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Gene Dmel\aux

General Information
Symbol	Dmel\aux	Species	D. melanogaster
Name	auxillin	Annotation symbol	CG1107
Feature type	protein_coding_gene	FlyBase ID	FBgn0037218
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	dAux
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82A1-82A1	Sequence location	3R:37,505..53,240 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene auxillin is referred to in FlyBase by the symbol Dmel\aux (CG1107, FBgn0037218). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. There is experimental evidence that it is involved in the biological process: sperm individualization; Notch signaling pathway; compound eye morphogenesis. 56 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; external compound sense organ; adult; thoracic segment; peripheral nervous system; portion of tissue; histaminergic neuron; cystic bulge. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: C2 calcium/lipid-binding domain, CaLB; DnaJ domain; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Tensin phosphatase, C2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult fat body, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630721_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of aux. Gene sequence location is 3R:37505..53240.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles aux[MI07608]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82A1-82A1   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82A-82B   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)	cu (Eun et al., 2007)
Right of (cM)	P{SUPor-P}KG08740 th (Eun et al., 2007)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\aux for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) aux-RA FBtr0078965  NM_164317   4410   1165 aux-RB FBtr0078966  NM_141181   4312   1165 aux-RC FBtr0336705  NM_001275314   4276   1153 aux-RD FBtr0336706  NM_001275315   4288   1157
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein aux-PA   FBpp0078604   127.9   1165   6.27     NP_730785   AAF52168 aux-PB   FBpp0078605   127.9   1165   6.27     NP_649438   AAF52169 aux-PC   FBpp0307686   126.7   1153   6.12     NP_001262243   AGB95626 aux-PD   FBpp0307687   127.1   1157   6.27     NP_001262244   AGB95627
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) DnaJ domain (IPR001623) Serine/threonine-protein kinase, active site (IPR008271) C2 calcium/lipid-binding domain, CaLB (IPR008973) Protein kinase-like domain (IPR011009) Tensin phosphatase, C2 domain (IPR014020)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390948   AA440032   AA440356   AA440431   AA440879   AA540712   AA978488   AE014297 AAF52168   AE014297 AAF52169   AE014297 AGB95626   AE014297 AGB95627   AI109975   AI513387   AW942337   AX094269   AY069440 AAL39585   AY231908   BF499427   BF499810   BG632484   BG636570   BI213921   BI229634   BI233135   BI234100   BI356952   BI364046   BI370762   BI483969   BI487050   BT031027   CA804729   CO178242   CO178437   CO273165   CO280045   CO283452   CO284469   CO295853   CO297131   CO299190   CO310792   CO317725   CO318007   CO321477   CO327806   CO329454   CZ468242   CZ469555   CZ486412   CZ486413   CZ488023   CZ488024   EC053029   EC053031   EC054488   EC055971   EC057063   EC058330   EC067328   EC071913   EC087579   EC091059   EC195802   EC220828   EC223395   EC227055   EC236022   EC238992   EC245377   EC247773   EC248991   EL874090   EV595834   GH747040   GH765078   GH779457   GH779647
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMY8 Q8T0A7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) garland cell primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) Comment:reported as salivary gland primordium embryonic stage 13 -- 16   embryonic/larval garland cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Golgi stack inferred from direct assay (Zhou et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult fat body, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart    1121.1 Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules  (599.1) Larval Fat Body    287.4 Larval Salivary Gland  (588.5) Larval Trachea  531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion  522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules  (559) Adult Fat Body    332.7 Adult Salivary Gland  (580.8) Adult Heart  (1121.1) Adult VirginFemale Spermatheca  529.3 Adult InseminatedFemale Spermatheca  (593.1) Adult Ovary  (546.2) Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart  (1121.1) Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart    1121.1 Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart    1121.1 Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules  599.1 Larval Fat Body    287.4 Larval Salivary Gland  588.5 Larval Trachea  531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion  522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules  559 Adult Fat Body    332.7 Adult Salivary Gland  580.8 Adult Heart  (1121.1) Adult VirginFemale Spermatheca  529.3 Adult InseminatedFemale Spermatheca  593.1 Adult Ovary  546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart  1121.1 Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    382.375 Larval Midgut    406.5 Larval Hindgut    466.9 Larval Malpighian Tubules    599.1 Larval Fat Body    287.4 Larval Salivary Gland    588.5 Larval Trachea    531.025 Larval Carcass    415.85 Adult Head    266.8 Adult Eye    453.625 Adult Brain    464.3 Adult Thoracic-Abdominal Ganglion    522.3 Adult Crop    291.8 Adult Midgut    445.9 Adult Hindgut    349.1 Adult Malpighian Tubules    559 Adult Fat Body    332.7 Adult Salivary Gland    580.8 Adult Heart    1121.1 Adult VirginFemale Spermatheca    529.3 Adult InseminatedFemale Spermatheca    593.1 Adult Ovary    546.2 Adult Testis    137.3 Adult Male Accessory Gland    348 Adult Carcass    231.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    266.8   NA  Eye    453.625   NA  Brain    464.3   382.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    522.3   NA  Crop    291.8   406.5  Midgut    445.9   466.9  Hindgut    349.1   599.1  Malpighian Tubules    559   287.4  Fat Body    332.7   588.5  Salivary Gland    580.8   NA  Heart    1121.1   531.025  Trachea    NA   NA  VirginFemale Spermatheca    529.3   NA  InseminatedFemale Spermatheca    593.1   NA  Ovary    546.2   NA  Testis    137.3   NA  Male Accessory Gland    348   415.85  Carcass    231.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female  (33) head, virgin 4-day female  (28) head, virgin 20-day female    22 head, mated 1-day female  (28) head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male  (41) head, mated 4-day male  (31) head, mated 20-day male  (28) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (39) digestive system, larvae L3 wandering  (29) digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8  (27) carcass, larvae L3 wandering  (34) carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (77) ovary, mated 4-day female  (76) testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female  (33) head, virgin 4-day female  28 head, virgin 20-day female    22 head, mated 1-day female  28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male  (41) head, mated 4-day male  31 head, mated 20-day male  28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (39) digestive system, larvae L3 wandering  29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8  27 carcass, larvae L3 wandering  (34) carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (77) ovary, mated 4-day female  (76) testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    33 head, virgin 4-day female    28 head, virgin 20-day female    22 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    21 head, mated 1-day male    41 head, mated 4-day male    31 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    39 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    19 digestive system, 4-day adult    21 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    21 fat body, pupae P8    27 carcass, larvae L3 wandering    34 carcass, 1-day adult    15 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    77 ovary, mated 4-day female    76 testis, mated 4-day male    22 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr  (55) embryo 04-06hr  (31) embryo 06-08hr  (33) embryo 08-10hr  (36) embryo 10-12hr  26 embryo 12-14hr  (30) embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr  26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day  (30) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (43) embryo 02-04hr  (55) embryo 04-06hr  31 embryo 06-08hr  (33) embryo 08-10hr  (36) embryo 10-12hr  26 embryo 12-14hr  30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr  26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day  30 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    43 embryo 02-04hr    55 embryo 04-06hr    31 embryo 06-08hr    33 embryo 08-10hr    36 embryo 10-12hr    26 embryo 12-14hr    30 embryo 14-16hr    25 embryo 16-18hr    25 embryo 18-20hr    22 embryo 20-22hr    24 embryo 22-24hr    26 larva L1    16 larva L2    14 larva L3 12hr old    12 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    19 white prepupae 24hr    21 pupae 2d postWPP    18 pupae 3d postWPP    15 pupae 4d postWPP    12 adult male 01day    15 adult male 05day    16 adult male 30day    14 adult female 01day    19 adult female 05day    30 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4    1 embryonic 1182-4H  (42) embryonic GM2  (77) embryonic Kc167  (68) embryonic S1  (56) embryonic S3  (59) leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8  (28) wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    4 wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3  (50) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2  (39) ovary fGS/OSS  (38) ovary OSC  (61) ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (59) Schneider line 2 Sg4    1 embryonic 1182-4H  (42) embryonic GM2  (77) embryonic Kc167  (68) embryonic S1  (56) embryonic S3  (59) leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8  28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (40) wing disc ML-DmD21    4 wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3  (50) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (36) tumorous blood cells mbn2  (39) ovary fGS/OSS  (38) ovary OSC  (61) ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    59 Schneider line 2 Sg4    1 embryonic 1182-4H    42 embryonic GM2    77 embryonic Kc167    68 embryonic S1    56 embryonic S3    59 leg disc CME L1    1 wing disc CME-W2    3 wing disc ML-DmD8    28 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    4 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    50 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    21 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    36 tumorous blood cells mbn2    39 ovary fGS/OSS    38 ovary OSC    61 ovary OSS    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  (32) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult  (30) Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (55) Caffeine 25 mg/ml 48 hrs, 4-day adult  (28) Paraquat 5 mM 48 hrs, 4-day adult  (46) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult  32 Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult  30 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (55) Caffeine 25 mg/ml 48 hrs, 4-day adult  28 Paraquat 5 mM 48 hrs, 4-day adult  (46) Paraquat 10 mM 48 hrs, 4-day adult  (37) Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    26 cold shock, 4-day adult    19 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    30 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    15 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    46 Paraquat 10 mM 48 hrs, 4-day adult    37 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD15107 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037218 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1107-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for aux Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with aux727) auxD136 auxF37 auxL7 lethal (with auxD128) auxK47 lethal (with auxD136) aux727 lethal (with auxF37) aux727 lethal (with auxI670K) auxW328X auxW1150X lethal (with auxK47) auxD128 lethal (with auxL7) aux727 lethal (with auxW328X) auxI670K lethal (with auxW1150X) auxI670K lethal (with Df(3R)ED5021) auxI670K lethal | cold sensitive (with auxK47) auxL7 lethal | cold sensitive (with auxL7) auxK47 lethal | embryonic stage auxW328X auxW1150X lethal | embryonic stage, with auxW328X/auxL78H auxΔJ.Scer\UAS.T:Disc\RFP-mRFP lethal | embryonic stage (with auxL78H), with auxΔJ.Scer\UAS.T:Disc\RFP-mRFP auxW328X lethal | embryonic stage (with auxW328X), with auxΔJ.Scer\UAS.T:Disc\RFP-mRFP auxL78H lethal | embryonic stage (with Df(3R)ED5021) auxF956X auxS214X auxW254X auxW328X auxW1150X lethal | larval stage (with auxL78H) auxW328X lethal | larval stage (with auxW328X) auxL78H lethal | pupal stage, with Scer\GAL4pnr-MD237 auxGD7187 viable auxI670K auxL7 viable (with auxD128) auxD136 auxK47 viable (with auxD136) auxD128 viable (with auxK47) auxD128 Sterility Allele female sterile auxI670K male sterile auxI670K male sterile (with auxG257E) auxI670K male sterile (with auxI670K) auxG257E auxL78H male sterile (with auxL78H) auxI670K Other Phenotypes Allele neuroanatomy defective auxdsRNA.cHa neuroanatomy defective | maternal effect auxI670K visible auxG257E auxI670K auxL7 auxL78H visible (with auxD128) auxD136 auxK47 visible (with auxD136) auxD128 visible (with auxK47) auxD128 Phenotype manifest in Allele anterior sternopleural bristle | ectopic auxI670K anterior sternopleural bristle | ectopic (with auxI670K) auxW328X auxW1150X anterior sternopleural bristle | ectopic (with auxW328X) auxI670K anterior sternopleural bristle | ectopic (with auxW1150X) auxI670K cystic bulge (with auxG257E) auxI670K cystic bulge (with auxI670K) auxL78H auxG257E cystic bulge (with auxL78H) auxI670K embryo auxdsRNA.cHa epidermis auxdsRNA.cHa eye auxL78H auxG257E auxI670K eye (with auxD128) auxK47 auxL7 eye (with auxG257E) auxI670K eye (with auxI670K) auxL78H auxG257E auxW328X auxW1150X eye (with auxK47) auxD128 eye (with auxL7) auxD128 eye (with auxL78H) auxI670K eye (with auxW328X) auxI670K eye (with auxW1150X) auxI670K eye | heat sensitive auxI670K eye photoreceptor cell (with aux727) auxD136 auxL7 eye photoreceptor cell (with auxD128) auxK47 eye photoreceptor cell (with auxD136) aux727 eye photoreceptor cell (with auxK47) auxD128 eye photoreceptor cell (with auxL7) aux727 eye photoreceptor cell | ectopic (with aux727) auxL7 eye photoreceptor cell | ectopic (with auxD128) auxK47 eye photoreceptor cell | ectopic (with auxK47) auxD128 eye photoreceptor cell | ectopic (with auxL7) aux727 eye photoreceptor cell | supernumerary (with auxG257E) auxI670K eye photoreceptor cell | supernumerary (with auxI670K) auxL78H auxG257E eye photoreceptor cell | supernumerary (with auxL78H) auxI670K individualization stage spermatid (with auxG257E) auxI670K individualization stage spermatid (with auxI670K) auxL78H auxG257E individualization stage spermatid (with auxL78H) auxI670K inner photoreceptor cell | supernumerary auxI670K male germline stem cell (with auxG257E) auxI670K male germline stem cell (with auxI670K) auxG257E notopleural bristle | ectopic auxI670K notopleural bristle | ectopic (with auxI670K) auxW328X auxW1150X notopleural bristle | ectopic (with auxW328X) auxI670K notopleural bristle | ectopic (with auxW1150X) auxI670K ommatidial precursor cluster | somatic clone auxL78H auxF956X ommatidium auxI670K ommatidium (with aux727) auxL7 ommatidium (with auxD128) auxK47 ommatidium (with auxK47) auxD128 ommatidium (with auxL7) aux727 outer photoreceptor cell | supernumerary auxI670K posterior crossvein auxI670K posterior crossvein (with auxI670K) auxW328X auxW1150X posterior crossvein (with auxW328X) auxI670K posterior crossvein (with auxW1150X) auxI670K presumptive embryonic/larval peripheral nervous system | maternal effect auxI670K scutellar bristle | ectopic auxI670K scutellar bristle | ectopic (with auxI670K) auxW328X auxW1150X scutellar bristle | ectopic (with auxW328X) auxI670K scutellar bristle | ectopic (with auxW1150X) auxI670K scutellar bristle | supernumerary (with auxG257E) auxI670K scutellar bristle | supernumerary (with auxI670K) auxL78H auxG257E scutellar bristle | supernumerary (with auxL78H) auxI670K sternopleural bristle | supernumerary (with auxG257E) auxI670K sternopleural bristle | supernumerary (with auxI670K) auxL78H auxG257E sternopleural bristle | supernumerary (with auxL78H) auxI670K ventral nerve cord | maternal effect auxI670K vibrissae auxI670K vibrissae (with auxI670K) auxW328X auxW1150X vibrissae (with auxW328X) auxI670K vibrissae (with auxW1150X) auxI670K wing (with auxC2) auxL7 wing (with auxD128) auxK47 wing (with auxK47) auxD128 wing (with auxL7) auxC2 wing blade (with auxD128) auxD136 auxK47 wing blade (with auxD136) auxD128 wing blade (with auxK47) auxD128 wing vein auxI670K wing vein (with auxI670K) auxW328X auxW1150X wing vein (with auxW328X) auxI670K wing vein (with auxW1150X) auxI670K wing vein | ectopic auxL7 wing vein | ectopic (with auxC2) auxL7 wing vein | ectopic (with auxD128) auxK47 wing vein | ectopic (with auxK47) auxD128 wing vein | ectopic (with auxL7) auxC2
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of aux Class Mutagen Stocks Known lesion aux727 ethyl methanesulfonate 1 Yes auxc02830 piggyBac transposase 1 -- auxc04852 piggyBac transposase 1 -- auxD128 ethyl methanesulfonate 1 Yes auxD136 ethyl methanesulfonate 1 Yes auxf03820 piggyBac transposase 1 -- auxf05446 piggyBac transposase 1 -- auxG6787 P-element activity 1 -- auxK47 ethyl methanesulfonate 1 Yes auxL7 ethyl methanesulfonate 1 Yes auxMB07514 1 -- auxMI07608 1 -- auxC2 ethyl methanesulfonate 0 Yes auxF37 ethyl methanesulfonate 0 -- auxF956X ethyl methanesulfonate 0 Yes auxG257E ethyl methanesulfonate 0 Yes auxI670K hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes auxJ26 ethyl methanesulfonate 0 Yes auxK48 ethyl methanesulfonate 0 Yes auxK5 ethyl methanesulfonate 0 Yes auxL24 ethyl methanesulfonate 0 Yes auxL78H ethyl methanesulfonate 0 Yes auxN7 ethyl methanesulfonate 0 Yes auxS214X 0 Yes auxW1150X 0 Yes auxW254X 0 Yes auxW328X 0 Yes
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of aux Class Mutagen Stocks Known lesion aux+t21 in vitro construct - genomic fragment 1 Yes auxCBD+J.Scer\UAS in vitro construct - regulatory fusion 1 Yes auxCBD+J in vitro construct - deletion 1 Yes auxGD7187 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes auxGL00213 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes auxGMR.PC in vitro construct - regulatory fusion 1 Yes auxHMS01935 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes auxJF03129 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes auxKK100927 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes auxCJ.DLL.DPF.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes auxCJ.DLL.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes auxCJ.DPF.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes auxCJ.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes auxCJ.βTub85D.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxdsRNA.cHa in vitro construct - RNAi 0 -- auxFL.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxFL.βTub85D.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxK+PTEN.Scer\UAS in vitro construct - regulatory fusion 0 Yes auxNIG.1107R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes auxro.PE in vitro construct - regulatory fusion 0 Yes auxScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes auxScer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxαTub84B.PE in vitro construct - regulatory fusion 0 Yes auxΔC.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes auxΔC.βTub85D.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxΔJ.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes auxΔJ.Scer\UAS in vitro construct - regulatory fusion 0 Yes auxΔJ.βTub85D.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes auxΔK.Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes auxΔK.βTub85D.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)ED5021 (Kandachar et al., 2008, Hagedorn et al., 2006)
Not disrupted in	Df(3R)ED5092 (Hagedorn et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7187} NA P{KK100927} NA P{NIG.1107R} NA P{TRiP.GL00213} NA P{TRiP.HMS01935} NA P{TRiP.JF03129} NA P{UAS-aux.CBD+J} NA P{UAS-aux.H} NA P{UAS-aux.K+PTEN} NA P{UAS-aux.mRFP.CJ.DLL.DPF} NA P{UAS-aux.mRFP.CJ.DLL} NA P{UAS-aux.mRFP.CJ.DPF} NA P{UAS-aux.mRFP.CJ} NA P{UAS-aux.mRFP.FL} NA P{UAS-aux.mRFP.ΔC} NA P{UAS-aux.mRFP.ΔJ} NA P{UAS-aux.mRFP.ΔK} NA P{UAS-aux.ΔJ} NA P{UAS-aux-RFP} NA characterization construct P{aux.CBD+J} NA P{aux+t21} NA P{ro-aux.E} NA P{αTub84B-aux.E} NA P{βTub85D-aux.mRFP.CJ} NA P{βTub85D-aux.mRFP.FL} NA P{βTub85D-aux.mRFP.ΔC} NA P{βTub85D-aux.mRFP.ΔJ} NA P{βTub85D-aux.mRFP.ΔK} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}auxMI07608 NA PBac{PB}auxc02830 NA PBac{PB}auxc04852 NA PBac{WH}auxf03820 NA PBac{WH}auxf05446 NA insertion of enhancer trap binary system Mi{ET1}auxMB07514 No insertion of mobile activating element P{EP}auxG6787 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Eun et al., 2008) Notch signaling pathway inferred from mutant phenotype (Hagedorn et al., 2006, Kandachar et al., 2008) sperm individualization inferred from mutant phenotype (Zhou et al., 2011)
Cellular Component
CV term Evidence References
Golgi stack inferred from direct assay (Zhou et al., 2011)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000) synaptic vesicle uncoating traceable author statement (Stimson and Ramaswami, 1999)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions aux allele Gene References unspecified Clc (Hagedorn et al., 2006) Hsc70-4 (Hagedorn et al., 2006) lqf (Eun et al., 2007) N (Hagedorn et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65749 DroID - A comprehensive database of gene and protein interactions. • FBgn0037218 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40527 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VMY8
Orthologs
OrthoDB Orthologs (48) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG641QWQ Dipteran inclusive ortholog search EOG6C2HJH Insect inclusive ortholog search EOG65QG86 Arthropod inclusive ortholog search EOG69GHXJ Metazoa inclusive ortholog search EOG63VBNJ
Orthologs in Drosophila Species (EOG641QWQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\aux     Drosophila simulans   Dsim\GD19706 Y   Drosophila sechellia   Dsec\GM10735 Y   Drosophila erecta   Dere\GG12187 Y   Drosophila yakuba   Dyak\auxillin Y   Drosophila ananassae   Dana\GF17690 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10740 Y   Drosophila persimilis   Dper\GL12305 Y   Drosophila willistoni   Dwil\GK12070 Y   Drosophila virilis   Dvir\GJ14155 Y   Drosophila mojavensis   Dmoj\GI22854 Y   Drosophila grimshawi   Dgri\GH18708 Y
Orthologs in non-Drosophila Dipterans (EOG6C2HJH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005425   Anopheles gambiae Malaria mosquito  Agam\AGAP003715   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008013
Orthologs in non-Dipteran Insects (EOG65QG86)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413462   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000708   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21252   Atta cephalotes Leafcutter ant  Acep\ACEP21260   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21853   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19188   Linepithema humile Argentine ant  Lhum\LH11157   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21524   Solenopsis invicta Red fire ant  Sinv\SINV14645   Acyrthosiphon pisum Pea aphid  Apim\ACYPI089162   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005127   Bombyx mori Silkmoth  Bmor\BGIBMGA012412   Bombyx mori Silkmoth  Bmor\BGIBMGA004687   Pediculus humanus Human body louse  Phum\PHUM047670   Tribolium castaneum Red flour beetle  Tcas\TC012067
Orthologs in non-Insect Arthropods (EOG69GHXJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_213883
Orthologs in non-Arthropod Metazoa (EOG63VBNJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tag-257   Caenorhabditis elegans Nematode  Cele\dnj-25   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000818gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019314gn   Danio rerio Zebrafish  Drer\dnajc6   Danio rerio Zebrafish  Drer\ENSDARG00000090654   Danio rerio Zebrafish  Drer\gak   Xenopus tropicalis Western clawed frog  Xtro\dnajc6   Xenopus tropicalis Western clawed frog  Xtro\gak   Gallus gallus Domestic chicken  Ggal\DNAJC6   Gallus gallus Domestic chicken  Ggal\GAK   Mus musculus House mouse  Mmus\Gak   Mus musculus House mouse  Mmus\ENSMUSG00000028528   Rattus norvegicus Norway rat  Rnor\Gak   Rattus norvegicus Norway rat  Rnor\Dnajc6   Homo sapiens Human  Hsap\GAK   Homo sapiens Human  Hsap\DNAJC6
Human Orthologs (2)
Gene OMIM HGNC Hsap\GAK     Hsap\DNAJC6
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19706 Drosophila sechellia Dsec\GM10735 Drosophila erecta Dere\GG12187 Drosophila yakuba Dyak\auxillin Drosophila ananassae Dana\GF17690 Drosophila pseudoobscura pseudoobscura Dpse\GA10740 Drosophila persimilis Dper\GL12305 Drosophila willistoni Dwil\GK12070 Drosophila virilis Dvir\GJ14155 Drosophila mojavensis Dmoj\GI22854 Drosophila grimshawi Dgri\GH18708
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	26277 w*; P{aux.CBD+J}2 26278 w*; P{UAS-aux.CBD+J}3 7113 w1118; P{GMR-auxillin.C}2 30174 w1118; P{EP}auxG6787 28509 y1 v1; P{TRiP.JF03129}attP2 25674 w*; auxL7/TM6B, Tb1
Harvard	- PBac{PB}auxc02830 - PBac{PB}auxc04852 - PBac{WH}auxf03820 - PBac{WH}auxf05446
VDRC	v103426 P{KK100927}VIE-260B v16182 w1118; P{GD7187}v16182
	More stocks available...
Genomic Clones ( 1 )
	BACR15O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15107 SD05837
Other clones	yak-em_CG1107
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13982 AT14567 GH26574 LD09735 LD14932 LD15024 LD15952 LD20493 LD30716 RE19568 RE27456 RE29422 RE29740 RE43258 RE49080 RE57502 RE66952 RE70555 SD14314
Other clones	10092 10910 43856 60943 78093 82802 99877 121646 164501 174729 190465 CK01.18B.A2 CK01.70C.D9 CK01.71C.D5 CK01.114A.A2 Dmel_neb_012693_0673_3352 EC053029 EC053031 EC054488 EC055971 EK056213 EK056712 EK109861 EK152306 EK163319 EK166134 EK174719 EK185745 EK211759 EK216060 EK222529 EK268910 EK270009 EK292856 EP08053 ESG0115a.B21_A10 GH09391 IP14147 RP001007043 RP001019846 RP001025348 RP001039678
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037218 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40527
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: auxillin CG1107 (Verstreken and Bellen, 2000.9.4)
Source for database merge of	Source for merge of: auxillin anon-WO0118547.393 (FlyBase, 1996-)
Additional comments	Source for merge of auxillin anon-WO0118547.393 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	aux is required in N signaling cells for Dl ligand internalization and signaling during eye morphogenesis. (Eun et al., 2008) aux regulates the internalisation of Dl to control activity of the N signalling pathway. (Hagedorn et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA540712 (inverted). This EST forms a 809bp contig with ESTs AA440879 and AA440431, and has sequence similarity to Human Cyclin G associated kinase gene. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141181 NM_164317 NM_001275314 NM_001275315 RefSeq (Proteins) • NP_649438 NP_730785 NP_001262243 NP_001262244 DDBJ / EMBL / GenBank • AA440032 AA540712 AAF52168 AAF52169 AAL39585 AGB95626 AGB95627 AW942337 AX094269 AY069440 CZ468242 CZ469555 CZ486412 CZ486413 CZ488023 CZ488024 Entrez Gene - A searchable database of RefSeq genes. • 40527 UniProtKB/TrEMBL • Q8T0A7 Q9VMY8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) DnaJ domain (IPR001623) Serine/threonine-protein kinase, active site (IPR008271) C2 calcium/lipid-binding domain, CaLB (IPR008973) Protein kinase-like domain (IPR011009) Tensin phosphatase, C2 domain (IPR014020) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15107
Linkouts
	BioGRID - A database of protein and genetic interactions • 65749 DroID - A comprehensive database of gene and protein interactions. • FBgn0037218 DRSC - Results from RNAi screens. • FBgn0037218 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037218 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1107-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037218 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40527 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/auxilin.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40527 modMine - Data generated by the modENCODE project. • FBgn0037218 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VMY8
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-WO0118547.393   aux (Eun et al., 2007, Eun et al., 2008, Cheli et al., 2010, Cheli et al., 2010, Japanese National Institute of Genetics, 2012.5.21) auxilin (Chang et al., 2004) auxillin   Auxillin/DNAJC6 (Wishart et al., 2012) CG1107 (Whitfield et al., 2002, Brody et al., 2002, Morrison et al., 2000, Hagedorn et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19, Ni et al., 2010.12.1) dAux (Hagedorn et al., 2006, Kandachar et al., 2008, Zhou et al., 2011) GAK (Morrison et al., 2000)
Name Synonym	auxilin (Chang et al., 2002, Bayraktar et al., 2006, Eun and Fischer, 2006, Eun et al., 2007, Hagedorn et al., 2006, Andreyeva et al., 2007, Eun et al., 2008, Korolchuk et al., 2007) Auxilin (Stimson and Ramaswami, 1999, Banks et al., 2011, Kandachar et al., 2008, Cheli et al., 2010) auxillin (Korolchuk et al., 2007, Rehwinkel et al., 2005)
Secondary FlyBase IDs
	FBgn0062044
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Wishart et al., 2012, PLoS Genet. 8(8): e1002936 Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. [FBrf0219374] Banks et al., 2011, PLoS ONE 6(3): e18259 The functions of auxilin and rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. [FBrf0213386] Zhou et al., 2011, Development 138(6): 1111--1120 Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. [FBrf0213068] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...