FlyBase Gene Report: Dmel\Gabat

General Information

Symbol

Dmel\Gabat

Species

D. melanogaster

Name

γ-aminobutyric acid transaminase

Annotation Symbol

CG7433

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036927

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

γ-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter γ-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism. [Date last reviewed: 2018-10-25] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GABA transaminase

Key Links

Genomic Location

Cytogenetic map

76D8-76E1

Sequence location

3L:19,997,714..20,000,686 [-]

Recombination map

3-46

RefSeq locus

NT_037436 REGION:19997714..20000686

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables 4-aminobutyrate transaminase activity

inferred from biological aspect of ancestor with PANTHER:PTN000944876

(assigned by GO_Central )

(Gaudet et al., 2011)

enables pyridoxal phosphate binding

inferred from biological aspect of ancestor with PANTHER:PTN000944876

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in regulation of carbohydrate metabolic process

inferred from mutant phenotype

(Maguire et al., 2015)

involved_in regulation of circadian sleep/wake cycle

inferred from mutant phenotype

(Chen et al., 2015)

involved_in regulation of glutamate metabolic process

inferred from mutant phenotype

(Maguire et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in gamma-aminobutyric acid catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000944876

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009)

inferred from direct assay

(Chen et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000241230

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

TRANSAMINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TRANSAMINASES -: Transaminases catalyze the interconversion of amino acids and oxoacids by transfer of amino groups.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gabat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gabat-RA

FBtr0074909

NM_140911

1782

486

Gabat-RB

FBtr0074908

NM_168829

1733

486

Gabat-RC

FBtr0302049

NM_001170008

2251

486

Gabat-RD

FBtr0344085

NM_001300196

1667

486

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Gabat-PA

FBpp0074678

54.6

486

8.88

NP_649168

AAF49081

Gabat-PB

FBpp0074677

54.6

486

8.88

NP_730476

AAN11644

Gabat-PC

FBpp0291259

54.6

486

8.88

NP_001163479

ACZ94750

Gabat-PD

FBpp0310512

54.6

486

8.88

NP_001287125

AHN58150

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

486 aa isoforms: Gabat-PA, Gabat-PB, Gabat-PC, Gabat-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gabat using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

germline cell

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic midgut chamber

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

embryonic/larval somatic muscle

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

midline ventral glial cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

medial dorsal subperineurial glial cell