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Gene Dmel\CG7770

General Information
Symbol	Dmel\CG7770	Species	D. melanogaster
Name		Annotation symbol	CG7770
Feature type	protein_coding_gene	FlyBase ID	FBgn0036918
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	76D4-76D5	Sequence location	3L:19,916,771..19,917,788 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG7770 (FBgn0036918). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: chaperone binding. There is experimental evidence that it is involved in the biological process: neurogenesis. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Prefoldin; Prefoldin beta-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635177_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG7770. Gene sequence location is 3L:19916771..19917788.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76D4-76D5   Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG7770 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG7770-RA FBtr0074894  NM_140902   650   125 CG7770-RB FBtr0330181  NM_001275150   847   125
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG7770-PA   FBpp0074663   14.4   125   8.80     NP_649159   AAF49093 CG7770-PB   FBpp0303214   14.4   125   8.80     NP_001262079   AGB94772
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin beta-like (IPR002777) Prefoldin (IPR009053)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA804008   AE014296 AAF49093   AE014296 AGB94772   AI517554   AI531979   AI945225   AI946359   AY118830 AAM50690   AY232131   BF488690   BI366717   BP544277   BP546238   BP552403   BP559073   CK660825   CO183349   CO187099   CO189179   CO195431   CO195477   CO272541   CO282439   CO290151   CO310237   CO320100   CO324893   EC071849   EC083897   EC090000   EC195392   EC202056   EC206430   EC226876   EC244741
UniProtKB/Swiss-Prot	Q9VW56
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with prefoldin complex inferred from direct assay (Guruharsha et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (644.2) Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea  (665.125) Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary  (697.9) Adult Testis  (751.6) Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea  665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary  697.9 Adult Testis  751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    644.2 Larval Midgut    293.8 Larval Hindgut    389.6 Larval Malpighian Tubules    304 Larval Fat Body    248.2 Larval Salivary Gland    491.4 Larval Trachea    665.125 Larval Carcass    493.525 Adult Head    343.6 Adult Eye    435.225 Adult Brain    403.8 Adult Thoracic-Abdominal Ganglion    373.5 Adult Crop    434.4 Adult Midgut    366.4 Adult Hindgut    381 Adult Malpighian Tubules    152.4 Adult Fat Body    229.6 Adult Salivary Gland    310.6 Adult Heart    267.325 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    175.4 Adult Ovary    697.9 Adult Testis    751.6 Adult Male Accessory Gland    378 Adult Carcass    185.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    343.6   NA  Eye    435.225   NA  Brain    403.8   644.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    373.5   NA  Crop    434.4   293.8  Midgut    366.4   389.6  Hindgut    381   304  Malpighian Tubules    152.4   248.2  Fat Body    229.6   491.4  Salivary Gland    310.6   NA  Heart    267.325   665.125  Trachea    NA   NA  VirginFemale Spermatheca    153.6   NA  InseminatedFemale Spermatheca    175.4   NA  Ovary    697.9   NA  Testis    751.6   NA  Male Accessory Gland    378   493.525  Carcass    185.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female    120 ovary, mated 4-day female    104 testis, mated 4-day male    319 accessory gland, mated 4-day male    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3  (106) central nervous system, pupae P8  (89) head, virgin 1-day female  (42) head, virgin 4-day female  (34) head, virgin 20-day female  (29) head, mated 1-day female  (32) head, mated 4-day female  (37) head, mated 20-day female  (29) head, mated 1-day male  (54) head, mated 4-day male  (58) head, mated 20-day male  (61) salivary gland, larvae L3 wandering  (32) salivary gland, white prepupae  (32) digestive system, larvae L3 wandering  (60) digestive system, 1-day adult  (65) digestive system, 4-day adult  (59) digestive system, 20-day adult  (41) fat body, larvae L3 wandering    19 fat body, white prepupae  (47) fat body, pupae P8  (85) carcass, larvae L3 wandering  (73) carcass, 1-day adult  (29) carcass, 4-day adult  (40) carcass, 20-day adult  (34) ovary, virgin 4-day female  (120) ovary, mated 4-day female  (104) testis, mated 4-day male  (319) accessory gland, mated 4-day male  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3  