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Gene Dmel\pex16

General Information
Symbol	Dmel\pex16	Species	D. melanogaster
Name	peroxin 16	Annotation symbol	CG3947
Feature type	protein_coding_gene	FlyBase ID	FBgn0037019
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	77E6-77E6	Sequence location	3L:20,769,866..20,771,365 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene peroxin 16 is referred to in FlyBase by the symbol Dmel\pex16 (CG3947, FBgn0037019). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: spermatocyte division. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peroxisome membrane protein, Pex16. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640826_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3947. Gene sequence location is 3L:20769866..20771365.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN27609 HFA11750 References Mast et al., 2011, Dis. Model Mech. 4(5): 659--672
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77E6-77E6   Limits computationally determined from genome sequence between P{EP}trblEP3519 and P{EP}fngEP3082&P{lacW}skdL7062
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pex16 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pex16-RA FBtr0078278  NM_140995   1440   341
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pex16-PA   FBpp0077936   39.4   341   10.37     NP_649252   AAF51636
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peroxisome membrane protein, Pex16 (IPR013919)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392915   AA540613   AA698821   AA735847   AA979457   AE014296 AAF51636   AI532766   AW942559   AY061286 AAL28834   BI370080   BI486129   CL527801   CO191864   CO268987   CO317053   EC071142   EC076804   EC204124   EC204268   EC260477   GH748834   GH750613   GH755162   GH757379   GH759108   GH759111   GH773202   GH773218   GH777547   GH777565   GH778833   GH780104   GH780791   GH781779   GH782259   GH784571   GH789348   GH789692   GH789767   GH793515   GH793771   GH794989   GH802193   GH802845   GH803383   GH803840   GH807388   GH808042   GH809296   GH809457   GH810539   GH813069   GH814573   GH817815   GH818397   GH818479   GH818927   GH819656   GH821319   GH823033   GH823680   GH829305   GH833041   GH834501   GH834906   GH837182   GH838778   GH840021   GH840274   GH840986   GH843382   GH843952   GH845897   GH846710   GH853975   GH854910   GH856273   GH860092   GH860433   GH860950   GH861170   GH863971   GH864309   GH866215   GH868202   GH868650   GH880243   GH880923   GH881320   GH881595   GH883990   GH887948   GH888824   GH888918   GH889498   GH893583   GH894115   GH894755   GH895277   GH896896   GH897540   GH900089   GH903741   GH904020   GH907690   GH910318   GH910345   GH911640   GH911823   GH913991   GH915232   GH917956   GH918348   GH918835   GH920889   GH922042   GH926557   GH930821   GH936538   GH936783   GH938489   GH938766
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VPB9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037019    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037019 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037019 expression level Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2490) embryo 02-04hr  (2366) embryo 04-06hr  (1991) embryo 06-08hr  (1502) embryo 08-10hr  (1620) embryo 10-12hr  (1695) embryo 12-14hr  (1417) embryo 14-16hr  (1155) embryo 16-18hr  (1577) embryo 18-20hr  (1849) embryo 20-22hr  (1811) embryo 22-24hr  (2020) larva L1  (1142) larva L2  (991) larva L3 12hr old  (729) larva L3 puffstage 1-2  (1391) larva L3 puffstage 3-6  (1008) larva L3 puffstage 7-9  (1138) white prepupae new  (970) white prepupae 12hr  (996) white prepupae 24hr  (877) pupae 2d postWPP  (763) pupae 3d postWPP  (557) pupae 4d postWPP  (713) adult male 01day  (939) adult male 05day  (1084) adult male 30day  (1017) adult female 01day  (1240) adult female 05day  (1833) adult female 30day  (1904) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2490) embryo 02-04hr  (2366) embryo 04-06hr  (1991) embryo 06-08hr  1502 embryo 08-10hr  (1620) embryo 10-12hr  (1695) embryo 12-14hr  1417 embryo 14-16hr    1155 embryo 16-18hr  (1577) embryo 18-20hr  (1849) embryo 20-22hr  (1811) embryo 22-24hr  (2020) larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day  (1833) adult female 30day  (1904) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037019 expression level Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2490) embryo 02-04hr  (2366) embryo 04-06hr  (1991) embryo 06-08hr  (1502) embryo 08-10hr  (1620) embryo 10-12hr  (1695) embryo 12-14hr  (1417) embryo 14-16hr  (1155) embryo 16-18hr  (1577) embryo 18-20hr  (1849) embryo 20-22hr  (1811) embryo 22-24hr  (2020) larva L1  (1142) larva L2  (991) larva L3 12hr old  (729) larva L3 puffstage 1-2  (1391) larva L3 puffstage 3-6  (1008) larva L3 puffstage 7-9  (1138) white prepupae new  (970) white prepupae 12hr  (996) white prepupae 24hr  (877) pupae 2d postWPP  (763) pupae 3d postWPP  (557) pupae 4d postWPP  (713) adult male 01day  (939) adult male 05day  (1084) adult male 30day  (1017) adult female 01day  (1240) adult female 05day  (1833) adult female 30day  (1904) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2490) embryo 02-04hr  2366 embryo 04-06hr  1991 embryo 06-08hr  1502 embryo 08-10hr  1620 embryo 10-12hr  1695 embryo 12-14hr  1417 embryo 14-16hr    1155 embryo 16-18hr  1577 embryo 18-20hr  1849 embryo 20-22hr  1811 embryo 22-24hr  2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day  1833 adult female 30day  1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2490 embryo 02-04hr    2366 embryo 04-06hr    1991 embryo 06-08hr    1502 embryo 08-10hr    1620 embryo 10-12hr    1695 embryo 12-14hr    1417 embryo 14-16hr    1155 embryo 16-18hr    1577 embryo 18-20hr    1849 embryo 20-22hr    1811 embryo 22-24hr    2020 larva L1    1142 larva L2    991 larva L3 12hr old    729 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    1008 larva L3 puffstage 7-9    1138 white prepupae new    970 white prepupae 12hr    996 white prepupae 24hr    877 pupae 2d postWPP    763 pupae 3d postWPP    557 pupae 4d postWPP    713 adult male 01day    939 adult male 05day    1084 adult male 30day    1017 adult female 01day    1240 adult female 05day    1833 adult female 30day    1904 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037019    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037019 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037019 expression level Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop  514.1 Adult Midgut  (641.2) Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037019 expression level Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop  514.1 Adult Midgut  641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    135.05 Larval Midgut    331.1 Larval Hindgut    111.8 Larval Malpighian Tubules    364.8 Larval Fat Body    166.3 Larval Salivary Gland    221.4 Larval Trachea    187.3 Larval Carcass    112.875 Adult Head    134.2 Adult Eye    145.325 Adult Brain    124 Adult Thoracic-Abdominal Ganglion    96.6 Adult Crop    514.1 Adult Midgut    641.2 Adult Hindgut    274.8 Adult Malpighian Tubules    394.6 Adult Fat Body    201.5 Adult Salivary Gland    152.2 Adult Heart    231.45 Adult VirginFemale Spermatheca    68.1 Adult InseminatedFemale Spermatheca    80.1 Adult Ovary    215 Adult Testis    36.3 Adult Male Accessory Gland    199.6 Adult Carcass    182 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    134.2   NA  Eye    145.325   NA  Brain    124   135.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    96.6   NA  Crop    514.1   331.1  Midgut    641.2   111.8  Hindgut    274.8   364.8  Malpighian Tubules    394.6   166.3  Fat Body    201.5   221.4  Salivary Gland    152.2   NA  Heart    231.45   187.3  Trachea    NA   NA  VirginFemale Spermatheca    68.1   NA  InseminatedFemale Spermatheca    80.1   NA  Ovary    215   NA  Testis    36.3   NA  Male Accessory Gland    199.6   112.875  Carcass    182 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3947-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable pex16EY05323 viable, with Scer\GAL4pnr-MD237 pex16GD10697 Sterility Allele fertile pex16EY05323 Other Phenotypes Allele cytokinesis defective pex16EY05323 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of pex16 Class Mutagen Stocks Known lesion pex16EY05323 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pex16 Class Mutagen Stocks Known lesion pex16GD10697 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes pex16KK107609 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK107609} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}pex16EY05323 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
spermatocyte division inferred from mutant phenotype (Chen et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
peroxisome organization inferred from sequence or structural similarity with NCBI_gi:4758898 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pex16 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037019 DroID - A comprehensive database of gene and protein interactions. • FBgn0037019
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24114 Dere\GG13286 Dgri\GH16755 Dmoj\GI13416 Dper\GL12754 Dpse\GA17796 Dsec\GM22189 Dsim\GD12164 Dvir\GJ11541 Dwil\GK12314 Dyak\GE22384
Curated drosophilid orthologs	Dpse\GA17796
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010461-PA Aedes aegypti (mosquito) AGAP002283-PA Anopheles gambiae (mosquito) XP_001121573.1 Apis mellifera (honey bee) XP_001944387.1 Acyrthosiphon pisum (pea aphid) At2g45690.1 Arabidopsis thaliana (wall cress) 85024 Batrachochytrium dendrobatidis (chytrid fungus) 222918 Branchiostoma floridae (lancelet) 257621 Branchiostoma floridae (lancelet) BGIBMGA002029-PA Bombyx mori (silk worm) ENSBTAP00000004065 Bos taurus (bovine) ENSCAFP00000035732 Canis familiaris (dog) ENSCINP00000001958 Ciona intestinalis (sea squirt) CPIJ013683 Culex pipens (mosquito) CPIJ020196 Culex pipens (mosquito) ENSCPOP00000014352 Cavia porcellus (guinea pig) ENSCSAVP00000008475 Ciona savignyi (sedentary tunicate) 152987 Capitella spl (polychaete worm) DDB0238079 Dictyostelium discoideum (amoeba) 307710 Daphnia pulex (daphnia) ENSDARP00000075468 Danio rerio (zebra fish) ENSECAP00000009623 Equus caballus (horse) ENSGALP00000013703 Gallus gallus (chicken) 185649 Hypsipyla robusta (cedar shoot borer) ENSP00000241041 Homo sapiens (human) ISCW013288-PA Ixodes scapularis (deer tick) 208740 Lottia gigantea (owl limpet) ENSMODP00000024809 Monodelphis domestica (gray opossum) ENSMMUP00000011645 Macaca mulatta (rhesus monkey) ENSMUSP00000028650 Mus musculus (house mouse) 231006 Nematostella vectensis (starlet anemone) XP_001600194.1 Nasonia vitripennis (wasp) ENSOANP00000003898 Ornithorynchus anatinus (platypus) LOC_Os02g03070.1 Oryza sativa (asian rice) PHUM000540-PA Pediculus humanus (human body louse) 114301 Physcomitrella patens (moss) 76428 Phytophthora ramorum (sudden oak death pathogen) 128912 Phytophthora sojae (root rot pathogen) 774323 Populus trichocarpa (black cottonwood) ENSPTRP00000006141 Pan troglodytes (chimpanzee) ENSRNOP00000008986 Rattus norvegicus (norway rat) 5003486 Sorghum bicolor (sorghum) XP_782904.2 Strongylocentrotus purpuratus (purple sea urchin) 32406 Trichoplax adhaerens (metazoa) XP_970655.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007413 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021308 Takifugu rubripes (pufferfish Takifugu) 90.m00173 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000002242 Xenopus tropicalis (frog) YALI0E16599g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17669 NV17314 LH10785 ISCW013288 FBgn0239607 FBgn0232650 FBgn0214324 FBgn0198799 FBgn0183901 FBgn0177060 JGI_V11_307710 FBgn0077805 FBgn0150360 FBgn0136172 FBgn0124226 FBgn0105558 FBgn0101108 CPIJ013683 CPIJ020196 BGIBMGA002029 ACYPI009372 GB18640 AGAP002283 AAEL010461 PHUM457620 GLEAN_07629
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	16651 y1 w67c23; P{EPgy2}pex16EY05323
VDRC	v34296 w1118; P{GD10697}v34296 v34297 w1118; P{GD10697}v34297 v40886 w1118; P{GD10697}v40886
Genomic Clones ( 2 )
	BACR22I16 BACR48C13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 119 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD20358
Other clones	DPiM_LD20358
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM09963 HL05752 LD12069 LD34034 RE56470 RE69508 SD04375
Other clones	117451 163135 165754 214251.44 CK01.122A.C4 EC32302 EK093242 EK266951 RP003022890 RP003045793 RP003049522 RP003051597 RP003056849 RP003068377 RP003070545 RP003079599 RP003079670 RP003080056 RP003084402 RP003093059 RP003093589 RP003097146 RP003120250 RP003124934 RP003133938 RP003135366 RP003141243 RP003141298 RP003157738 RP003161319 RP003169479 RP003176736 RP003189784 RP003190014 RP003192028 RP003193469 RP003198723 RP003202818 RP003208477 RP003209395 RP003211587 RP003213783 RP003215391 RP003215895 RP003220820 RP003232005 RP003236999 RP003239896 RP003247662 RP003251178 RP003260340 RP003264694 RP003264846 RP003267086 RP003268073 RP003271523 RP003277842 RP003285731 RP003305965 RP003311010 RP003312851 RP003318251 RP003320901 RP003321077 RP003321085 RP003389852 RP003390838 RP003403675 RP003404855 RP003413659 RP003430886 RP003434226 RP003434929 RP003438818 RP003443054 RP003464496 RP003465452 RP003469611 RP003473647 RP003479310 RP003481528 RP003491417 RP003502873 RP003522260 RP003526817 RP003528347 RP003533680 RP003535019 RP003540850 RP003550397 RP003550811 RP003551281 RP003553250 RP003553348 RP003563712 RP003571275 RP003575227 RP003579238 RP003587952 RP003603182 RP003618423 RP003621726 RP003627235 RP003628506 RP003657584 RP003658511 RP003659693 RP003664101 RP003668145 RP003673483
