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Gene Dmel\CG10512

General Information
Symbol	Dmel\CG10512	Species	D. melanogaster
Name		Annotation symbol	CG10512
Feature type	protein_coding_gene	FlyBase ID	FBgn0037057
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78C2-78C2	Sequence location	3L:21,196,020..21,201,194 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10512 (FBgn0037057). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: oxidoreductase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process. 6 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Malate/L-lactate dehydrogenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult midgut, adult Malpighian tubules, adult salivary gland, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1636843_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of CG10512. Gene sequence location is 3L:21196020..21201194.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN30640 HFA11615
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78C2-78C2   Limits computationally determined from genome sequence between P{EP}chbEP3403 and P{PZ}ppl00217
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10512 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10512-RA FBtr0078297  NM_141032   2012   446 CG10512-RB FBtr0078298  NM_168889   1844   381 CG10512-RC FBtr0078299  NM_168890   1689   361 CG10512-RD FBtr0078300  NM_206411   1661   361
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10512-PA   FBpp0077954   47.1   446   8.38     NP_649289   AAF51687 CG10512-PB   FBpp0077955   40.2   381   7.78     NP_730605   AAN12158 CG10512-PC   FBpp0077956   38.0   361   6.78     NP_730606   AAN12159 CG10512-PD   FBpp0077957   38.0   361   6.78     NP_996133   AAS65086
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Malate/L-lactate dehydrogenase (IPR003767)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698281   AA820512   AE014296 AAF51687   AE014296 AAN12158   AE014296 AAN12159   AE014296 AAS65086   AI106900   AI455444   AI531251   AI532960   AI533563   AI543677   AI944669   AW940218   AY047551 AAK77283   BI165784   BI166186   BI168598   BI170461   BI213475   BI228197   BI231018   BI232086   BI239471   BI239685   BI241614   BI361455   BI374356   BI486829   BI632291   BI632461   BI633825   BI639615   BP541109   BT044163   BZ286356   CA806245   CK656962   CO195487   CO293109   CO321803   CO340058   CZ474202   CZ474464   EC075171   EC233271   EC246244   EC260283   EL885530   EL885649
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPT9 Q8IPU0 Q961U7 Q9VP68
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037057    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037057 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037057 expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr  (123) embryo 04-06hr  (250) embryo 06-08hr  (2497) embryo 08-10hr  (5114) embryo 10-12hr  (5475) embryo 12-14hr  (2622) embryo 14-16hr  (1064) embryo 16-18hr  (1237) embryo 18-20hr  (2724) embryo 20-22hr  (8113) embryo 22-24hr  (7104) larva L1  (9721) larva L2  (8497) larva L3 12hr old  (8264) larva L3 puffstage 1-2  (7108) larva L3 puffstage 3-6  (4702) larva L3 puffstage 7-9  (2046) white prepupae new  (1047) white prepupae 12hr  (2211) white prepupae 24hr  (773) pupae 2d postWPP  (913) pupae 3d postWPP  (2086) pupae 4d postWPP  (1394) adult male 01day  (2075) adult male 05day  (2013) adult male 30day  (1811) adult female 01day  (1127) adult female 05day  (708) adult female 30day  (878) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr  (2497) embryo 08-10hr  (5114) embryo 10-12hr  (5475) embryo 12-14hr  (2622) embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr  (2724) embryo 20-22hr  (8113) embryo 22-24hr  (7104) larva L1  (9721) larva L2  (8497) larva L3 12hr old  (8264) larva L3 puffstage 1-2  (7108) larva L3 puffstage 3-6  (4702) larva L3 puffstage 7-9  (2046) white prepupae new    1047 white prepupae 12hr  (2211) white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP  (2086) pupae 4d postWPP    1394 adult male 01day  (2075) adult male 05day  (2013) adult male 30day  (1811) adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037057 expression level Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr  123 embryo 04-06hr  (250) embryo 06-08hr  (2497) embryo 08-10hr  (5114) embryo 10-12hr  (5475) embryo 12-14hr  (2622) embryo 14-16hr  (1064) embryo 16-18hr  (1237) embryo 18-20hr  (2724) embryo 20-22hr  (8113) embryo 22-24hr  (7104) larva L1  (9721) larva L2  (8497) larva L3 12hr old  (8264) larva L3 puffstage 1-2  (7108) larva L3 puffstage 3-6  (4702) larva L3 puffstage 7-9  (2046) white prepupae new  (1047) white prepupae 12hr  (2211) white prepupae 24hr  (773) pupae 2d postWPP  (913) pupae 3d postWPP  (2086) pupae 4d postWPP  (1394) adult male 01day  (2075) adult male 05day  (2013) adult male 30day  (1811) adult female 01day  (1127) adult female 05day  (708) adult female 30day  (878) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr  (2497) embryo 08-10hr  (5114) embryo 10-12hr  (5475) embryo 12-14hr  (2622) embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr  (2724) embryo 20-22hr  (8113) embryo 22-24hr  (7104) larva L1  (9721) larva L2  (8497) larva L3 12hr old  (8264) larva L3 puffstage 1-2  (7108) larva L3 puffstage 3-6  (4702) larva L3 puffstage 7-9  2046 white prepupae new    1047 white prepupae 12hr  2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP  2086 pupae 4d postWPP    1394 adult male 01day  2075 adult male 05day  2013 adult male 30day  1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    69 embryo 02-04hr    123 embryo 04-06hr    250 embryo 06-08hr    2497 embryo 08-10hr    5114 embryo 10-12hr    5475 embryo 12-14hr    2622 embryo 14-16hr    1064 embryo 16-18hr    1237 embryo 18-20hr    2724 embryo 20-22hr    8113 embryo 22-24hr    7104 larva L1    9721 larva L2    8497 larva L3 12hr old    8264 larva L3 puffstage 1-2    7108 larva L3 puffstage 3-6    4702 larva L3 puffstage 7-9    2046 white prepupae new    1047 white prepupae 12hr    2211 white prepupae 24hr    773 pupae 2d postWPP    913 pupae 3d postWPP    2086 pupae 4d postWPP    1394 adult male 01day    2075 adult male 05day    2013 adult male 30day    1811 adult female 01day    1127 adult female 05day    708 adult female 30day    878 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037057    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037057 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult spermathecae, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, adult midgut, adult Malpighian tubules, adult salivary gland, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037057 expression level Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut    1101.4 Larval Hindgut    1183.9 Larval Malpighian Tubules    3686.5 Larval Fat Body    1265.6 Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass    1979.15 Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body    1102.6 Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca    1841.7 Adult InseminatedFemale Spermatheca    1523.2 Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut  (1101.4) Larval Hindgut  (1183.9) Larval Malpighian Tubules  (3686.5) Larval Fat Body  (1265.6) Larval Salivary Gland  (951.3) Larval Trachea    330.15 Larval Carcass  (1979.15) Adult Head  520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut  (707.9) Adult Malpighian Tubules    491.8 Adult Fat Body  (1102.6) Adult Salivary Gland    223.7 Adult Heart  (548.3) Adult VirginFemale Spermatheca  (1841.7) Adult InseminatedFemale Spermatheca  (1523.2) Adult Ovary    34.8 Adult Testis  501.5 Adult Male Accessory Gland    38.8 Adult Carcass  (584.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut  (1101.4) Larval Hindgut  (1183.9) Larval Malpighian Tubules  (3686.5) Larval Fat Body  (1265.6) Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass  (1979.15) Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body  (1102.6) Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca  (1841.7) Adult InseminatedFemale Spermatheca  (1523.2) Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut    1101.4 Larval Hindgut    1183.9 Larval Malpighian Tubules    3686.5 Larval Fat Body    1265.6 Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass    1979.15 Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body    1102.6 Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca    1841.7 Adult InseminatedFemale Spermatheca    1523.2 Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037057 expression level Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut    1101.4 Larval Hindgut    1183.9 Larval Malpighian Tubules    3686.5 Larval Fat Body    1265.6 Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass    1979.15 Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body    1102.6 Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca    1841.7 Adult InseminatedFemale Spermatheca    1523.2 Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut  (1101.4) Larval Hindgut  (1183.9) Larval Malpighian Tubules  (3686.5) Larval Fat Body  (1265.6) Larval Salivary Gland  (951.3) Larval Trachea    330.15 Larval Carcass  (1979.15) Adult Head  520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut  707.9 Adult Malpighian Tubules    491.8 Adult Fat Body  (1102.6) Adult Salivary Gland    223.7 Adult Heart  548.3 Adult VirginFemale Spermatheca  (1841.7) Adult InseminatedFemale Spermatheca  (1523.2) Adult Ovary    34.8 Adult Testis  501.5 Adult Male Accessory Gland    38.8 Adult Carcass  584.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut  1101.4 Larval Hindgut  1183.9 Larval Malpighian Tubules  (3686.5) Larval Fat Body  1265.6 Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass  (1979.15) Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body  1102.6 Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca  (1841.7) Adult InseminatedFemale Spermatheca  1523.2 Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    485.975 Larval Midgut    1101.4 Larval Hindgut    1183.9 Larval Malpighian Tubules    3686.5 Larval Fat Body    1265.6 Larval Salivary Gland    951.3 Larval Trachea    330.15 Larval Carcass    1979.15 Adult Head    520.8 Adult Eye    247.6 Adult Brain    232.5 Adult Thoracic-Abdominal Ganglion    329.9 Adult Crop    486.3 Adult Midgut    169.2 Adult Hindgut    707.9 Adult Malpighian Tubules    491.8 Adult Fat Body    1102.6 Adult Salivary Gland    223.7 Adult Heart    548.3 Adult VirginFemale Spermatheca    1841.7 Adult InseminatedFemale Spermatheca    1523.2 Adult Ovary    34.8 Adult Testis    501.5 Adult Male Accessory Gland    38.8 Adult Carcass    584.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    520.8   NA  Eye    247.6   NA  Brain    232.5   485.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    329.9   NA  Crop    486.3   1101.4  Midgut    169.2   1183.9  Hindgut    707.9   3686.5  Malpighian Tubules    491.8   1265.6  Fat Body    1102.6   951.3  Salivary Gland    223.7   NA  Heart    548.3   330.15  Trachea    NA   NA  VirginFemale Spermatheca    1841.7   NA  InseminatedFemale Spermatheca    1523.2   NA  Ovary    34.8   NA  Testis    501.5   NA  Male Accessory Gland    38.8   1979.15  Carcass    584.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037057 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10512-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG10512 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CG10512GD6998 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG10512GD6998 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 CG10512GD6998
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CG10512 Class Mutagen Stocks Known lesion CG10512d04902 P-element activity 1 -- CG10512EY00040 P-element activity 1 Yes CG10512CPTI003660 piggyBac transposase 0 Yes CG10512d05332 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10512 Class Mutagen Stocks Known lesion CG10512GD6998 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10512KK110640 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6998} NA P{KK110640} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG10512EY00040 NA P{XP}CG10512d04902 NA P{XP}CG10512d05332 NA miscellaneous insertions PBac{768.FSVS-0}CG10512CPTI003660 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
oxidoreductase activity inferred from electronic annotation with InterPro:IPR003767 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR003767 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10512 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65588 DroID - A comprehensive database of gene and protein interactions. • FBgn0037057 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40339
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24300 Dere\GG16165 Dgri\GH14969 Dmoj\GI13129 Dper\GL24667 Dpse\GA10363 Dsec\GM22347 Dsim\GD17648 Dvir\GJ13877 Dwil\GK16815 Dyak\GE19733
Curated drosophilid orthologs	Dpse\GA10363
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006576-PA Anopheles gambiae (mosquito) XP_393999.2 Apis mellifera (honey bee) 122671 Branchiostoma floridae (lancelet) XP_001893379.1 Brugia malayi (roundworm nematode) BGIBMGA004130-PA Bombyx mori (silk worm) CBP00765 Caenorhabditis briggsae (nematode) CE21229 Caenorhabditis elegans (worm) ENSCINP00000021758 Ciona intestinalis (sea squirt) CPIJ016732 Culex pipens (mosquito) RP13626 Caenorhabditis remanei (nematode) 19149 Capitella spl (polychaete worm) 214190 Daphnia pulex (daphnia) NP_415050.1 Escherichia coli K12 (bacteria) XP_655601 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004639 Gymnopilus aculeatus (mushroom) 191945 Hypsipyla robusta (cedar shoot borer) ISCW018085-PA Ixodes scapularis (deer tick) 223255 Lottia gigantea (owl limpet) 202059 Nematostella vectensis (starlet anemone) XP_001600695.1 Nasonia vitripennis (wasp) ENSORLP00000002622 Oryzias latipes (japanese killifish) 24465 Ostreococcus tauri (green alga) PHUM004806-PA Pediculus humanus (human body louse) PP27702 Pristionchus pacificus (nematode) 589795 Populus trichocarpa (black cottonwood) Smp_129610 Schistosoma mansoni (trematode parasite) XP_789073.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967440.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011298 Tetraodon nigroviridis (green spotted pufferfish) 25953 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041508 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057456 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16943 LH24639 ISCW018085 FBgn0240256 FBgn0237066 FBgn0218815 FBgn0201096 FBgn0189198 FBgn0177217 JGI_V11_214190 FBgn0070420 FBgn0162255 FBgn0135886 FBgn0122444 FBgn0119612 FBgn0108400 FBgn0101294 CPIJ016732 BGIBMGA004130 BGIBMGA003989 GB15543 AGAP006576 AAEL000314 PB21995 PHUM377890 GLEAN_09052 GLEAN_09053
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	14802 y1 w67c23; P{EPgy2}CG10512EY00040 CG33056EY00040
Harvard	- P{XP}CG10512d04902
VDRC	v102080 P{KK110640}VIE-260B v27272 w1118; P{GD6998}v27272/TM3
Genomic Clones ( 2 )
	BACR02C22 BACR24H03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06154
Other clones	FI03684
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL04207 LP22841 RE05742 RE06230 RE09404 RE11912 RE16696 RE18882 RE25656 RE28095 RE35959 RE36251 RE38729 RE45672 RE61920 RE70304 SD02210 SD04622 SD05439 SD10549 SD22246 SD26032 SD26248 SD27991
Other clones	19540 59821 72851 214339.50 bs04a05 EC40462 EK186425 EK201729 EP09943 ESG012c.E21_A10 FGA010F09 IP16911 IP17011 LD24279
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037057 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40339
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141032 NM_168889 NM_168890 NM_206411 RefSeq (Proteins) • NP_649289 NP_730605 NP_730606 NP_996133 DDBJ / EMBL / GenBank • AAF51687 AAK77283 AAN12158 AAN12159 AAS65086 AI106900 AI533563 AI944669 AW940218 AY047551 BZ286356 CZ474202 CZ474464 Entrez Gene - A searchable database of RefSeq genes. • 40339 UniProtKB/TrEMBL • Q8IPT9 Q8IPU0 Q9VP68 Q961U7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Malate/L-lactate dehydrogenase (IPR003767)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65588 DroID - A comprehensive database of gene and protein interactions. • FBgn0037057 DRSC - Results from RNAi screens. • FBgn0037057 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037057 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10512-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037057 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40339 InParanoid A subset of ortholog calls from InParanoid. • AGAP006576-PA Anopheles gambiae (mosquito) XP_393999.2 Apis mellifera (honey bee) 122671 Branchiostoma floridae (lancelet) XP_001893379.1 Brugia malayi (roundworm nematode) BGIBMGA004130-PA Bombyx mori (silk worm) CBP00765 Caenorhabditis briggsae (nematode) CE21229 Caenorhabditis elegans (worm) ENSCINP00000021758 Ciona intestinalis (sea squirt) CPIJ016732 Culex pipens (mosquito) RP13626 Caenorhabditis remanei (nematode) 19149 Capitella spl (polychaete worm) 214190 Daphnia pulex (daphnia) NP_415050.1 Escherichia coli K12 (bacteria) XP_655601 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000004639 Gymnopilus aculeatus (mushroom) 191945 Hypsipyla robusta (cedar shoot borer) ISCW018085-PA Ixodes scapularis (deer tick) 223255 Lottia gigantea (owl limpet) 202059 Nematostella vectensis (starlet anemone) XP_001600695.1 Nasonia vitripennis (wasp) ENSORLP00000002622 Oryzias latipes (japanese killifish) 24465 Ostreococcus tauri (green alga) PHUM004806-PA Pediculus humanus (human body louse) PP27702 Pristionchus pacificus (nematode) 589795 Populus trichocarpa (black cottonwood) Smp_129610 Schistosoma mansoni (trematode parasite) XP_789073.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967440.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011298 Tetraodon nigroviridis (green spotted pufferfish) 25953 Thalassiosira pseudonana (marine diatom) ENSTRUP00000041508 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057456 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40339 modMine - Data generated by the modENCODE project. • FBgn0037057 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16943 LH24639 ISCW018085 FBgn0240256 FBgn0237066 FBgn0218815 FBgn0201096 FBgn0189198 FBgn0177217 JGI_V11_214190 FBgn0070420 FBgn0162255 FBgn0135886 FBgn0122444 FBgn0119612 FBgn0108400 FBgn0101294 CPIJ016732 BGIBMGA004130 BGIBMGA003989 GB15543 AGAP006576 AAEL000314 PB21995 PHUM377890 GLEAN_09052 GLEAN_09053
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG10512 (Keleman et al., 2009.8.5, Willis et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Asha et al., 2003, Genetics 163(1): 203--215 Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	FlyProt project., 2011.8.8, CPTI protein trap lines available from the Kyoto Stock Center. CPTI protein trap lines available from the Kyoto Stock Center. [FBrf0214588] Knowles-Barley, 2011.8.24, BrainTrap expression curation. BrainTrap expression curation. [FBrf0215202] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]