FB2020_06, released Dec 22, 2020

Gene: Dmel\RhoBTB

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General Information
Symbol
Dmel\RhoBTB
Species
D. melanogaster
Name
Rho-related BTB domain containing
Annotation Symbol
CG5701
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036980
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

RhoGTPase, RhoX

Key Links
Genomic Location
Cytogenetic map
77B6-77B9
Sequence location
3L:20,376,242..20,382,398 [+]
Recombination map

3-47

RefSeq locus
NT_037436 REGION:20376242..20382398
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632671
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cortical cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in engulfment of apoptotic cell
inferred from biological aspect of ancestor with PANTHER:PTN001178289
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in establishment or maintenance of cell polarity
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in small GTPase mediated signal transduction
inferred from electronic annotation with InterPro:IPR003578
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cell projection
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasmic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in intracellular membrane-bounded organelle
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001530052
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RHO GTPASES -
Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\RhoBTB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012, Graveley et al., 2011)
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RhoBTB-RA
FBtr0078185
NM_140959
3257
745
RhoBTB-RB
FBtr0330157
NM_001275178
3257
783
RhoBTB-RC
FBtr0330158
NM_001275179
2974
738
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
RhoBTB-PA
FBpp0077843
85.4
745
6.80
NP_649216
AAF51585
RhoBTB-PB
FBpp0303190
89.6
783
7.00
NP_001262107
AGB94800
RhoBTB-PC
FBpp0303191
84.6
738
6.80
NP_001262108
AGB94801
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoBTB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RhoBTB in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RhoBTB
Transgenic constructs containing regulatory region of RhoBTB
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RHOBTB1
12 of 15
Yes
Yes
Hsap\RHOBTB2
12 of 15
Yes
Yes
1  
Hsap\RHOBTB3
2 of 15
No
Yes
Hsap\CDC42
1 of 15
No
No
0  
Hsap\RAC1
1 of 15
No
No
3  
Hsap\RAC2
1 of 15
No
No
1  
Hsap\RAC3
1 of 15
No
No
Hsap\RHOA
1 of 15
No
No
4  
Hsap\RHOB
1 of 15
No
No
1  
Hsap\RHOC
1 of 15
No
No
1  
Hsap\RHOD
1 of 15
No
No
Hsap\RHOF
1 of 15
No
No
Hsap\RHOG
1 of 15
No
No
Hsap\RHOH
1 of 15
No
No
Hsap\RHOJ
1 of 15
No
No
Hsap\RHOQ
1 of 15
No
No
Hsap\RHOU
1 of 15
No
No
Hsap\RHOV
1 of 15
No
No
Hsap\RND1
1 of 15
No
Yes
Hsap\RND2
1 of 15
No
Yes
Hsap\RND3
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rhobtb2
12 of 15
Yes
Yes
Mmus\Rhobtb1
11 of 15
No
Yes
Mmus\Rhobtb3
2 of 15
No
Yes
Mmus\4930544G11Rik
1 of 15
No
No
Mmus\Cdc42
1 of 15
No
No
Mmus\Rac1
1 of 15
No
No
Mmus\Rac2
1 of 15
No
No
Mmus\Rac3
1 of 15
No
No
Mmus\Rhoa
1 of 15
No
No
Mmus\Rhob
1 of 15
No
No
Mmus\Rhoc
1 of 15
No
No
Mmus\Rhod
1 of 15
No
No
Mmus\Rhof
1 of 15
No
No
Mmus\Rhog
1 of 15
No
No
Mmus\Rhoh
1 of 15
No
No
Mmus\Rhoj
1 of 15
No
No
Mmus\Rhoq
1 of 15
No
No
Mmus\Rhou
1 of 15
No
No
Mmus\Rhov
1 of 15
No
No
Mmus\Rnd1
1 of 15
No
Yes
Mmus\Rnd2
1 of 15
No
Yes
Mmus\Rnd3
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (19)
Rnor\Rhobtb2
12 of 13
Yes
Yes
Rnor\Rhobtb1
6 of 13
No
Yes
Rnor\Rhobtb3
2 of 13
No
Yes
Rnor\Cdc42
1 of 13
No
No
Rnor\Rac1
1 of 13
No
No
Rnor\Rac2
1 of 13
No
No
Rnor\Rhoa
1 of 13
No
No
Rnor\Rhob
1 of 13
No
No
Rnor\Rhoc
1 of 13
No
No
Rnor\Rhod
1 of 13
