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Gene Dmel\Syx6

General Information
Symbol	Dmel\Syx6	Species	D. melanogaster
Name	Syntaxin 6	Annotation symbol	CG7736
Feature type	protein_coding_gene	FlyBase ID	FBgn0037084
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	47D7-47E1	Sequence location	2R:7,107,046..7,109,987 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Syntaxin 6 is referred to in FlyBase by the symbol Dmel\Syx6 (CG7736, FBgn0037084). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: SNAP receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: synaptic vesicle docking involved in exocytosis. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Syntaxin 6, N-terminal; Target SNARE coiled-coil domain; t-SNARE. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639075_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Syx6. Gene sequence location is 2R:7107046..7109987.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA07032 BKN29340
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47D7-47E1   Limits computationally determined from genome sequence between P{EP}shnEP2359&P{EP}shnEP644 and P{PZ}rM547
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Syx6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Syx6-RB FBtr0088103  NM_206093   1731   226 Syx6-RD FBtr0088104  NM_206092   1982   323 Syx6-RE FBtr0088102  NM_206094   2087   339
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Syx6-PB   FBpp0087204   25.1   226   6.57     NP_995815   AAF58710 Syx6-PD   FBpp0087205   36.6   323   6.02     NP_995814   AAM68720 Syx6-PE   FBpp0087203   38.2   339   6.39     NP_995816   AAM68721
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) t-SNARE (IPR010989) Syntaxin 6, N-terminal (IPR015260)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58710   AE013599 AAM68720   AE013599 AAM68721   AI516648   AY089525   BF487494   BG638734   BI214793   BI230517   BI238683   BI242796   BI242849   BI357807   BI363614   BI570431   BP555407   BT001663 AAN71418   BT003505 AAO39509   BT021399 AAX33547   CL943644   CO178833   CO183157   CO190993   CO266363   CO276291   CO276493   CO281630   CO286250   CO294864   CO299428   CO301215   CO301311   DN154064   DN154299   EC073426   EC080945   EC085551   EC086968   EC087061   EC201394   EC211449   EC212594   EC218833   EC221929   EC234694   EC247467   ES695979   GH769895
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q5BI25 Q86P32 Q7JRF1 Q7JY00
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037084    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037084 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 12-18 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037084 expression level Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3702) embryo 02-04hr  (1650) embryo 04-06hr  (1221) embryo 06-08hr  (925) embryo 08-10hr  (785) embryo 10-12hr  (874) embryo 12-14hr  (916) embryo 14-16hr  (1823) embryo 16-18hr  (1670) embryo 18-20hr  (1335) embryo 20-22hr  (873) embryo 22-24hr  (976) larva L1  (1099) larva L2  (729) larva L3 12hr old  (478) larva L3 puffstage 1-2  (783) larva L3 puffstage 3-6  (1039) larva L3 puffstage 7-9  (1171) white prepupae new  (1106) white prepupae 12hr  (1311) white prepupae 24hr  (1607) pupae 2d postWPP  (1576) pupae 3d postWPP  (1224) pupae 4d postWPP  (1252) adult male 01day  (1554) adult male 05day  (2337) adult male 30day  (2424) adult female 01day  (1709) adult female 05day  (2133) adult female 30day  (2120) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3702) embryo 02-04hr  (1650) embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr  (1823) embryo 16-18hr  (1670) embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr  (1607) pupae 2d postWPP  (1576) pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day  (1554) adult male 05day  (2337) adult male 30day  (2424) adult female 01day  (1709) adult female 05day  (2133) adult female 30day  (2120) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037084 expression level Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3702) embryo 02-04hr  (1650) embryo 04-06hr  (1221) embryo 06-08hr  (925) embryo 08-10hr  (785) embryo 10-12hr  (874) embryo 12-14hr  (916) embryo 14-16hr  (1823) embryo 16-18hr  (1670) embryo 18-20hr  (1335) embryo 20-22hr  (873) embryo 22-24hr  (976) larva L1  (1099) larva L2  (729) larva L3 12hr old  (478) larva L3 puffstage 1-2  (783) larva L3 puffstage 3-6  (1039) larva L3 puffstage 7-9  (1171) white prepupae new  (1106) white prepupae 12hr  (1311) white prepupae 24hr  (1607) pupae 2d postWPP  (1576) pupae 3d postWPP  (1224) pupae 4d postWPP  (1252) adult male 01day  (1554) adult male 05day  (2337) adult male 30day  (2424) adult female 01day  (1709) adult female 05day  (2133) adult female 30day  (2120) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3702) embryo 02-04hr  1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr  1823 embryo 16-18hr  1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr  1607 pupae 2d postWPP  1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day  1554 adult male 05day  2337 adult male 30day  2424 adult female 01day  1709 adult female 05day  2133 adult female 30day  2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3702 embryo 02-04hr    1650 embryo 04-06hr    1221 embryo 06-08hr    925 embryo 08-10hr    785 embryo 10-12hr    874 embryo 12-14hr    916 embryo 14-16hr    1823 embryo 16-18hr    1670 embryo 18-20hr    1335 embryo 20-22hr    873 embryo 22-24hr    976 larva L1    1099 larva L2    729 larva L3 12hr old    478 larva L3 puffstage 1-2    783 larva L3 puffstage 3-6    1039 larva L3 puffstage 7-9    1171 white prepupae new    1106 white prepupae 12hr    1311 white prepupae 24hr    1607 pupae 2d postWPP    1576 pupae 3d postWPP    1224 pupae 4d postWPP    1252 adult male 01day    1554 adult male 05day    2337 adult male 30day    2424 adult female 01day    1709 adult female 05day    2133 adult female 30day    2120 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037084    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037084 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037084 expression level Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain  (751.7) Adult Thoracic-Abdominal Ganglion  (749) Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037084 expression level Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain  751.7 Adult Thoracic-Abdominal Ganglion  749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    283.9 Larval Midgut    356.6 Larval Hindgut    175 Larval Malpighian Tubules    283.7 Larval Fat Body    140.8 Larval Salivary Gland    242.3 Larval Trachea    90.875 Larval Carcass    78.575 Adult Head    285.2 Adult Eye    437.2 Adult Brain    751.7 Adult Thoracic-Abdominal Ganglion    749 Adult Crop    113.9 Adult Midgut    466.6 Adult Hindgut    190.5 Adult Malpighian Tubules    263.3 Adult Fat Body    90.9 Adult Salivary Gland    482.7 Adult Heart    112.825 Adult VirginFemale Spermatheca    153.6 Adult InseminatedFemale Spermatheca    174.2 Adult Ovary    297.5 Adult Testis    145.4 Adult Male Accessory Gland    219.7 Adult Carcass    104.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    285.2   NA  Eye    437.2   NA  Brain    751.7   283.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    749   NA  Crop    113.9   356.6  Midgut    466.6   175  Hindgut    190.5   283.7  Malpighian Tubules    263.3   140.8  Fat Body    90.9   242.3  Salivary Gland    482.7   NA  Heart    112.825   90.875  Trachea    NA   NA  VirginFemale Spermatheca    153.6   NA  InseminatedFemale Spermatheca    174.2   NA  Ovary    297.5   NA  Testis    145.4   NA  Male Accessory Gland    219.7   78.575  Carcass    104.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037084 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7736-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Syx6 Stages(s) 1-3 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Syx6EY14508 viable, with Scer\GAL4pnr-MD237 Syx6GD422 Sterility Allele fertile Syx6EY14508 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Syx6 Class Mutagen Stocks Known lesion Syx6EY14508 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Syx6 Class Mutagen Stocks Known lesion Syx6GD422 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Syx6JF03125 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Syx6KK109340 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6060 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD422} NA P{KK109340} NA P{TRiP.JF03125} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}Syx6EY14508 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
SNAP receptor activity inferred from sequence or structural similarity (Littleton, 2000) non-traceable author statement (Littleton et al., 1999)
Biological Process
CV term Evidence References
Golgi vesicle transport inferred from electronic annotation with InterPro:IPR015260 (FlyBase Curators et al., 2004-) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic vesicle docking involved in exocytosis inferred from sequence or structural similarity (Littleton, 2000) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR010989, InterPro:IPR015260 (FlyBase Curators et al., 2004-) plasma membrane inferred from sequence or structural similarity (Littleton, 2000) non-traceable author statement (Littleton et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Syx6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65620 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037084 DroID - A comprehensive database of gene and protein interactions. • FBgn0037084 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40373
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12527 Dere\GG20169 Dgri\GH21291 Dmoj\GI19781 Dper\GL19968 Dpse\GA24086 Dsec\GM21258 Dsim\GD10772 Dvir\GJ17697 Dwil\GK20954 Dyak\GE12858
Curated drosophilid orthologs	Dpse\GA20552
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004168-PA Aedes aegypti (mosquito) AGAP006251-PA Anopheles gambiae (mosquito) XP_393125.2 Apis mellifera (honey bee) 89160 Batrachochytrium dendrobatidis (chytrid fungus) 116588 Branchiostoma floridae (lancelet) BGIBMGA000589-PA Bombyx mori (silk worm) ENSBTAP00000021753 Bos taurus (bovine) CAL0002206 Candida albicans (a form of yeast) ENSCAFP00000025111 Canis familiaris (dog) cn08395 Cryptococcus neoformans (yeast-like fungus) CPIJ004576 Culex pipens (mosquito) ENSCPOP00000010394 Cavia porcellus (guinea pig) 130559 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000005102 Ciona savignyi (sedentary tunicate) 183705 Capitella spl (polychaete worm) DDB0231556 Dictyostelium discoideum (amoeba) 113324 Daphnia pulex (daphnia) ENSDARP00000062726 Danio rerio (zebra fish) ENSECAP00000009681 Equus caballus (horse) ENSGACP00000017634 Gymnopilus aculeatus (mushroom) 67123 Hypsipyla robusta (cedar shoot borer) ENSP00000242770 Homo sapiens (human) ISCW000036-PA Ixodes scapularis (deer tick) 129177 Lottia gigantea (owl limpet) 22769 Monocosta brevicollis (choanoflagellate) ENSMMUP00000031786 Macaca mulatta (rhesus monkey) ENSOANP00000001538 Ornithorynchus anatinus (platypus) ENSORLP00000024914 Oryzias latipes (japanese killifish) LOC_Os11g06740.1 Oryza sativa (asian rice) 12462 Ostreococcus tauri (green alga) PF14_0500 Plasmodium falciparum (protozoal parasite) PHUM005791-PA Pediculus humanus (human body louse) 128040 Physcomitrella patens (moss) ENSPPYP00000010788 Pongo pygmaeus (orangutan) 47858 Phytophthora ramorum (sudden oak death pathogen) 817835 Populus trichocarpa (black cottonwood) ENSPTRP00000018023 Pan troglodytes (chimpanzee) PVX_117855 Plasmodium vivax (protozoal parasite) 4759054 Sorghum bicolor (sorghum) Smp_104960 Schistosoma mansoni (trematode parasite) SPBC36B7.07 Schizosaccharomyces pombe (fission yeast) XP_780210.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967493.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005262 Tetraodon nigroviridis (green spotted pufferfish) 24585 Thalassiosira pseudonana (marine diatom) ENSXETP00000050036 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19431 NV25440 LH14574 ISCW000036 FBgn0230577 FBgn0222946 FBgn0204866 FBgn0182536 FBgn0176139 JGI_V11_113324 FBgn0245485 FBgn0157565 FBgn0142518 FBgn0128753 FBgn0112363 FBgn0089564 CPIJ004576 BGIBMGA000589 ACYPI003005 GB13262 AGAP006251 AAEL004168 PHUM484770 GLEAN_03074
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	20941 y1 w67c23; P{EPgy2}Syx6EY14508 28505 y1 v1; P{TRiP.JF03125}attP2/TM3, Sb1
VDRC	v104795 P{KK109340}VIE-260B v1501 w1118; P{GD422}v1501 v1578 w1118; P{GD422}v1578/CyO v1579 w1118; P{GD422}v1579/CyO
Genomic Clones ( 1 )
	BACR09B12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL02043 LD12915 RE35194 RE48509
Other clones	DPiM_RE48509
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT22305 LD34402 LD42583 RE14211 RE20919 RE44384
Other clones	35504 42603 56514 56520 58108 74002 75345 77711 78353 78987 CK01.62C.G5 CK01.80B.A4 EC25021 EK050427 EK057658 EK062234 EK120262 EK121139 EK146152 EK157737 EK171236 EK175435 EK180437 EK180706 EK207852 EK211135 FGM235B03 RE40227 RE40294 RH02754 RP01650
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037084 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40373
