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Gene Dmel\Mkp3

General Information
Symbol	Dmel\Mkp3	Species	D. melanogaster
Name	Mitogen-activated protein kinase phosphatase 3	Annotation symbol	CG14080
Feature type	protein_coding_gene	FlyBase ID	FBgn0036844
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	DMKP-3
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	75F6-75F6	Sequence location	3L:19,060,832..19,079,522 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mitogen-activated protein kinase phosphatase 3 is referred to in FlyBase by the symbol Dmel\Mkp3 (CG14080, FBgn0036844). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatase activity. There is experimental evidence that it is involved in the biological process: protein dephosphorylation; primary branching, open tracheal system; cell-cell adhesion; regulation of cell proliferation; imaginal disc-derived wing vein specification; maintenance of epithelial integrity, open tracheal system; mucosal immune response; negative regulation of MAPKKK cascade. 50 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; external compound sense organ; thoracic segment; tracheal branch primordium; late extended germ band embryo; peripheral nervous system; dorsal branch primordium; histaminergic neuron. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dual specificity phosphatase, catalytic domain; Dual specificity phosphatase, subgroup, catalytic domain; Dual specificity protein phosphatase (MAP kinase phosphatase); MAP kinase phosphatase; Protein-tyrosine/Dual-specificity phosphatase; Rhodanese-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, larval trachea, adult ovary. Gene sequence location is 3L:19060832..19079522.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA10085 BKN60425 BKN27688 BKN60370 HFA10084
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75F6-75F6   Limits computationally determined from genome sequence between P{lacW}l(3)j4E6j4E6 and P{EP}MESR6EP3142
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mkp3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mkp3-RA FBtr0075036  NM_168785   2053   241 Mkp3-RB FBtr0075035  NM_140830   2480   411
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mkp3-PA   FBpp0074803   26.6   241   6.67     NP_730385   AAF49193 Mkp3-PB   FBpp0074802   45.8   411   6.50     NP_649087   AAF49192
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) Protein-tyrosine/Dual-specificity phosphatase (IPR000387) Rhodanese-like (IPR001763) MAP kinase phosphatase (IPR008343) Dual specificity protein phosphatase (MAP kinase phosphatase) (IPR014393) Dual specificity phosphatase, subgroup, catalytic domain (IPR020422)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202433   AA938844   AE014296 AAF49192   AE014296 AAF49193   AI517187   AI534012   AW944456   AY043264 AAK85311   AY060472 AAL25511   BG637604   BI166904   BI168143   BI213974   BI240973   BI373333   BI373527   BI481698   BI577875   BI633628   BP545266   BP547256   BP549058   BT003536 AAO39540   CO262651   CO276188   CO279601   CO290886   CO290889   CO294317   CO299354   CO306858   CO308483   CO311887   CO315724   CO318678   CO329503   CZ468044   CZ469758   CZ472387   CZ476430   CZ476431   CZ476662   CZ479014   CZ486069   CZ486070   CZ487865   EC052231   EC052336   EC059130   EC080162   EC080452   EC085149   EC089021   EC089752   EC198335   EC217892   EC224447   EC226583   EC226767   EC237855   EC243400   EC248314   EL869944   EV596822   EV599538
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VVW5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   eye disc posterior to the morphogenetic furrow | restricted   (Rintelen et al., 2003) Comment:stripe of expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036844    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036844 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036844 expression level Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2099) embryo 02-04hr  (1764) embryo 04-06hr  (960) embryo 06-08hr  (1088) embryo 08-10hr  (1294) embryo 10-12hr  (1803) embryo 12-14hr  (1594) embryo 14-16hr  (1615) embryo 16-18hr  (1357) embryo 18-20hr  (1916) embryo 20-22hr  (1108) embryo 22-24hr  (1313) larva L1  (684) larva L2  (408) larva L3 12hr old  (274) larva L3 puffstage 1-2  (236) larva L3 puffstage 3-6  (477) larva L3 puffstage 7-9  (730) white prepupae new  (876) white prepupae 12hr  (1073) white prepupae 24hr  (1321) pupae 2d postWPP  (1218) pupae 3d postWPP  (696) pupae 4d postWPP  (1986) adult male 01day  (509) adult male 05day  (526) adult male 30day  (508) adult female 01day  (869) adult female 05day  (1596) adult female 30day  (1589) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2099) embryo 02-04hr  (1764) embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr  (1803) embryo 12-14hr  (1594) embryo 14-16hr  (1615) embryo 16-18hr    1357 embryo 18-20hr  (1916) embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP  (1986) adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day  (1596) adult female 30day  (1589) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036844 expression level Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2099) embryo 02-04hr  (1764) embryo 04-06hr  (960) embryo 06-08hr  (1088) embryo 08-10hr  (1294) embryo 10-12hr  (1803) embryo 12-14hr  (1594) embryo 14-16hr  (1615) embryo 16-18hr  (1357) embryo 18-20hr  (1916) embryo 20-22hr  (1108) embryo 22-24hr  (1313) larva L1  (684) larva L2  (408) larva L3 12hr old  (274) larva L3 puffstage 1-2  (236) larva L3 puffstage 3-6  (477) larva L3 puffstage 7-9  (730) white prepupae new  (876) white prepupae 12hr  (1073) white prepupae 24hr  (1321) pupae 2d postWPP  (1218) pupae 3d postWPP  (696) pupae 4d postWPP  (1986) adult male 01day  (509) adult male 05day  (526) adult male 30day  (508) adult female 01day  (869) adult female 05day  (1596) adult female 30day  (1589) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2099 embryo 02-04hr  1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr  1803 embryo 12-14hr  1594 embryo 14-16hr  1615 embryo 16-18hr    1357 embryo 18-20hr  1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP  1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day  1596 adult female 30day  1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2099 embryo 02-04hr    1764 embryo 04-06hr    960 embryo 06-08hr    1088 embryo 08-10hr    1294 embryo 10-12hr    1803 embryo 12-14hr    1594 embryo 14-16hr    1615 embryo 16-18hr    1357 embryo 18-20hr    1916 embryo 20-22hr    1108 embryo 22-24hr    1313 larva L1    684 larva L2    408 larva L3 12hr old    274 larva L3 puffstage 1-2    236 larva L3 puffstage 3-6    477 larva L3 puffstage 7-9    730 white prepupae new    876 white prepupae 12hr    1073 white prepupae 24hr    1321 pupae 2d postWPP    1218 pupae 3d postWPP    696 pupae 4d postWPP    1986 adult male 01day    509 adult male 05day    526 adult male 30day    508 adult female 01day    869 adult female 05day    1596 adult female 30day    1589 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036844    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036844 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036844 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14080-RA;CG14080-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mkp3 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4MD-638 Mkp3GS160 Mkp3GS.S Mkp3GSM76 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Mkp3GD8219 viable Mkp3M76-R2b viable (with Mkp31), with Scer\GAL4[-]: Mkp32 viable (with Mkp32), with Scer\GAL4[-]: Mkp31 Sterility Allele fertile (with