FlyBase Gene Report: Dmel\slif

General Information

Symbol

Dmel\slif

Species

D. melanogaster

Name

slimfast

Annotation Symbol

CG11128

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037203

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

80B2-80B2

Sequence location

3L:22,881,045..22,893,821 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:22881045..22893821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables basic amino acid transmembrane transporter activity

inferred from direct assay

(Colombani et al., 2003)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables amino acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN001718573

(assigned by GO_Central )

(Gaudet et al., 2011)

enables arginine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000208312

(assigned by GO_Central )

(Gaudet et al., 2011)

enables L-lysine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000208312

(assigned by GO_Central )

(Gaudet et al., 2011)

enables L-ornithine transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000208312

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in amino acid import across plasma membrane

inferred from direct assay

(Colombani et al., 2003)

involved_in defense response to Gram-negative bacterium

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in lipid homeostasis

inferred from mutant phenotype

(Gutierrez et al., 2007)

involved_in negative regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

involved_in regulation of growth

inferred from mutant phenotype

(Colombani et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in amino acid transport

inferred from biological aspect of ancestor with PANTHER:PTN001718573

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in L-arginine import across plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000208312

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in L-ornithine transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000208312

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of plasma membrane

inferred by curator from GO:0015174

(Colombani et al., 2003)

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000926816

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CATIONIC AMINO ACID TRANSPORTERS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CATIONIC AMINO ACID TRANSPORTERS -: Members of the cationic amino acid transporters (CATs) transport cationic amino acids by facilitated diffusion across membranes. (Adapted from FBrf0207965 and PMID:14770310).

Summary (Interactive Fly)

Amino acid transporter - downregulation within the fat body causes a global growth defect involving TSC/TOR signaling in the fat body and a remote inhibition of organismal growth

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\slif for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

slif-RA

FBtr0078555

NM_168977

2744

604

slif-RB

FBtr0078557

NM_168978

2523

604

slif-RC

FBtr0078556

NM_141171

2653

604

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

slif-PA

FBpp0078206

66.0

604

6.16

NP_730764

AAF51881

slif-PB

FBpp0078208

66.0

604

6.16

NP_730765

AAF51880

slif-PC

FBpp0078207

66.0

604

6.16

NP_649428

AAF51882

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

604 aa isoforms: slif-PA, slif-PB, slif-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\slif using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

organism | ubiquitous

(Colombani et al., 2003)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic salivary gland duct

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

embryonic/larval salivary gland common duct

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Romero-Calderon et al., 2007)

adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

Additional Descriptive Data

slif transcript is detected in most larval tissues but high expression is observed in the gut and the fat body.

(Colombani et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval fat body

(Hennig et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

slif protein is localized primarily to the cell surface, with peak levels just before the plasma membrane, in fat body cells.

(Hennig et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\slif in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\slif

View exonic expression by tissue for Dmel\slif

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037203

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037203

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11128-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11128

Flygut - An atlas of the Drosophila adult midgut

FBgn0037203

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\slif

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of slif

Transgenic constructs containing regulatory region of slif

Deletions and Duplications ( 1 )

Disrupted in

Df(3L)Exel6139

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | partially, with Scer\GAL4^Bx-MS1096

slif^UY681

partially lethal

slif¹

viable

slif^EY03570

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

slif^GD12619

viable, with Scer\GAL4^Mef2.PR

slif^GD12619

viable, with Scer\GAL4^pnr-MD237

slif^GD12619

viable, with Scer\GAL4^tin.CΔ4

slif^GD12619

Sterility

Allele

fertile

slif^EY03570

Other Phenotypes

Allele

body size defective | larval stage, with Scer\GAL4^ple.TH-D'

slif^UY681

decreased cell number

slif¹

decreased cell number, with Scer\GAL4^Bx-MS1096

slif^UY681

decreased cell number (with Df(3L)Δ1AK), with Scer\GAL4^Bx-MS1096

slif^UY681

decreased cell size

slif¹

decreased cell size, with Scer\GAL4^Bx-MS1096

slif^UY681

decreased cell size, with Scer\GAL4^nub-AC-62

slif^UAS.cCa

decreased cell size, with Scer\GAL4^ppl.PP

slif^UY681

decreased cell size (with Df(3L)Δ1AK), with Scer\GAL4^Bx-MS1096

slif^UY681

decreased occurrence of cell division | larval stage, with Scer\GAL4^Cg.PA

slif^UY681

developmental rate defective, with Scer\GAL4^ppl.PP

slif^UY681

feeding behavior defective | adult stage | female, with Scer\GAL4^fit.PS

slif^UY681

feeding behavior defective | larval stage, with Scer\GAL4^ple.PF

slif^UY681

feeding behavior defective | larval stage, with Scer\GAL4^ple.TH-D'

slif^UY681

increased cell number, with Scer\GAL4^nub-AC-62

slif^UAS.cCa

increased cell number | pupal stage, with Scer\GAL4^fkh.PH

slif^KK101643

some die during larval stage | partially, with Scer\GAL4^Bx-MS1096

slif^UY681

visible

slif¹

Phenotype manifest in

Allele

embryonic/larval fat body

slif¹

embryonic/larval fat body, with Scer\GAL4^Bx-MS1096

slif^UY681

embryonic/larval fat body, with Scer\GAL4^ppl.PP

slif^UY681

larva, with Scer\GAL4^ppl.PP

slif^UY681

larval neuroblast, with Scer\GAL4^Cg.PA

slif^UY681

lipid droplet & larval fat body, with Scer\GAL4^ppl.PP

slif^UY681

lipid droplet & larval oenocyte, with Scer\GAL4^Lsp2.PH

slif^UY681

lipid droplet & larval oenocyte, with Scer\GAL4^ppl.PP

slif^UY681

salivary gland | pupal stage, with Scer\GAL4^fkh.PH

slif^KK101643

wing, with Scer\GAL4^Bx-MS1096

slif^UY681

wing, with Scer\GAL4^nub-AC-62

slif^UAS.cCa

wing (with Df(3L)Δ1AK), with Scer\GAL4^Bx-MS1096

slif^UY681

wing blade posterior compartment, with Scer\GAL4^en-e16E

slif^UY681

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC7A1

13 of 15

Yes

Hsap\SLC7A3

12 of 15

Yes

Hsap\SLC7A2

11 of 15

Yes

6 of 15

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc7a3

13 of 15

Yes

Mmus\Slc7a1

12 of 15

Yes

Mmus\Slc7a2

11 of 15

Yes

Mmus\AU018091

10 of 15

Yes

5 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (24)

Rnor\Slc7a1

12 of 13

Yes

Rnor\Slc7a3

10 of 13

Yes

Rnor\Slc7a2

9 of 13

Yes

Rnor\LOC292543

6 of 13

Yes

5 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (21)

Xtro\slc7a1

8 of 12

Yes

Xtro\slc7a2.1

7 of 12

Xtro\slc7a2.2

7 of 12

Yes

Xtro\slc7a3

7 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (34)

Drer\slc7a1a

13 of 15

Yes

Drer\slc7a3b

12 of 15

Yes

Drer\slc7a3a

11 of 15

Yes

Drer\slc7a2

10 of 15

Yes

Drer\slc7a1b

8 of 15

Yes

Drer\slc7a4

6 of 15

Drer\zgc:175280

6 of 15

Yes

4 of 15

4 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Drer\si:cabz01090193.1

1 of 15

Drer\si:ch211-59d13.2

1 of 15

Drer\si:dkeyp-120h9.1

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\B0454.6

5 of 15

Yes

Cele\F23F1.6

5 of 15

Yes

Cele\C50D2.2

4 of 15

Cele\Y53F4B.12

4 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (10)

Atha\CAT4

8 of 9

Yes

Atha\CAT2

7 of 9

Atha\CAT3

7 of 9

Atha\CAT9

5 of 9

Yes

Atha\AAT1

4 of 9

Yes

Atha\CAT5

4 of 9

Yes

Atha\CAT8

4 of 9

Yes

Atha\CAT6

3 of 9

Yes

Atha\CAT7

3 of 9

Yes

Atha\BAT1

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (25)

Scer\AGP3

4 of 15

Yes

Scer\BAP3

4 of 15

Yes

Scer\HIP1

4 of 15

Yes

Scer\AGP1

3 of 15

Yes

Scer\ALP1

3 of 15

Yes

Scer\BAP2

3 of 15

Scer\CAN1

3 of 15

Yes

Scer\GAP1

3 of 15

Yes

Scer\GNP1

3 of 15

Scer\MMP1

3 of 15

Scer\SAM3

3 of 15

Yes

Scer\TAT1

3 of 15

Scer\UGA4

3 of 15

Yes

Scer\AGP2

2 of 15

Yes

Scer\DIP5

2 of 15

Yes

Scer\LYP1

2 of 15

Yes

Scer\PUT4

2 of 15

Yes

Scer\SSY1

2 of 15

Yes

Scer\TAT2

2 of 15

Yes

Scer\BIO5

1 of 15

Yes

Scer\HNM1

1 of 15

Yes

Scer\MUP1

1 of 15

Scer\MUP3

1 of 15

Scer\TPO5

1 of 15

Yes

Scer\VHC1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (10)

Spom\isp5

2 of 12

Yes

Spom\SPBPB2B2.01

2 of 12

Yes

Spom\SPCC584.13

2 of 12

Yes

Spom\SPCC965.11c

2 of 12

Yes

Spom\SPCPB1C11.02

2 of 12

Yes

Spom\cat1

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905MC )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10777

Drosophila persimilis

Dper\GL24975

Drosophila willistoni

Dwil\GK12893

Drosophila virilis

Dvir\GJ11799

Drosophila mojavensis

Dmoj\GI13437

Drosophila grimshawi

Dgri\GH16777

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502OC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022504

Musca domestica

House fly

Mdoa\17022571

Glossina morsitans

Tsetse fly

Gmor\GMOY005344

Glossina morsitans

Tsetse fly

Gmor\GMOY003854

Glossina morsitans

Tsetse fly

Gmor\GMOY002307

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12266

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00580

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06987

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010988

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009362

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012131

Anopheles darlingi

American malaria mosquito

Adar\ADAC005887

Anopheles darlingi

American malaria mosquito

Adar\ADAC005880

Anopheles darlingi

American malaria mosquito

Adar\ADAC005895

Anopheles darlingi

American malaria mosquito

Adar\ADAC005882

Anopheles gambiae

Malaria mosquito

Agam\AGAP010561

Anopheles gambiae

Malaria mosquito

Agam\AGAP010563

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004246

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004245

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004244

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08OC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA014238

Bombyx mori

Silkmoth

Bmor\BGIBMGA014266

Bombyx mori

Silkmoth

Bmor\BGIBMGA014265

Danaus plexippus

Monarch butterfly

Dple\DPOGS201195-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201194-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201174-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL018011

Heliconius melpomene

Postman butterfly

Hmel\HMEL018014

Apis florea

Little honeybee

Aflo\2727405140

Apis florea

Little honeybee

Aflo\2226385828

Apis mellifera

Western honey bee

Amel\GB43098

Apis mellifera

Western honey bee

Amel\GB46448

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23019

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22837

Bombus terrestris

Buff-tailed bumblebee

Bter\15210491

Bombus terrestris

Buff-tailed bumblebee

Bter\15214202

Linepithema humile

Argentine ant

Lhum\LH12669

Linepithema humile

Argentine ant

Lhum\LH11005

Linepithema humile

Argentine ant

Lhum\LH22022

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000e1e

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0000af

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010226

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006689

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07333

Tribolium castaneum

Red flour beetle

Tcas\TC001941

Tribolium castaneum

Red flour beetle

Tcas\TC034265

Pediculus humanus

Human body louse

Phum\PHUM258130

Pediculus humanus

Human body louse

Phum\PHUM169840

Rhodnius prolixus

Kissing bug

Rpro\RPRC015423

Rhodnius prolixus

Kissing bug

Rpro\RPRC004799

Cimex lectularius

Bed bug

Clec\CLEC003171

Cimex lectularius

Bed bug

Clec\CLEC000649

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005118

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003923

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008904

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005156

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003240

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003523

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005472

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008323

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002633

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000584

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00743

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_00747

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X083W )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005129

Strigamia maritima

European centipede

Smar\SMAR001724

Strigamia maritima

European centipede

Smar\SMAR005136

Ixodes scapularis

Black-legged tick

Isca\ISCW023458

Ixodes scapularis

Black-legged tick

Isca\ISCW007095

Ixodes scapularis

Black-legged tick

Isca\ISCW001425

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68025.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59748.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73640.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75452.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g12290

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g07880

Tetranychus urticae

Two-spotted spider mite

Turt\tetur30g00540

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g01010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g07990

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_21886

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_46947

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_236331

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05NM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a4_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a4_5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a14_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a4_3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a14

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc7a4_1

Ciona intestinalis

Vase tunicate

Cint\LOC100187499

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000017277

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007337

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000009305

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004391

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022693

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000019724

Gallus gallus

Domestic chicken

Ggal\SLC7A4

Gallus gallus

Domestic chicken

Ggal\SLC7A1

Gallus gallus

Domestic chicken

Ggal\SLC7A14

Gallus gallus

Domestic chicken

Ggal\SLC7A3

Gallus gallus

Domestic chicken

Ggal\SLC7A2

Gallus gallus

Domestic chicken

Ggal\LOC770309

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

10 of 10

8 of 10

7 of 10

6 of 10

2 of 10

mnd

2 of 10

sbm

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

kcc

1 of 10

Ncc69

1 of 10

NKCC

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

slif^UY681

ameliorates cancer

modeled by dlg1^GD4689, Ras85D^V12.UAS

(Katheder et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC7A1; solute carrier family 7 member 1

13 of 15

104615

SLC7A3; solute carrier family 7 member 3

12 of 15

300443

SLC7A2; solute carrier family 7 member 2

11 of 15

601872

SLC7A4; solute carrier family 7 member 4

6 of 15

603752

SLC7A14; solute carrier family 7 member 14

4 of 15

615720

RETINITIS PIGMENTOSA 68; RP68

retinitis pigmentosa 68

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

slif

suppressible

Gcn2

(Bjordal et al., 2014)

slif

suppressible

hppy

(Resnik-Docampo and de Celis, 2011)

slif

enhanceable

hppy

(Resnik-Docampo and de Celis, 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pten

enhanceable

slif

(Nowak et al., 2013)

Pten

suppressible

slif

(Nowak et al., 2013)

Ras85D|dlg1

suppressible

slif

(Katheder et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65738

DroID - A comprehensive database of gene and protein interactions.

FBgn0037203

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40510

MIST (genetic) - An integrated Molecular Interaction Database

slif

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Amino acid transport across the plasma membrane

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

80B2-80B2

Sequence location

3L:22,881,045..22,893,821 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

80B2-80B2

Limits computationally determined from genome sequence between P{lacW}l(3)j1B10^j1B10 and P{lacW}l(3)j2C4^j2C4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-44.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

52661

w¹¹¹⁸; P{UAS-slif.C}3/TM3, Sb¹

34177

y¹ w^*; Mi{MIC}slif^MI01305

19906

y¹ w^67c23; P{EPgy2}slif^EY03570

52655

y¹ w^*; P{Mae-UAS.6.11}slif^UY681

85574

w¹¹¹⁸; PBac{RB}slif^e03156/TM6B, Tb¹

83531

y¹ sc^* v¹ sev²¹; P{TKO.GS04300}attP40

VDRC

v110425

P{KK101643}VIE-260B

v26786

w¹¹¹⁸ P{GD12619}v26786

v45587

w¹¹¹⁸; P{GD12619}v45587

v45588

w¹¹¹⁸; P{GD12619}v45588

v45589

w¹¹¹⁸; P{GD12619}v45589

v45590

w¹¹¹⁸; P{GD12619}v45590

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (29)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD37241

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037203

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037203

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40510

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hennig et al., 2006)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: slif CG11128

(Leopold, 2003.3.18)

Source for database merge of

Additional comments

Other Comments

The localisation and levels of slif are sensitive to Tor activity, with high levels of Tor signaling resulting in accumulation of slif near the cell surface, and decreased Tor signaling leading to slif down-regulation.

(Hennig et al., 2006)

Identification: in a screen for growth modifiers.

(Colombani et al., 2003)

Disruption of slif function in the fat body results in a developmental growth defect similar to that seen under amino acid deprivation.

(Colombani et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40510

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VNP7

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037203

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037203

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11128

Flygut - An atlas of the Drosophila adult midgut

FBgn0037203

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40510

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11128

modMine - A data warehouse for the modENCODE project

FBgn0037203

Linkouts

BioGRID - A database of protein and genetic interactions.

65738

DroID - A comprehensive database of gene and protein interactions.

FBgn0037203

DRSC - Results frm RNAi screens

FBgn0037203

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037203

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11128-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037203

FlyMine - An integrated database for Drosophila genomics

FBgn0037203

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40510

MIST (genetic) - An integrated Molecular Interaction Database

slif

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Amino acid transport across the plasma membrane

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG11128

(Limmer et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Romero-Calderon et al., 2007, Corradini et al., 2003, Giot et al., 2003, Raisin et al., 2003)

SLIF

(Homem et al., 2015, Miyamoto et al., 2013)

Slif

(Inoue et al., 2018, Sun et al., 2017, Agrawal et al., 2016, Wang et al., 2014, Andersen et al., 2013, Homem and Knoblich, 2012, Rajan and Perrimon, 2011, Storelli et al., 2011, Cronin et al., 2009, Nuzhdin et al., 2009, Arquier et al., 2008)

slimfast

(Agrawal et al., 2016)

Name Synonyms

Slim fast

(Das and Dobens, 2015)

Slimfast

(Álvarez-Rendón et al., 2018, Sun et al., 2017, Homem et al., 2015, Nowak et al., 2013, Shim et al., 2013, Hennig et al., 2006)

slimfast

(Lin et al., 2019, Brookheart and Duncan, 2016, Strigini and Leulier, 2016, Nässel et al., 2015, Bjordal et al., 2014, Ghosh et al., 2014, Miyamoto et al., 2013, Turner et al., 2011, Géminard et al., 2009, Gutierrez et al., 2007, Hall et al., 2007, Colombani et al., 2003)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (100)

The following external sites may use different assemblies or annotations than FlyBase.

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