FlyBase Gene Report: Dmel\Cdk12

General Information

Symbol

Dmel\Cdk12

Species

D. melanogaster

Name

Cyclin-dependent kinase 12

Annotation Symbol

CG7597

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037093

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

AC017581

Key Links

Genomic Location

Cytogenetic map

78D4-78D5

Sequence location

3L:21,516,306..21,522,684 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:21516306..21522684

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cyclin binding

inferred from physical interaction with UniProtKB:Q961D1

(assigned by UniProt )

(Bartkowiak et al., 2010)

enables RNA polymerase II CTD heptapeptide repeat kinase activity

inferred from direct assay

(Bartkowiak et al., 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables cyclin binding

inferred from biological aspect of ancestor with PANTHER:PTN000623455

(assigned by GO_Central )

(Gaudet et al., 2011)

enables cyclin-dependent protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000001622

(FlyBase Curators, 2008--)

enables RNA polymerase II CTD heptapeptide repeat kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001936021

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with SGD:S000001622

(FlyBase Curators, 2008--)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in phosphorylation of RNA polymerase II C-terminal domain

inferred from direct assay

(assigned by UniProt )

(Bartkowiak et al., 2010)

involved_in transcription by RNA polymerase II

inferred from mutant phenotype

(Ashton-Beaucage et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in phosphorylation of RNA polymerase II C-terminal domain

inferred from biological aspect of ancestor with PANTHER:PTN001936021

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of transcription elongation from RNA polymerase II promoter

inferred from biological aspect of ancestor with PANTHER:PTN001936021

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein phosphorylation

inferred from sequence or structural similarity with SGD:S000001622

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in transcription elongation from RNA polymerase II promoter

inferred from biological aspect of ancestor with PANTHER:PTN000623455

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in nuclear chromosome

inferred from direct assay

(assigned by UniProt )

(Bartkowiak et al., 2010)

part_of nuclear cyclin-dependent protein kinase holoenzyme complex

inferred from direct assay

(assigned by UniProt )

(Bartkowiak et al., 2010)

located_in polytene chromosome puff

inferred from direct assay

(Bartkowiak et al., 2010)

located_in polytene chromosome

inferred from direct assay

(Bartkowiak et al., 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN001936021

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN001936021

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of cyclin/CDK positive transcription elongation factor complex

inferred from biological aspect of ancestor with PANTHER:PTN000623455

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (Q9VP22)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES -: Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).

Protein Function (UniProtKB)

Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation.

(UniProt, Q9VP22)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cdk12 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cdk12-RA

FBtr0078358

NM_141068

4772

1157

Cdk12-RB

FBtr0078357

NM_168912

4530

1157

Cdk12-RC

FBtr0332716

NM_001275238

4244

1157

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cdk12-PA

FBpp0078014

128.3

1157

10.19

NP_649325

AAF51738

Cdk12-PB

FBpp0078013

128.3

1157

10.19

NP_730643

AAN12171

Cdk12-PC

FBpp0304962

128.3

1157

10.19

NP_001262167

AGB94860

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1157 aa isoforms: Cdk12-PA, Cdk12-PB, Cdk12-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with cyclin CycK.

(UniProt, Q9VP22)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk12 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nuclear chromosome

inferred from direct assay

(assigned by UniProt )

(Bartkowiak et al., 2010)

part_of nuclear cyclin-dependent protein kinase holoenzyme complex

inferred from direct assay

(assigned by UniProt )

(Bartkowiak et al., 2010)

located_in polytene chromosome puff

inferred from direct assay

(Bartkowiak et al., 2010)

located_in polytene chromosome

inferred from direct assay

(Bartkowiak et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cdk12 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cdk12

View exonic expression by tissue for Dmel\Cdk12

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037093

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037093

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7597-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7597

Flygut - An atlas of the Drosophila adult midgut

FBgn0037093

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cdk12

Transgenic constructs containing regulatory region of Cdk12

Deletions and Duplications ( 1 )

Partially disrupted in

Df(3L)SAK^Aa74

(Aydogan et al., 2018)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Cdk12^GD9926

lethal, with Scer\GAL4^Mef2.PR

Cdk12^GD9926

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Cdk12^GD9926

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cdk12^GD9926

viable, with Scer\GAL4^tin.CΔ4

Cdk12^GD9926

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Cdk12^GL00031

female sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Cdk12^HMS00155

Other Phenotypes

Allele

neuroanatomy defective | larval stage

Cdk12^GD9926

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Cdk12^GD9926

small body | adult stage, with Scer\GAL4^Ilp2.PR

Cdk12^GD9926

some die during pupal stage, with Scer\GAL4^pnr-MD237

Cdk12^GD9926

Phenotype manifest in

Allele

ganglion mother cell | larval stage

Cdk12^GD9926

larval neuroblast | larval stage

Cdk12^GD9926

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CDK13

12 of 15

Yes

Hsap\CDK12

11 of 15

Yes

3 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cdk12

12 of 15

Yes

Mmus\Cdk13

12 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (7)

Rnor\Cdk12

10 of 13

Yes

Rnor\Cdk13

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (5)

Xtro\cdk12

8 of 12

Yes

Xtro\cdk13

7 of 12

Yes

Xtro\cdk9

3 of 12

Xtro\cdk10

1 of 12

Xtro\cdk11b

1 of 12

Danio rerio (Zebrafish) (7)

Drer\cdk12

12 of 15

Yes

Drer\cdk9

3 of 15

Drer\cdk13

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\cdk-12

12 of 15

Yes

3 of 15

2 of 15

2 of 15

1 of 15

Yes

Cele\cdk-8

1 of 15

Cele\dyf-18

1 of 15

Cele\ZC123.4

1 of 15

Arabidopsis thaliana (thale-cress) (22)

Atha\CDKC2

5 of 9

Yes

Atha\CDKC;1

5 of 9

Yes

Atha\AT1G03740

4 of 9

Yes

Atha\AT1G33770

4 of 9

Yes

Atha\AT1G53050

4 of 9

Yes

Atha\AT1G54610

4 of 9

Yes

Atha\AT1G71530

4 of 9

Yes

Atha\AT3G05050

4 of 9

Yes

Atha\AT4G10010

4 of 9

Yes

Atha\AT5G44290

4 of 9

Yes

Atha\cdc2cAt

4 of 9

Yes

Atha\AT1G09600

3 of 9

Yes

Atha\AT1G74330

3 of 9

Yes

Atha\IBS1

3 of 9

Yes

2 of 9

2 of 9

2 of 9

2 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\CTK1

7 of 15

Yes

Scer\SGV1

3 of 15

Scer\CAK1

1 of 15

Scer\FPK1

1 of 15

Yes

Scer\SNF1

1 of 15

Scer\SSN3

1 of 15

Scer\SWE1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\lsk1

8 of 12

Yes

Spom\cdk9

3 of 12

Spom\pom1

1 of 12

Spom\SPCC70.05c

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901QT )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20468

Drosophila persimilis

Dper\GL11886

Drosophila willistoni

Dwil\GK20415

Drosophila virilis

Dvir\GJ11831

Drosophila mojavensis

Dmoj\GI13468

Drosophila grimshawi

Dgri\GH16743

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915042I )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17026416

Glossina morsitans

Tsetse fly

Gmor\GMOY005037

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05754

Mayetiola destructor

Hessian fly

Mdes\Mdes009835

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009364

Anopheles darlingi

American malaria mosquito

Adar\ADAC003610

Anopheles gambiae

Malaria mosquito

Agam\AGAP004780

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004253

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03UD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009883

Danaus plexippus

Monarch butterfly

Dple\DPOGS200830-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL011467

Apis florea

Little honeybee

Aflo\2187615572

Apis mellifera

Western honey bee

Amel\GB53657

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17261

Bombus terrestris

Buff-tailed bumblebee

Bter\15210363

Linepithema humile

Argentine ant

Lhum\LH24398

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001660

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002787

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01986

Tribolium castaneum

Red flour beetle

Tcas\TC011738

Pediculus humanus

Human body louse

Phum\PHUM467150

Rhodnius prolixus

Kissing bug

Rpro\RPRC007535

Cimex lectularius

Bed bug

Clec\CLEC000765

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009417

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009082

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01365

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03RK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65069.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g00430