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40293
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: pex16 CG3947 (Chen et al., 2010)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140995 RefSeq (Proteins) • NP_649252 DDBJ / EMBL / GenBank • AA540613 AAF51636 AAL28834 AW942559 AY061286 CL527801 Entrez Gene - A searchable database of RefSeq genes. • 40293 UniProtKB/TrEMBL • Q9VPB9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peroxisome membrane protein, Pex16 (IPR013919)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037019 DroID - A comprehensive database of gene and protein interactions. • FBgn0037019 DRSC - Results from RNAi screens. • FBgn0037019 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3947-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40293 InParanoid A subset of ortholog calls from InParanoid. • AAEL010461-PA Aedes aegypti (mosquito) AGAP002283-PA Anopheles gambiae (mosquito) XP_001121573.1 Apis mellifera (honey bee) XP_001944387.1 Acyrthosiphon pisum (pea aphid) At2g45690.1 Arabidopsis thaliana (wall cress) 85024 Batrachochytrium dendrobatidis (chytrid fungus) 222918 Branchiostoma floridae (lancelet) 257621 Branchiostoma floridae (lancelet) BGIBMGA002029-PA Bombyx mori (silk worm) ENSBTAP00000004065 Bos taurus (bovine) ENSCAFP00000035732 Canis familiaris (dog) ENSCINP00000001958 Ciona intestinalis (sea squirt) CPIJ013683 Culex pipens (mosquito) CPIJ020196 Culex pipens (mosquito) ENSCPOP00000014352 Cavia porcellus (guinea pig) ENSCSAVP00000008475 Ciona savignyi (sedentary tunicate) 152987 Capitella spl (polychaete worm) DDB0238079 Dictyostelium discoideum (amoeba) 307710 Daphnia pulex (daphnia) ENSDARP00000075468 Danio rerio (zebra fish) ENSECAP00000009623 Equus caballus (horse) ENSGALP00000013703 Gallus gallus (chicken) 185649 Hypsipyla robusta (cedar shoot borer) ENSP00000241041 Homo sapiens (human) ISCW013288-PA Ixodes scapularis (deer tick) 208740 Lottia gigantea (owl limpet) ENSMODP00000024809 Monodelphis domestica (gray opossum) ENSMMUP00000011645 Macaca mulatta (rhesus monkey) ENSMUSP00000028650 Mus musculus (house mouse) 231006 Nematostella vectensis (starlet anemone) XP_001600194.1 Nasonia vitripennis (wasp) ENSOANP00000003898 Ornithorynchus anatinus (platypus) LOC_Os02g03070.1 Oryza sativa (asian rice) PHUM000540-PA Pediculus humanus (human body louse) 114301 Physcomitrella patens (moss) 76428 Phytophthora ramorum (sudden oak death pathogen) 128912 Phytophthora sojae (root rot pathogen) 774323 Populus trichocarpa (black cottonwood) ENSPTRP00000006141 Pan troglodytes (chimpanzee) ENSRNOP00000008986 Rattus norvegicus (norway rat) 5003486 Sorghum bicolor (sorghum) XP_782904.2 Strongylocentrotus purpuratus (purple sea urchin) 32406 Trichoplax adhaerens (metazoa) XP_970655.1 Tribolium castaneum (red flour beetle) ENSTNIP00000007413 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000021308 Takifugu rubripes (pufferfish Takifugu) 90.m00173 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000002242 Xenopus tropicalis (frog) YALI0E16599g Yarrowia lipolytica (nonconventional yeast) modMine - Data generated by the modENCODE project. • FBgn0037019 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17669 NV17314 LH10785 ISCW013288 FBgn0239607 FBgn0232650 FBgn0214324 FBgn0198799 FBgn0183901 FBgn0177060 JGI_V11_307710 FBgn0077805 FBgn0150360 FBgn0136172 FBgn0124226 FBgn0105558 FBgn0101108 CPIJ013683 CPIJ020196 BGIBMGA002029 ACYPI009372 GB18640 AGAP002283 AAEL010461 PHUM457620 GLEAN_07629
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG3947 (Keleman et al., 2009.8.5) pex16 (Chen et al., 2010)
Name Synonym	peroxin 16
Secondary FlyBase IDs
References ( 11 )
Research paper	Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. [FBrf0215017] Chen et al., 2010, Hum. Mol. Genet. 19(3): 494--505 Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. [FBrf0209624] Inlow and Restifo, 2004, Genetics 166(2): 835--881 Molecular and comparative genetics of mental retardation. [FBrf0174714]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Heiman, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126693]