106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female  (120) ovary, mated 4-day female  104 testis, mated 4-day male  (319) accessory gland, mated 4-day male    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female    120 ovary, mated 4-day female    104 testis, mated 4-day male    319 accessory gland, mated 4-day male    71 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female    120 ovary, mated 4-day female    104 testis, mated 4-day male    319 accessory gland, mated 4-day male    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (114) central nervous system, larvae L3  (106) central nervous system, pupae P8  (89) head, virgin 1-day female  (42) head, virgin 4-day female  (34) head, virgin 20-day female  29 head, mated 1-day female  32 head, mated 4-day female  (37) head, mated 20-day female  29 head, mated 1-day male  (54) head, mated 4-day male  (58) head, mated 20-day male  (61) salivary gland, larvae L3 wandering  32 salivary gland, white prepupae  32 digestive system, larvae L3 wandering  (60) digestive system, 1-day adult  (65) digestive system, 4-day adult  (59) digestive system, 20-day adult  (41) fat body, larvae L3 wandering    19 fat body, white prepupae  (47) fat body, pupae P8  (85) carcass, larvae L3 wandering  (73) carcass, 1-day adult  29 carcass, 4-day adult  (40) carcass, 20-day adult  (34) ovary, virgin 4-day female  (120) ovary, mated 4-day female  (104) testis, mated 4-day male  (319) accessory gland, mated 4-day male  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  114 central nervous system, larvae L3  106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female  120 ovary, mated 4-day female  104 testis, mated 4-day male  (319) accessory gland, mated 4-day male    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    114 central nervous system, larvae L3    106 central nervous system, pupae P8    89 head, virgin 1-day female    42 head, virgin 4-day female    34 head, virgin 20-day female    29 head, mated 1-day female    32 head, mated 4-day female    37 head, mated 20-day female    29 head, mated 1-day male    54 head, mated 4-day male    58 head, mated 20-day male    61 salivary gland, larvae L3 wandering    32 salivary gland, white prepupae    32 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    65 digestive system, 4-day adult    59 digestive system, 20-day adult    41 fat body, larvae L3 wandering    19 fat body, white prepupae    47 fat body, pupae P8    85 carcass, larvae L3 wandering    73 carcass, 1-day adult    29 carcass, 4-day adult    40 carcass, 20-day adult    34 ovary, virgin 4-day female    120 ovary, mated 4-day female    104 testis, mated 4-day male    319 accessory gland, mated 4-day male    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (64) embryo 02-04hr  (34) embryo 04-06hr  (58) embryo 06-08hr  (57) embryo 08-10hr  (62) embryo 10-12hr  (89) embryo 12-14hr  (60) embryo 14-16hr  (36) embryo 16-18hr  (48) embryo 18-20hr  (41) embryo 20-22hr  (39) embryo 22-24hr  (41) larva L1  (54) larva L2  (67) larva L3 12hr old  (56) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (53) white prepupae new  (46) white prepupae 12hr  (50) white prepupae 24hr  (62) pupae 2d postWPP  (69) pupae 3d postWPP  (67) pupae 4d postWPP  (29) adult male 01day  (46) adult male 05day  (55) adult male 30day  (42) adult female 01day  (31) adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (64) embryo 02-04hr  (34) embryo 04-06hr  (58) embryo 06-08hr  (57) embryo 08-10hr  (62) embryo 10-12hr  (89) embryo 12-14hr  (60) embryo 14-16hr  (36) embryo 16-18hr  (48) embryo 18-20hr  (41) embryo 20-22hr  (39) embryo 22-24hr  (41) larva L1  (54) larva L2  (67) larva L3 12hr old  (56) larva L3 puffstage 1-2  (39) larva L3 puffstage 3-6  (40) larva L3 puffstage 7-9  (53) white prepupae new  (46) white prepupae 12hr  (50) white prepupae 24hr  (62) pupae 2d postWPP  (69) pupae 3d postWPP  (67) pupae 4d postWPP  29 adult male 01day  (46) adult male 05day  (55) adult male 30day  (42) adult female 01day  31 adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    64 embryo 02-04hr    34 embryo 04-06hr    58 embryo 06-08hr    57 embryo 08-10hr    62 embryo 10-12hr    89 embryo 12-14hr    60 embryo 14-16hr    36 embryo 16-18hr    48 embryo 18-20hr    41 embryo 20-22hr    39 embryo 22-24hr    41 larva L1    54 larva L2    67 larva L3 12hr old    56 larva L3 puffstage 1-2    39 larva L3 puffstage 3-6    40 larva L3 puffstage 7-9    53 white prepupae new    46 white prepupae 12hr    50 white prepupae 24hr    62 pupae 2d postWPP    69 pupae 3d postWPP    67 pupae 4d postWPP    29 adult male 01day    46 adult male 05day    55 adult male 30day    42 adult female 01day    31 