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Gene Dmel\CG9769

General Information
Symbol	Dmel\CG9769	Species	D. melanogaster
Name		Annotation symbol	CG9769
Feature type	protein_coding_gene	FlyBase ID	FBgn0037270
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	eIF3-S5
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82D2-82D2	Sequence location	3R:538,604..539,904 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG9769 (FBgn0037270). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: JAB1/Mov34/MPN/PAD-1; Rpn11/EIF3F C-terminal domain. Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1632103_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG9769. Gene sequence location is 3R:538604..539904.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms positive regulation of Notch signaling pathway
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82D2-82D2   Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG9769 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG9769-RA FBtr0078892  NM_141232   1301   280
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG9769-PA   FBpp0078532   31.1   280   6.50     NP_649489   AAF52101
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • JAB1/Mov34/MPN/PAD-1 (IPR000555) Rpn11/EIF3F C-terminal domain (IPR024969) Eukaryotic translation initiation factor 3 subunit F (IPR027531)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264189   AA801676   AA817430   AA940972   AA942225   AE014297 AAF52101   AI062632   AI107787   AI109399   AI134049   AI386514   AI402224   AI402744   AI517503   AI546264   AQ254892   AY118972 AAM50832   BG632264   BG637188   BI168234   BI169994   BI214674   BI215007   BI215971   BI228611   BI229612   BI235703   BI242293   BI242561   BI243855   BI353290   BI354716   BI362708   BI368053   BI371191   BI374294   BI481794   BI487199   BI563724   BI568204   BI568506   BI583746   BI584181   BI584256   BI584520   BI585123   BI586396   BI587073   BI587223   BI587340   BI605062   BI605707   BI605898   BI610753   BI611566   BI613640   BI620678   BI621374   BI621384   BI621588   BI622241   BI625118   BI625126   BI628710   BI630059   BI630545   BI631013   BI632554   BI633161   BI633221   BI633415   BI637243   BP546039   BX013121   BX042076   BX065636   CA807606   CO155398   CO283711   CO302397   CO311829   CO311932   CO318779   CO323658   CO338752   EC064966   EC064989   EC074049   EC084419   EC198787   EC209909   EC210917   EC223011   EC227215   EC261096   EC267164   EL885387   EV577423   EV593066   EV594181   GH749282   GH749680   GH752237   GH757229   GH758642   GH770236   GH770319   GH771319   GH771699   GH772552   GH774051   GH774502   GH776509   GH776788   GH782102   GH788403   GH789432   GH789775   GH790632   GH793136   GH793529   GH797150   GH797713   GH798348   GH799632   GH803054   GH803957   GH813706   GH816349   GH819964   GH821141   GH826017   GH828410   GH834621   GH835055   GH835505   GH840328   GH843225   GH843508   GH847836   GH850365   GH850884   GH851985   GH853589   GH855092   GH858321   GH858657   GH858785   GH858973   GH859534   GH864662   GH866646   GH867211   GH871269   GH871879   GH872867   GH878442   GH879211   GH881256   GH883340   GH884339   GH885024   GH885788   GH885933   GH887898   GH891629   GH892952   GH895631   GH897269   GH901240   GH901587   GH901810   GH902415   GH905580   GH908370   GH909272   GH909314   GH911043   GH913981   GH919455   GH920015   GH920971   GH922444   GH923068   GH923738   GH923833   GH925877   GH930199   GH936250   GH938910
UniProtKB/Swiss-Prot	Q9VN50
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1094.475 Larval Midgut    641.9 Larval Hindgut    1198.7 Larval Malpighian Tubules    1279.6 Larval Fat Body    734.2 Larval Salivary Gland    2132.2 Larval Trachea    1078.775 Larval Carcass    1164.775 Adult Head    904.1 Adult Eye    1527.675 Adult Brain    1115 Adult Thoracic-Abdominal Ganglion    1319.9 Adult Crop    1145 Adult Midgut    849 Adult Hindgut    1281.4 Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland    1756.2 Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland    1583.7 Adult Carcass    844.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1094.475) Larval Midgut  (641.9) Larval Hindgut  (1198.7) Larval Malpighian Tubules  (1279.6) Larval Fat Body  (734.2) Larval Salivary Gland  (2132.2) Larval Trachea  (1078.775) Larval Carcass  (1164.775) Adult Head  (904.1) Adult Eye  (1527.675) Adult Brain  (1115) Adult Thoracic-Abdominal Ganglion  (1319.9) Adult Crop  (1145) Adult Midgut  (849) Adult Hindgut  (1281.4) Adult Malpighian Tubules  (722.8) Adult Fat Body  (996.2) Adult Salivary Gland  (1756.2) Adult Heart  (778.7) Adult VirginFemale Spermatheca  (757.9) Adult InseminatedFemale Spermatheca  (706.7) Adult Ovary  (610.5) Adult Testis    117 Adult Male Accessory Gland  (1583.7) Adult Carcass  (844.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1094.475) Larval Midgut    641.9 Larval Hindgut  (1198.7) Larval Malpighian Tubules  (1279.6) Larval Fat Body    734.2 Larval Salivary Gland  (2132.2) Larval Trachea  (1078.775) Larval Carcass  (1164.775) Adult Head    904.1 Adult Eye  (1527.675) Adult Brain  (1115) Adult Thoracic-Abdominal Ganglion  (1319.9) Adult Crop  (1145) Adult Midgut    849 Adult Hindgut  (1281.4) Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland  (1756.2) Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland  (1583.7) Adult Carcass    844.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1094.475 Larval Midgut    641.9 Larval Hindgut    1198.7 Larval Malpighian Tubules    1279.6 Larval Fat Body    734.2 Larval Salivary Gland    2132.2 Larval Trachea    1078.775 Larval Carcass    1164.775 Adult Head    904.1 Adult Eye    1527.675 Adult Brain    1115 Adult Thoracic-Abdominal Ganglion    1319.9 Adult Crop    1145 Adult Midgut    849 Adult Hindgut    1281.4 Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland    1756.2 Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland    1583.7 Adult Carcass    844.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1094.475 Larval Midgut    641.9 Larval Hindgut    1198.7 Larval Malpighian Tubules    1279.6 Larval Fat Body    734.2 Larval Salivary Gland    2132.2 Larval Trachea    1078.775 Larval Carcass    1164.775 Adult Head    904.1 Adult Eye    1527.675 Adult Brain    1115 Adult Thoracic-Abdominal Ganglion    1319.9 Adult Crop    1145 Adult Midgut    849 Adult Hindgut    1281.4 Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland    1756.2 Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland    1583.7 Adult Carcass    844.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1094.475) Larval Midgut  641.9 Larval Hindgut  (1198.7) Larval Malpighian Tubules  (1279.6) Larval Fat Body  734.2 Larval Salivary Gland  (2132.2) Larval Trachea  (1078.775) Larval Carcass  (1164.775) Adult Head  (904.1) Adult Eye  (1527.675) Adult Brain  (1115) Adult Thoracic-Abdominal Ganglion  (1319.9) Adult Crop  (1145) Adult Midgut  (849) Adult Hindgut  (1281.4) Adult Malpighian Tubules  722.8 Adult Fat Body  (996.2) Adult Salivary Gland  (1756.2) Adult Heart  778.7 Adult VirginFemale Spermatheca  757.9 Adult InseminatedFemale Spermatheca  706.7 Adult Ovary  610.5 Adult Testis    117 Adult Male Accessory Gland  (1583.7) Adult Carcass  (844.9) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1094.475 Larval Midgut    641.9 Larval Hindgut  1198.7 Larval Malpighian Tubules  1279.6 Larval Fat Body    734.2 Larval Salivary Gland  (2132.2) Larval Trachea  1078.775 Larval Carcass  1164.775 Adult Head    904.1 Adult Eye  1527.675 Adult Brain  1115 Adult Thoracic-Abdominal Ganglion  1319.9 Adult Crop  1145 Adult Midgut    849 Adult Hindgut  1281.4 Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland  (1756.2) Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland  1583.7 Adult Carcass    844.