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Gene Dmel\Mes2

General Information
Symbol	Dmel\Mes2	Species	D. melanogaster
Name	Mesoderm-expressed 2	Annotation symbol	CG11100
Feature type	protein_coding_gene	FlyBase ID	FBgn0037207
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	adfR
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	80C1-80C1	Sequence location	3L:22,938,757..22,945,348 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mesoderm-expressed 2 is referred to in FlyBase by the symbol Dmel\Mes2 (CG11100, FBgn0037207). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: instar larval development; imaginal disc development; embryonic development via the syncytial blastoderm; ecdysis, chitin-based cuticle. 17 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic epidermis; haltere; wing; embryonic leading edge cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: MADF domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult heart, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632548_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Mes2. Gene sequence location is 3L:22938757..22945348.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 80C1-80C1   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mes2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 DGC clone SD10763 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mes2-RB FBtr0078561  NM_168979   2302   437 Mes2-RC FBtr0078563  NM_168980   2208   372
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mes2-PB   FBpp0078212   48.0   437   6.20     NP_730768   AAF51886 Mes2-PC   FBpp0078214   41.1   372   5.27     NP_730769   AAN12211
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • MADF domain (IPR006578)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF51886   AE014296 AAN12211   AI534752   AI543199   AI544271   AI544292   AW944611   AW944658   AY052141 AAK93565   AY060486 AAL25525   BG637287   BH759361   BI168324   BI215141   BI234405   BI240621   BI366951   BI369938   BI484895   BI578995   BI579803   BI641171   BP551946   BT001889 AAN71663   CO156500   CO262010   CO262048   CO262958   CO265959   CO266613   CO266635   CO267206   CO268416   CO268946   CO270893   CO275542   CO280673   CO290047   CO292822   CO295513   CO301905   CO308951   CO309009   CO310754   CO316153   CO319784   CO320697   CO324505   CO329240   CO329874   CO331835   CZ472362   CZ472985   CZ475784   CZ477458   CZ477685   CZ477726   CZ483728   DN153805   EC059463   EC059615   EC060693   EC061471   EC067309   EC070294   EC077750   EC077752   EC082347   EC087575   EC199092   EC199394   EC200292   EC201162   EC208583   EC212148   EC216077   EC219530   EC219531   EC221863   EC227654   EC231451   EC239389   EC250423   EV584092   GH945278   GH945497   GH949445   GH952493   GH957868   GH962199   GH967541   GH970360   GH972195   GH981850   GH982601   GH982964   GH984573
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IG95 Q9VNP3 Q95ST8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) head mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | faint & ubiquitous   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi trunk mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 5   mesoderm anlage   (Stathopoulos et al., 2002) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) fat body/gonad primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal histoblast nest abdominal   (Fisher et al., 2012) dorsal imaginal precursor   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic central brain surface glia   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic proventriculus inner layer   (Fisher et al., 2012) embryonic/larval circulatory system   (Fisher et al., 2012) embryonic/larval dorsal vessel   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval oenocyte   (Fisher et al., 2012) embryonic/larval pericardial cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral imaginal precursor   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6 -- 11   trunk mesoderm   • nucleus (Zimmermann et al., 2006) embryonic stage 12 -- 16   CNS glial cell   • nucleus (Zimmermann et al., 2006) PNS glial cell   • nucleus (Zimmermann et al., 2006) embryonic somatic muscle | subset   • nucleus (Zimmermann et al., 2006) Comment:derived from the trunk mesoderm embryonic stage 16   embryonic fat body   • nucleus (Zimmermann et al., 2006) embryonic/larval lymph gland   • nucleus (Zimmermann et al., 2006) embryonic pericardial cell   • nucleus (Zimmermann et al., 2006) embryonic hemocyte   • nucleus (Zimmermann et al., 2006) larval stage   myoblast   • nucleus (Zimmermann et al., 2006) glial cell of embryonic/larval central nervous system   • nucleus (Zimmermann et al., 2006) wing disc   • nucleus (Zimmermann et al., 2006)