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    264 Schneider line 2 Sg4    233 embryonic 1182-4H    107 embryonic GM2    152 embryonic Kc167    162 embryonic S1    122 embryonic S3    105 leg disc CME L1    186 wing disc CME-W2    175 wing disc ML-DmD8    105 wing disc ML-DmD9    139 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    312 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC    158 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (264) Schneider line 2 Sg4  (233) embryonic 1182-4H  (107) embryonic GM2  (152) embryonic Kc167  (162) embryonic S1  (122) embryonic S3  (105) leg disc CME L1  (186) wing disc CME-W2  (175) wing disc ML-DmD8  (105) wing disc ML-DmD9  (139) wing disc ML-DmD16-c3  (94) wing disc ML-DmD21  (312) wing disc ML-DmD32  (73) haltere disc ML-DmD17-c3  (103) eye-antennal disc ML-DmD11  (99) antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1  (92) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (90) tumorous blood cells mbn2  (91) ovary fGS/OSS  (91) ovary OSC  (158) ovary OSS  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (264) Schneider line 2 Sg4  (233) embryonic 1182-4H  107 embryonic GM2  (152) embryonic Kc167  (162) embryonic S1  (122) embryonic S3  105 leg disc CME L1  (186) wing disc CME-W2  (175) wing disc ML-DmD8  105 wing disc ML-DmD9  (139) wing disc ML-DmD16-c3    94 wing disc ML-DmD21  (312) wing disc ML-DmD32    73 haltere disc ML-DmD17-c3  103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC  (158) ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    264 Schneider line 2 Sg4    233 embryonic 1182-4H    107 embryonic GM2    152 embryonic Kc167    162 embryonic S1    122 embryonic S3    105 leg disc CME L1    186 wing disc CME-W2    175 wing disc ML-DmD8    105 wing disc ML-DmD9    139 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    312 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC    158 ovary OSS    62 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    264 Schneider line 2 Sg4    233 embryonic 1182-4H    107 embryonic GM2    152 embryonic Kc167    162 embryonic S1    122 embryonic S3    105 leg disc CME L1    186 wing disc CME-W2    175 wing disc ML-DmD8    105 wing disc ML-DmD9    139 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    312 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC    158 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (264) Schneider line 2 Sg4  (233) embryonic 1182-4H  (107) embryonic GM2  (152) embryonic Kc167  (162) embryonic S1  (122) embryonic S3  (105) leg disc CME L1  (186) wing disc CME-W2  (175) wing disc ML-DmD8  (105) wing disc ML-DmD9  (139) wing disc ML-DmD16-c3  (94) wing disc ML-DmD21  (312) wing disc ML-DmD32  (73) haltere disc ML-DmD17-c3  (103) eye-antennal disc ML-DmD11  (99) antennal disc ML-DmD20-c5  (134) mixed discs ML-DmD4-c1  (92) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (90) tumorous blood cells mbn2  (91) ovary fGS/OSS  (91) ovary OSC  (158) ovary OSS  (62) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (264) Schneider line 2 Sg4  (233) embryonic 1182-4H  107 embryonic GM2  (152) embryonic Kc167  (162) embryonic S1  122 embryonic S3  105 leg disc CME L1  (186) wing disc CME-W2  (175) wing disc ML-DmD8  105 wing disc ML-DmD9  139 wing disc ML-DmD16-c3    94 wing disc ML-DmD21  (312) wing disc ML-DmD32    73 haltere disc ML-DmD17-c3  103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5  134 mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC  (158) ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    264 Schneider line 2 Sg4    233 embryonic 1182-4H    107 embryonic GM2    152 embryonic Kc167    162 embryonic S1    122 embryonic S3    105 leg disc CME L1    186 wing disc CME-W2    175 wing disc ML-DmD8    105 wing disc ML-DmD9    139 wing disc ML-DmD16-c3    94 wing disc ML-DmD21    312 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    103 eye-antennal disc ML-DmD11    99 antennal disc ML-DmD20-c5    134 mixed discs ML-DmD4-c1    92 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    90 tumorous blood cells mbn2    91 ovary fGS/OSS    91 ovary OSC    158 ovary OSS    62 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (48) cold shock, 4-day adult  (35) heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  (94) Cadmium 50 mM 12 hrs, larvae L3  (82) Cadmium 50 mM 48 hrs, 4-day adult  (73) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3  (50) Copper 15 mM 48 hrs, 4-day adult  (91) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (75) Ethanol 10% 3 hrs, larvae L3  (67) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (46) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (84) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3  (96) Rotenone 8 