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Syx6 CG7736 (McLennan, 2001.5.22)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_206092 NM_206093 NM_206094 RefSeq (Proteins) • NP_995814 NP_995815 NP_995816 DDBJ / EMBL / GenBank • AAF58710 AAM68720 AAM68721 AAN71418 AAO39509 AAX33547 BI238683 BI363614 BT001663 BT003505 BT021399 CL943644 Entrez Gene - A searchable database of RefSeq genes. • 40373 UniProtKB/TrEMBL • Q5BI25 Q7JRF1 Q7JY00 Q86P32
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) t-SNARE (IPR010989) Syntaxin 6, N-terminal (IPR015260)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65620 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037084 DroID - A comprehensive database of gene and protein interactions. • FBgn0037084 DRSC - Results from RNAi screens. • FBgn0037084 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037084 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7736-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037084 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40373 InParanoid A subset of ortholog calls from InParanoid. • AAEL004168-PA Aedes aegypti (mosquito) AGAP006251-PA Anopheles gambiae (mosquito) XP_393125.2 Apis mellifera (honey bee) 89160 Batrachochytrium dendrobatidis (chytrid fungus) 116588 Branchiostoma floridae (lancelet) BGIBMGA000589-PA Bombyx mori (silk worm) ENSBTAP00000021753 Bos taurus (bovine) CAL0002206 Candida albicans (a form of yeast) ENSCAFP00000025111 Canis familiaris (dog) cn08395 Cryptococcus neoformans (yeast-like fungus) CPIJ004576 Culex pipens (mosquito) ENSCPOP00000010394 Cavia porcellus (guinea pig) 130559 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000005102 Ciona savignyi (sedentary tunicate) 183705 Capitella spl (polychaete worm) DDB0231556 Dictyostelium discoideum (amoeba) 113324 Daphnia pulex (daphnia) ENSDARP00000062726 Danio rerio (zebra fish) ENSECAP00000009681 Equus caballus (horse) ENSGACP00000017634 Gymnopilus aculeatus (mushroom) 67123 Hypsipyla robusta (cedar shoot borer) ENSP00000242770 Homo sapiens (human) ISCW000036-PA Ixodes scapularis (deer tick) 129177 Lottia gigantea (owl limpet) 22769 Monocosta brevicollis (choanoflagellate) ENSMMUP00000031786 Macaca mulatta (rhesus monkey) ENSOANP00000001538 Ornithorynchus anatinus (platypus) ENSORLP00000024914 Oryzias latipes (japanese killifish) LOC_Os11g06740.1 Oryza sativa (asian rice) 12462 Ostreococcus tauri (green alga) PF14_0500 Plasmodium falciparum (protozoal parasite) PHUM005791-PA Pediculus humanus (human body louse) 128040 Physcomitrella patens (moss) ENSPPYP00000010788 Pongo pygmaeus (orangutan) 47858 Phytophthora ramorum (sudden oak death pathogen) 817835 Populus trichocarpa (black cottonwood) ENSPTRP00000018023 Pan troglodytes (chimpanzee) PVX_117855 Plasmodium vivax (protozoal parasite) 4759054 Sorghum bicolor (sorghum) Smp_104960 Schistosoma mansoni (trematode parasite) SPBC36B7.07 Schizosaccharomyces pombe (fission yeast) XP_780210.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967493.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005262 Tetraodon nigroviridis (green spotted pufferfish) 24585 Thalassiosira pseudonana (marine diatom) ENSXETP00000050036 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40373 modMine - Data generated by the modENCODE project. • FBgn0037084 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19431 NV25440 LH14574 ISCW000036 FBgn0230577 FBgn0222946 FBgn0204866 FBgn0182536 FBgn0176139 JGI_V11_113324 FBgn0245485 FBgn0157565 FBgn0142518 FBgn0128753 FBgn0112363 FBgn0089564 CPIJ004576 BGIBMGA000589 ACYPI003005 GB13262 AGAP006251 AAEL004168 PHUM484770 GLEAN_03074
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG7736 (Whitfield et al., 2002, Robertson, 2001.7.7, Bock, 2000.10.26, Dorer et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Pessa et al., 2010) CT23545 (Otake et al., 2002) DmSyx6 (McLennan, 2001.5.22) Dm Syx6 (Littleton, 2000) SYN6 (Dorer et al., 2006) Syx (Wagh et al., 2006) Syx6 (Pessa et al., 2010) SYX6/10 (Lloyd et al., 2000)
Name Synonym	syntaxin (Dumstrei et al., 2003) Syntaxin (Kittel et al., 2006, Wagh et al., 2006, Hossain et al., 2008, Pereanu and Hartenstein, 2006) Syntaxin 6 (McLennan, 2001.5.22)
Secondary FlyBase IDs
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Pessa et al., 2010, PLoS ONE 5(10): e13215 Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways. [FBrf0212091] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...