FlyBase Gene Report: Dmel\RhoBTB

General Information

Symbol

Dmel\RhoBTB

Species

D. melanogaster

Name

Rho-related BTB domain containing

Annotation Symbol

CG5701

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036980

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

RhoGTPase, RhoX

Key Links

Genomic Location

Cytogenetic map

77B6-77B9

Sequence location

3L:20,376,242..20,382,398 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:20376242..20382398

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN000632671

(assigned by GO_Central )

(Gaudet et al., 2011)

enables GTPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000632671

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein kinase binding

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (8 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Howell et al., 2012)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in actin filament organization

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in cortical cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in engulfment of apoptotic cell

inferred from biological aspect of ancestor with PANTHER:PTN001178289

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in establishment or maintenance of cell polarity

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of cell shape

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in small GTPase mediated signal transduction

inferred from electronic annotation with InterPro:IPR003578

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

is_active_in cell cortex

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in cell projection

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in cytoplasmic vesicle

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001530052

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

RHO GTPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

RHO GTPASES -: Rho (Ras Homologous) GTPases are members of the Ras superfamily of small GTPases. They are best characterized for their roles in regulating actin organization. (Adapted from PMID:15731001).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RhoBTB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PG08)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RhoBTB-RA

FBtr0078185

NM_140959

3257

745

RhoBTB-RB

FBtr0330157

NM_001275178

3257

783

RhoBTB-RC

FBtr0330158

NM_001275179

2974

738

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

RhoBTB-PA

FBpp0077843

85.4

745

6.80

NP_649216

AAF51585

RhoBTB-PB

FBpp0303190

89.6

783

7.00

NP_001262107

AGB94800

RhoBTB-PC

FBpp0303191

84.6

738

6.80

NP_001262108

AGB94801

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoBTB using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RhoBTB_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RhoBTB in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RhoBTB

View exonic expression by tissue for Dmel\RhoBTB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036980

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40249/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036980

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036980

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036980

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5701

Flygut - An atlas of the Drosophila adult midgut

FBgn0036980

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\RhoBTB

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RhoBTB

Transgenic constructs containing regulatory region of RhoBTB

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6136

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal immune response | larval stage

RhoBTB^MB07044

abnormal locomotor behavior | adult stage, with Scer\GAL4^DJ757

RhoBTB^UAS.cSa

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

abnormal locomotor behavior | adult stage, with Scer\GAL4^RapGAP1-OK6

RhoBTB^UAS.cSa

abnormal locomotor behavior | adult stage, with Scer\GAL4^repo

RhoBTB^UAS.cSa

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42

RhoBTB^UAS.cSa

bang sensitive, with Scer\GAL4^elav.PU

Phenotype manifest in

Allele

dendritic branch | third instar larval stage, with Scer\GAL4⁴⁷⁷, Scer\GAL4^ppk.PG

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4⁴⁷⁷, Scer\GAL4^ppk.PG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RHOBTB1

12 of 15

Yes

Hsap\RHOBTB2

12 of 15

Yes

Hsap\RHOBTB3

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\RND2

1 of 15

Yes

Hsap\RND3

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rhobtb2

12 of 15

Yes

Mmus\Rhobtb1

11 of 15

Yes

Mmus\Rhobtb3

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Rnd2

1 of 15

Yes

Mmus\Rnd3

1 of 15

Yes

Rattus norvegicus (Norway rat) (19)

Rnor\Rhobtb2

12 of 13

Yes

Rnor\Rhobtb1

6 of 13

Yes

Rnor\Rhobtb3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rnd3

1 of 13

Yes

Rnor\RSA-14-44

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\rhobtb2

8 of 12

Yes

Xtro\rhobtb1

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\rnd3

1 of 12

Yes

Danio rerio (Zebrafish) (38)

Drer\rhobtb2b

11 of 15

Yes

Drer\rhobtb4

11 of 15

Yes

Drer\rhobtb1

9 of 15

Yes

Drer\rhobtb2a

6 of 15

Yes

Drer\LOC100331257

2 of 15

Yes

Drer\si:dkey-6b12.5

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\rnd1b

1 of 15

Yes

Drer\rnd2

1 of 15

Yes

Drer\rnd3a

1 of 15

Yes

Drer\rnd3b

1 of 15

Yes

Drer\si:ch211-1f22.1

1 of 15

Drer\si:ch211-1f22.2

1 of 15

Drer\si:ch211-133l11.10

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\cdc-42

1 of 15

Yes

Cele\ced-10

1 of 15

Yes

Cele\chw-1

1 of 15

Yes

Cele\crp-1

1 of 15

Yes

Cele\mig-2

1 of 15

Yes

Cele\rac-2

1 of 15

Yes

Cele\rho-1

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (11)

Atha\ARAC1

1 of 9

Yes

Atha\ARAC5

1 of 9

Yes

Atha\ARAC9

1 of 9

Yes

Atha\RAC2

1 of 9

Yes

Atha\RAC3

1 of 9

Yes

Atha\RAC6

1 of 9

Yes

Atha\RAC10

1 of 9

Yes

Atha\ROP1

1 of 9

Yes

Atha\ROP2

1 of 9

Yes

Atha\ROP9

1 of 9

Yes

Atha\ROP10

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\RHO1

2 of 15

Yes

Scer\RHO2

2 of 15

Yes

Scer\RHO3

2 of 15

Yes

Scer\RHO4

2 of 15

Yes

Scer\CDC42

1 of 15

Scer\RHO5

1 of 15

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\rho1

1 of 12

Yes

Spom\rho2

1 of 12

Yes

Spom\rho3

1 of 12

Yes

Spom\rho4

1 of 12

Yes

Spom\rho5

1 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

3 of 10

Mtl

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

developmental and epileptic encephalopathy 64

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

RhoBTB^HMS00411

model of idiopathic generalized epilepsy

CEA

(Straub et al., 2018)

RhoBTB^HMC03199

model of cancer

CEA with yki^UAS.cUa

(Nguyen et al., 2020)

RhoBTB^VSH330130

model of cancer

CEA with yki^UAS.cUa

(Nguyen et al., 2020)

RhoBTB^UAS.cSa

model of idiopathic generalized epilepsy

CEA

(Straub et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

RhoBTB^VSH330130

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Onur et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 15

607351

12 of 15

607352

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 64; DEE64

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RhoBTB - conu

anti tag coimmunoprecipitation, anti tag western blot

(Neisch et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Nsf2

suppressible

RhoBTB

(Laviolette et al., 2005)

pbl

suppressible

RhoBTB

(Gregory et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65509

DroID - A comprehensive database of gene and protein interactions.

FBgn0036980

MIST (protein-protein) - An integrated Molecular Interaction Database

RhoBTB

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036980

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Rho GTPase cycle

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

77B6-77B9

Sequence location

3L:20,376,242..20,382,398 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77B6-77B9

Limits computationally determined from genome sequence between P{PZ}eRF1⁰⁰¹⁰³ and P{EP}trbl^EP3519

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

77B6-77B9

(Montell, 2000.3.4)

77B-77B

(Afshar, 2000.1.5)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26065

w¹¹¹⁸; Mi{ET1}RhoBTB^MB07044

51461

y¹ v¹; P{TRiP.HMC03199}attP40

44478

y¹ v¹; P{TRiP.HMC02368}attP40/CyO

77600

w¹¹¹⁸; PBac{IT.GAL4}RhoBTB^1198-G4

44952

y¹ w^*; Mi{MIC}RhoBTB^MI08374

17090

w¹¹¹⁸; P{EP}RhoBTB^EP3099/TM3, Sb¹

32416

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00411}attP2

57920

y¹ w^*; Mi{MIC}RhoBTB^MI12308/TM3, Sb¹ Ser¹

91336

y¹ w^*; TI{CRIMIC.TG4.1}RhoBTB^{CR01867-TG4.1}/TM3, Sb¹ Ser¹

Kyoto

200027

y¹ w^67c23; P{GSV1}Ide^GS51/TM3, Sb¹ Ser¹

VDRC

v330130

P{VSH330130}attP40

v100815

P{KK108794}VIE-260B

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (165)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD24835

Other clones

DPiM_LD24835

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036980

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036980

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40249

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: RhoBTB RhoX

(Montell, 2004.1.30)

Source for identity of: RhoBTB CG5701

(FlyBase, 1996-)

Source for database merge of

Source for merge of: RhoBTB RhoGTPase

(Bayraktaroglu, 2000.5.25)

Additional comments

Source for identity of RhoBTB CG5701 was sequence comparison ( date:000327 ).

(FlyBase, 1996-)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40249

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PG08

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PG08

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036980

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036980

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40249/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036980

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RhoBTB_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036980

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036980

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5701

Flygut - An atlas of the Drosophila adult midgut

FBgn0036980

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036980

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40249

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012457

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5701

MARRVEL_MODEL - MARRVEL (model organism gene)

40249

modMine - A data warehouse for the modENCODE project

FBgn0036980

Linkouts

BioGRID - A database of protein and genetic interactions.

65509

DroID - A comprehensive database of gene and protein interactions.

FBgn0036980

DRSC - Results frm RNAi screens

FBgn0036980

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036980

FlyMine - An integrated database for Drosophila genomics

FBgn0036980

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ubiquitin mediated proteolysis

MIST (protein-protein) - An integrated Molecular Interaction Database

RhoBTB

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Rho GTPase cycle

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

28574635

(Rojas et al., 2012)

CG5701

(Meadows, 2017.1.11, Howell et al., 2012, Li et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Carrera et al., 2008, Laviolette et al., 2005, Colicelli, 2004, Lee et al., 2003, Rogers et al., 2003)