μg 12 hrs, larvae L3  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (48) cold shock, 4-day adult  (35) heat shock, 4-day adult  (70) Cadmium 50 mM 6 hrs, larvae L3  (94) Cadmium 50 mM 12 hrs, larvae L3  (82) Cadmium 50 mM 48 hrs, 4-day adult  (73) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3  (50) Copper 15 mM 48 hrs, 4-day adult  (91) Zinc 5 mM 12 hrs, larvae L3  (52) Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  (79) Ethanol 5% 3 hrs, larvae L3  (75) Ethanol 10% 3 hrs, larvae L3  (67) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (46) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (84) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (96) Paraquat 10 mM 48 hrs, 4-day adult  (70) Rotenone 2 μg 12 hrs, larvae L3  (96) Rotenone 8 μg 12 hrs, larvae L3  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    35 heat shock, 4-day adult    70 Cadmium 50 mM 6 hrs, larvae L3    94 Cadmium 50 mM 12 hrs, larvae L3    82 Cadmium 50 mM 48 hrs, 4-day adult    73 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    91 Zinc 5 mM 12 hrs, larvae L3    52 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    79 Ethanol 5% 3 hrs, larvae L3    75 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    46 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    84 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    96 Paraquat 10 mM 48 hrs, 4-day adult    70 Rotenone 2 μg 12 hrs, larvae L3    96 Rotenone 8 μg 12 hrs, larvae L3    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH28557 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7770-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CG7770GD10604 lethal, with Scer\GAL4pnr-MD237 CG7770GD10604 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG7770GD10604 Other Phenotypes Allele neuroanatomy defective | larval stage CG7770GD10604 Phenotype manifest in Allele ganglion mother cell | larval stage CG7770GD10604
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG7770 Class Mutagen Stocks Known lesion CG7770G5054 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG7770 Class Mutagen Stocks Known lesion CG7770GD10604 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG7770KK108999 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG7770NIG.7770R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10604} NA P{KK108999} NA P{NIG.7770R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG7770G5054 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
colocalizes_with prefoldin complex inferred from direct assay (Guruharsha et al., 2011)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
chaperone binding inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) unfolded protein binding inferred from electronic annotation with InterPro:IPR002777 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
'de novo' protein folding inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) protein folding inferred from electronic annotation with InterPro:IPR002777 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
prefoldin complex inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG7770 - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - CG10252 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG7770 - CG10635 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG7770 - CG13900 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - CG13993 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG7770 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - CG7048 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG7770 - CG8617 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG7770 - CoVb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - Gαq anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - KFase experimental knowledge based (Guruharsha et al., 2011) CG7770 - Pi4KIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - cbx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG7770 - l(3)01239 experimental knowledge based (Guruharsha et al., 2011) CG7770 - mgr experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG7770 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65443 DroID - A comprehensive database of gene and protein interactions. • FBgn0036918 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40176
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6K9BZV Dipteran inclusive ortholog search EOG6FN4T5 Insect inclusive ortholog search EOG6C86Q3 Arthropod inclusive ortholog search EOG6VX0NV Metazoa inclusive ortholog search EOG6VF2V2