Additional Descriptive Data
	Mes2 protein is a nuclear protein detected in the trunk mesoderm starting at late gastrulation. It is restricted to the mesoderm until embryonic stage 10. Starting in stage 11, expression expands to include the neurogenic ectoderm. Expression then declines in muscles derived from the trunk mesoderm. The neuronal expression becomes restricted to glial cells and it is expressed in all glial cells of the central and peripheral nervous systems. At late embryonic stages, Mes2 is detected in tissues derived from the head mesoderm such as fat body, lymph glands, pericardial nephrocytes, and hemocytes. (Zimmermann et al., 2006)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Zimmermann et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult heart, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (717.625) Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body  (858.1) Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body  530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body  (858.1) Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body  530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    717.625 Larval Midgut    67.3 Larval Hindgut    70.1 Larval Malpighian Tubules    22.8 Larval Fat Body    858.1 Larval Salivary Gland    7 Larval Trachea    14.15 Larval Carcass    71.275 Adult Head    130.6 Adult Eye    59.65 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    186.9 Adult Crop    9.6 Adult Midgut    55.8 Adult Hindgut    19.4 Adult Malpighian Tubules    12.3 Adult Fat Body    530 Adult Salivary Gland    13.6 Adult Heart    276.85 Adult VirginFemale Spermatheca    374.9 Adult InseminatedFemale Spermatheca    390.2 Adult Ovary    391.9 Adult Testis    7.6 Adult Male Accessory Gland    8.4 Adult Carcass    174.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    130.6   NA  Eye    59.65   NA  Brain    121.8   717.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    186.9   NA  Crop    9.6   67.3  Midgut    55.8   70.1  Hindgut    19.4   22.8  Malpighian Tubules    no informative data   858.1  Fat Body    530   7  Salivary Gland    no informative data   NA  Heart    276.85   14.15  Trachea    NA   NA  VirginFemale Spermatheca    374.9   NA  InseminatedFemale Spermatheca    390.2   NA  Ovary    391.9   NA  Testis    7.6   NA  Male Accessory Gland    8.4   71.275  Carcass    174.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  (30) central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae  26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (63) ovary, mated 4-day female  (42) testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3  30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae  26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (63) ovary, mated 4-day female  (42) testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    30 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    6 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    4 fat body, larvae L3 wandering    10 fat body, white prepupae    26 fat body, pupae P8    18 carcass, larvae L3 wandering    6 carcass, 1-day adult    6 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    63 ovary, mated 4-day female    42 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    19 embryo 04-06hr  (48) embryo 06-08hr  (52) embryo 08-10hr  (40) embryo 10-12hr  (41) embryo 12-14hr  26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    19 embryo 04-06hr  (48) embryo 06-08hr  (52) embryo 08-10hr  (40) embryo 10-12hr  (41) embryo 12-14hr  26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    19 embryo 04-06hr    48 embryo 06-08hr    52 embryo 08-10hr    40 embryo 10-12hr    41 embryo 12-14hr    26 embryo 14-16hr    15 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    4 embryo 22-24hr    5 larva L1    4 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    12 white prepupae new    14 white prepupae 12hr    17 white prepupae 24hr    11 pupae 2d postWPP    7 pupae 3d postWPP    5 pupae 4d postWPP    3 adult male 01day    4 adult male 05day    4 adult male 30day    3 adult female 01day    10 adult female 05day    19 adult female 30day    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    106 embryonic 1182-4H    45 embryonic GM2    107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    217 ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  (106) embryonic 1182-4H  (45) embryonic GM2  (107) embryonic Kc167  (92) embryonic S1  (100) embryonic S3  (82) leg disc CME L1  (80) wing disc CME-W2  (58) wing disc ML-DmD8  (83) wing disc ML-DmD9  (56) wing disc ML-DmD16-c3  (68) wing disc ML-DmD21  (68) wing disc ML-DmD32  (69) haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (89) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  (32) tumorous blood cells mbn2  (217) ovary fGS/OSS  (31) ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  106 embryonic 1182-4H    45 embryonic GM2  107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2  (217) ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    106 embryonic 1182-4H    45 embryonic GM2    107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    217 ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    106 embryonic 1182-4H    45 embryonic GM2    107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    217 ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  (106) embryonic 1182-4H  (45) embryonic GM2  (107) embryonic Kc167  (92) embryonic S1  (100) embryonic S3  (82) leg disc CME L1  (80) wing disc CME-W2  (58) wing disc ML-DmD8  (83) wing disc ML-DmD9  (56) wing disc ML-DmD16-c3  (68) wing disc ML-DmD21  (68) wing disc ML-DmD32  (69) haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (89) mixed discs ML-DmD4-c1  (95) CNS ML-DmBG1-c1  (45) CNS ML-DmBG2-c2  32 tumorous blood cells mbn2  (217) ovary fGS/OSS  31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (163) Schneider line 2 Sg4  106 embryonic 1182-4H    45 embryonic GM2  107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2  (217) ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    163 Schneider line 2 Sg4    106 embryonic 1182-4H    45 embryonic GM2    107 embryonic Kc167    92 embryonic S1    100 embryonic S3    82 leg disc CME L1    80 wing disc CME-W2    58 wing disc ML-DmD8    83 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    68 wing disc ML-DmD21    68 wing disc ML-DmD32    69 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    95 CNS ML-DmBG1-c1    45 CNS ML-DmBG2-c2    32 tumorous blood cells mbn2    217 ovary fGS/OSS    31 ovary OSC    21 ovary OSS    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (28) Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult  (34) Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    34 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    28 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • SD09884 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037207 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11100-RA;CG11100-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mes2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4da.G32 Mes2Scer\UAS.cZa lethal, with Scer\GAL4nos.PG Mes2Scer\UAS.cZa lethal, with Scer\GAL4pnr-MD237 Mes2GD4628 lethal, with Scer\GAL4prd.RG1 Mes2Scer\UAS.cZa lethal, with Scer\GAL4repo.PU Mes2Scer\UAS.cZa lethal, with Scer\GAL4tub.PU Mes2Scer\UAS.cZa lethal, with Scer\GAL4Ubi Mes2Scer\UAS.cZa lethal | embryonic stage, with Scer\GAL469B Mes2Scer\UAS.cZa lethal | first instar larval stage Mes2KG02901 lethal | first instar larval stage, with Scer\GAL4how-24B, Scer\GAL4twi.PB Mes2Scer\UAS.cZa lethal | first instar larval stage, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PB Mes2Scer\UAS.cZa lethal | first instar larval stage, with Scer\GAL4twi.2PE Mes2Scer\UAS.cZa lethal | first instar larval stage | germline clone Mes2KG02901 lethal | larval stage, with Scer\GAL471B Mes2Scer\UAS.cZa lethal | pupal stage, with Scer\GAL4Bx-MS1096 Mes2Scer\UAS.cZa lethal | second instar larval stage, with Scer\GAL4gcm.PU Mes2Scer\UAS.cZa viable Mes201 Other Phenotypes Allele body size defective | first instar larval stage Mes2KG02901 hypoactive | first instar larval stage Mes2KG02901 Phenotype manifest in Allele embryonic/first instar larval cuticle Mes2KG02901 embryonic/first instar larval cuticle | germline clone Mes2KG02901 embryonic dorsal epidermis | dorsal closure stage, with Scer\GAL4da.G32 Mes2Scer\UAS.cZa embryonic dorsal epidermis | dorsal closure stage, with Scer\GAL4nos.PG Mes2Scer\UAS.cZa embryonic dorsal epidermis | dorsal closure stage, with Scer\GAL4Ubi Mes2Scer\UAS.cZa embryonic epidermis, with Scer\GAL469B Mes2Scer\UAS.cZa embryonic leading edge cell, with Scer\GAL469B Mes2Scer\UAS.cZa haltere, with Scer\GAL4Bx-MS1096 Mes2Scer\UAS.cZa wing, with Scer\GAL4Bx-MS1096 Mes2Scer\UAS.cZa
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Mes2 Class Mutagen Stocks Known lesion Mes2KG02901 amorphic allele - genetic evidence P-element activity 1 Yes Mes201 1 Yes Mes2d01660 P-element activity 1 -- Mes2d10836 P-element activity 1 -- Mes2d11440 P-element activity 1 -- Mes2f01255 piggyBac transposase 1 -- Mes2MB07230 1 -- Mes2MI06804 1 -- Mes2d02763 P-element activity 0 -- Mes2d07515 P-element activity 0 -- Mes2d11349 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mes2 Class Mutagen Stocks Known lesion Mes2GD4628 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mes2HMS00460 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mes2+t12 in vitro construct - genomic fragment 0 Yes Mes2KK115780 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mes2NIG.11100R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mes2Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ED5017 (Zimmermann et al., 2006) Df(3L)Exel6139 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4628} NA P{KK115780} NA P{NIG.11100R} NA P{TRiP.HMS00460} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}Mes2d01660 NA P{XP}Mes2d02763 NA P{XP}Mes2d07515 NA P{XP}Mes2d10836 NA P{XP}Mes2d11349 NA P{XP}Mes2d11440 NA miscellaneous insertions Mi{MIC}Mes2MI06804 NA P{SUPor-P}Mes2KG02901 NA P{UAST-YFP.Rab1}Mes201 NA PBac{WH}Mes2f01255 NA insertion of enhancer trap binary system Mi{ET1}Mes2MB07230 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
ecdysis, chitin-based cuticle inferred from mutant phenotype (Zimmermann et al., 2006) embryonic development via the syncytial blastoderm inferred from mutant phenotype (Zimmermann et al., 2004) imaginal disc development inferred from mutant phenotype (Zimmermann et al., 2004) instar larval development inferred from mutant phenotype (Zimmermann et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Zimmermann et al., 2006)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Zimmermann et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mes2 - CG12768 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Mes2 - CG6543 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Mes2 - CG6617 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Mes2 - CtBP anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Mes2 - Spindly anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Mes2 - eIF-4B anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mes2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65742 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037207 DroID - A comprehensive database of gene and protein interactions. • FBgn0037207 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40514
Orthologs
OrthoDB Orthologs (19) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6575SJ Dipteran inclusive ortholog search EOG6H1B4Z Insect inclusive ortholog search EOG6SN0K1 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6PW1TC
Orthologs in Drosophila Species (EOG6575SJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mes2     Drosophila simulans   Dsim\GD15063 Y   Drosophila sechellia   Dsec\GM22483 Y   Drosophila erecta   Dere\GG16292 Y   Drosophila yakuba   Dyak\Mes2 Y   Drosophila yakuba   Dyak\GE22651     Drosophila ananassae   Dana\GF11009 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10759 Y   Drosophila persimilis   Dper\GL24979     Drosophila persimilis   Dper\GL24980     Drosophila willistoni   Dwil\GK12966 Y   Drosophila virilis   Dvir\GJ11803 Y   Drosophila mojavensis   Dmoj\GI13441 Y   Drosophila grimshawi   Dgri\GH16780 Y
