FlyBase Gene Report: Dmel\srl

General Information

Symbol

Dmel\srl

Species

D. melanogaster

Name

spargel

Annotation Symbol

CG9809

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037248

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

transcriptional coactivator - required for the expression of multiple genes encoding mitochondrial proteins - mediates mitochondrial activity, cell growth and transcription of target genes in response to insulin signalling (Interactive Fly, srl )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

dPGC-1, PGC-1, dPGC1, PGC-1α

Key Links

Genomic Location

Cytogenetic map

82B1-82B1

Sequence location

3R:4,422,483..4,429,335 [-]

Recombination map

3-47.1

RefSeq locus

NT_033777 REGION:4422483..4429335

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

enables nuclear receptor coactivator activity

inferred from biological aspect of ancestor with PANTHER:PTN000399017

(assigned by GO_Central )

(Gaudet et al., 2011)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR000504

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables transcription factor binding

inferred from electronic annotation with InterPro:IPR034605

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in energy homeostasis

inferred from mutant phenotype

(Rera et al., 2011)

involved_in negative regulation of insulin receptor signaling pathway

inferred from mutant phenotype

(Tiefenböck et al., 2010)

involved_in neuron cellular homeostasis

inferred from mutant phenotype

(Ng et al., 2017)

involved_in positive regulation of oxidative phosphorylation

inferred from genetic interaction with FLYBASE:Ets97D; FB:FBgn0004510

(Tiefenböck et al., 2010)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Tiefenböck et al., 2010)

involved_in response to oxidative stress

inferred from mutant phenotype

(Mukherjee et al., 2014)

involved_in tissue homeostasis

inferred from mutant phenotype

(Rera et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in positive regulation of DNA-binding transcription factor activity

inferred from biological aspect of ancestor with PANTHER:PTN000399017

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000399017

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Tiefenböck et al., 2010)

located_in nuclear speck

inferred from direct assay

(Mukherjee and Duttaroy, 2013)

located_in nucleus

inferred from direct assay

(Tiefenböck et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000399017

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Pathway (FlyBase)

Negative Regulators of Insulin-like Receptor Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Negative Regulators of Insulin-like Receptor Signaling Pathway -: Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\srl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

srl-RB

FBtr0078946

NM_168996

4568

1067

srl-RD

FBtr0301244

NM_168997

4136

1058

srl-RE

FBtr0336458

NM_141212

4237

1067

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

srl-PB

FBpp0078586

118.8

1067

9.60

NP_730835

AAN13314

srl-PD

FBpp0290462

117.6

1058

9.61

NP_730836

AAN13315

srl-PE

FBpp0307564

118.8

1067

9.60

NP_649469

AAF52127

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1067 aa isoforms: srl-PB, srl-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\srl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

srl_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval somatic muscle

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

fat body

(Tiefenböck et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Tiefenböck et al., 2010)

located_in nuclear speck

inferred from direct assay

(Mukherjee and Duttaroy, 2013)

located_in nucleus

inferred from direct assay

(Tiefenböck et al., 2010)

Expression Deduced from Reporters

Reporter: PBac{754.P.FSVS-0}srl^CPTI003074

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

ellipsoid body

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

adult mushroom body gamma-lobe

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\srl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\srl

View exonic expression by tissue for Dmel\srl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037248

DRscDB

40562/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0037248

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9809-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9809

Flygut - An atlas of the Drosophila adult midgut

FBgn0037248

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\srl

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of srl

Transgenic constructs containing regulatory region of srl

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)ED5046

(Tiefenböck et al., 2010)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage, with Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, Scer\GAL4^nos.PG

srl^HMS00857

viable

srl^EY05931

Sterility

Allele

female semi-sterile

srl^KG08646

female semi-sterile, with Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, Scer\GAL4^nos.PG

srl^HMS00857

female sterile

srl^KG08646

female sterile germline-dependent, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

