FlyBase Gene Report: Dmel\ZnT77C

General Information

Symbol

Dmel\ZnT77C

Species

D. melanogaster

Name

Zinc transporter 77C

Annotation Symbol

CG5130

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037000

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Zinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dZnT77C

Key Links

Genomic Location

Cytogenetic map

77C4-77C6

Sequence location

3L:20,484,293..20,494,921 [-]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:20484293..20494921

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables zinc efflux transmembrane transporter activity

inferred from direct assay

(Qin et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables zinc ion transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000901728

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred by curator from GO:0016323

(Lye et al., 2013)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in detoxification of zinc ion

inferred from mutant phenotype

(Lye et al., 2013)

involved_in zinc ion transmembrane transport

inferred from mutant phenotype

(Qin et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cellular zinc ion homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN000901728

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in detoxification of zinc ion

inferred from biological aspect of ancestor with PANTHER:PTN000901729

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in zinc ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000901728

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in basolateral plasma membrane

inferred from direct assay

(Lye et al., 2013)

located_in plasma membrane

inferred from direct assay

(Qin et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in integral component of membrane

inferred from biological aspect of ancestor with PANTHER:PTN000901728

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SLC30 FAMILY OF ZINC TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Zinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

SLC30 FAMILY OF ZINC TRANSPORTERS -: Solute carrier family 30 (SLC30) or Zinc Transporters (ZnT) proteins transport Zn²⁺ from the cytosol across the plasma membrane or organelle membranes allowing accumulation into intracellular compartments. (Adapted from FBrf0220942).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ZnT77C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPE3)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ZnT77C-RA

FBtr0078220

NM_140976

2287

513

ZnT77C-RB

FBtr0078221

NM_168859

2277

513

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ZnT77C-PA

FBpp0077878

56.9

513

6.90

FBpp0077879

56.9

513

6.90

Q9VPE3

NP_730541

AAN12133

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

513 aa isoforms: ZnT77C-PA, ZnT77C-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ZnT77C using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

yolk

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 7 -- 8

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in basolateral plasma membrane

inferred from direct assay

(Lye et al., 2013)

located_in plasma membrane

inferred from direct assay

(Qin et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ZnT77C in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ZnT77C

View exonic expression by tissue for Dmel\ZnT77C

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037000

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40271/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037000

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037000

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037000

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5130

Flygut - An atlas of the Drosophila adult midgut

FBgn0037000

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\ZnT77C

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ZnT77C

Transgenic constructs containing regulatory region of ZnT77C

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ZnT77C^GD2749

viable, with Scer\GAL4^Mef2.PR

ZnT77C^GD2749

viable, with Scer\GAL4^pnr-MD237

ZnT77C^GD2749

viable, with Scer\GAL4^Tub.PU

Sterility

Allele

fertile

ZnT77C^EY12052

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC30A1

5 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\SLC30A7

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (9)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc30a1

4 of 15

Yes

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Slc30a7

1 of 15

Rattus norvegicus (Norway rat) (8)

Rnor\Slc30a1

4 of 13

Yes

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Rnor\Slc30a7

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\slc30a1

4 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\slc30a7

1 of 12

Danio rerio (Zebrafish) (10)

Drer\LOC100002134

4 of 15

Yes

Drer\slc30a1a

4 of 15

Yes

Drer\slc30a1b

4 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\slc30a7

1 of 15

Drer\slc30a10

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\cdf-1

6 of 15

Yes

Cele\ttm-1

2 of 15

Cele\cdf-2

1 of 15

Cele\toc-1

1 of 15

Yes

Cele\Y105E8A.3

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\COT1

3 of 15

Yes

Scer\ZRC1

3 of 15

Yes

Scer\MMT1

1 of 15

Scer\MMT2

1 of 15

Scer\MSC2

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\zhf1

2 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

4 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC30A1; solute carrier family 30 member 1

5 of 15

609521

SLC30A10; solute carrier family 30 member 10

3 of 15

611146

HYPERMANGANESEMIA WITH DYSTONIA 1; HMNDYT1

hypermanganesemia with dystonia 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

suppressible

(Dechen et al., 2015)

Zip71B

enhanceable

ZnT77C

(Dechen et al., 2015)

ZnT86D

enhanceable

ZnT77C

(Dechen et al., 2015)

ZnT86D

suppressible

ZnT77C

(Dechen et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037000

MIST (genetic) - An integrated Molecular Interaction Database

ZnT77C

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037000

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Metal ion SLC transporters

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

77C4-77C6

Sequence location

3L:20,484,293..20,494,921 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77C4-77C6

Limits computationally determined from genome sequence between P{EP}trbl^EP3519 and P{EP}fng^EP3082&P{lacW}skd^L7062

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43041

y¹ w^*; Mi{MIC}ZnT77C^MI06058

12473

w¹¹¹⁸; P{GT1}ZnT77C^BG01465 ND-39^BG01465

56899

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04120}attP40

20726

y¹ w^67c23; P{EPgy2}ZnT77C^EY12052 ND-39^EY12052

VDRC

v5390

w¹¹¹⁸; P{GD2749}v5390

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE32485

Other clones

FI23527

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037000

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037000

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40271

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: ZnT77C CG5130

(Lye et al., 2012)

Source for database merge of

Source for merge of: CG5130 anon-WO0118547.435

(FlyBase, 1996-)

Additional comments

Source for merge of CG5130 anon-WO0118547.435 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40271

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPE3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPE3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037000

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037000

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40271/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037000

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037000

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037000

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5130

Flygut - An atlas of the Drosophila adult midgut

FBgn0037000

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037000

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40271

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5130

MARRVEL_MODEL - MARRVEL (model organism gene)

40271

modMine - A data warehouse for the modENCODE project

FBgn0037000

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037000

DRSC - Results frm RNAi screens

FBgn0037000

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037000

FlyMine - An integrated database for Drosophila genomics

FBgn0037000

MIST (genetic) - An integrated Molecular Interaction Database

ZnT77C

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Metal ion SLC transporters

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG5130

(Yin et al., 2017, Richards and Burke, 2016, Xiao and Zhou, 2016, Qin et al., 2013, Ni et al., 2010.12.1, Buszczak et al., 2007, Lipatov et al., 2005, Wang et al., 2004)

ZNT77C

(Richards and Burke, 2016)

ZnT77C

anon-WO0118547.435

cg5130

(Lye et al., 2012)

dZnT1h

(Qin et al., 2013)

dZnT77C

(Calap-Quintana et al., 2017, Yin et al., 2017, Xiao and Zhou, 2016, Dechen et al., 2015, Lye et al., 2013, Qin et al., 2013, Lye et al., 2012, Lye et al., 2012)

Name Synonyms

Zinc transporter 77C

Secondary FlyBase IDs

FBgn0062008

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections