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Gene Dmel\RhoBTB

General Information
Symbol	Dmel\RhoBTB	Species	D. melanogaster
Name	Rho-related BTB domain containing	Annotation symbol	CG5701
Feature type	protein_coding_gene	FlyBase ID	FBgn0036980
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	RhoGTPase
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	77B6-77B9	Sequence location	3L:20,369,342..20,375,498 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rho-related BTB domain containing is referred to in FlyBase by the symbol Dmel\RhoBTB (CG5701, FBgn0036980). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: GTPase activity. There is experimental evidence that it is involved in the biological process: melanotic encapsulation of foreign target. 7 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rho type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624530_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RhoBTB. Gene sequence location is 3L:20369342..20375498.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms cellular_component
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77B6-77B9   Limits computationally determined from genome sequence between P{PZ}eRF100103 and P{EP}trblEP3519
Experimentally Determined Cytological Location
Cytogenetic map Notes References 77B6-77B9     (Montell, 2000.3.4) 77B-77B     (Afshar, 2000.1.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RhoBTB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45 Stop-codon suppression (UGA) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RhoBTB-RA FBtr0078185  NM_140959   3257   745 RhoBTB-RB FBtr0330157  NM_001275178   3257   783 RhoBTB-RC FBtr0330158  NM_001275179   2974   738
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RhoBTB-PA   FBpp0077843   85.4   745   6.80     NP_649216   AAF51585 RhoBTB-PB   FBpp0303190   89.6   783   7.00     NP_001262107   AGB94800 RhoBTB-PC   FBpp0303191   84.6   738   6.80     NP_001262108   AGB94801
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ-like (IPR000210) Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) BTB/POZ (IPR013069) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Small GTPase superfamily, Rho type (IPR003578)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142020   AA202603   AA263246   AA391042   AA439507   AA441189   AA539638   AA567582   AA696868   AA698517   AA816460   AA816797   AA816977   AA820885   AA820901   AA941332   AA941631   AA949485   AA949734   AA949957   AA951635   AA978914   AE014296 AAF51585   AF217287 AAF44065   AF221547 AAF34654   AE014296 AGB94800   AE014296 AGB94801   AI134642   AI238104   AI257344   AI257620   AI258923   AI294108   AI455544   AI456202   AI456946   AI511888   AI512456   AI514924   AI515105   AI515106   AI515341   AI516122   AI516507   AI519362   AI519664   AI534038   AQ025278   AY051710 AAK93134   BF494687   BG632799   BG637331   BI163854   BI164033   BI167084   BI168893   BI170643   BI171059   BI172198   BI173502   BI212913   BI213868   BI215620   BI216594   BI229184   BI229201   BI230015   BI237124   BI237331   BI238067   BI241122   BI243885   BI361534   BI364225   BI364461   BI365808   BI577210   BI578162   BI607550   CA805017   CK131752   CK659811   CO189998   CO191847   CO266395   CO271948   CO293060   CO296658   CO300356   CO313499   CO321662   CO322480   CO324253   CO327228   CO327646   CO329200   CO336460   CO340020   CO343344   CZ480544   EC061564   EC063075   EC065102   EC077502   EC078802   EC085394   EC086635   EC200831   EC220493   EC241286   EC246361   EC259551   EC265083   GH751082   GH756596   GH758376   GH759733   GH783119   GH789967   GH793457   GH798822   GH806492   GH807641   GH810972   GH813592   GH816292   GH824934   GH826831   GH827638   GH828117   GH829185   GH833677   GH835831   GH836501   GH838363   GH842744   GH843100   GH843953   GH845069   GH846136   GH846258   GH849678   GH851792   GH853229   GH853230   GH857498   GH858121   GH860108   GH860481   GH861011   GH868420   GH868779   GH875299   GH883706   GH883729   GH883932   GH889035   GH894280   GH898013   GH910183   GH911041   GH912757   GH913295   GH917950   GH920160   GH920477   GH922851   GH927471   GH930578   GH931202   GH931913   GH935232   GH936200   GH936722   GH937317   GH942482
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPG7 Q7KJ62
