General Information Symbol Dmel\ CG5618Species D. melanogaster Name Annotation symbol CG5618 Feature type protein_coding_gene FlyBase ID FBgn0036975 Gene Model Status Current Stock availability 3 publicly
available Genomic Location Chromosome (arm) 3L Recombination map Cytogenetic map 77B5-77B5 Sequence location 3L:20,346,549..20,349,732 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG5618 (FBgn0036975). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : sulfinoalanine decarboxylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : carboxylic acid metabolic process; proteolysis.
4 alleles are reported . No phenotypic data is available. It has
3 annotated transcripts and
3 annotated polypeptides .
Protein features are: Dipeptidyl-peptidase 3; Pyridoxal phosphate-dependent decarboxylase; Pyridoxal phosphate-dependent transferase; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult midgut, adult Malpighian tubules, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1623238_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG5618. Gene sequence location is
3L:20346549..20349732 .
User Contributed Data
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.39
Gene model reviewed during 5.45
Low-frequency RNA-seq exon junction(s) not annotated.
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
1996.8
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
(1996.8)
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
(684.4)
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
(794.6)
Adult Hindgut
147.9
Adult Malpighian Tubules
(720.3)
Adult Fat Body
(540)
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
(621)
Adult InseminatedFemale Spermatheca
(903.9)
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
(546.6)
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
(1996.8)
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
1996.8
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
1996.8
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
(1996.8)
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
(903.9)
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
(1996.8)
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
41.35
Larval Midgut
504.8
Larval Hindgut
114.8
Larval Malpighian Tubules
345.5
Larval Fat Body
1996.8
Larval Salivary Gland
82.3
Larval Trachea
91.225
Larval Carcass
62.575
Adult Head
684.4
Adult Eye
263.925
Adult Brain
147
Adult Thoracic-Abdominal Ganglion
127.8
Adult Crop
119.7
Adult Midgut
794.6
Adult Hindgut
147.9
Adult Malpighian Tubules
720.3
Adult Fat Body
540
Adult Salivary Gland
73.2
Adult Heart
332.425
Adult VirginFemale Spermatheca
621
Adult InseminatedFemale Spermatheca
903.9
Adult Ovary
10.5
Adult Testis
14.6
Adult Male Accessory Gland
54.5
Adult Carcass
546.6
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
684.4
NA
Eye
263.925
NA
Brain
147
41.35
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
127.8
NA
Crop
119.7
504.8
Midgut
794.6
114.8
Hindgut
147.9
345.5
Malpighian Tubules
720.3
1996.8
Fat Body
540
82.3
Salivary Gland
73.2
NA
Heart
332.425
91.225
Trachea
NA
NA
VirginFemale Spermatheca
621
NA
InseminatedFemale Spermatheca
903.9
NA
Ovary
no informative data
NA
Testis
14.6
NA
Male Accessory Gland
54.5
62.575
Carcass
546.6
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
373
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
(27)
head, virgin 4-day female
18
head, virgin 20-day female
(31)
head, mated 1-day female
17
head, mated 4-day female
(29)
head, mated 20-day female
(30)
head, mated 1-day male
26
head, mated 4-day male
(34)
head, mated 20-day male
(31)
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
(40)
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
(35)
digestive system, 4-day adult
23
digestive system, 20-day adult
(28)
fat body, larvae L3 wandering
8
fat body, white prepupae
(373)
fat body, pupae P8
(44)
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
(373)
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
373
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
373
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
(34)
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
(40)
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
(35)
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
(373)
fat body, pupae P8
(44)
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
(373)
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
7
central nervous system, larvae L3
11
central nervous system, pupae P8
16
head, virgin 1-day female
27
head, virgin 4-day female
18
head, virgin 20-day female
31
head, mated 1-day female
17
head, mated 4-day female
29
head, mated 20-day female
30
head, mated 1-day male
26
head, mated 4-day male
34
head, mated 20-day male
31
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
40
digestive system, larvae L3 wandering
22
digestive system, 1-day adult
35
digestive system, 4-day adult
23
digestive system, 20-day adult
28
fat body, larvae L3 wandering
8
fat body, white prepupae
373
fat body, pupae P8
44
carcass, larvae L3 wandering
18
carcass, 1-day adult
14
carcass, 4-day adult
18
carcass, 20-day adult
14
ovary, virgin 4-day female
2
ovary, mated 4-day female
1
testis, mated 4-day male
5
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
163
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
(35)
larva L3 puffstage 7-9
(90)
white prepupae new
(163)
white prepupae 12hr
(73)
white prepupae 24hr
(63)
pupae 2d postWPP
(69)
pupae 3d postWPP
(32)
pupae 4d postWPP
17
adult male 01day
(33)
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
(163)
