FB2020_06, released Dec 22, 2020

Gene: Dmel\ZnT77C

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General Information
Symbol
Dmel\ZnT77C
Species
D. melanogaster
Name
Zinc transporter 77C
Annotation Symbol
CG5130
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037000
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Zinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

dZnT77C

Key Links
Genomic Location
Cytogenetic map
77C4-77C6
Sequence location
3L:20,484,293..20,494,921 [-]
Recombination map

3-47

RefSeq locus
NT_037436 REGION:20484293..20494921
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables zinc efflux transmembrane transporter activity
inferred from direct assay
(Qin et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000901728
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0016323
(Lye et al., 2013)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in detoxification of zinc ion
inferred from mutant phenotype
(Lye et al., 2013)
involved_in zinc ion transmembrane transport
inferred from mutant phenotype
(Qin et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cellular zinc ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000901728
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in zinc ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000901728
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Lye et al., 2013)
located_in plasma membrane
inferred from direct assay
(Qin et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR002524
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000901728
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC30 FAMILY OF ZINC TRANSPORTERS -
Solute carrier family 30 (SLC30) or Zinc Transporters (ZnT) proteins transport Zn2+ from the cytosol across the plasma membrane or organelle membranes allowing accumulation into intracellular compartments. (Adapted from FBrf0220942).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ZnT77C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ZnT77C-RA
FBtr0078220
NM_140976
2287
513
ZnT77C-RB
FBtr0078221
NM_168859
2277
513
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ZnT77C-PA
FBpp0077878
56.9
513
6.90
NP_649233
AAF51612
ZnT77C-PB
FBpp0077879
56.9
513
6.90
NP_730541
AAN12133
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