No
No
Rnor\Rhof
1 of 13
No
No
Rnor\Rhog
1 of 13
No
No
Rnor\Rhoh
1 of 13
No
No
Rnor\Rhoj
1 of 13
No
No
Rnor\Rhoq
1 of 13
No
No
Rnor\Rhov
1 of 13
No
No
Rnor\Rnd2
1 of 13
No
Yes
Rnor\Rnd3
1 of 13
No
Yes
Rnor\RSA-14-44
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\rhobtb2
8 of 12
Yes
Yes
Xtro\rhobtb1
7 of 12
No
Yes
Xtro\cdc42
1 of 12
No
No
Xtro\rac1
1 of 12
No
No
Xtro\rac2
1 of 12
No
No
Xtro\rhoa.2
1 of 12
No
No
Xtro\rhoa
1 of 12
No
No
Xtro\rhobtb3
1 of 12
No
Yes
Xtro\rhob
1 of 12
No
No
Xtro\rhoc
1 of 12
No
No
Xtro\rhof
1 of 12
No
No
Xtro\rhoj
1 of 12
No
No
Xtro\rhoq
1 of 12
No
No
Xtro\rhou
1 of 12
No
No
Xtro\rhov
1 of 12
No
No
Xtro\rnd1
1 of 12
No
Yes
Xtro\rnd3
1 of 12
No
Yes
Danio rerio (Zebrafish) (38)
Drer\rhobtb2b
11 of 15
Yes
Yes
Drer\rhobtb4
11 of 15
Yes
Yes
Drer\rhobtb1
9 of 15
No
Yes
Drer\rhobtb2a
6 of 15
No
Yes
Drer\LOC100331257
2 of 15
No
Yes
Drer\si:dkey-6b12.5
2 of 15
No
Yes
Drer\cdc42
1 of 15
No
No
Drer\cdc42l2
1 of 15
No
No
Drer\cdc42l
1 of 15
No
No
Drer\rac1a
1 of 15
No
No
Drer\rac1b
1 of 15
No
No
Drer\rac1l
1 of 15
No
No
Drer\rac3a
1 of 15
No
No
Drer\rac3b
1 of 15
No
No
Drer\rhoaa
1 of 15
No
No
Drer\rhoab
1 of 15
No
No
Drer\rhoac
1 of 15
No
No
Drer\rhoca
1 of 15
No
No
Drer\rhocb
1 of 15
No
No
Drer\rhof
1 of 15
No
No
Drer\rhoga
1 of 15
No
No
Drer\rhogb
1 of 15
No
No
Drer\rhogc
1 of 15
No
No
Drer\rhogd
1 of 15
No
No
Drer\rhoh
1 of 15
No
No
Drer\rhoj
1 of 15
No
No
Drer\rhoq
1 of 15
No
No
Drer\rhoua
1 of 15
No
No
Drer\rhoub
1 of 15
No
No
Drer\rhov
1 of 15
No
No
Drer\rnd1a
1 of 15
No
Yes
Drer\rnd1b
1 of 15
No
Yes
Drer\rnd2
1 of 15
No
Yes
Drer\rnd3a
1 of 15
No
Yes
Drer\rnd3b
1 of 15
No
Yes
Drer\si:ch211-1f22.1
1 of 15
No
No
Drer\si:ch211-1f22.2
1 of 15
No
No
Drer\si:ch211-133l11.10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\cdc-42
1 of 15
Yes
No
Cele\ced-10
1 of 15
Yes
No
Cele\chw-1
1 of 15
Yes
No
Cele\crp-1
1 of 15
Yes
No
Cele\mig-2
1 of 15
Yes
No
Cele\rac-2
1 of 15
Yes
No
Cele\rho-1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (11)
Atha\ARAC1
1 of 9
Yes
No
Atha\ARAC5
1 of 9
Yes
No
Atha\ARAC9
1 of 9
Yes
No
Atha\RAC2
1 of 9
Yes
No
Atha\RAC3
1 of 9
Yes
No
Atha\RAC6
1 of 9
Yes
No
Atha\RAC10
1 of 9
Yes
No
Atha\ROP1
1 of 9
Yes
No
Atha\ROP2
1 of 9
Yes
No
Atha\ROP9
1 of 9
Yes
No
Atha\ROP10
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\RHO1
2 of 15
Yes
No
Scer\RHO2
2 of 15
Yes
No
Scer\RHO3
2 of 15
Yes
No
Scer\RHO4
2 of 15
Yes
No
Scer\CDC42
1 of 15
No
No
1  
Scer\RHO5
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\rho1
1 of 12
Yes
No
Spom\rho2
1 of 12
Yes
No
Spom\rho3
1 of 12
Yes
No
Spom\rho4
1 of 12
Yes
Yes
Spom\rho5
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919030H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007166
Drosophila simulans
Dsim\GD14882
Drosophila sechellia
Dsec\GM22285
Drosophila erecta
Dere\GG16109
Drosophila yakuba
Dyak\GE19673
Drosophila ananassae
Dana\GF10335
Drosophila pseudoobscura pseudoobscura
Dpse\GA19068
Drosophila persimilis
Dper\GL11881
Drosophila willistoni
Dwil\GK16960
Drosophila virilis
Dvir\GJ13537
Drosophila mojavensis
Dmoj\GI11838
Drosophila grimshawi
Dgri\GH16972
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501UZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022555
Glossina morsitans
Tsetse fly
Gmor\GMOY000934
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05702
Mayetiola destructor
Hessian fly
Mdes\Mdes000394
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003587
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014636
Anopheles darlingi
American malaria mosquito
Adar\ADAC005974
Anopheles gambiae
Malaria mosquito
Agam\AGAP006474
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012218