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
163
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
163
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
(35)
larva L3 puffstage 7-9
(90)
white prepupae new
(163)
white prepupae 12hr
(73)
white prepupae 24hr
(63)
pupae 2d postWPP
(69)
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
(33)
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
(163)
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
0
embryo 02-04hr
2
embryo 04-06hr
6
embryo 06-08hr
13
embryo 08-10hr
18
embryo 10-12hr
17
embryo 12-14hr
23
embryo 14-16hr
20
embryo 16-18hr
18
embryo 18-20hr
15
embryo 20-22hr
20
embryo 22-24hr
22
larva L1
19
larva L2
23
larva L3 12hr old
13
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
35
larva L3 puffstage 7-9
90
white prepupae new
163
white prepupae 12hr
73
white prepupae 24hr
63
pupae 2d postWPP
69
pupae 3d postWPP
32
pupae 4d postWPP
17
adult male 01day
33
adult male 05day
23
adult male 30day
20
adult female 01day
26
adult female 05day
16
adult female 30day
18
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
23
Schneider line 2 Sg4
21
embryonic 1182-4H
19
embryonic GM2
9
embryonic Kc167
22
embryonic S1
4
embryonic S3
19
leg disc CME L1
11
wing disc CME-W2
10
wing disc ML-DmD8
7
wing disc ML-DmD9
11
wing disc ML-DmD16-c3
3
wing disc ML-DmD21
3
wing disc ML-DmD32
7
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
4
antennal disc ML-DmD20-c5
6
mixed discs ML-DmD4-c1
3
CNS ML-DmBG1-c1
4
CNS ML-DmBG2-c2
6
tumorous blood cells mbn2
3
ovary fGS/OSS
8
ovary OSC
8
ovary OSS
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
(32)
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
19
cold shock, 4-day adult
19
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
13
Cadmium 50 mM 12 hrs, larvae L3
32
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
8
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
14
Zinc 4.5 mM 48 hrs, 4-day adult
11
Ethanol 2.5% 3 hrs, larvae L3
12
Ethanol 5% 3 hrs, larvae L3
14
Ethanol 10% 3 hrs, larvae L3
10
Caffeine 1.5 mg/ml 4 hrs, larvae L3
9
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
5
Caffeine 25 mg/ml 48 hrs, 4-day adult
13
Paraquat 5 mM 48 hrs, 4-day adult
10
Paraquat 10 mM 48 hrs, 4-day adult
8
Rotenone 2 μg 12 hrs, larvae L3
14
Rotenone 8 μg 12 hrs, larvae L3
10
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 1 ) For All Classical Alleles Show Allele of
CG5618 Class Mutagen Stocks Known lesion CG5618f05961 2 --
Alleles Carried on Transgenic Constructs
( 3 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 6 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 6 terms ) Molecular Function inferred from sequence or structural similarity with
EMBL:X94152 Biological Process Cellular Component Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (62)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6GF40T )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6NS3M1 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6G1KBW )
Apis mellifera
Western honey bee
Amel\Gad1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013618
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH13707
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH13706
Atta cephalotes
Leafcutter ant
Acep\ACEP23106
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO14299
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL21197
Linepithema humile
Argentine ant
Lhum\LH17751
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB26181
Solenopsis invicta
Red fire ant
Sinv\SINV22220
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6QFTVQ )
Orthologs in non-Arthropod Metazoa
(EOG6QCCZV )
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Gallus gallus
Domestic chicken
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (4)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 3 )Bloomington Harvard Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 20 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 1 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 20 )Research paper Ellis and Carney, 2010, BMC Genomics 11: 558Mating alters gene expression patterns in Drosophila melanogaster male heads. [FBrf0212156] Fujikawa et al., 2009, Gene 446(1): 11--17Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila. [FBrf0208557] Ueda et al., 2002, J. Biol. Chem. 277(16): 14048--14052Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. [FBrf0149598] Supplementary material The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Personal communication to FlyBase Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Perkins et al., 2009.8.10, Update to TRiP stock collection.Update to TRiP stock collection. [FBrf0208863] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file)Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data.Exelixis CG deletion data. [FBrf0184335] Gene Disruption Project members, 2001-, (Computer file)(Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] FlyBase analysis FlyBase, 1992-, FlyBase curation.FlyBase curation. [FBrf0105495] Stock list Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.RNAi stocks available from NIG-FLY. [FBrf0218457] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073] Curated genome annotation Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.][Annotations performed at the Celera Jamboreee.] [FBrf0126651] FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.][Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Gong, 1999.11, [Annotations performed at the Celera Jamboreee.][Annotations performed at the Celera Jamboreee.] [FBrf0126669]