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Gene Dmel\Cont

General Information
Symbol	Dmel\Cont	Species	D. melanogaster
Name	Contactin	Annotation symbol	CG1084
Feature type	protein_coding_gene	FlyBase ID	FBgn0037240
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	DCONT
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82A5-82A5	Sequence location	3R:207,032..212,741 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Contactin is referred to in FlyBase by the symbol Dmel\Cont (CG1084, FBgn0037240). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: nerve maturation; establishment of glial blood-brain barrier; septate junction assembly; axon ensheathment. 7 alleles are reported. The phenotypes of these alleles are annotated with: salivary gland; trichogen cell; abdominal lateral pentascolopidial chordotonal organ lch5. It has one annotated transcript and one annotated polypeptide. Protein features are: C-type lectin; C-type lectin fold; C-type lectin-like; Fibronectin, type III; Herpesvirus UL45-like; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval fat body, adult female reproductive system, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637017_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cont. Gene sequence location is 3R:207032..212741.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN20450 HFA12149
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82A5-82A5   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cont for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD28757 appears problematic: incomplete CDS Structure based on FBrf0149570 (FastA sequence of Cont). GC splice donor site postulated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cont-RA FBtr0078917  NM_141204   4739   1390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cont-PA   FBpp0078557   158.2   1390   6.77     NP_649461   AAF52137
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C-type lectin (IPR001304) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) C-type lectin-like (IPR016186) C-type lectin fold (IPR016187) Herpesvirus UL45-like (IPR008646) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697510   AA950263   AE014297 AAF52137   AI386864   AI388837   AW942905   AY095040 AAM11368   AY229991 AAP44004   BG632960   BI162823   BI212753   BI484522   BP545186   BP545187   BP546360   BP558456   BP558457   BT021333 AAX33481   BT083421   CO264542   CO264606   CO269965   CO271154   CO271552   CO272362   CO283911   CO297228   CO305351   CO308920   CO320791   CO323832   CO343285   CZ470091   EC060093   EC072410   EC074698   EC075842   EC087003   EC088368   EC197281   EC197657   EC204775   EC209221   EC210701   EC220406   EC222531   EC226640   EC227664   EC236002   EC244304   EC252384   EC258961   ES695975   ES696154   ES696155   FE863466   FE863539   FE863696   FE863793   FE863855   FE863927   GH739269   GH740219   GH744506   GH746477
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VN14
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0037240    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0037240 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0037240 expression level Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr    10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2333) embryo 02-04hr  (2859) embryo 04-06hr  (3669) embryo 06-08hr  (7528) embryo 08-10hr  (9932) embryo 10-12hr  (9617) embryo 12-14hr  (10572) embryo 14-16hr  (5686) embryo 16-18hr  (5008) embryo 18-20hr  (4154) embryo 20-22hr  (3154) embryo 22-24hr  (3723) larva L1  (2097) larva L2  (1399) larva L3 12hr old  (1195) larva L3 puffstage 1-2  (1717) larva L3 puffstage 3-6  (2856) larva L3 puffstage 7-9  (3700) white prepupae new  (3633) white prepupae 12hr  (3142) white prepupae 24hr  (5620) pupae 2d postWPP  (4421) pupae 3d postWPP  (4052) pupae 4d postWPP  (1180) adult male 01day  (1496) adult male 05day  (1710) adult male 30day  (1757) adult female 01day  (1223) adult female 05day  (1918) adult female 30day  (1831) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2333) embryo 02-04hr  (2859) embryo 04-06hr  (3669) embryo 06-08hr  (7528) embryo 08-10hr  (9932) embryo 10-12hr  (9617) embryo 12-14hr  (10572) embryo 14-16hr  (5686) embryo 16-18hr  (5008) embryo 18-20hr  (4154) embryo 20-22hr  (3154) embryo 22-24hr  (3723) larva L1  (2097) larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2  (1717) larva L3 puffstage 3-6  (2856) larva L3 puffstage 7-9  (3700) white prepupae new  (3633) white prepupae 12hr  (3142) white prepupae 24hr  (5620) pupae 2d postWPP  (4421) pupae 3d postWPP  (4052) pupae 4d postWPP    1180 adult male 01day  1496 adult male 05day  (1710) adult male 30day  (1757) adult female 01day    1223 adult female 05day  (1918) adult female 30day  (1831) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr  10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr    10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0037240 expression level Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr    10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2333) embryo 02-04hr  (2859) embryo 04-06hr  (3669) embryo 06-08hr  (7528) embryo 08-10hr  (9932) embryo 10-12hr  (9617) embryo 12-14hr  (10572) embryo 14-16hr  (5686) embryo 16-18hr  (5008) embryo 18-20hr  (4154) embryo 20-22hr  (3154) embryo 22-24hr  (3723) larva L1  (2097) larva L2  (1399) larva L3 12hr old  (1195) larva L3 puffstage 1-2  (1717) larva L3 puffstage 3-6  (2856) larva L3 puffstage 7-9  (3700) white prepupae new  (3633) white prepupae 12hr  (3142) white prepupae 24hr  (5620) pupae 2d postWPP  (4421) pupae 3d postWPP  (4052) pupae 4d postWPP  (1180) adult male 01day  (1496) adult male 05day  (1710) adult male 30day  (1757) adult female 01day  (1223) adult female 05day  (1918) adult female 30day  (1831) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2333 embryo 02-04hr  (2859) embryo 04-06hr  (3669) embryo 06-08hr  (7528) embryo 08-10hr  (9932) embryo 10-12hr  (9617) embryo 12-14hr  (10572) embryo 14-16hr  (5686) embryo 16-18hr  (5008) embryo 18-20hr  (4154) embryo 20-22hr  (3154) embryo 22-24hr  (3723) larva L1  2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2  1717 larva L3 puffstage 3-6  (2856) larva L3 puffstage 7-9  (3700) white prepupae new  (3633) white prepupae 12hr  (3142) white prepupae 24hr  (5620) pupae 2d postWPP  (4421) pupae 3d postWPP  (4052) pupae 4d postWPP    1180 adult male 01day  1496 adult male 05day  1710 adult male 30day  1757 adult female 01day    1223 adult female 05day  1918 adult female 30day  1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr  10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2333 embryo 02-04hr    2859 embryo 04-06hr    3669 embryo 06-08hr    7528 embryo 08-10hr    9932 embryo 10-12hr    9617 embryo 12-14hr    10572 embryo 14-16hr    5686 embryo 16-18hr    5008 embryo 18-20hr    4154 embryo 20-22hr    3154 embryo 22-24hr    3723 larva L1    2097 larva L2    1399 larva L3 12hr old    1195 larva L3 puffstage 1-2    1717 larva L3 puffstage 3-6    2856 larva L3 puffstage 7-9    3700 white prepupae new    3633 white prepupae 12hr    3142 white prepupae 24hr    5620 pupae 2d postWPP    4421 pupae 3d postWPP    4052 pupae 4d postWPP    1180 adult male 01day    1496 adult male 05day    1710 adult male 30day    1757 adult female 01day    1223 adult female 05day    1918 adult female 30day    1831 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0037240    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0037240 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval fat body, adult female reproductive system, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0037240 expression level Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea    1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut  (652.7) Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland  (591.3) Larval Trachea  (1019.45) Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop  (927) Adult Midgut    47.8 Adult Hindgut  (578.4) Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland  (667.6) Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca  (587) Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland  (741.2) Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea  1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea    1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0037240 expression level Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea    1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut  652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland  591.3 Larval Trachea  (1019.45) Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop  (927) Adult Midgut    47.8 Adult Hindgut  578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland  667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca  587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland  741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea  1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    283.575 Larval Midgut    58.2 Larval Hindgut    652.7 Larval Malpighian Tubules    21.5 Larval Fat Body    179 Larval Salivary Gland    591.3 Larval Trachea    1019.45 Larval Carcass    425.55 Adult Head    330.5 Adult Eye    304.975 Adult Brain    142.3 Adult Thoracic-Abdominal Ganglion    139.1 Adult Crop    927 Adult Midgut    47.8 Adult Hindgut    578.4 Adult Malpighian Tubules    41.7 Adult Fat Body    87.1 Adult Salivary Gland    667.6 Adult Heart    68.05 Adult VirginFemale Spermatheca    403.3 Adult InseminatedFemale Spermatheca    587 Adult Ovary    327.4 Adult Testis    235 Adult Male Accessory Gland    741.2 Adult Carcass    247.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    330.5   NA  Eye    304.975   NA  Brain    142.3   283.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    139.1   NA  Crop    927   58.2  Midgut    47.8   652.7  Hindgut    578.4   21.5  Malpighian Tubules    41.7   179  Fat Body    87.1   591.3  Salivary Gland    667.6   NA  Heart    68.05   1019.45  Trachea    NA   NA  VirginFemale Spermatheca    403.3   NA  InseminatedFemale Spermatheca    587   NA  Ovary    327.4   NA  Testis    235   NA  Male Accessory Gland    741.2   425.55  Carcass    247.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1084-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cont Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Contex956 viable, with Scer\GAL4pnr-MD237 ContGD12610 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 ContGD12610 Phenotype manifest in Allele abdominal lateral pentascolopidial chordotonal organ lch5 Contex956 axolemma & nerve Contex956 embryonic epidermis & pleated septate junction Contex956 salivary gland Contex956 scolopidium & abdominal lateral pentascolopidial chordotonal organ lch5 Contex956 septate junction & peripheral glial cell Contex956 trichogen cell, with Scer\GAL4pnr-MD237 ContGD12610
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Cont Class Mutagen Stocks Known lesion Contc05549 piggyBac transposase 0 -- Contex956 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cont Class Mutagen Stocks Known lesion ContGD12610 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ContHM05134 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ContHMS00186 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cont+t7 in vitro construct - genomic fragment 0 Yes Conths.PF in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)XM3 (Faivre-Sarrailh et al., 2004)
Partially disrupted in	Df(3L)ex956 (Faivre-Sarrailh et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12610} NA P{TRiP.HM05134} NA P{TRiP.HMS00186} NA heat-shock construct P{hs-Cont.F} NA characterization construct P{Cont.+t7} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Contc05549 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon ensheathment inferred from mutant phenotype (Banerjee et al., 2006) establishment of glial blood-brain barrier inferred from mutant phenotype (Stork et al., 2008) nerve maturation inferred from mutant phenotype (Banerjee et al., 2006) septate junction assembly inferred from mutant phenotype (Banerjee et al., 2006) inferred from mutant phenotype (assigned by UniProtKB) (Faivre-Sarrailh et al., 2004)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010) pleated septate junction inferred from direct assay (assigned by UniProtKB) (Faivre-Sarrailh et al., 2004) septate junction inferred from direct assay (assigned by UniProtKB) (Faivre-Sarrailh et al., 2004)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR001304, InterPro:IPR016186, InterPro:IPR016187 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from sequence or structural similarity with UniProtKB:P28685 (FlyBase, 1992-) establishment or maintenance of epithelial cell apical/basal polarity inferred by curator from GO:0005918 (assigned by UniProtKB) (Faivre-Sarrailh et al., 2004)
Cellular Component
CV term Evidence References
septate junction non-traceable author statement (Faivre-Sarrailh, 2003.2.4)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cont allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65773 DroID - A comprehensive database of gene and protein interactions. • FBgn0037240 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40553
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18209 Dere\GG12351 Dgri\GH14075 Dmoj\GI10608 Dper\GL21461 Dpse\GA10588 Dsec\GM10750 Dvir\GJ22962 Dwil\GK13528 Dyak\GE25412
Curated drosophilid orthologs	Dpse\GA10588
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006958-PA Aedes aegypti (mosquito) AGAP000007-PA Anopheles gambiae (mosquito) XP_395773.3 Apis mellifera (honey bee) XP_001944343.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000042896 Bos taurus (bovine) CBP28301 Caenorhabditis briggsae (nematode) CE25803 Caenorhabditis elegans (worm) ENSCAFP00000009558 Canis familiaris (dog) CPIJ017939 Culex pipens (mosquito) ENSCPOP00000010566 Cavia porcellus (guinea pig) RP39025 Caenorhabditis remanei (nematode) ENSCSAVP00000007428 Ciona savignyi (sedentary tunicate) 180331 Capitella spl (polychaete worm) 303516 Daphnia pulex (daphnia) ENSDARP00000078933 Danio rerio (zebra fish) ENSECAP00000011998 Equus caballus (horse) ENSGACP00000015171 Gymnopilus aculeatus (mushroom) ENSGALP00000013429 Gallus gallus (chicken) 185513 Hypsipyla robusta (cedar shoot borer) ENSP00000377804 Homo sapiens (human) ISCW017078-PA Ixodes scapularis (deer tick) ENSMODP00000005325 Monodelphis domestica (gray opossum) ENSMMUP00000027969 Macaca mulatta (rhesus monkey) ENSMUSP00000032159 Mus musculus (house mouse) XP_001605461.1 Nasonia vitripennis (wasp) ENSOANP00000021255 Ornithorynchus anatinus (platypus) ENSORLP00000013236 Oryzias latipes (japanese killifish) PHUM002334-PA Pediculus humanus (human body louse) ENSPPYP00000005041 Pongo pygmaeus (orangutan) ENSPPYP00000015332 Pongo pygmaeus (orangutan) ENSPTRP00000026088 Pan troglodytes (chimpanzee) ENSRNOP00000008221 Rattus norvegicus (norway rat) Smp_176350 Schistosoma mansoni (trematode parasite) XP_001181157.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967335.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019080 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028154 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000034472 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14411 NV11952 LH13096 ISCW017078 FBgn0242483 FBgn0215536 FBgn0210065 FBgn0191214 FBgn0191213 FBgn0165696 JGI_V11_303516 FBgn0070645 FBgn0159054 FBgn0133372 FBgn0121551 FBgn0104641 FBgn0095227 CPIJ017939 BGIBMGA002413 ACYPI007334 ACYPI005526 GB11810 IGL1 AAEL006958 PHUM206760 GLEAN_13632
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28923 y1 v1; P{TRiP.HM05134}attP2 34867 y1 sc* v1; P{TRiP.HMS00186}attP2/TM3, Sb1
VDRC	v28294 w1118; P{GD12610}v28294 v40613 w1118; P{GD12610}v40613
Genomic Clones ( 2 )
	BACR15E02 BACR30G03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28757 RE02061
Other clones	RT02589
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19865 HL02676 RE17894 RE67637
Other clones	145 8195 30504 30606 40182 45599 64907 77788 78227 82809 118386 156550 181677 183366 214503.61 214535.73 CK01.126C.E7 CK01.167A.F5 CK01.169B.D4 EK097020 EK102123 EK103846 EK106910 EK139536 EK139716 EK164802 EK191627 EK216431 EK248263 EK259661 EK288213 EP16454 FGC029H10 FGH105E10 FGM315B03 GH17219 RC0-DP0007-150700-011-H08 RC0-DP0007-150700-011-H09 RC0-DP0010-150700-011-F05 RM07483 RM07683 RM07783 RM07883 RM07983 RM08083 RP001011497 RP001015056 RP001015565 RP001020071
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40553
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cont CG1084 (Faivre-Sarrailh, 2002.3.6)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141204 RefSeq (Proteins) • NP_649461 DDBJ / EMBL / GenBank • AA950263 AAF52137 AAM11368 AAP44004 AAX33481 AW942905 AY095040 AY229991 BI162823 BT021333 CZ470091 Entrez Gene - A searchable database of RefSeq genes. • 40553 UniProtKB/TrEMBL • Q9VN14
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C-type lectin (IPR001304) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Fibronectin, type III (IPR003961) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) C-type lectin-like (IPR016186) C-type lectin fold (IPR016187) Herpesvirus UL45-like (IPR008646) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65773 DroID - A comprehensive database of gene and protein interactions. • FBgn0037240 DRSC - Results from RNAi screens. • FBgn0037240 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037240 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1084-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037240 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40553 InParanoid A subset of ortholog calls from InParanoid. • AAEL006958-PA Aedes aegypti (mosquito) AGAP000007-PA Anopheles gambiae (mosquito) XP_395773.3 Apis mellifera (honey bee) XP_001944343.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000042896 Bos taurus (bovine) CBP28301 Caenorhabditis briggsae (nematode) CE25803 Caenorhabditis elegans (worm) ENSCAFP00000009558 Canis familiaris (dog) CPIJ017939 Culex pipens (mosquito) ENSCPOP00000010566 Cavia porcellus (guinea pig) RP39025 Caenorhabditis remanei (nematode) ENSCSAVP00000007428 Ciona savignyi (sedentary tunicate) 180331 Capitella spl (polychaete worm) 303516 Daphnia pulex (daphnia) ENSDARP00000078933 Danio rerio (zebra fish) ENSECAP00000011998 Equus caballus (horse) ENSGACP00000015171 Gymnopilus aculeatus (mushroom) ENSGALP00000013429 Gallus gallus (chicken) 185513 Hypsipyla robusta (cedar shoot borer) ENSP00000377804 Homo sapiens (human) ISCW017078-PA Ixodes scapularis (deer tick) ENSMODP00000005325 Monodelphis domestica (gray opossum) ENSMMUP00000027969 Macaca mulatta (rhesus monkey) ENSMUSP00000032159 Mus musculus (house mouse) XP_001605461.1 Nasonia vitripennis (wasp) ENSOANP00000021255 Ornithorynchus anatinus (platypus) ENSORLP00000013236 Oryzias latipes (japanese killifish) PHUM002334-PA Pediculus humanus (human body louse) ENSPPYP00000005041 Pongo pygmaeus (orangutan) ENSPPYP00000015332 Pongo pygmaeus (orangutan) ENSPTRP00000026088 Pan troglodytes (chimpanzee) ENSRNOP00000008221 Rattus norvegicus (norway rat) Smp_176350 Schistosoma mansoni (trematode parasite) XP_001181157.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967335.1 Tribolium castaneum (red flour beetle) ENSTNIP00000019080 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000028154 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000034472 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/contactin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40553 modMine - Data generated by the modENCODE project. • FBgn0037240 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14411 NV11952 LH13096 ISCW017078 FBgn0242483 FBgn0215536 FBgn0210065 FBgn0191214 FBgn0191213 FBgn0165696 JGI_V11_303516 FBgn0070645 FBgn0159054 FBgn0133372 FBgn0121551 FBgn0104641 FBgn0095227 CPIJ017939 BGIBMGA002413 ACYPI007334 ACYPI005526 GB11810 IGL1 AAEL006958 PHUM206760 GLEAN_13632
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG1084 (Vogel et al., 2003, Faivre-Sarrailh, 2002.3.7, Perkins et al., 2009, Khanna et al., 2010, Rhiner et al., 2010, Ni et al., 2011.7.19, Cammarato et al., 2011) Cont (Furuse and Tsukita, 2006, Schneider et al., 2006, Laval et al., 2008, Buffin and Gho, 2010) cont (Faivre-Sarrailh et al., 2004, Banerjee et al., 2006, Yi et al., 2008, Laval et al., 2008) CT1481 (Hynes and Zhao, 2000) D-Axonin (Vogel et al., 2003) DCONT (Bhat, 2003, Faivre-Sarrailh et al., 2001)
Name Synonym	contactin (Bhat, 2003, Yi et al., 2008, Rhiner et al., 2010) Contactin (Faivre-Sarrailh et al., 2001, Daneman and Barres, 2005, Stork et al., 2008, Tiklová et al., 2007, Wang et al., 2006, Laval et al., 2008, Khanna et al., 2010, Khanna et al., 2010, Buffin and Gho, 2010, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBan0001084
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 7 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Khanna et al., 2010, BMC Genomics 11(1): 302 Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210923] Rhiner et al., 2010, Dev. Cell 18(6): 985--998 Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. [FBrf0211273] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...