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Gene Dmel\ORMDL

General Information
Symbol	Dmel\ORMDL	Species	D. melanogaster
Name	ORMDL	Annotation symbol	CG14577
Feature type	protein_coding_gene	FlyBase ID	FBgn0037110
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	78E1-78E1	Sequence location	3L:21,628,405..21,629,351 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ORMDL is referred to in FlyBase by the symbol Dmel\ORMDL (CG14577, FBgn0037110). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ORMDL. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630754_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ORMDL. Gene sequence location is 3L:21628405..21629351.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78E1-78E1   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ORMDL for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ORMDL-RA FBtr0078423  NM_168929   674   154
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ORMDL-PA   FBpp0078077   17.6   154   9.59     NP_730669   AAF51758
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ORMDL (IPR007203)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF51758   AF395703 AAM43501   BP544517   BP552093   BT023364   BT029397   CO153474   CO193829   CO288435   CO295909   CO338280   EC087125   EC240292   EC242053   EC257155   EC267291   EL869836
UniProtKB/Swiss-Prot	Q9VP04
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 3 -- 5   organism | ubiquitous & uniform   (Hjelmqvist et al., 2002) embryonic stage 11 -- 12   germ band   (Hjelmqvist et al., 2002) embryonic stage 14 -- 17   ectoderm derivative   (Hjelmqvist et al., 2002) third instar larval stage   wing disc   (Hjelmqvist et al., 2002) haltere disc   (Hjelmqvist et al., 2002) ventral thoracic disc   (Hjelmqvist et al., 2002) eye-antennal disc   (Hjelmqvist et al., 2002)
Additional Descriptive Data
	ORMDL transcript is expressed homogenously in syncitial and cellularized blastoderms. At germ band extension, ORMDL transcript is expressed in the germ band layer. At later stages, ORMDL transcript is localized to all ectodermal tissues. It is also ubiquitously distributed in wing, lag, haltere, and eye-antennal imaginal discs. (Hjelmqvist et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult midgut, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland    1135.2 Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop  (739.4) Adult Midgut  (561.6) Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland  (1135.2) Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland  (1135.2) Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland    1135.2 Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland    1135.2 Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop  739.4 Adult Midgut  561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland  (1135.2) Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland  1135.2 Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    105.975 Larval Midgut    419.1 Larval Hindgut    173.1 Larval Malpighian Tubules    327.6 Larval Fat Body    343.4 Larval Salivary Gland    326.4 Larval Trachea    166.575 Larval Carcass    132.55 Adult Head    203.7 Adult Eye    166.1 Adult Brain    154.9 Adult Thoracic-Abdominal Ganglion    126.7 Adult Crop    739.4 Adult Midgut    561.6 Adult Hindgut    378.5 Adult Malpighian Tubules    228.9 Adult Fat Body    351.1 Adult Salivary Gland    1135.2 Adult Heart    341.575 Adult VirginFemale Spermatheca    215.8 Adult InseminatedFemale Spermatheca    187.3 Adult Ovary    231.3 Adult Testis    59.9 Adult Male Accessory Gland    433.8 Adult Carcass    313.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    203.7   NA  Eye    166.1   NA  Brain    154.9   105.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    126.7   NA  Crop    739.4   419.1  Midgut    561.6   173.1  Hindgut    378.5   327.6  Malpighian Tubules    228.9   343.4  Fat Body    351.1   326.4  Salivary Gland    1135.2   NA  Heart    341.575   166.575  Trachea    NA   NA  VirginFemale Spermatheca    215.8   NA  InseminatedFemale Spermatheca    187.3   NA  Ovary    231.3   NA  Testis    59.9   NA  Male Accessory Gland    433.8   132.55  Carcass    313.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    10 central nervous system, larvae L3    6 central nervous system, pupae P8    5 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    12 head, mated 1-day female    4 head, mated 4-day female    6 head, mated 20-day female    8 head, mated 1-day male    6 head, mated 4-day male    10 head, mated 20-day male    15 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    23 digestive system, 4-day adult    16 digestive system, 20-day adult    19 fat body, larvae L3 wandering    10 fat body, white prepupae    8 fat body, pupae P8    3 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    10 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    8 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2  (28) larva L3 12hr old  (28) larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  (30) larva L3 puffstage 7-9  (30) white prepupae new  (30) white prepupae 12hr  (27) white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day  26 adult male 05day  (33) adult male 30day  (32) adult female 01day  (38) adult female 05day  (41) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2  28 larva L3 12hr old  28 larva L3 puffstage 1-2  (35) larva L3 puffstage 3-6  30 larva L3 puffstage 7-9  30 white prepupae new  30 white prepupae 12hr  27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day  26 adult male 05day  (33) adult male 30day  32 adult female 01day  (38) adult female 05day  (41) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    5 embryo 04-06hr    12 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    10 embryo 14-16hr    12 embryo 16-18hr    12 embryo 18-20hr    15 embryo 20-22hr    19 embryo 22-24hr    18 larva L1    23 larva L2    28 larva L3 12hr old    28 larva L3 puffstage 1-2    35 larva L3 puffstage 3-6    30 larva L3 puffstage 7-9    30 white prepupae new    30 white prepupae 12hr    27 white prepupae 24hr    22 pupae 2d postWPP    17 pupae 3d postWPP    13 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    33 adult male 30day    32 adult female 01day    38 adult female 05day    41 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21  (27) wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21  27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    13 embryonic 1182-4H    14 embryonic GM2    21 embryonic Kc167    13 embryonic S1    18 embryonic S3    14 leg disc CME L1    9 wing disc CME-W2    6 wing disc ML-DmD8    11 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    27 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    20 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    10 ovary fGS/OSS    7 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    13 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    16 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    12 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • IP01962 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037110 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14577-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable ORMDLe03591 viable, with Scer\GAL4pnr-MD237 ORMDLGD3899 Sterility Allele fertile ORMDLe03591 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of ORMDL Class Mutagen Stocks Known lesion ORMDLe03591 piggyBac transposase 1 -- ORMDLCPTI002636 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ORMDL Class Mutagen Stocks Known lesion ORMDLGD3899 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ORMDLKK109157 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ORMDLNIG.14577R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3899} NA P{KK109157} NA P{NIG.14577R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{769.FSVS-1}ORMDLCPTI002636 NA PBac{RB}ORMDLe03591 NA insertion of mobile activating element P{EPgy2}EY01286 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a biological process or molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane non-traceable author statement (Hjelmqvist, 2001.6.28) integral to membrane inferred from electronic annotation with InterPro:IPR007203 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ORMDL - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) ORMDL - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ORMDL allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65648 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037110 DroID - A comprehensive database of gene and protein interactions. • FBgn0037110 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40404
Orthologs
OrthoDB Orthologs (35) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SJ61D Dipteran inclusive ortholog search EOG6NCMP3 Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search EOG6T76KT Metazoa inclusive ortholog search EOG67HJK3
Orthologs in Drosophila Species (EOG6SJ61D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ORMDL     Drosophila simulans   Dsim\GD14981 Y   Drosophila sechellia   Dsec\GM22391 Y   Drosophila erecta   Dere\GG16210 Y   Drosophila yakuba   Dyak\GE23040     Drosophila yakuba   Dyak\GE19779 Y   Drosophila ananassae   Dana\GF23733 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13094 Y   Drosophila persimilis   Dper\GL24847 Y   Drosophila willistoni   Dwil\GK17050 Y   Drosophila virilis   Dvir\GJ11230 Y   Drosophila mojavensis   Dmoj\GI11551 Y   Drosophila grimshawi   Dgri\GH16360 Y
Orthologs in non-Drosophila Dipterans (EOG6NCMP3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012130   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009363   Anopheles gambiae Malaria mosquito  Agam\AGAP010566   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004248
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (EOG6T76KT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_43172
Orthologs in non-Arthropod Metazoa (EOG67HJK3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028448gn   Danio rerio Zebrafish  Drer\ormdl2   Danio rerio Zebrafish  Drer\ormdl3   Danio rerio Zebrafish  Drer\ormdl1   Xenopus tropicalis Western clawed frog  Xtro\ormdl2   Xenopus tropicalis Western clawed frog  Xtro\ormdl1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000013491   Gallus gallus Domestic chicken  Ggal\ENSGALG00000014637   Mus musculus House mouse  Mmus\Ormdl1   Mus musculus House mouse  Mmus\Ormdl2   Mus musculus House mouse  Mmus\Ormdl3   Rattus norvegicus Norway rat  Rnor\Ormdl2   Rattus norvegicus Norway rat  Rnor\LOC100188936   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030445   Homo sapiens Human  Hsap\ORMDL3   Homo sapiens Human  Hsap\ORMDL2   Homo sapiens Human  Hsap\ORMDL1
Human Orthologs (3)
Gene OMIM HGNC Hsap\ORMDL3     Hsap\ORMDL2     Hsap\ORMDL1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14981 Drosophila sechellia Dsec\GM22391 Drosophila erecta Dere\GG16210 Drosophila yakuba Dyak\GE19779 Drosophila ananassae Dana\GF23733 Drosophila pseudoobscura pseudoobscura Dpse\GA13094 Drosophila persimilis Dper\GL24847 Drosophila willistoni Dwil\GK17050 Drosophila virilis Dvir\GJ11230 Drosophila mojavensis Dmoj\GI11551 Drosophila grimshawi Dgri\GH16360
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	18169 w1118; PBac{RB}ORMDLe03591
VDRC	v101436 P{KK109157}VIE-260B v9116 w1118; P{GD3899}v9116 v9117 w1118; P{GD3899}v9117
Genomic Clones ( 1 )
	BACR26P10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01962 IP01963
Other clones	DPiM_IP01962
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	79926 214449.52 522444 CK01.2B.D3 CK01.87A.D9 EC36864 EK068515 EK212151 EN02036 EN16401 FGC026C10 FGM216G04 IP01961
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037110 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40404
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ORMDL CG14577 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of ORMDL CG14577 was sequence comparison (date:020710). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168929 RefSeq (Proteins) • NP_730669 DDBJ / EMBL / GenBank • AAF51758 AAM43501 AF395703 Entrez Gene - A searchable database of RefSeq genes. • 40404 UniProtKB/Swiss-Prot • Q9VP04
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ORMDL (IPR007203) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP01962
Linkouts
	BioGRID - A database of protein and genetic interactions • 65648 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037110 DroID - A comprehensive database of gene and protein interactions. • FBgn0037110 DRSC - Results from RNAi screens. • FBgn0037110 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037110 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14577-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037110 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40404 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40404 modMine - Data generated by the modENCODE project. • FBgn0037110
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG14577 (Keleman et al., 2009.8.5) ORMDL (Hjelmqvist et al., 2002, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	ORMDL
Secondary FlyBase IDs
References ( 19 )
Research paper	Hjelmqvist et al., 2002, Genome Biol. 3(6): RESEARCH0027 ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. [FBrf0151340]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	FlyProt project., 2011.8.8, CPTI protein trap lines available from the Kyoto Stock Center. CPTI protein trap lines available from the Kyoto Stock Center. [FBrf0214588] Knowles-Barley, 2011.8.24, BrainTrap expression curation. BrainTrap expression curation. [FBrf0215202] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
DNA/RNA sequence record	Hjelmqvist, 2001.6.28, GenBank/EMBL/DDBJ: AF395703 Drosophila melanogaster ORMDL mRNA, partial cds. [FBrf0150922]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]