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) apoptotic amnioserosa   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic/larval circulatory system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval pericardial cell   (Fisher et al., 2012) gonad   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules    1439 Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules    1590.5 Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules  (1439) Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules  (1590.5) Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary  (549.4) Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules  (1439) Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules  (1590.5) Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules    1439 Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules    1590.5 Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules    1439 Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules    1590.5 Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules  (1439) Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules  (1590.5) Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary  549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules  1439 Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules  1590.5 Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    346.425 Larval Midgut    146.1 Larval Hindgut    401.7 Larval Malpighian Tubules    1439 Larval Fat Body    261.7 Larval Salivary Gland    120.9 Larval Trachea    210.825 Larval Carcass    156.875 Adult Head    223.5 Adult Eye    219.05 Adult Brain    478 Adult Thoracic-Abdominal Ganglion    438.8 Adult Crop    231.3 Adult Midgut    133.9 Adult Hindgut    401.7 Adult Malpighian Tubules    1590.5 Adult Fat Body    272.2 Adult Salivary Gland    217.6 Adult Heart    252.375 Adult VirginFemale Spermatheca    484.6 Adult InseminatedFemale Spermatheca    446.5 Adult Ovary    549.4 Adult Testis    78.9 Adult Male Accessory Gland    233.5 Adult Carcass    306.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    223.5   NA  Eye    219.05   NA  Brain    478   346.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    438.8   NA  Crop    231.3   146.1  Midgut    133.9   401.7  Hindgut    401.7   1439  Malpighian Tubules    1590.5   261.7  Fat Body    272.2   120.9  Salivary Gland    217.6   NA  Heart    252.375   210.825  Trachea    NA   NA  VirginFemale Spermatheca    484.6   NA  InseminatedFemale Spermatheca    446.5   NA  Ovary    549.4   NA  Testis    78.9   NA  Male Accessory Gland    233.5   156.875  Carcass    306.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8  26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (33) testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8  26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (33) testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    19 central nervous system, pupae P8    26 head, virgin 1-day female    9 head, virgin 4-day female    9 head, virgin 20-day female    14 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    10 head, mated 1-day male    12 head, mated 4-day male    14 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    6 digestive system, 4-day adult    8 digestive system, 20-day adult    9 fat body, larvae L3 wandering    3 fat body, white prepupae    8 fat body, pupae P8    14 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    7 ovary, virgin 4-day female    39 ovary, mated 4-day female    33 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (91) embryo 04-06hr  (31) embryo 06-08hr  (27) embryo 08-10hr  (36) embryo 10-12hr  (28) embryo 12-14hr  (28) embryo 14-16hr  (33) embryo 16-18hr  (27) embryo 18-20hr    16 embryo 20-22hr  (33) embryo 22-24hr  (33) larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  (36) larva L3 puffstage 7-9  (60) white prepupae new  (82) white prepupae 12hr  (63) white prepupae 24hr  (51) pupae 2d postWPP  (35) pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day  (34) adult female 05day  (50) adult female 30day  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (91) embryo 04-06hr  31 embryo 06-08hr  27 embryo 08-10hr  (36) embryo 10-12hr  28 embryo 12-14hr  28 embryo 14-16hr  (33) embryo 16-18hr  27 embryo 18-20hr    16 embryo 20-22hr  (33) embryo 22-24hr  (33) larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6  (36) larva L3 