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Gene Dmel\CG11523

General Information
Symbol	Dmel\CG11523	Species	D. melanogaster
Name		Annotation symbol	CG11523
Feature type	protein_coding_gene	FlyBase ID	FBgn0037156
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	79D3-79D3	Sequence location	3L:22,258,906..22,259,779 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11523 (FBgn0037156). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: GSKIP/TIF31 domain; Protein of unknown function DUF727. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1625684_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11523. Gene sequence location is 3L:22258906..22259779.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79D3-79D3   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11523 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency (upstream) RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11523-RA FBtr0078511  NM_141129   874   158
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11523-PA   FBpp0078163   17.9   158   3.85     NP_649386   AAF51815
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF727 (IPR007967) GSKIP/TIF31 domain (IPR023231)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540359   AA694926   AE014296 AAF51815   AI404768   AI515049   AW941151   AY118463 AAM49832   CO155124   CO155477   CO190983   CO284452   EC207041   EC266571   EV575589   GH953136   GH954223   GH962264   GH962624   GH963350   GH965452   GH968779   GH969726   GH971809   GH973343   GH974069   GH984677
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VNV2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    159.35 Larval Midgut    75.2 Larval Hindgut    76 Larval Malpighian Tubules    132 Larval Fat Body    54.3 Larval Salivary Gland    144 Larval Trachea    127.175 Larval Carcass    82.825 Adult Head    107.5 Adult Eye    174.65 Adult Brain    197.8 Adult Thoracic-Abdominal Ganglion    173.9 Adult Crop    116.9 Adult Midgut    149.5 Adult Hindgut    85.8 Adult Malpighian Tubules    127.2 Adult Fat Body    44.6 Adult Salivary Gland    211.7 Adult Heart    78.225 Adult VirginFemale Spermatheca    51.3 Adult InseminatedFemale Spermatheca    62.7 Adult Ovary    364 Adult Testis    114 Adult Male Accessory Gland    147.1 Adult Carcass    57.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    107.5   NA  Eye    174.65   NA  Brain    197.8   159.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.9   NA  Crop    116.9   75.2  Midgut    149.5   76  Hindgut    85.8   132  Malpighian Tubules    127.2   54.3  Fat Body    44.6   144  Salivary Gland    211.7   NA  Heart    78.225   127.175  Trachea    NA   NA  VirginFemale Spermatheca    51.3   NA  InseminatedFemale Spermatheca    62.7   NA  Ovary    364   NA  Testis    114   NA  Male Accessory Gland    147.1   82.825  Carcass    57.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  (37) ovary, mated 4-day female  (32) testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female  (37) ovary, mated 4-day female  32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    7 central nervous system, pupae P8    7 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    4 head, mated 1-day male    11 head, mated 4-day male    11 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    9 digestive system, 4-day adult    10 digestive system, 20-day adult    9 fat body, larvae L3 wandering    1 fat body, white prepupae    4 fat body, pupae P8    4 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    37 ovary, mated 4-day female    32 testis, mated 4-day male    11 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    115 embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (101) embryo 02-04hr  (115) embryo 04-06hr  (47) embryo 06-08hr  (49) embryo 08-10hr  (53) embryo 10-12hr  (40) embryo 12-14hr  (31) embryo 14-16hr  (35) embryo 16-18hr  (29) embryo 18-20hr    19 embryo 20-22hr  (33) embryo 22-24hr    25 larva L1  26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr  (27) pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day  (36) adult female 05day  (52) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  101 embryo 02-04hr  (115) embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    115 embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    115 embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (101) embryo 02-04hr  (115) embryo 04-06hr  (47) embryo 06-08hr  (49) embryo 08-10hr  (53) embryo 10-12hr  (40) embryo 12-14hr  31 embryo 14-16hr  (35) embryo 16-18hr  29 embryo 18-20hr    19 embryo 20-22hr  (33) embryo 22-24hr    25 larva L1  26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr  27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day  (36) adult female 05day  (52) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  101 embryo 02-04hr  115 embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    115 embryo 04-06hr    47 embryo 06-08hr    49 embryo 08-10hr    53 embryo 10-12hr    40 embryo 12-14hr    31 embryo 14-16hr    35 embryo 16-18hr    29 embryo 18-20hr    19 embryo 20-22hr    33 embryo 22-24hr    25 larva L1    26 larva L2    25 larva L3 12hr old    20 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    24 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    23 adult male 30day    23 adult female 01day    36 adult female 05day    52 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS    107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (30) Schneider line 2 Sg4    10 embryonic 1182-4H  (38) embryonic GM2  (35) embryonic Kc167    16 embryonic S1    16 embryonic S3  (31) leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (33) wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  (27) ovary fGS/OSS  (107) ovary OSC  (31) ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS  107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS    107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS    107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  30 Schneider line 2 Sg4    10 embryonic 1182-4H  (38) embryonic GM2  (35) embryonic Kc167    16 embryonic S1    16 embryonic S3  31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9  32 wing disc ML-DmD16-c3  (33) wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1  (36) CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  27 ovary fGS/OSS  (107) ovary OSC  31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS  107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    30 Schneider line 2 Sg4    10 embryonic 1182-4H    38 embryonic GM2    35 embryonic Kc167    16 embryonic S1    16 embryonic S3    31 leg disc CME L1    18 wing disc CME-W2    9 wing disc ML-DmD8    11 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    22 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    12 CNS ML-DmBG1-c1    36 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    27 ovary fGS/OSS    107 ovary OSC    31 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (31) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (30) Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    30 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM01793 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037156 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11523-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG11523 Stages(s) 4-6 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 CG11523GD7321 viable CG11523f05435 viable, with Scer\GAL4pnr-MD237 CG11523GD16779 Sterility Allele fertile CG11523f05435 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG11523 Class Mutagen Stocks Known lesion CG11523f05435 piggyBac transposase 2 -- CG11523GT-001020 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11523 Class Mutagen Stocks Known lesion CG11523GD16779 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11523GD7321 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11523KK108250 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11523NIG.11523R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7321} NA P{GD16779} NA P{KK108250} NA P{NIG.11523R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}CG11523GT-001020 NA PBac{WH}CG11523f05435 NA PBac{WH}Ddx1f05056 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG11523 - CG4325 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG11523 - CG6084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - Ntf-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG11523 - mus209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG11523 - sgg experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG11523 - sti anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11523 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65695 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037156 DroID - A comprehensive database of gene and protein interactions. • FBgn0037156 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40458
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G1N31 Dipteran inclusive ortholog search EOG6VX2FQ Insect inclusive ortholog search EOG6WDC8N Arthropod inclusive ortholog search EOG6Q83F7 Metazoa inclusive ortholog search EOG6TBH6H
Orthologs in Drosophila Species (EOG6G1N31)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG11523     Drosophila simulans   Dsim\GD12072 Y   Drosophila sechellia   Dsec\GM22096 Y   Drosophila erecta   Dere\GG13185 Y   Drosophila yakuba   Dyak\GE19510 Y   Drosophila yakuba   Dyak\GE23011     Drosophila ananassae   Dana\GF23488 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11049 Y   Drosophila persimilis   Dper\GL25448 Y   Drosophila willistoni   Dwil\GK17087 Y   Drosophila virilis   Dvir\GJ11772 Y   Drosophila mojavensis   Dmoj\GI11517 Y   Drosophila grimshawi   Dgri\GH16900 Y
Orthologs in non-Drosophila Dipterans (EOG6VX2FQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016435
Orthologs in non-Dipteran Insects (EOG6WDC8N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50389   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010878   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12206   Atta cephalotes Leafcutter ant  Acep\ACEP18003   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21968   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15195   Linepithema humile Argentine ant  Lhum\LH24777   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24379   Solenopsis invicta Red fire ant  Sinv\SINV18606   Bombyx mori Silkmoth  Bmor\BGIBMGA014426   Pediculus humanus Human body louse  Phum\PHUM268440   Tribolium castaneum Red flour beetle  Tcas\TC003546
Orthologs in non-Insect Arthropods (EOG6Q83F7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ythdc2   Ixodes scapularis Deer tick  Isca\ISCW011072
Orthologs in non-Arthropod Metazoa (EOG6TBH6H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C06A12.3   Caenorhabditis elegans Nematode  Cele\Y43F8B.2   Caenorhabditis elegans Nematode  Cele\T24H7.3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022422gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001732gn   Danio rerio Zebrafish  Drer\zgc:55683   Xenopus tropicalis Western clawed frog  Xtro\c14orf129   Gallus gallus Domestic chicken  Ggal\GSKIP   Mus musculus House mouse  Mmus\4933433P14Rik   Rattus norvegicus Norway rat  Rnor\Gskip   Homo sapiens Human  Hsap\GSKIP
Human Orthologs (1)
Gene OMIM HGNC Hsap\GSKIP
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12072 Drosophila sechellia Dsec\GM22096 Drosophila erecta Dere\GG13185 Drosophila yakuba Dyak\GE19510 Drosophila ananassae Dana\GF23488 Drosophila pseudoobscura pseudoobscura Dpse\GA11049 Drosophila persimilis Dper\GL25448 Drosophila willistoni Dwil\GK17087 Drosophila virilis Dvir\GJ11772 Drosophila mojavensis Dmoj\GI11517 Drosophila grimshawi Dgri\GH16900
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18863 w1118; PBac{WH}CG11523f05435 20995 w1118; P{GT1}CG11523GT-001020
Harvard	- PBac{WH}CG11523f05435
VDRC	v106810 P{KK108250}VIE-260B v16210 w1118; P{GD7321}v16210 v46794 w1118; P{GD16779}v46794
Genomic Clones ( 1 )
	BACR48E10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM01793
Other clones	DPiM_GM01793
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24596 LD19822 LD46724
Other clones	524896 CK01.62C.C3 Dmel_dig_016917_0663_2408 EK050410 EK166110 EN05425 EN06130 RP004117609 RP004134299 RP004251512 RP004370345 RP004382980 RP004407166 RP004436894 RP004450218 RP004492468 RP004515482 RP004522559 RP004527516
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037156 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40458
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141129 RefSeq (Proteins) • NP_649386 DDBJ / EMBL / GenBank • AA694926 AAF51815 AAM49832 AW941151 AY118463 Entrez Gene - A searchable database of RefSeq genes. • 40458 UniProtKB/TrEMBL • Q9VNV2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF727 (IPR007967) GSKIP/TIF31 domain (IPR023231) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM01793
Linkouts
	BioGRID - A database of protein and genetic interactions • 65695 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037156 DroID - A comprehensive database of gene and protein interactions. • FBgn0037156 DRSC - Results from RNAi screens. • FBgn0037156 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037156 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11523-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037156 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40458 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40458 modMine - Data generated by the modENCODE project. • FBgn0037156
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11523 (Edwards et al., 2006, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Edwards et al., 2006, PLoS Genet. 2(9): e154 Quantitative genomics of aggressive behavior in Drosophila melanogaster. [FBrf0195262]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Ryder, 2004.9.23, RS lines for Bloomington. RS lines for Bloomington. [FBrf0179866] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]