Orthologs in Drosophila Species (EOG6K9BZV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG7770     Drosophila simulans   Dsim\GD14838 Y   Drosophila sechellia   Dsec\GM19687 Y   Drosophila erecta   Dere\GG16068 Y   Drosophila yakuba   Dyak\GE19635 Y   Drosophila ananassae   Dana\GF23604 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20575 Y   Drosophila persimilis   Dper\GL22669 Y   Drosophila willistoni   Dwil\GK16968 Y   Drosophila virilis   Dvir\GJ13994 Y   Drosophila mojavensis   Dmoj\GI13658 Y   Drosophila grimshawi   Dgri\GH16329 Y
Orthologs in non-Drosophila Dipterans (EOG6FN4T5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001103   Anopheles gambiae Malaria mosquito  Agam\AGAP012235   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005722
Orthologs in non-Dipteran Insects (EOG6C86Q3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552807   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG026653   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18071   Atta cephalotes Leafcutter ant  Acep\ACEP19449   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17116   Linepithema humile Argentine ant  Lhum\LH12070   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12064   Solenopsis invicta Red fire ant  Sinv\SINV13693   Solenopsis invicta Red fire ant  Sinv\SINV12909   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009995   Bombyx mori Silkmoth  Bmor\BGIBMGA006474   Pediculus humanus Human body louse  Phum\PHUM130930   Tribolium castaneum Red flour beetle  Tcas\TC000098
Orthologs in non-Insect Arthropods (EOG6VX0NV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ndhF   Ixodes scapularis Deer tick  Isca\ISCW010951
Orthologs in non-Arthropod Metazoa (EOG6VF2V2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pfd-6   Danio rerio Zebrafish  Drer\pfdn6   Xenopus tropicalis Western clawed frog  Xtro\pfdn6   Mus musculus House mouse  Mmus\H2-Ke2   Rattus norvegicus Norway rat  Rnor\Pfdn6   Homo sapiens Human  Hsap\PFDN6
Human Orthologs (1)
Gene OMIM HGNC Hsap\PFDN6
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14838 Drosophila sechellia Dsec\GM19687 Drosophila erecta Dere\GG16068 Drosophila yakuba Dyak\GE19635 Drosophila ananassae Dana\GF23604 Drosophila pseudoobscura pseudoobscura Dpse\GA20575 Drosophila persimilis Dper\GL22669 Drosophila willistoni Dwil\GK16968 Drosophila virilis Dvir\GJ13994 Drosophila mojavensis Dmoj\GI13658 Drosophila grimshawi Dgri\GH16329
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27476 y1 w*; P{EP}CG7770G5054
VDRC	v101541 P{KK108999}VIE-260B v34203 w1118; P{GD10604}v34203 v34204 w1118; P{GD10604}v34204
Genomic Clones ( 1 )
	BACR13N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 32 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH28557
Other clones	yak-ad_CG7770
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM12515 LP19721 RE52313 SD03302
Other clones	8789 30982 33516 98308 161591 177325 AT24225 bs10d06 bs24c04 CK01.29D.B6 CK01.53D.B10 EC25539 EC40329 EC40446 EK026230 EK043339 EK073207 EK107545 EK160502 EK195109 EK220842 EK282228 FGC025A05 FGH104C07 FGM218E11 FGM318G03
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40176
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG7770 BcDNA:GH28557 (FlyBase, 1996-)
Additional comments	Source for merge of CG7770 BcDNA:GH28557 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140902 NM_001275150 RefSeq (Proteins) • NP_649159 NP_001262079 DDBJ / EMBL / GenBank • AAF49093 AAM50690 AGB94772 AI517554 AI945225 AI946359 AY118830 Entrez Gene - A searchable database of RefSeq genes. • 40176 UniProtKB/Swiss-Prot • Q9VW56
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prefoldin beta-like (IPR002777) Prefoldin (IPR009053) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH28557
Linkouts
	BioGRID - A database of protein and genetic interactions • 65443 DroID - A comprehensive database of gene and protein interactions. • FBgn0036918 DRSC - Results from RNAi screens. • FBgn0036918 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7770-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40176 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40176 modMine - Data generated by the modENCODE project. • FBgn0036918
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:GH28557   CG7770 (Keleman et al., 2009.8.5, Gandhi et al., 2007, Cooper et al., 2010, Guruharsha et al., 2011, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
	FBgn0063213
References ( 20 )
Research paper	Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cooper et al., 2010, Genetics 185(3): 811--822 Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Gandhi et al., 2007, Nat. Genet. 38(3): Supplementary Information [FBrf0208882] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.5.5, BDGP_2009_0507.GenExel.xml BDGP_2009_0507.GenExel.xml [FBrf0207859] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9VW56 PROBABLE PREFOLDIN SUBUNIT 6. [FBrf0136242]