank • AAF49210 ACL83324 Entrez Gene - A searchable database of RefSeq genes. • 40065 UniProtKB/TrEMBL • Q4V504 Q9VVU7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036829 DRSC - Results from RNAi screens. • FBgn0036829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14076-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40065 modMine - Data generated by the modENCODE project. • FBgn0036829
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG14076 (Lee et al., 2009, Croset et al., 2010, Benton et al., 2009, Font-Burgada et al., 2008, Keleman et al., 2009.8.5, Tsubouchi et al., 2012) CT33663 (Littleton and Ganetzky, 2000) DmelIR75d (Croset et al., 2010) Ir75d (Izutsu et al., 2012, Wasbrough et al., 2010, Tsubouchi et al., 2012, Senthilan et al., 2012) IR75d (Silbering et al., 2011, Marshall et al., 2010, Benton et al., 2009, Benton et al., 2009, Croset et al., 2010)
Name Synonym	CG14076   ionotropic receptor 75d (Benton et al., 2009) Ionotropic receptor 75d (Tsubouchi et al., 2012)
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 4 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Silbering et al., 2011, J. Neurosci. 31(38): 13357--13375 Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. [FBrf0215822] Show all research papers ...