puffstage 7-9  (60) white prepupae new  (82) white prepupae 12hr  (63) white prepupae 24hr  (51) pupae 2d postWPP  (35) pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day  (34) adult female 05day  (50) adult female 30day  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    91 embryo 04-06hr    31 embryo 06-08hr    27 embryo 08-10hr    36 embryo 10-12hr    28 embryo 12-14hr    28 embryo 14-16hr    33 embryo 16-18hr    27 embryo 18-20hr    16 embryo 20-22hr    33 embryo 22-24hr    33 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    20 larva L3 puffstage 3-6    36 larva L3 puffstage 7-9    60 white prepupae new    82 white prepupae 12hr    63 white prepupae 24hr    51 pupae 2d postWPP    35 pupae 3d postWPP    19 pupae 4d postWPP    14 adult male 01day    18 adult male 05day    20 adult male 30day    23 adult female 01day    34 adult female 05day    50 adult female 30day    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4  26 embryonic 1182-4H  26 embryonic GM2  (32) embryonic Kc167  (35) embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9  26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2  (44) tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4  26 embryonic 1182-4H  26 embryonic GM2  32 embryonic Kc167  (35) embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9  26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2  (44) tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    26 embryonic 1182-4H    26 embryonic GM2    32 embryonic Kc167    35 embryonic S1    13 embryonic S3    22 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    22 wing disc ML-DmD9    26 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    22 wing disc ML-DmD32    13 haltere disc ML-DmD17-c3    22 eye-antennal disc ML-DmD11    15 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    44 tumorous blood cells mbn2    14 ovary fGS/OSS    19 ovary OSC    11 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    8 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD24835 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036980 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5701-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for RhoBTB Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele immune response defective | larval stage RhoBTBMB07044 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of RhoBTB Class Mutagen Stocks Known lesion RhoBTBe02774 piggyBac transposase 1 -- RhoBTBEP3099 P-element activity 1 -- RhoBTBGS51 1 Yes RhoBTBMB07044 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RhoBTB Class Mutagen Stocks Known lesion RhoBTBHMS00411 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoBTBKK108794 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RhoBTBGD6074 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6136 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6074} NA P{KK108794} NA P{TRiP.HMS00411} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}RhoBTBEP3099 NA P{GSV1}IdeGS51 NA miscellaneous insertions PBac{RB}RhoBTBe02774 NA insertion of enhancer trap binary system Mi{ET1}RhoBTBMB07044 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
melanotic encapsulation of foreign target inferred from mutant phenotype (Howell et al., 2012)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Edwards, 1999.12.16) inferred from sequence or structural similarity with EMBL:AF014371 (FlyBase, 1992-) non-traceable author statement (Silver and Montell, 2000, Afshar, 2000.1.5) GTP binding inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR003578 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
RhoBTB - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG10418 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG10628 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG14786 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG3731 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG5447 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG7194 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG8728 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG8963 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - CG9344 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Cul-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Ip259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Mtr3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - RpS11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - fax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL43 