513 aa isoforms: ZnT77C-PA, ZnT77C-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ZnT77C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in basolateral plasma membrane
inferred from direct assay
(Lye et al., 2013)
located_in plasma membrane
inferred from direct assay
(Qin et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ZnT77C in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ZnT77C
Transgenic constructs containing regulatory region of ZnT77C
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4Tub.PU
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC30A1
5 of 15
Yes
No
2  
Hsap\SLC30A10
3 of 15
No
No
Hsap\SLC30A3
2 of 15
No
No
Hsap\SLC30A4
2 of 15
No
No
1  
Hsap\SLC30A8
2 of 15
No
No
1  
Hsap\SLC30A2
1 of 15
No
No
1  
Hsap\SLC30A5
1 of 15
No
No
1  
Hsap\SLC30A6
1 of 15
No
Yes
Hsap\SLC30A7
1 of 15
No
No
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc30a1
4 of 15
Yes
No
Mmus\Slc30a10
3 of 15
No
No
Mmus\Slc30a3
2 of 15
No
No
Mmus\Slc30a4
2 of 15
No
No
Mmus\Slc30a8
2 of 15
No
No
Mmus\Slc30a2
1 of 15
No
No
Mmus\Slc30a5
1 of 15
No
No
Mmus\Slc30a6
1 of 15
No
Yes
Mmus\Slc30a7
1 of 15
No
No
Rattus norvegicus (Norway rat) (8)
Rnor\Slc30a1
4 of 13
Yes
No
Rnor\Slc30a10
3 of 13
No
No
Rnor\Slc30a3
2 of 13
No
No
Rnor\Slc30a4
2 of 13
No
No
Rnor\Slc30a8
2 of 13
No
No
Rnor\Slc30a5
1 of 13
No
No
Rnor\Slc30a6
1 of 13
No
Yes
Rnor\Slc30a7
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\slc30a1
4 of 12
Yes
No
Xtro\slc30a10
3 of 12
No
No
Xtro\slc30a4
2 of 12
No
No
Xtro\slc30a8
2 of 12
No
No
Xtro\LOC101730999
1 of 12
No
Yes
Xtro\slc30a2
1 of 12
No
No
Xtro\slc30a3
1 of 12
No
No
Xtro\slc30a5
1 of 12
No
No
Xtro\slc30a6
1 of 12
No
Yes
Xtro\slc30a7
1 of 12
No
No
Danio rerio (Zebrafish) (10)
Drer\LOC100002134
4 of 15
Yes
Yes
Drer\slc30a1a
4 of 15
Yes
No
Drer\slc30a1b
4 of 15
Yes
No
Drer\slc30a4
2 of 15
No
No
Drer\slc30a8
2 of 15
No
No
Drer\slc30a2
1 of 15
No
No
Drer\slc30a5
1 of 15
No
No
Drer\slc30a6
1 of 15
No
Yes
Drer\slc30a7
1 of 15
No
No
Drer\slc30a10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\cdf-1
6 of 15
Yes
No
Cele\ttm-1
2 of 15
No
No
Cele\cdf-2
1 of 15
No
No
Cele\toc-1
1 of 15
No
Yes
Cele\Y105E8A.3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\COT1
3 of 15
Yes
No
Scer\ZRC1
3 of 15
Yes
No
Scer\MMT1
1 of 15
No
No
Scer\MMT2
1 of 15
No
No
Scer\MSC2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\zhf1
2 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907I5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004334
Drosophila simulans
Dsim\GD12181
Drosophila sechellia
Dsec\GM22209
Drosophila erecta
Dere\GG13305
Drosophila yakuba
Dyak\GE22395
Drosophila yakuba
Dyak\GE22741
Drosophila ananassae
Dana\GF24127
Drosophila pseudoobscura pseudoobscura
Dpse\GA18680
Drosophila persimilis
Dper\GL12772
Drosophila willistoni
Dwil\GK12338
Drosophila virilis
Dvir\GJ13781
Drosophila mojavensis
Dmoj\GI11907
Drosophila grimshawi
Dgri\GH17013
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503CL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006911
Musca domestica
House fly
Mdoa\17004759
Glossina morsitans
Tsetse fly
Gmor\GMOY002078
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06902
Mayetiola destructor
Hessian fly
Mdes\Mdes014686
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010511
Anopheles darlingi
American malaria mosquito
Adar\ADAC006102
Anopheles gambiae
Malaria mosquito
Agam\AGAP010794
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015040
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04RN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2616276916
Apis mellifera
Western honey bee
Amel\GB54850
Apis mellifera
Western honey bee
Amel\GB54851
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10010
Bombus terrestris
Buff-tailed bumblebee
Bter\15204648
Linepithema humile
Argentine ant
Lhum\LH21869
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030a1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009127
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04516
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00912
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08296
Pediculus humanus
Human body louse
Phum\PHUM055490
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004512
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02635
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04NZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007241
Ixodes scapularis
Black-legged tick
Isca\ISCW009193
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74066.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g00430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_313112
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ZnT63C
4 of 10
ZnT33D
2 of 10
ZnT35C
2 of 10
ZnT41F
2 of 10
ZnT86D
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC30A1; solute carrier family 30 member 1
    5 of 15
    609521
         
        SLC30A10; solute carrier family 30 member 10
        3 of 15
        611146
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Zip42C.1|ZnT63C
        enhanceable
        ZnT77C
        (Lye et al., 2013)
        Zip42C.1|ZnT63C
        suppressible
        ZnT77C
        (Lye et al., 2013)
        Zip71B
        enhanceable
        ZnT77C
        (Dechen et al., 2015)
        Zip71B
        suppressible
        ZnT77C
        (Dechen et al., 2015)
        ZnT86D
        enhanceable
        ZnT77C
        (Dechen et al., 2015)
        ZnT86D
        suppressible
        ZnT77C
        (Dechen et al., 2015)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-47

        Cytogenetic map
        77C4-77C6
        Sequence location
        3L:20,484,293..20,494,921 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        77C4-77C6
        Limits computationally determined from genome sequence between P{EP}trblEP3519 and P{EP}fngEP3082&P{lacW}skdL7062
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-47

        (FlyBase, 2016)

        3-43.6

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (12)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (26)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: ZnT77C CG5130

        (Lye et al., 2012)
        Source for database merge of

        Source for merge of: CG5130 anon-WO0118547.435

        (FlyBase, 1996-)
        Additional comments

        Source for merge of CG5130 anon-WO0118547.435 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 39 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (8)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (36)