Gene Dmel\isoQC

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General Information

Symbol

Dmel\isoQC

Species

D. melanogaster

Name

iso Glutaminyl cyclase

Annotation symbol

CG5976

Feature type

protein_coding_gene

FlyBase ID

FBgn0036999

Gene Model Status

Current

Stock availability

5 publicly available

Also Known As

isoDromeQC

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

77C4-77C4

Sequence location

3L:20,467,566..20,470,103 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene iso Glutaminyl cyclase is referred to in FlyBase by the symbol Dmel\isoQC (CG5976, FBgn0036999). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: glutaminyl-peptide cyclotransferase activity. There is experimental evidence that it is involved in the biological process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase M28. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1637876_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG5976. Gene sequence location is 3L:20467566..20470103.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77C4-77C4

Limits computationally determined from genome sequence between P{EP}trbl^EP3519 and P{EP}fng^EP3082&P{lacW}skd^L7062

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\isoQC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

isoQC-RA

FBtr0078200

NM_176373

1975

352

isoQC-RB

FBtr0078199

NM_176372

1617

354

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

isoQC-PA

FBpp0077858

40.3

352

6.63

NP_788551

AAO41279

isoQC-PB

FBpp0077857

40.8

354

6.85

NP_788550

AAF51610

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Peptidase M28 (IPR007484)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

extracellular region

inferred from direct assay

(Schilling et al., 2007)

mitochondrion

inferred from direct assay

(Schilling et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult midgut, adult ovary, adult male accessory gland.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		(592.2)
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		27.45
Larval Midgut		140.7
Larval Hindgut		46.8
Larval Malpighian Tubules		98.8
Larval Fat Body		71.7
Larval Salivary Gland		79.4
Larval Trachea		41.975
Larval Carcass		42.325
Adult Head		49.5
Adult Eye		47.975
Adult Brain		54.5
Adult Thoracic-Abdominal Ganglion		55.3
Adult Crop		79
Adult Midgut		140.4
Adult Hindgut		62.4
Adult Malpighian Tubules		55.4
Adult Fat Body		56.5
Adult Salivary Gland		592.2
Adult Heart		74.825
Adult VirginFemale Spermatheca		46.2
Adult InseminatedFemale Spermatheca		55.9
Adult Ovary		107.6
Adult Testis		19.5
Adult Male Accessory Gland		157.2
Adult Carcass		61.5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	49.5
NA	Eye	47.975
NA	Brain	54.5
27.45	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	55.3
NA	Crop	79
140.7	Midgut	140.4
46.8	Hindgut	62.4
98.8	Malpighian Tubules	55.4
71.7	Fat Body	56.5
79.4	Salivary Gland	592.2
NA	Heart	74.825
41.975	Trachea	NA
NA	VirginFemale Spermatheca	46.2
NA	InseminatedFemale Spermatheca	55.9
NA	Ovary	107.6
NA	Testis	19.5
NA	Male Accessory Gland	157.2
42.325	Carcass	61.5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		547
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		(547)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		(547)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		547
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		547
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		(547)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		(547)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		4
central nervous system, larvae L3		2
central nervous system, pupae P8		2
head, virgin 1-day female		4
head, virgin 4-day female		2
head, virgin 20-day female		3
head, mated 1-day female		2
head, mated 4-day female		3
head, mated 20-day female		3
head, mated 1-day male		3
head, mated 4-day male		4
head, mated 20-day male		6
salivary gland, larvae L3 wandering		24
salivary gland, white prepupae		547
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		8
digestive system, 20-day adult		6
fat body, larvae L3 wandering		2
fat body, white prepupae		8
fat body, pupae P8		3
carcass, larvae L3 wandering		5
carcass, 1-day adult		3
carcass, 4-day adult		4
carcass, 20-day adult		3
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		1
accessory gland, mated 4-day male		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		(30)
embryo 12-14hr		(31)
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		21
embryo 02-04hr		11
embryo 04-06hr		16
embryo 06-08hr		20
embryo 08-10hr		24
embryo 10-12hr		30
embryo 12-14hr		31
embryo 14-16hr		23
embryo 16-18hr		20
embryo 18-20hr		12
embryo 20-22hr		12
embryo 22-24hr		13
larva L1		11
larva L2		14
larva L3 12hr old		9
larva L3 puffstage 1-2		8
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		15
white prepupae new		24
white prepupae 12hr		7
white prepupae 24hr		8
pupae 2d postWPP		12
pupae 3d postWPP		10
pupae 4d postWPP		8
adult male 01day		9
adult male 05day		9
adult male 30day		9
adult female 01day		12
adult female 05day		16
adult female 30day		17
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		9
Schneider line 2 Sg4		6
embryonic 1182-4H		9
embryonic GM2		15
embryonic Kc167		7
embryonic S1		7
embryonic S3		20
leg disc CME L1		8
wing disc CME-W2		7
wing disc ML-DmD8		5
wing disc ML-DmD9		6
wing disc ML-DmD16-c3		6
wing disc ML-DmD21		3
wing disc ML-DmD32		4
haltere disc ML-DmD17-c3		6
eye-antennal disc ML-DmD11		9
antennal disc ML-DmD20-c5		6
mixed discs ML-DmD4-c1		6
CNS ML-DmBG1-c1		7
CNS ML-DmBG2-c2		13
tumorous blood cells mbn2		6
ovary fGS/OSS		3
ovary OSC		4
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		20
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		6
Cadmium 50 mM 12 hrs, larvae L3		8
Cadmium 50 mM 48 hrs, 4-day adult		6
Cadmium 100 mM 48 hrs, 4-day adult		7
Copper 0.5 mM 12 hrs, larvae L3		3
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		5
Ethanol 2.5% 3 hrs, larvae L3		10
Ethanol 5% 3 hrs, larvae L3		6
Ethanol 10% 3 hrs, larvae L3		7
Caffeine 1.5 mg/ml 4 hrs, larvae L3		6
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		10
Caffeine 25 mg/ml 48 hrs, 4-day adult		9
Paraquat 5 mM 48 hrs, 4-day adult		8
Paraquat 10 mM 48 hrs, 4-day adult		8
Rotenone 2 μg 12 hrs, larvae L3		7
Rotenone 8 μg 12 hrs, larvae L3		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0036999

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG5976-RB

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 4 )

For All Classical Alleles Show

Allele of isoQC	Stocks	Known lesion
isoQC^c04389	1	--
isoQC^e01201	1	--
isoQC^f05019	1	--
isoQC^PL00429	1	Yes

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of isoQC	Class	Mutagen	Stocks	Known lesion
isoQC^KK108983		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
isoQC^GD462		in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes