FB2020_06, released Dec 22, 2020

Gene: Dmel\srl

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General Information
Symbol
Dmel\srl
Species
D. melanogaster
Name
spargel
Annotation Symbol
CG9809
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037248
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

dPGC-1, PGC-1, dPGC1, PGC-1α

Key Links
Genomic Location
Cytogenetic map
82B1-82B1
Sequence location
3R:4,422,483..4,429,335 [-]
Recombination map

3-47.1

RefSeq locus
NT_033777 REGION:4422483..4429335
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables mRNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
enables nuclear receptor transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN000399017
(assigned by GO_Central )
(Gaudet et al., 2011)
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR000504
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000399017
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in cellular response to insulin stimulus
inferred from mutant phenotype
(Tiefenböck et al., 2010)
involved_in energy homeostasis
inferred from mutant phenotype
(Rera et al., 2011)
involved_in negative regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Tiefenböck et al., 2010)
involved_in neuron cellular homeostasis
inferred from mutant phenotype
(Ng et al., 2017)
involved_in positive regulation of cell growth
inferred from mutant phenotype
(Mukherjee and Duttaroy, 2013)
involved_in positive regulation of oxidative phosphorylation
inferred from genetic interaction with FLYBASE:Ets97D; FB:FBgn0004510
(Tiefenböck et al., 2010)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Tiefenböck et al., 2010)
involved_in response to oxidative stress
inferred from mutant phenotype
(Mukherjee et al., 2014)
involved_in tissue homeostasis
inferred from mutant phenotype
(Rera et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN000399017
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000399017
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Tiefenböck et al., 2010)
located_in nuclear speck
inferred from direct assay
(Mukherjee and Duttaroy, 2013)
located_in nucleus
inferred from direct assay
(Tiefenböck et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000399017
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Summary (Interactive Fly)

transcriptional coactivator - required for the expression of multiple genes encoding mitochondrial proteins - mediates mitochondrial activity, cell growth and transcription of target genes in response to insulin signalling

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\srl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
srl-RB
FBtr0078946
NM_168996
4568
1067
srl-RD
FBtr0301244
NM_168997
4136
1058
srl-RE
FBtr0336458
NM_141212
4237
1067
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
srl-PB
FBpp0078586
118.8
1067
9.60
NP_730835
AAN13314
srl-PD
FBpp0290462
117.6
1058
9.61
NP_730836
AAN13315
srl-PE
FBpp0307564
118.8
1067
9.60
NP_649469
AAF52127
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1067 aa isoforms: srl-PB, srl-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\srl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Tiefenböck et al., 2010)
located_in nuclear speck
inferred from direct assay
(Mukherjee and Duttaroy, 2013)
located_in nucleus
inferred from direct assay
(Tiefenböck et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\srl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of srl
Transgenic constructs containing regulatory region of srl
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of embryonic stage, with Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nos.PG
viable
Sterility
Allele
female semi-sterile
female semi-sterile, with Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nos.PG
female sterile
female sterile germline-dependent, with Scer\GAL4VP16.mat.αTub67C
fertile
fertile, with Scer\GAL4esg-05730B
Other Phenotypes
Allele
aging defective, with Scer\GAL4da.G32
aging defective, with Scer\GAL4αTub84B.Switch.PK
decreased cell number | adult stage
decreased cell number | adult stage, with Scer\GAL4Ddc.PL
decreased cell size | cell autonomous | somatic clone, with Scer\GAL4Act.PU
decreased fecundity | female
decreased fecundity | female, with Scer\GAL4VP16.mat.αTub67C
decreased fecundity | female, with Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nos.PG
developmental rate defective
locomotor behavior defective | adult stage
locomotor behavior defective | adult stage | progressive, with Scer\GAL4Ddc.PU
long lived, with Scer\GAL4bun-GSG5961
long lived, with Scer\GAL4Ddc.PU
long lived, with Scer\GAL4esg-05730B
long lived, with Scer\GAL4TIGS-2
long lived | RU486 conditional, with Scer\GAL4bun-GSG5961
long lived | RU486 conditional, with Scer\GAL4Switch1.106
oxidative stress response defective | adult stage, with Scer\GAL4Act.PU
short lived
short lived, with Scer\GAL4da.G32
short lived, with Scer\GAL4Ddc.PU
short lived, with Scer\GAL4αTub84B.Switch.PK
size defective | adult stage | female, with Scer\GAL4VP16.mat.αTub67C
small body
small body (with Df(3R)ED5046)
visible, with Scer\GAL4GMR.PU
visible | heat sensitive, with Scer\GAL4GMR.PU
wild-type
Phenotype manifest in
Allele
adult hindgut, with Scer\GAL4esg-05730B
adult midgut, with Scer\GAL4esg-05730B
dopaminergic PPL1 neuron | adult stage
dopaminergic PPL1 neuron | adult stage, with Scer\GAL4Ddc.PL
dopaminergic PPM3 neuron | adult stage
egg chamber, with Scer\GAL4VP16.mat.αTub67C
fat body
female germline ring canal, with Scer\GAL4VP16.mat.αTub67C
flight muscle | adult stage
flight muscle | adult stage, with Scer\GAL4Ddc.PL
flight muscle | adult stage, with Scer\GAL4how-24B
follicle cell, with Scer\GAL4VP16.mat.αTub67C
interommatidial bristle, with Scer\GAL4GMR.PU
lipid droplet
mitochondrial membrane, with Scer\GAL4da.G32
mitochondrial membrane, with Scer\GAL4esg-05730B
mitochondrion, with Scer\GAL4da.G32
mitochondrion, with Scer\GAL4esg-05730B
mitochondrion | adult stage
mitochondrion | adult stage, with Scer\GAL4Ddc.PL
mitochondrion | adult stage, with Scer\GAL4how-24B
mitochondrion | female | oogenesis, with Scer\GAL4VP16.mat.αTub67C
ommatidium, with Scer\GAL4GMR.PU
ommatidium | supernumerary | heat sensitive, with Scer\GAL4GMR.PU
oocyte, with Scer\GAL4VP16.mat.αTub67C
ovariole
ovary
ovary, with Scer\GAL4VP16.mat.αTub67C
vitelline membrane, with Scer\GAL4VP16.mat.αTub67C
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PPARGC1A
8 of 15
Yes
Yes
Hsap\PPRC1
6 of 15
No
Yes
Hsap\PPARGC1B
4 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ppargc1a
7 of 15
Yes
Yes
Mmus\Pprc1
6 of 15
No
Yes
Mmus\Ppargc1b
3 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Ppargc1a
6 of 13
Yes
Yes
Rnor\Pprc1
6 of 13
Yes
Yes
Rnor\Ppargc1b
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\ppargc1a
5 of 12
Yes
Yes
Xtro\pprc1
5 of 12
Yes
Yes
Xtro\ppargc1b
3 of 12
No
Yes
Xtro\LOC101735043
1 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\ppargc1a
8 of 15
Yes
Yes
Drer\pprc1
8 of 15
Yes
Yes
Drer\ppargc1b
3 of 15
No
Yes
Drer\si:dkey-93h22.8
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902FY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007623
Drosophila simulans
Dsim\GD19679
Drosophila sechellia
Dsec\GM10702
Drosophila erecta
Dere\GG11576
Drosophila yakuba
Dyak\GE25351
Drosophila ananassae
Dana\GF16809
Drosophila pseudoobscura pseudoobscura
Dpse\GA22050
Drosophila persimilis
Dper\GL22351
Drosophila willistoni
Dwil\GK13755
Drosophila virilis
Dvir\GJ10730
Drosophila mojavensis
Dmoj\GI22074
Drosophila grimshawi
Dgri\GH18535
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915019P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016683
Glossina morsitans
Tsetse fly
Gmor\GMOY002545
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13664
Mayetiola destructor
Hessian fly
Mdes\Mdes003438
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003768
Anopheles darlingi
American malaria mosquito
Adar\ADAC007006
Anopheles gambiae
Malaria mosquito
Agam\AGAP004361
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003888
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01IG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010808
Danaus plexippus
Monarch butterfly
Dple\DPOGS204068-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013132
Apis florea
Little honeybee
Aflo\3121650900
Apis mellifera
Western honey bee
Amel\GB42317
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12669
Bombus terrestris
Buff-tailed bumblebee
Bter\15211343
Linepithema humile
Argentine ant
Lhum\LH12897
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003018
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022176
Tribolium castaneum
Red flour beetle
Tcas\TC011963
Pediculus humanus
Human body louse
Phum\PHUM027650
Rhodnius prolixus
Kissing bug
Rpro\RPRC005629
Cimex lectularius
Bed bug
Clec\CLEC003019
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005386
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01GM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68074.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_53493
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G029M )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_879
Gallus gallus
Domestic chicken
Ggal\PPRC1
Gallus gallus
Domestic chicken
Ggal\PPARGC1B
Gallus gallus
Domestic chicken
Ggal\PPARGC1A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 6 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PPARGC1A; PPARG coactivator 1 alpha
8 of 15
604517
      PPRC1; PPARG related coactivator 1
      6 of 15
      617462
          PPARGC1B; PPARG coactivator 1 beta
          4 of 15
          608886
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser
              View in Interactions Browser
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              srl - CG17019
              anti tag coimmunoprecipitation, anti tag western blot
              (Wei et al., 2018)
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              srl
              enhanceable
              Ets97D
              (Tiefenböck et al., 2010)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Baldspot
              suppressible
              srl
              (Senyilmaz et al., 2015)
              CG17019
              suppressible
              srl
              (Wei et al., 2018)
              Ets97D
              enhanceable
              srl
              (Tiefenböck et al., 2010)
              foxo
              suppressible
              srl
              (Mukherjee and Duttaroy, 2013)
              gig
              suppressible
              srl
              (Mukherjee and Duttaroy, 2013)
              InR
              suppressible
              srl
              (Tiefenböck et al., 2010)
              LamC
              suppressible
              srl
              (Chandran et al., 2019)
              LamC
              enhanceable
              srl
              (Chandran et al., 2019)
              N
              suppressible
              srl
              (Lee et al., 2013)
              Pi3K92E
              suppressible
              srl
              (Tiefenböck et al., 2010)
              S6k
              suppressible
              srl
              (Mukherjee and Duttaroy, 2013)
              sesB
              suppressible
              srl
              (Vartiainen et al., 2014)
              tko
              suppressible
              srl
              (Chen et al., 2012)
              Tor
              suppressible
              srl
              (Mukherjee and Duttaroy, 2013)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              Pathways
              Signaling Pathways (FlyBase)
              Negative Regulators of Insulin-like Receptor Signaling Pathway -
              Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
              Metabolic Pathways
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map

              3-47.1

              Cytogenetic map
              82B1-82B1
              Sequence location
              3R:4,422,483..4,429,335 [-]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              82B1-82B1
              Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              3-47.1

              (FlyBase, 2016)

              3-44.1

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (11)
              Genomic Clones (15)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (55)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Basar et al., 2019, George and Jacobs, 2019)

              monoclonal

              (Basar et al., 2019)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Spargel CG9809

              (Khokhar et al., 2008)

              Source for identity of: srl Spargel

              (Tiefenböck et al., 2010)
              Source for database merge of
              Additional comments
              Other Comments

              srl is a terminal effector in the insulin-TOR pathway, acting below tor, S6k, gig and foxo.

              (Mukherjee and Duttaroy, 2013)

              Spargel activity in somatic stem cell lineages within the digestive tract regulates tissue homeostasis in the aged intestine.

              (Rera et al., 2011)
              Origin and Etymology
              Discoverer
              Etymology

              Named 'spargel' after the lean phenotype of mutants ('Spargel' is asparagus in German).

              (Tiefenböck et al., 2010)
              Identification
              External Crossreferences and Linkouts ( 48 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              Synonyms and Secondary IDs (26)
              Reported As
              Symbol Synonym
              CG 9809
              (Neretti et al., 2009)
              CG9809
              (Meadows, 2017.1.11, Fukuoh et al., 2014, Rera et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Hartmann et al., 2011, Rera et al., 2011, Buffin and Gho, 2010, Fernández-Ayala et al., 2010, Ni et al., 2010.12.1, Tiefenböck et al., 2010, Baltzer et al., 2009, Keleman et al., 2009.8.5, Telonis-Scott et al., 2009, Khokhar et al., 2008, Tiefenböck et al., 2007, V.Mirouse and St Johnston, 2007)
              DmPGC-1
              (Ruetenik et al., 2016)
              DmPGC-1/spargel
              (Ruetenik et al., 2016)
              DmPGC-1α
              (Ruetenik et al., 2016)
              PCG1-α
              (Wen et al., 2019)
              PGC-1
              (Guida et al., 2019, Gumeni et al., 2019, Diop et al., 2015, Lee et al., 2013)
              PGC-1-alpha
              (Neretti et al., 2009)
              PGC-1/srl
              (Diop et al., 2015)
              PGC-1alpha
              (Thanh et al., 2020)
              PGC-1α
              (Pirooznia et al., 2020, Xia et al., 2020)
              Spargel
              (Owusu-Ansah and Perrimon, 2014, Fernández-Ayala et al., 2010, Tiefenböck et al., 2010)
              Srl
              (Sakakibara et al., 2018, Staats et al., 2018, Tain et al., 2017, Ma et al., 2016, Diop and Bodmer, 2015, Chen et al., 2012, Tiefenböck et al., 2010)
              cg9809
              (Lasko, 2000)
              dPCG1α
              (Lee et al., 2013)
              dPGC
              (Gee et al., 2008)
              dPGC-1
              (Wei et al., 2020, Chandran et al., 2019, Wei et al., 2018, Jasper, 2015, Rogers and Rogina, 2015, Mukherjee et al., 2014, Owusu-Ansah and Perrimon, 2014, Rogers and Rogina, 2014, Rana et al., 2013, Rera et al., 2013, Rera et al., 2011, Lee et al., 2010)
              dPGC-1α
              (Di Cristo et al., 2019)
              dPGC1
              (Kim et al., 2020, Banerjee et al., 2013)
              spargel
              (Jacobs et al., 2020, Ruetenik et al., 2016, Rera et al., 2011, De Luca et al., 2010)
              srl
              (Baenas and Wagner, 2019, Basar et al., 2019, Bouska et al., 2019, Chen et al., 2019, Evangelakou et al., 2019, Gumeni et al., 2019, Liu et al., 2019, Staats et al., 2019, Frattini et al., 2018, Staats et al., 2018, Staats et al., 2018, Ng et al., 2017, Transgenic RNAi Project members, 2017-, Baenas et al., 2016, Merzetti and Staveley, 2016, Merzetti and Staveley, 2015, Mukherjee et al., 2014, Vartiainen et al., 2014, Mukherjee and Duttaroy, 2013, Tiefenböck et al., 2010)
              Name Synonyms
              CG9809
              PGC-1/spargel
              (Guida et al., 2019)
              PPARG coactivator 1α
              (Xia et al., 2020)
              PPARGC1A
              (Mendez et al., 2016)
              Spargel
              (Pirooznia et al., 2020, Texada et al., 2020, Sênos Demarco et al., 2019, Xu et al., 2019, Edenharter et al., 2018, Brookheart et al., 2017, Ma et al., 2016, Diop and Bodmer, 2015, Senyilmaz et al., 2015, Piccirillo et al., 2014, Tufi et al., 2014, Mukherjee and Duttaroy, 2013, Rera et al., 2013, Chen et al., 2012, Islam et al., 2012, Tiefenböck et al., 2010, Baltzer et al., 2009, Khokhar et al., 2008, Tiefenböck et al., 2007, V.Mirouse and St Johnston, 2007)
              peroxisome proliferator-activated receptor gamma coactivator-1alpha
              (Thanh et al., 2020)
              peroxisome proliferator-activated receptor γ coactivator 1
              (Lee et al., 2010)
              spargel
              (Chandran et al., 2019, Di Cristo et al., 2019, Staats et al., 2019, Frattini et al., 2018, Laha et al., 2017, Ng et al., 2017, Baenas et al., 2016, Mendez et al., 2016, Chartier et al., 2015, Rogers and Rogina, 2015, Wagner et al., 2015, Mukherjee et al., 2014, Rogers and Rogina, 2014, Vartiainen et al., 2014, De Luca et al., 2010, Tiefenböck et al., 2010, Baltzer et al., 2009)
              Secondary FlyBase IDs
              • FBan0009809
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (109)