Mkp31), with Scer\GAL4[-]: Mkp32 fertile (with Mkp32), with Scer\GAL4[-]: Mkp31 Other Phenotypes Allele cell shape defective, with Scer\GAL4btl.PS Mkp3GS801 increased cell death, with Scer\GAL4da.G32 Mkp3GD8219 short lived, with Scer\GAL4da.G32 Mkp3GD8219 visible, with Scer\GAL4en-GAL4-33 Mkp3Scer\UAS.cRa visible, with Scer\GAL4hs.2sev Mkp31 Mkp32 Mkp33 Mkp34 Mkp311 visible (with Mkp31), with Scer\GAL4[-]: Mkp32 visible (with Mkp32), with Scer\GAL4[-]: Mkp31 wild-type, with Scer\GAL4[-]: Mkp311 Phenotype manifest in Allele adult posterior midgut epithelium, with Scer\GAL4da.G32 Mkp3GD8219 dorsal branch primordium Mkp35J4 dorsal branch primordium, with Scer\GAL4btl.PS Mkp3GS801 embryonic trachea & cortical actin cytoskeleton, with Scer\GAL4btl.PS Mkp3GS801 eye Mkp3hs.sev eye, with Scer\GAL4hs.2sev Mkp31 Mkp311 Mkp32 Mkp33 Mkp34 eye photoreceptor cell Mkp3hs.sev eye photoreceptor cell | supernumerary (with Mkp31), with Scer\GAL4[-]: Mkp32 eye photoreceptor cell | supernumerary (with Mkp32), with Scer\GAL4[-]: Mkp31 ganglionic branch primordium, with Scer\GAL4btl.PS Mkp3GS801 macrochaeta, with Scer\GAL4sca-C253 Mkp3GSM76 mesothoracic tergum, with Scer\GAL4bs-1348 Mkp3GSM76 midgut, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B Mkp3Scer\UAS.cRa photoreceptor cell, with Scer\GAL4hs.2sev Mkp3Scer\UAS.cRa photoreceptor cell R3, with Scer\GAL4hs.2sev Mkp3Scer\UAS.cRa photoreceptor cell R3 (with Mkp31), with Scer\GAL4[-]: Mkp32 photoreceptor cell R3 (with Mkp32), with Scer\GAL4[-]: Mkp31 photoreceptor cell R4, with Scer\GAL4hs.2sev Mkp3Scer\UAS.cRa photoreceptor cell R4 (with Mkp31), with Scer\GAL4[-]: Mkp32 photoreceptor cell R4 (with Mkp32), with Scer\GAL4[-]: Mkp31 photoreceptor cell R7 | supernumerary (with Mkp31), with Scer\GAL4[-]: Mkp32 photoreceptor cell R7 | supernumerary (with Mkp32), with Scer\GAL4[-]: Mkp31 tracheal branch primordium Mkp3M76-R2b tracheal branch primordium, with Scer\GAL469B Mkp3GS801 tracheal branch primordium, with Scer\GAL4arm.PS Mkp3GS801 tracheal branch primordium, with Scer\GAL4btl.PS Mkp3GSM76 Mkp3GS801 Mkp3GS10283 tracheal branch primordium, with Scer\GAL4ptc-559.1 Mkp3GS801 tracheolar cell, with Scer\GAL469B Mkp3GS801 tracheolar cell, with Scer\GAL4arm.PS Mkp3GS801 tracheolar cell, with Scer\GAL4btl.PS Mkp3GS801 tracheolar cell, with Scer\GAL4ptc-559.1 Mkp3GS801 wing, with Scer\GAL4MD-638 Mkp3GSM76 wing hinge, with Scer\GAL4MD-638 Mkp3GSM76 wing vein, with Scer\GAL4en-GAL4-33 Mkp3Scer\UAS.cRa wing vein | ectopic Mkp3M76-R2b Mkp3M76-M wing vein | ectopic (with Mkp3M76-M) Mkp3M76-R2b wing vein | ectopic (with Mkp3M76-R2b) Mkp3M76-M wing vein | supernumerary (with Mkp31), with Scer\GAL4[-]: Mkp32 wing vein | supernumerary (with Mkp32), with Scer\GAL4[-]: Mkp31 wing vein L2, with Scer\GAL4dpp.3KK Mkp3GSM76 wing vein L2, with Scer\GAL4salm-459.2 Mkp3GSM76 wing vein L3, with Scer\GAL4dpp.3KK Mkp3GSM76 wing vein L3, with Scer\GAL4Mkp3-NP3460 Mkp3GSM76 wing vein L4, with Scer\GAL4dpp.3KK Mkp3GSM76 wing vein L4, with Scer\GAL4Mkp3-NP3460 Mkp3GSM76 wing vein L4, with Scer\GAL4salm-459.2 Mkp3GSM76 wing vein L5, with Scer\GAL4dpp.3KK Mkp3GSM76 wing vein L5, with Scer\GAL4Mkp3-NP3460 Mkp3GSM76
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of Mkp3 Class Mutagen Stocks Known lesion Mkp3KG09109 2 -- Mkp35-SZ-3489 1 -- Mkp3d01703 P-element activity 1 -- Mkp3d08832 P-element activity 1 -- Mkp3e01205 piggyBac transposase 1 -- Mkp3e01514 1 -- Mkp3EY02009a P-element activity 1 -- Mkp3f03498 piggyBac transposase 1 -- Mkp3f05234 piggyBac transposase 1 -- Mkp3MI02654 1 -- Mkp3NP3460 P-element activity 1 -- Mkp3UM-8314-3 1 -- Mkp310 ethyl methanesulfonate 0 Yes Mkp311 Delta2-3 0 Yes Mkp31 loss of function allele Delta2-3 0 Yes Mkp32 loss of function allele Delta2-3 0 Yes Mkp33 loss of function allele Delta2-3 0 Yes Mkp34 loss of function allele