srl^EY05931

fertile, with Scer\GAL4^esg-05730B

srl^UAS.cRa

Other Phenotypes

Allele

abnormal aging, with Scer\GAL4^da.G32

srl^UAS.cRa

abnormal aging, with Scer\GAL4^{αTub84B.Switch.PK}

srl^UAS.cRa

abnormal developmental rate

srl^KG08646

abnormal locomotor behavior | adult stage

srl^KG08646

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Ddc.PU

abnormal oxidative stress response | adult stage, with Scer\GAL4^Act.PU

srl^EY05931

abnormal size | adult stage | female, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

decreased body size

srl^KG08646

decreased body size (with Df(3R)ED5046)

srl^KG08646

decreased cell number | adult stage

srl^KG08646

decreased cell number | adult stage, with Scer\GAL4^Ddc.PL

srl^KK100201

decreased cell number | adult stage | progressive, with Scer\GAL4^ple.PF

srl^UAS.cRa

decreased cell size | cell autonomous | somatic clone, with Scer\GAL4^Act.PU

srl^{dsRNA.UAS.cUa}

decreased fecundity | female

srl^KG08646

decreased fecundity | female, with Scer\GAL4^{VP16.mat.αTub67C}

decreased fecundity | female, with Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu, Scer\GAL4^nos.PG

srl^HMS00857

long lived, with Scer\GAL4^bun-GSG5961

srl^UAS.cRa

long lived, with Scer\GAL4^Ddc.PU

srl^HMS00857

long lived, with Scer\GAL4^esg-05730B

srl^UAS.cRa

long lived, with Scer\GAL4^TIGS-2

srl^UAS.cRa

long lived | RU486 conditional, with Scer\GAL4^bun-GSG5961

srl^UAS.cRa

long lived | RU486 conditional, with Scer\GAL4^Switch1.106

srl^UAS.cRa

short lived

srl^KG08646

short lived, with Scer\GAL4^da.G32

srl^UAS.cRa

short lived, with Scer\GAL4^Ddc.PU

srl^EY05931

short lived, with Scer\GAL4^{αTub84B.Switch.PK}

srl^UAS.cRa

visible, with Scer\GAL4^GMR.PU

visible | heat sensitive, with Scer\GAL4^GMR.PU

srl^EY05931

wild-type

srl^rev1

Phenotype manifest in

Allele

adult hindgut, with Scer\GAL4^esg-05730B

srl^UAS.cRa

adult midgut, with Scer\GAL4^esg-05730B

srl^UAS.cRa

dopaminergic PPL1 neuron | adult stage

srl^KG08646

dopaminergic PPL1 neuron | adult stage, with Scer\GAL4^Ddc.PL

srl^KK100201

dopaminergic PPM3 neuron | adult stage

srl^KG08646

egg chamber, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

eye, with Scer\GAL4^GMR.PU

fat body

srl^KG08646

female germline ring canal, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

flight muscle | adult stage

srl^KG08646

flight muscle | adult stage, with Scer\GAL4^Ddc.PL

srl^KK100201

flight muscle | adult stage, with Scer\GAL4^how-24B

srl^KK100201

follicle cell, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

interommatidial bristle, with Scer\GAL4^GMR.PU

interommatidial bristle | decreased number, with Scer\GAL4^GMR.PU

lipid droplet

srl^KG08646

mitochondrial membrane, with Scer\GAL4^da.G32

srl^UAS.cRa

mitochondrial membrane, with Scer\GAL4^esg-05730B

srl^UAS.cRa

mitochondrion, with Scer\GAL4^da.G32

srl^UAS.cRa

mitochondrion, with Scer\GAL4^esg-05730B

srl^UAS.cRa

mitochondrion | adult stage

srl^KG08646

mitochondrion | adult stage, with Scer\GAL4^Ddc.PL

srl^KK100201

mitochondrion | adult stage, with Scer\GAL4^how-24B

srl^KK100201

mitochondrion | adult stage, with Scer\GAL4^ple.PF

srl^UAS.cRa

mitochondrion | female | oogenesis, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

ommatidium, with Scer\GAL4^GMR.PU

ommatidium | decreased number, with Scer\GAL4^GMR.PU

ommatidium | increased number | heat sensitive, with Scer\GAL4^GMR.PU

srl^EY05931

oocyte, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

ovariole

srl^KG08646

ovary

srl^KG08646

ovary, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

vitelline membrane, with Scer\GAL4^{VP16.mat.αTub67C}

srl^HMS00857

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPARGC1A

8 of 15

Yes

Hsap\PPRC1

6 of 15

Yes

Hsap\PPARGC1B

4 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppargc1a

7 of 15

Yes

Mmus\Pprc1

6 of 15

Yes

Mmus\Ppargc1b

3 of 15

Yes

Rattus norvegicus (Norway rat) (3)

Rnor\Ppargc1a

6 of 13

Yes

Rnor\Pprc1

6 of 13

Yes

Rnor\Ppargc1b

3 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\ppargc1a

5 of 12

Yes

Xtro\pprc1

5 of 12

Yes

Xtro\ppargc1b

3 of 12

Yes

Xtro\LOC101735043

1 of 12

Yes

Danio rerio (Zebrafish) (4)

Drer\ppargc1a

8 of 15

Yes

Drer\pprc1

8 of 15

Yes

Drer\ppargc1b

3 of 15

Yes

Drer\si:dkey-93h22.8

2 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902FY )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22050

Drosophila persimilis

Dper\GL22351

Drosophila willistoni

Dwil\GK13755

Drosophila virilis

Dvir\GJ10730

Drosophila mojavensis

Dmoj\GI22074

Drosophila grimshawi

Dgri\GH18535

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915019P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17016683

Glossina morsitans

Tsetse fly

Gmor\GMOY002545

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13664

Mayetiola destructor

Hessian fly

Mdes\Mdes003438

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003768

Anopheles darlingi

American malaria mosquito

Adar\ADAC007006

Anopheles gambiae

Malaria mosquito

Agam\AGAP004361

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003888

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01IG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010808

Danaus plexippus

Monarch butterfly

Dple\DPOGS204068-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL013132

Apis florea

Little honeybee

Aflo\3121650900

Apis mellifera

Western honey bee

Amel\GB42317

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12669

Bombus terrestris

Buff-tailed bumblebee

Bter\15211343

Linepithema humile

Argentine ant

Lhum\LH12897

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:003018

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG022176

Tribolium castaneum

Red flour beetle

Tcas\TC011963

Pediculus humanus

Human body louse

Phum\PHUM027650

Rhodnius prolixus

Kissing bug

Rpro\RPRC005629

Cimex lectularius

Bed bug

Clec\CLEC003019

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005386

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01GM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68074.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_53493

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G029M )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_879

Gallus gallus

Domestic chicken

Ggal\PPRC1

Gallus gallus

Domestic chicken

Ggal\PPARGC1B

Gallus gallus

Domestic chicken

Ggal\PPARGC1A

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Parkinson disease (postulated), PGC-1-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

srl^EY05931

model of Parkinson's disease

CEA

(Merzetti and Staveley, 2015)

srl^KG08646

model of Parkinson's disease

CEA

(Ng et al., 2017)

srl^KK100201

model of Parkinson's disease

CEA

(Ng et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 6 )

Allele

Disease

Interaction

References

srl^HMS00857

ameliorates high grade glioma

modeled by Hsap\FGFR3::Hsap\TACC3^UAS.cFa

(Frattini et al., 2018)

DOES NOT ameliorate high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Frattini et al., 2018)

srl^HMS00858

ameliorates high grade glioma

modeled by Hsap\FGFR3::Hsap\TACC3^UAS.cFa

(Frattini et al., 2018)

srl^UAS.cTa

ameliorates Parkinson's disease

modeled by park¹

(Ng et al., 2017)

modeled by Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Ng et al., 2017)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Ruetenik et al., 2016)

srl^KK100201

model of Parkinson's disease

is NOT ameliorated by AMPKα^TD.UAS

(Ng et al., 2017)

exacerbates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

ameliorates high grade glioma

modeled by Hsap\FGFR3::Hsap\TACC3^UAS.cFa

(Frattini et al., 2018)

DOES NOT ameliorate high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Frattini et al., 2018)

srl^GL01019

ameliorates high grade glioma

modeled by Hsap\FGFR3::Hsap\TACC3^UAS.cFa

(Frattini et al., 2018)

srl^UAS.cRa

ameliorates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPARGC1A; PPARG coactivator 1 alpha

8 of 15

604517

PPRC1; PPARG related coactivator 1

6 of 15

617462

PPARGC1B; PPARG coactivator 1 beta

4 of 15

608886

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

srl - CG17019

anti tag coimmunoprecipitation, anti tag western blot

(Wei et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

srl

enhanceable

Ets97D

(Tiefenböck et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Baldspot

suppressible

srl

(Senyilmaz et al., 2015)

suppressible

(Wei et al., 2018)

enhanceable

(Tiefenböck et al., 2010)

foxo

suppressible

srl

(Mukherjee and Duttaroy, 2013)

gig

suppressible

srl

(Mukherjee and Duttaroy, 2013)

InR

suppressible

srl

(Tiefenböck et al., 2010)

LamC

suppressible

srl

(Chandran et al., 2019)

LamC

enhanceable

srl

(Chandran et al., 2019)

suppressible

srl

(Lee et al., 2013)

park

suppressible

srl

(Pirooznia et al., 2020)

Pi3K92E

suppressible

srl

(Tiefenböck et al., 2010)

Pink1

suppressible

srl

(Pirooznia et al., 2020)

S6k

suppressible

srl

(Mukherjee and Duttaroy, 2013)

sesB

suppressible

srl

(Vartiainen et al., 2014)

tko

suppressible

srl

(Chen et al., 2012)

Tor

suppressible

srl

(Mukherjee and Duttaroy, 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65781

DroID - A comprehensive database of gene and protein interactions.

FBgn0037248

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Insulin-like Receptor Signaling Pathway -: Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.1

Cytogenetic map

82B1-82B1

Sequence location

3R:4,422,483..4,429,335 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82B1-82B1

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.1

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

20009

y¹ w^67c23; P{EPgy2}srl^EY05931

85847

y¹ sc^* v¹ sev²¹; P{TKO.GS04135}attP40

33914

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00857}attP2

33915

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00858}attP2

57043

y¹ sc^* v¹ sev²¹; P{TRiP.GL01019}attP40

14965

y¹; P{SUPor-P}srl^KG08646 ry⁵⁰⁶/TM3, Sb¹ Ser¹

92715

y¹ w^*; TI{CRIMIC.TG4.2}srl^{CR70135-TG4.2}/TM3, Sb¹ Ser¹

Kyoto

112396

w^*; P{GawB}srl^NP0914 / CyO

115349

w¹¹¹⁸; PBac{754.P.FSVS-0}srl^CPTI003074

103793

w^*; P{GawB}srl^NP0861 / TM3, Ser¹

VDRC

v330271

P{VSH330271}attP40

v103355

P{KK100201}VIE-260B

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (55)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18188

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037248

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037248

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40562

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Basar et al., 2019, George and Jacobs, 2019)

monoclonal

(Basar et al., 2019)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Spargel CG9809

(Khokhar et al., 2008)

Source for identity of: srl Spargel

(Tiefenböck et al., 2010)

Source for database merge of

Additional comments

Other Comments

srl is a terminal effector in the insulin-TOR pathway, acting below tor, S6k, gig and foxo.

(Mukherjee and Duttaroy, 2013)

Spargel activity in somatic stem cell lineages within the digestive tract regulates tissue homeostasis in the aged intestine.

(Rera et al., 2011)

Origin and Etymology

Discoverer

Etymology

Named 'spargel' after the lean phenotype of mutants ('Spargel' is asparagus in German).