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpL52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - msn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - tsu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) RhoBTB - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RhoBTB allele Gene References unspecified Nsf2 (Laviolette et al., 2005) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65509 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036980 DroID - A comprehensive database of gene and protein interactions. • FBgn0036980 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40249
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6S1TSM Dipteran inclusive ortholog search EOG6MW8F6 Insect inclusive ortholog search EOG6FBGNX Arthropod inclusive ortholog search EOG644J1C Metazoa inclusive ortholog search EOG6JHR7J
Orthologs in Drosophila Species (EOG6S1TSM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RhoBTB     Drosophila simulans   Dsim\GD14882 Y   Drosophila sechellia   Dsec\GM22285 Y   Drosophila erecta   Dere\GG16109 Y   Drosophila yakuba   Dyak\GE19673 Y   Drosophila ananassae   Dana\GF10335 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19068 Y   Drosophila persimilis   Dper\GL11881 Y   Drosophila willistoni   Dwil\GK16960 Y   Drosophila virilis   Dvir\GJ13537 Y   Drosophila mojavensis   Dmoj\GI11838 Y   Drosophila grimshawi   Dgri\GH16972 Y
Orthologs in non-Drosophila Dipterans (EOG6MW8F6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003587   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014636   Anopheles gambiae Malaria mosquito  Agam\AGAP006474   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012218
Orthologs in non-Dipteran Insects (EOG6FBGNX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49505   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005792   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21690   Atta cephalotes Leafcutter ant  Acep\ACEP22808   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21186   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12545   Linepithema humile Argentine ant  Lhum\LH18074   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25337   Solenopsis invicta Red fire ant  Sinv\SINV18234   Bombyx mori Silkmoth  Bmor\BGIBMGA000033   Pediculus humanus Human body louse  Phum\PHUM025340   Tribolium castaneum Red flour beetle  Tcas\TC012457
Orthologs in non-Insect Arthropods (EOG644J1C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpoB   Ixodes scapularis Deer tick  Isca\ISCW010048
Orthologs in non-Arthropod Metazoa (EOG6JHR7J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011722gn   Danio rerio Zebrafish  Drer\ENSDARG00000079468   Danio rerio Zebrafish  Drer\si:dkey-263f15.2   Danio rerio Zebrafish  Drer\rhobtb2a   Danio rerio Zebrafish  Drer\rhobtb2b   Xenopus tropicalis Western clawed frog  Xtro\rhobtb2   Xenopus tropicalis Western clawed frog  Xtro\rhobtb1   Gallus gallus Domestic chicken  Ggal\RHOBTB2   Gallus gallus Domestic chicken  Ggal\RHOBTB1   Mus musculus House mouse  Mmus\Rhobtb1   Mus musculus House mouse  Mmus\Rhobtb2   Rattus norvegicus Norway rat  Rnor\Rhobtb1   Rattus norvegicus Norway rat  Rnor\Rhobtb2   Homo sapiens Human  Hsap\RHOBTB1   Homo sapiens Human  Hsap\RHOBTB2
Human Orthologs (2)
Gene OMIM HGNC Hsap\RHOBTB1     Hsap\RHOBTB2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14882 Drosophila sechellia Dsec\GM22285 Drosophila erecta Dere\GG16109 Drosophila yakuba Dyak\GE19673 Drosophila ananassae Dana\GF10335 Drosophila pseudoobscura pseudoobscura Dpse\GA19068 Drosophila persimilis Dper\GL11881 Drosophila willistoni Dwil\GK16960 Drosophila virilis Dvir\GJ13537 Drosophila mojavensis Dmoj\GI11838 Drosophila grimshawi Dgri\GH16972
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	26065 w1118; Mi{ET1}RhoBTBMB07044 32416 y1 sc* v1; P{TRiP.HMS00411}attP2 17090 w1118; P{EP}RhoBTBEP3099/TM3, Sb1
Harvard	- PBac{RB}RhoBTBe02774
Kyoto	200027 y1 w67c23; P{GSV1}IdeGS51/TM3, Sb1 Ser1
VDRC	v100815 P{KK108794}VIE-260B
Genomic Clones ( 2 )
	BACR02B14 BACR16G09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 167 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24835
Other clones	DPiM_LD24835
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03409 GH12161 GM08602 HL01482 HL04846 LD01819 LD02776 LD06344 LD09919 LD10380 LD14094 LD16091 LD17913 LD21922 LD24813 LD25423 LD25871 LD28537 LD29510 LD29729 LD32270 LD33115 LD36073 LD37123 LD38920 LD39327 LD41879 LD42396 LD43445 LD44337 LD46558 LD46794 LD46796 LD47114 LP02230 LP05672 LP06034 LP07412 LP12747 LP17850 RE03370 RE03594 RE07379 RE09792 RE12166 RE12727 RE14488 RE16434 RE18180 RE19494 RE22188 RE23787 RE26914 RE26933 RE27932 RE33288 RE33545 RE34439 RE38138 RE41692 RE45788 RE49289 RE49568 RE51189 RE70862 RE71987 RH74639 SD06512 SD15265
Other clones	89 35547 53920 61244 62431 65956 72731 105565 148182 190158 214275.54 557883 CK01.56D.G4 CK00123 EC32241 EK045858 EK105253 EK146239 EK178023 EK186127 EK188226 EK193055 EK201611 EK214605 EK233106 EK292239 EN12561 EP06509 EP07809 EP09904 EP16622 ESG0116a.B21_H02 GH14096 RP003020780 RP003029503 RP003047062 RP003103383 RP003103663 RP003104083 RP003113327 RP003113340 RP003117699 RP003130409 RP003134182 RP003134264 RP003139244 RP003160044 RP003174508 RP003177391 RP003201390 RP003207878 RP003240552 RP003241818 RP003247355 RP003264760 RP003286860 RP003294678 RP003295583 RP003296983 RP003323661 RP003325993 RP003328358 RP003329980 RP003335644 RP003335968 RP003343253 RP003384198 RP003401187 RP003410094 RP003419325 RP003459651 RP003461166 RP003462948 RP003467157 RP003467913 RP003470104 RP003472987 RP003476007 RP003478978 RP003484597 RP003523939 RP003529041 RP003548988 RP003551638 RP003555899 RP003556646 RP003558328 RP003568847 RP003587982 RP003609872 RP003610430 RP003615886 RP003623090 RP003634246 RP003671348 RP003673458
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036980 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40249
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RhoBTB CG5701 (FlyBase, 1996-) Source for identity of: RhoBTB RhoX (Montell, 2004.1.30)
Source for database merge of	Source for merge of: RhoBTB RhoGTPase (Bayraktaroglu, 2000.5.25)
Additional comments	Source for identity of RhoBTB CG5701 was sequence comparison (date:000327). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140959 NM_001275178 NM_001275179 RefSeq (Proteins) • NP_649216 NP_001262107 NP_001262108 DDBJ / EMBL / GenBank • AA391042 AA820901 AAF34654 AAF44065 AAF51585 AAK93134 AF217287 AF221547 AGB94800 AGB94801 AI455544 AQ025278 AY051710 CZ480544 Entrez Gene - A searchable database of RefSeq genes. • 40249 UniProtKB/TrEMBL • Q7KJ62 Q9VPG7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ fold (IPR011333) BTB/POZ-like (IPR000210) Small GTPase superfamily (IPR001806) Small GTP-binding protein domain (IPR005225) BTB/POZ (IPR013069) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Small GTPase superfamily, Rho type (IPR003578) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD24835
Linkouts
	BioGRID - A database of protein and genetic interactions • 65509 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036980 DroID - A comprehensive database of gene and protein interactions. • FBgn0036980 DRSC - Results from RNAi screens. • FBgn0036980 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036980 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5701-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036980 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40249 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40249 modMine - Data generated by the modENCODE project. • FBgn0036980
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	28574635 (Rojas et al., 2012) CG5701 (Lee et al., 2003, Laviolette et al., 2005, Rogers et al., 2003, Carrera et al., 2008, Keleman et al., 2009.8.5, Li et al., 2010, Ni et al., 2010.12.1, Howell et al., 2012, Colicelli, 2004) RhoBTB (Cao et al., 2008, Laviolette et al., 2005, Gregory et al., 2007, Rogers et al., 2003, Bakal et al., 2007, Jungreis et al., 2011, Carrera et al., 2008, Zeitlinger et al., 2007, Howell et al., 2012, Blanke and Jackle, 2006) RhoGTPase (Petit et al., 2002, Bayraktaroglu, 2000.5.25, ) RhoX (Montell, 2000.3.4, )
Name Synonym	RhoBTB   Rho-related BTB domain containing
Secondary FlyBase IDs
	FBgn0040289 FBgn0041190
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 11 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Howell et al., 2012, Immunogenetics 64(2): 155--161 A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...