Delta2-3 0 Yes Mkp35 ethyl methanesulfonate 0 Yes Mkp35J4 P-element activity 0 Yes Mkp36 ethyl methanesulfonate 0 Yes Mkp37 ethyl methanesulfonate 0 Yes Mkp38 ethyl methanesulfonate 0 Yes Mkp39 ethyl methanesulfonate 0 Yes Mkp3c02582 piggyBac transposase 0 -- Mkp3c05137 piggyBac transposase 0 -- Mkp3d09294 P-element activity 0 -- Mkp3GS.S P-element activity 0 Yes Mkp3GS10283 0 -- Mkp3GS160 P-element activity 0 Yes Mkp3GS801 0 -- Mkp3GSM76 0 -- Mkp3M76-M loss of function allele ethyl methanesulfonate 0 Yes Mkp3M76-R2b loss of function allele ethyl methanesulfonate 0 Yes Mkp3P3 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mkp3 Class Mutagen Stocks Known lesion Mkp3GD8219 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Mkp3Act5C.PK in vitro construct - regulatory fusion 0 Yes Mkp3Act5C.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mkp3CA.Act5C.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Mkp3CA.Act5C in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3CA.MtnA.T:SV5\V5 in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Mkp3CA.RR.Act5C in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3CA.RR.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3dsRNA.cKa in vitro construct - RNAi 0 Yes Mkp3hs.sev in vitro construct - regulatory fusion 0 Yes Mkp3MtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Mkp3RR.Act5C.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3RR.Act5C in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3RR.MtnA.T:SV5\V5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Mkp3Scer\UAS.cRa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8219} NA P{UAS-Mkp3.R} NA heat-shock construct P{hs-sev-Mkp3.R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MESR6EP3142 NA P{EP}Mkp31 NA P{EP}Mkp32 NA P{EP}Mkp33 NA P{EP}Mkp34 NA P{EP}Mkp311 NA P{EPgy2}EY02009b NA P{EPgy2}Mkp3EY02009a NA P{GSV1}EP-160EP-160 NA P{GSV1}Mkp3GS160 NA P{GSV1}Mkp3GS801 NA P{GSV1}Mkp3GS.S NA P{GSV1}Mkp3GSM76 NA P{GSV6}Mkp3GS10283 NA P{XP}Mkp3d01703 NA P{XP}Mkp3d08832 NA P{XP}Mkp3d09294 NA miscellaneous insertions Mi{MIC}Mkp3MI02654 NA P{RS3}Mkp3UM-8314-3 NA P{RS5}Mkp35-SZ-3489 NA P{SUPor-P}KG04065 NA P{SUPor-P}Mkp3KG09109 NA PBac{PB}Mkp3c02582 NA PBac{PB}Mkp3c05137 NA PBac{RB}Mkp3e01205 NA PBac{RB}Mkp3e01514 NA PBac{WH}Mkp3f03498 NA PBac{WH}Mkp3f05234 NA insertion of enhancer trap binary system P{GawB}Mkp3NP3460 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
phosphatase activity inferred from direct assay (Kim et al., 2002)
Biological Process
CV term Evidence References
cell-cell adhesion inferred from mutant phenotype (Cela and Llimargas, 2006) imaginal disc-derived wing vein specification inferred from mutant phenotype (Gomez et al., 2005) maintenance of epithelial integrity, open tracheal system inferred from mutant phenotype (Cela and Llimargas, 2006) mucosal immune response inferred from mutant phenotype (Ha et al., 2009) negative regulation of MAPKKK cascade inferred from mutant phenotype (Gomez et al., 2005) primary branching, open tracheal system inferred from mutant phenotype (Cela and Llimargas, 2006) protein dephosphorylation inferred from direct assay (Kim et al., 2002) regulation of cell proliferation inferred from genetic interaction with Egfr (Jiang and Edgar, 2009)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Kim et al., 2002)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