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02DH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000033
Danaus plexippus
Monarch butterfly
Dple\DPOGS210262-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008625
Apis florea
Little honeybee
Aflo\2570137076
Apis mellifera
Western honey bee
Amel\GB49505
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15691
Bombus terrestris
Buff-tailed bumblebee
Bter\15210914
Bombus terrestris
Buff-tailed bumblebee
Bter\15202043
Linepithema humile
Argentine ant
Lhum\LH18074
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002cd7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005792
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10076
Tribolium castaneum
Red flour beetle
Tcas\TC012457
Pediculus humanus
Human body louse
Phum\PHUM025340
Rhodnius prolixus
Kissing bug
Rpro\RPRC010913
Cimex lectularius
Bed bug
Clec\CLEC007610
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09513
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02AY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015120
Ixodes scapularis
Black-legged tick
Isca\ISCW010048
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82124.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69417.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82123.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_225906
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03I3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-RhoBTB
Ciona intestinalis
Vase tunicate
Cint\LOC100185717
Gallus gallus
Domestic chicken
Ggal\RHOBTB2
Gallus gallus
Domestic chicken
Ggal\RHOBTB1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cdc42
3 of 10
Mtl
3 of 10
Rac1
3 of 10
Rac2
3 of 10
Rho1
3 of 10
Miro
2 of 10
RhoL
2 of 10
RhoU
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RHOBTB1; Rho related BTB domain containing 1
12 of 15
607351
      RHOBTB2; Rho related BTB domain containing 2
      12 of 15
      607352
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        RhoBTB - conu
        anti tag coimmunoprecipitation, anti tag western blot
        (Neisch et al., 2013)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Nsf2
        suppressible
        RhoBTB
        (Laviolette et al., 2005)
        pbl
        suppressible
        RhoBTB
        (Gregory et al., 2007)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-47

        Cytogenetic map
        77B6-77B9
        Sequence location
        3L:20,376,242..20,382,398 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        77B6-77B9
        Limits computationally determined from genome sequence between P{PZ}eRF100103 and P{EP}trblEP3519
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        77B6-77B9
        (Montell, 2000.3.4)
        77B-77B
        (Afshar, 2000.1.5)
        Experimentally Determined Recombination Data
        Location

        3-47

        (FlyBase, 2016)

        3-43.6

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (12)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (165)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: RhoBTB RhoX

        (Montell, 2004.1.30)

        Source for identity of: RhoBTB CG5701

        (FlyBase, 1996-)
        Source for database merge of

        Source for merge of: RhoBTB RhoGTPase

        (Bayraktaroglu, 2000.5.25)
        Additional comments

        Source for identity of RhoBTB CG5701 was sequence comparison ( date:000327 ).

        (FlyBase, 1996-)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

        (Rogers et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 52 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (6)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (61)