(Tiefenböck et al., 2010)

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40562

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037248

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037248

DRscDB

40562/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0037248

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

srl_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9809

Flygut - An atlas of the Drosophila adult midgut

FBgn0037248

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40562

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011963

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9809

MARRVEL_MODEL

40562

modMine - A data warehouse for the modENCODE project

FBgn0037248

Linkouts

BioGRID - A database of protein and genetic interactions.

65781

DroID - A comprehensive database of gene and protein interactions.

FBgn0037248

DRSC - Results frm RNAi screens

FBgn0037248

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9809-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037248

FlyMine - An integrated database for Drosophila genomics

FBgn0037248

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Synonyms and Secondary IDs (27)

Reported As

Symbol Synonym

CG 9809

(Neretti et al., 2009)

CG9809

(Meadows, 2017.1.11, Fukuoh et al., 2014, Rera et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Hartmann et al., 2011, Rera et al., 2011, Buffin and Gho, 2010, Fernández-Ayala et al., 2010, Ni et al., 2010.12.1, Tiefenböck et al., 2010, Baltzer et al., 2009, Keleman et al., 2009.8.5, Telonis-Scott et al., 2009, Khokhar et al., 2008, Tiefenböck et al., 2007, V.Mirouse and St Johnston, 2007)

DmPGC-1

(Ruetenik et al., 2016)

DmPGC-1/spargel

(Ruetenik et al., 2016)

DmPGC-1α

(Ruetenik et al., 2016)

PCG1-α

(Wen et al., 2019)

PGC-1

(Luckhart and Riehle, 2020, Guida et al., 2019, Gumeni et al., 2019, Diop et al., 2015, Lee et al., 2013)

PGC-1-alpha

(Neretti et al., 2009)

PGC-1alpha

(Thanh et al., 2020)

PGC-1α

(Bjedov and Rallis, 2020, Pirooznia et al., 2020, Xia et al., 2020)

PGC1

(Delanoue et al., 2016)

Spargel

(Owusu-Ansah and Perrimon, 2014, Fernández-Ayala et al., 2010, Tiefenböck et al., 2010)

Srl

(Sakakibara et al., 2018, Staats et al., 2018, Tain et al., 2017, Ma et al., 2016, Diop and Bodmer, 2015, Chen et al., 2012, Tiefenböck et al., 2010)

cg9809

(Lasko, 2000)

dPCG1α

(Lee et al., 2013)

dPGC

(Gee et al., 2008)

dPGC-1

(Wei et al., 2020, Chandran et al., 2019, Wei et al., 2018, Jasper, 2015, Rogers and Rogina, 2015, Mukherjee et al., 2014, Owusu-Ansah and Perrimon, 2014, Rogers and Rogina, 2014, Rana et al., 2013, Rera et al., 2013, Rera et al., 2011, Lee et al., 2010)

dPGC-1α

(Di Cristo et al., 2019)

dPGC1

(Tiwari and Mandal, 2021, Kim et al., 2020, Banerjee et al., 2013)

dh-PPRC1

(Shi et al., 2021)

spargel

(Jacobs et al., 2020, Ruetenik et al., 2016, Rera et al., 2011, De Luca et al., 2010)

Name Synonyms

CG9809

PGC-1/spargel

(Guida et al., 2019)

PPARG coactivator 1α

(Xia et al., 2020)

PPARGC1A

(Mendez et al., 2016)

peroxisome proliferator-activated receptor gamma coactivator-1alpha

(Thanh et al., 2020)

peroxisome proliferator-activated receptor γ coactivator 1

(Lee et al., 2010)

spargel

(Chandran et al., 2019, Di Cristo et al., 2019, Staats et al., 2019, Frattini et al., 2018, Laha et al., 2017, Ng et al., 2017, Baenas et al., 2016, Mendez et al., 2016, Chartier et al., 2015, Rogers and Rogina, 2015, Wagner et al., 2015, Mukherjee et al., 2014, Rogers and Rogina, 2014, Vartiainen et al., 2014, De Luca et al., 2010, Tiefenböck et al., 2010, Baltzer et al., 2009)

Secondary FlyBase IDs

FBan0009809

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (121)

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