MAP kinase tyrosine/serine/threonine phosphatase activity inferred from sequence or structural similarity with EMBL:U43223 (FlyBase, 1992-) protein tyrosine/serine/threonine phosphatase activity inferred from sequence or structural similarity with EMBL:U43223 (FlyBase, 1992-) non-traceable author statement (Morrison et al., 2000) protein tyrosine phosphatase activity inferred from electronic annotation with InterPro:IPR014393 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein dephosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mkp3 allele Gene References Mkp31 Egfr (Rintelen et al., 2003) PTP-ER (Rintelen et al., 2003) rl (Rintelen et al., 2003) Mkp32 Egfr (Rintelen et al., 2003) PTP-ER (Rintelen et al., 2003) rl (Rintelen et al., 2003) Mkp35J4 PTP-ER (Rintelen et al., 2003) Mkp3hs.sev rl (Rintelen et al., 2003) sev (Rintelen et al., 2003) unspecified btl (Cela and Llimargas, 2006) rl (Gomez et al., 2005, Cela and Llimargas, 2006)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036844 DroID - A comprehensive database of gene and protein interactions. • FBgn0036844 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40081
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10784 Dere\GG13428 Dgri\GH16949 Dmoj\GI11809 Dper\GL21927 Dpse\GA12750 Dsec\GM14895 Dsim\GD12305 Dvir\GJ13512 Dwil\GK12504 Dyak\GE22525
Curated drosophilid orthologs	Dpse\GA12750
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001145-PA Aedes aegypti (mosquito) AGAP012237-PA Anopheles gambiae (mosquito) XP_001943978.1 Acyrthosiphon pisum (pea aphid) At2g04550.1 Arabidopsis thaliana (wall cress) 261371 Branchiostoma floridae (lancelet) BGIBMGA004701-PA Bombyx mori (silk worm) ENSBTAP00000029212 Bos taurus (bovine) CBP32416 Caenorhabditis briggsae (nematode) CE31151 Caenorhabditis elegans (worm) ENSCAFP00000014564 Canis familiaris (dog) ENSCINP00000016341 Ciona intestinalis (sea squirt) CPIJ005718 Culex pipens (mosquito) ENSCPOP00000006065 Cavia porcellus (guinea pig) RP08880 Caenorhabditis remanei (nematode) ENSCSAVP00000014473 Ciona savignyi (sedentary tunicate) 182593 Capitella spl (polychaete worm) DDB0238478 Dictyostelium discoideum (amoeba) 3151 Daphnia pulex (daphnia) ENSDARP00000095325 Danio rerio (zebra fish) ENSECAP00000021949 Equus caballus (horse) ENSGACP00000009316 Gymnopilus aculeatus (mushroom) ENSGALP00000037562 Gallus gallus (chicken) 86834 Hypsipyla robusta (cedar shoot borer) ENSP00000296483 Homo sapiens (human) ISCW007877-PA Ixodes scapularis (deer tick) 113325 Lottia gigantea (owl limpet) 8130 Monocosta brevicollis (choanoflagellate) ENSMODP00000014700 Monodelphis domestica (gray opossum) ENSMMUP00000007008 Macaca mulatta (rhesus monkey) ENSMUSP00000070194 Mus musculus (house mouse) 92609 Nematostella vectensis (starlet anemone) XP_001606103.1 Nasonia vitripennis (wasp) ENSOANP00000023391 Ornithorynchus anatinus (platypus) ENSORLP00000005992 Oryzias latipes (japanese killifish) PHUM001408-PA Pediculus humanus (human body louse) ENSPPYP00000005492 Pongo pygmaeus (orangutan) 130461 Phytophthora sojae (root rot pathogen) ENSPTRP00000025876 Pan troglodytes (chimpanzee) ENSRNOP00000014770 Rattus norvegicus (norway rat) XP_794377.1 Strongylocentrotus purpuratus (purple sea urchin) 59016 Trichoplax adhaerens (metazoa) XP_971654.2 Tribolium castaneum (red flour beetle) ENSTNIP00000017858 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019330 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047332 Xenopus tropicalis (frog) YALI0F00858g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10161 LH11144 ISCW007877 FBgn0239989 FBgn0239744 FBgn0214514 FBgn0200736 FBgn0184039 FBgn0169816 JGI_V11_3151 FBgn0072796 FBgn0159520 FBgn0134568 FBgn0124420 FBgn0120109 FBgn0105700 FBgn0087824 CPIJ005718 BGIBMGA004701 ACYPI009654 GB10863 AGAP012237 AAEL001145 PB21509 PHUM046720 GLEAN_12676
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	36023 y1 w*; Mi{MIC}Mkp3MI02654
Harvard	- P{XP}Mkp3d01703 - P{XP}Mkp3d08832 - PBac{RB}Mkp3e01205 - PBac{RB}Mkp3e01514 - PBac{WH}Mkp3f03498 - PBac{WH}Mkp3f05234
Kyoto	104513 w*; P{GawB}Mkp3NP3460 124475 w1118; P{RS3}Mkp3UM-8314-3 126095 w1118; P{RS5}Mkp35-SZ-3489
VDRC	v23911 w1118 P{GD8219}v23911 v45415 w1118; P{GD8219}v45415
	More stocks available...
Genomic Clones ( 1 )
	BACR48M06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE08706 SD06439
Other clones	DPiM_RE08706
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27844 LD02618 RE07150 RE19640 RE37942 RE60593 RE60842 RE64291 RE71634 SD27763
Other clones	21281 47280 76476 103885 145218 149587 154280 159249 172713 CK01.14C.G5 CK01.32B.G7 CK01.32D.E6 CK01.102A.F1 CK01.146A.E3 Dmel_neb_010605_0858_0756 Dmel_neb_011785_0950_0392 EC052231 EC052336 EK075501 EK075505 EK086021 EK119918 EK135452 EK175142 EK206546 EK227135 EK252615 EK258430 EK262317 EK273413 EK293002 FGC030D03 FGH115A10 FGM003D08 GM13896 IP02080
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036844 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40081
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mkp3 CG14081 (FlyBase, 1996-)
Additional comments	Source for merge of Mkp3 CG14081 was sequence comparison (date:020814). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140830 NM_168785 RefSeq (Proteins) • NP_649087 NP_730385 DDBJ / EMBL / GenBank • AA938844 AAF49192 AAF49193 AAK85311 AAL25511 AAO39540 AI534012 AW944456 AY043264 AY060472 BG637604 BI168143 BT003536 CZ468044 CZ469758 CZ472387 CZ476430 CZ476431 CZ476662 CZ479014 CZ486069 CZ486070 CZ487865 Entrez Gene - A searchable database of RefSeq genes. • 40081 UniProtKB/TrEMBL • Q9VVW5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) Protein-tyrosine/Dual-specificity phosphatase (IPR000387) Rhodanese-like (IPR001763) MAP kinase phosphatase (IPR008343) Dual specificity protein phosphatase (MAP kinase phosphatase) (IPR014393) Dual specificity phosphatase, subgroup, catalytic domain (IPR020422)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036844 DroID - A comprehensive database of gene and protein interactions. • FBgn0036844 DRSC - Results from RNAi screens. • FBgn0036844 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036844 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14080-RA;CG14080-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036844 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40081 InParanoid A subset of ortholog calls from InParanoid. • AAEL001145-PA Aedes aegypti (mosquito) AGAP012237-PA Anopheles gambiae (mosquito) XP_001943978.1 Acyrthosiphon pisum (pea aphid) At2g04550.1 Arabidopsis thaliana (wall cress) 261371 Branchiostoma floridae (lancelet) BGIBMGA004701-PA Bombyx mori (silk worm) ENSBTAP00000029212 Bos taurus (bovine) CBP32416 Caenorhabditis briggsae (nematode) CE31151 Caenorhabditis elegans (worm) ENSCAFP00000014564 Canis familiaris (dog) ENSCINP00000016341 Ciona intestinalis (sea squirt) CPIJ005718 Culex pipens (mosquito) ENSCPOP00000006065 Cavia porcellus (guinea pig) RP08880 Caenorhabditis remanei (nematode) ENSCSAVP00000014473 Ciona savignyi (sedentary tunicate) 182593 Capitella spl (polychaete worm) DDB0238478 Dictyostelium discoideum (amoeba) 3151 Daphnia pulex (daphnia) ENSDARP00000095325 Danio rerio (zebra fish) ENSECAP00000021949 Equus caballus (horse) ENSGACP00000009316 Gymnopilus aculeatus (mushroom) ENSGALP00000037562 Gallus gallus (chicken) 86834 Hypsipyla robusta (cedar shoot borer) ENSP00000296483 Homo sapiens (human) ISCW007877-PA Ixodes scapularis (deer tick) 113325 Lottia gigantea (owl limpet) 8130 Monocosta brevicollis (choanoflagellate) ENSMODP00000014700 Monodelphis domestica (gray opossum) ENSMMUP00000007008 Macaca mulatta (rhesus monkey) ENSMUSP00000070194 Mus musculus (house mouse) 92609 Nematostella vectensis (starlet anemone) XP_001606103.1 Nasonia vitripennis (wasp) ENSOANP00000023391 Ornithorynchus anatinus (platypus) ENSORLP00000005992 Oryzias latipes (japanese killifish) PHUM001408-PA Pediculus humanus (human body louse) ENSPPYP00000005492 Pongo pygmaeus (orangutan) 130461 Phytophthora sojae (root rot pathogen) ENSPTRP00000025876 Pan troglodytes (chimpanzee) ENSRNOP00000014770 Rattus norvegicus (norway rat) XP_794377.1 Strongylocentrotus purpuratus (purple sea urchin) 59016 Trichoplax adhaerens (metazoa) XP_971654.2 Tribolium castaneum (red flour beetle) ENSTNIP00000017858 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000019330 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047332 Xenopus tropicalis (frog) YALI0F00858g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40081 modMine - Data generated by the modENCODE project. • FBgn0036844 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10161 LH11144 ISCW007877 FBgn0239989 FBgn0239744 FBgn0214514 FBgn0200736 FBgn0184039 FBgn0169816 JGI_V11_3151 FBgn0072796 FBgn0159520 FBgn0134568 FBgn0124420 FBgn0120109 FBgn0105700 FBgn0087824 CPIJ005718 BGIBMGA004701 ACYPI009654 GB10863 AGAP012237 AAEL001145 PB21509 PHUM046720 GLEAN_12676
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG14080 (Molnar et al., 2006, Zimmermann et al., 2006) CG14081 (Kim et al., 2004) Dmkp3 (Rintelen et al., 2003) DMKP-3 (Kwon et al., 2002, Kim et al., 2002, Kim et al., 2004, Lee et al., 2008) Mkp3 (Cela and Llimargas, 2006, Ha et al., 2009, de Navascués and Modolell, 2007, Molnar et al., 2006, Mogila et al., 2006, Bruinsma et al., 2007, Franciscovich et al., 2008, Jiang and Edgar, 2009, Hurlbut et al., 2009, Buchon et al., 2009, Liu et al., 2008, Ha et al., 2009) MKP3 (Sotillos and De Celis, 2005, Gomez et al., 2005, Arancio et al., 2010, Terriente-Félix and de Celis, 2009, Lievens et al., 2005, Buchon et al., 2010, Jiang et al., 2011) mkp3 (Krejcí et al., 2009, Chang et al., 2008) mkp-3 (Helman et al., 2011) unnamed (Walchli et al., 2000)
Name Synonym	Drosophila MKP-3 (Kim et al., 2004) MAP Kinase Phosphatase 3 (Cela and Llimargas, 2006, Jiang et al., 2011) Map kinase phosphatase 3 (Hurlbut et al., 2009) MAPK phosphatase-3 (Sotillos and De Celis, 2005) MAPK phosphatase 3 (Buchon et al., 2010) Mitogen-activated protein kinase phosphatase 3 (Kim et al., 2002, Morozova et al., 2007) MKP-3-like (Choi, 2001.6.30) MKP-like (Morrison et al., 2000)
Secondary FlyBase IDs
	FBgn0036845
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Helman et al., 2011, Curr. Biol. 21(13): 1102--1110 Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression. [FBrf0214255] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...