Orthologs in non-Drosophila Dipterans (EOG6H1B4Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014049 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007318 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801745 Y
Orthologs in non-Dipteran Insects (EOG6SN0K1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Camponotus floridanus Florida carpenter ant  Cflo\CFLO18280 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6PW1TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\madf-7 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15063 Drosophila sechellia Dsec\GM22483 Drosophila erecta Dere\GG16292 Drosophila yakuba Dyak\Mes2 Drosophila ananassae Dana\GF11009 Drosophila pseudoobscura pseudoobscura Dpse\GA10759 Drosophila willistoni Dwil\GK12966 Drosophila virilis Dvir\GJ11803 Drosophila mojavensis Dmoj\GI13441 Drosophila grimshawi Dgri\GH16780
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	25262 w1118; Mi{ET1}Mes2MB07230 42435 y1 w*; Mi{MIC}Mes2MI06804 24104 y1 w*; P{UAST-YFP.Rab1}Mes201 32460 y1 sc* v1; P{TRiP.HMS00460}attP2 13765 y1 w67c23; P{SUPor-P}Mes2KG02901 ry506
Harvard	- P{XP}Mes2d01660 - P{XP}Mes2d10836 - P{XP}Mes2d11440 - PBac{WH}Mes2f01255
VDRC	v37782 w1118; P{GD4628}v37782
Genomic Clones ( 1 )
	BACR48E05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 80 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD09884 SD10763 SD15211
Other clones	DPiM_SD09884
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE09032 RE21365 RE30103 RE37505 RE52606 RE56280 RE68070 RE72955 RE73885 SD07758 SD10790 SD24379
Other clones	15140 34237 34658 36570 41740 58850 66095 72348 99741 156768 156833 176074 180890 181237 190129 191417 CK01.93C.B6 CK01.103C.G1 CK01.110C.F2 CK01.121D.E7 CK01.122A.D12 Dmel_dig_000372_0664_0288 EK072939 EK083640 EK084017 EK086925 EK091302 EK093020 EK093148 EK100940 EK117860 EK144555 EK147039 EK147104 EK149111 EK154610 EK182556 EK193954 EK201026 EK210406 EK222435 EK259753 EK259914 EK263807 EK280733 EK287238 EK292330 EK294055 EK301808 EN08206 FGM215G05 RP004048424 RP004143578 RP004185558 RP004196726 RP004214437 RP004219683 RP004227718 RP004230328 RP004231731 RP004401284 RP004428366 RP004466262 RP004527968
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037207 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40514
Antibody Information
	polyclonal (Zimmermann et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mes2 CG11100 (Stathopoulos et al., 2002)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168979 NM_168980 RefSeq (Proteins) • NP_730768 NP_730769 DDBJ / EMBL / GenBank • AAF51886 AAK93565 AAL25525 AAN12211 AAN71663 AI543199 AI544271 AW944611 AW944658 AY052141 AY060486 BG637287 BH759361 BT001889 CZ472362 CZ472985 CZ475784 CZ477458 CZ477685 CZ477726 CZ483728 Entrez Gene - A searchable database of RefSeq genes. • 40514 UniProtKB/TrEMBL • Q8IG95 Q9VNP3 Q95ST8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • MADF domain (IPR006578) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD09884
Linkouts
	BioGRID - A database of protein and genetic interactions • 65742 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0037207 DroID - A comprehensive database of gene and protein interactions. • FBgn0037207 DRSC - Results from RNAi screens. • FBgn0037207 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037207 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11100-RA;CG11100-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037207 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40514 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40514 modMine - Data generated by the modENCODE project. • FBgn0037207
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	adfR (Zimmermann et al., 2005, Zimmermann et al., 2004) CG11100 (Freeman et al., 2003, Corradini et al., 2003, Butler et al., 2003, Stathopoulos et al., 2002, Giot et al., 2003, Zimmermann et al., 2006, Ni et al., 2010.12.1, Casola et al., 2007, Keleman et al., 2009.8.5) Mes2 (Terry et al., 2006, Zhang et al., 2007, Frise et al., 2010, Choksi et al., 2006, Hendrix et al., 2008, Boettiger and Levine, 2009, Japanese National Institute of Genetics, 2012.5.21) mes2 (Zimmermann et al., 2006)
Name Synonym	Mes2   Mesoderm-expressed 2
Secondary FlyBase IDs
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...