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_299554

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08Z8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cdc2l5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cdk9

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008843

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000013019

Gallus gallus

Domestic chicken

Ggal\CDK9

Gallus gallus

Domestic chicken

Ggal\CDK13

Gallus gallus

Domestic chicken

Ggal\CDK12

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDK13; cyclin dependent kinase 13

12 of 15

603309

CONGENITAL HEART DEFECTS, DYSMORPHIC FACIAL FEATURES, AND INTELLECTUAL DEVELOPMENTAL DISORDER; CHDFIDD

CDK12; cyclin dependent kinase 12

11 of 15

615514

CDK9; cyclin dependent kinase 9

3 of 15

603251

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cdk12 - CycK

experimental knowledge based, anti bait coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Bartkowiak et al., 2010)

Cdk12 - RpII215

enzymatic study, autoradiography

(Bartkowiak et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with cyclin CycK.

(UniProt, Q9VP22 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037093

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40385

MIST (protein-protein) - An integrated Molecular Interaction Database

Cdk12

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

78D4-78D5

Sequence location

3L:21,516,306..21,522,684 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78D4-78D5

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

37825

y¹ w^*; Mi{MIC}Cdk12^MI04583

35163

y¹ sc^* v¹ sev²¹; P{TRiP.GL00031}attP2

42775

y¹ sc^* v¹ sev²¹; P{TRiP.GL01137}attP2

83979

y¹ sc^* v¹ sev²¹; P{TKO.GS04068}attP40

34838

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00155}attP2

14118

y¹ w^67c23; P{SUPor-P}Cdk12^KG05512 ry⁵⁰⁶

VDRC

v25508

w¹¹¹⁸; P{GD9926}v25508

v25510

w¹¹¹⁸; P{GD9926}v25510/TM3

v341643

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00739}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (133)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI05563

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037093

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037093

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40385

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Bartkowiak et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Cdk12 CG7597

(Bartkowiak et al., 2010)

Source for database merge of

Source for merge of: CG7597 AC017581

(Butler, 2000.11.13)

Source for merge of: CG7597 anon-WO0140519.165

(FlyBase, 1996-)

Additional comments

Source for merge of CG7597 anon-WO0140519.165 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells, an increase in the proportion of S phase cells and a decrease in mitotic index are seen.

(Bettencourt-Dias et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40385

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VP22

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PG50

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037093

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037093

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7597

Flygut - An atlas of the Drosophila adult midgut

FBgn0037093

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40385

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7597

modMine - A data warehouse for the modENCODE project

FBgn0037093

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VP22

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0037093

DRSC - Results frm RNAi screens

FBgn0037093

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037093

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7597-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037093

FlyMine - An integrated database for Drosophila genomics

FBgn0037093

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40385

MIST (protein-protein) - An integrated Molecular Interaction Database

Cdk12

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

AC017581

(Liu and Kipreos, 2000)

CDK12

(Pan et al., 2015)

CG7597

(Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Rohn et al., 2011, White et al., 2011, Bartkowiak et al., 2010, Ni et al., 2010.12.1, Zhou et al., 2008, Stroschein-Stevenson et al., 2006)

Cdk12

(Hall et al., 2019, Transgenic RNAi Project members, 2017-, Dahlberg et al., 2015, Kwong et al., 2015, Ashton-Beaucage et al., 2014, Hasygar and Hietakangas, 2014, Sopko et al., 2014, Schaaf et al., 2013, Rodrigues et al., 2012)

anon-WO0140519.165

cg7597

(Mattila et al., 2008)

dCDK12

(Bartkowiak et al., 2010)

dCdk12

(Goodman et al., 2019)

gi24668141

(Phatnani and Greenleaf, 2006)

Name Synonyms

Cyclin-dependent kinase 12

Secondary FlyBase IDs

FBgn0043014
FBgn0044713

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (73)

The following external sites may use different assemblies or annotations than FlyBase.

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