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1094.475 Larval Midgut    641.9 Larval Hindgut    1198.7 Larval Malpighian Tubules    1279.6 Larval Fat Body    734.2 Larval Salivary Gland    2132.2 Larval Trachea    1078.775 Larval Carcass    1164.775 Adult Head    904.1 Adult Eye    1527.675 Adult Brain    1115 Adult Thoracic-Abdominal Ganglion    1319.9 Adult Crop    1145 Adult Midgut    849 Adult Hindgut    1281.4 Adult Malpighian Tubules    722.8 Adult Fat Body    996.2 Adult Salivary Gland    1756.2 Adult Heart    778.7 Adult VirginFemale Spermatheca    757.9 Adult InseminatedFemale Spermatheca    706.7 Adult Ovary    610.5 Adult Testis    117 Adult Male Accessory Gland    1583.7 Adult Carcass    844.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    904.1   NA  Eye    1527.675   NA  Brain    1115   1094.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1319.9   NA  Crop    1145   641.9  Midgut    849   1198.7  Hindgut    1281.4   1279.6  Malpighian Tubules    722.8   734.2  Fat Body    996.2   2132.2  Salivary Gland    1756.2   NA  Heart    778.7   1078.775  Trachea    NA   NA  VirginFemale Spermatheca    757.9   NA  InseminatedFemale Spermatheca    706.7   NA  Ovary    610.5   NA  Testis    117   NA  Male Accessory Gland    1583.7   1164.775  Carcass    844.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    190 central nervous system, larvae L3    174 central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female    114 head, virgin 20-day female    114 head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male    103 head, mated 4-day male    105 head, mated 20-day male    158 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    216 digestive system, larvae L3 wandering    127 digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8    140 carcass, larvae L3 wandering    143 carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult    103 ovary, virgin 4-day female    147 ovary, mated 4-day female    158 testis, mated 4-day male    68 accessory gland, mated 4-day male    167 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (190) central nervous system, larvae L3  (174) central nervous system, pupae P8  (85) head, virgin 1-day female  (84) head, virgin 4-day female  (114) head, virgin 20-day female  (114) head, mated 1-day female  (79) head, mated 4-day female  (88) head, mated 20-day female  (91) head, mated 1-day male  (103) head, mated 4-day male  (105) head, mated 20-day male  (158) salivary gland, larvae L3 wandering  (96) salivary gland, white prepupae  (216) digestive system, larvae L3 wandering  (127) digestive system, 1-day adult  (89) digestive system, 4-day adult  (67) digestive system, 20-day adult  (99) fat body, larvae L3 wandering  (68) fat body, white prepupae  (60) fat body, pupae P8  (140) carcass, larvae L3 wandering  (143) carcass, 1-day adult  (73) carcass, 4-day adult  (78) carcass, 20-day adult  (103) ovary, virgin 4-day female  (147) ovary, mated 4-day female  (158) testis, mated 4-day male  (68) accessory gland, mated 4-day male  (167) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (190) central nervous system, larvae L3  (174) central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female  (114) head, virgin 20-day female  (114) head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male  103 head, mated 4-day male  105 head, mated 20-day male  (158) salivary gland, larvae L3 wandering    96 salivary gland, white prepupae  (216) digestive system, larvae L3 wandering  (127) digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8  (140) carcass, larvae L3 wandering  (143) carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult  103 ovary, virgin 4-day female  (147) ovary, mated 4-day female  (158) testis, mated 4-day male    68 accessory gland, mated 4-day male  (167) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    190 central nervous system, larvae L3    174 central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female    114 head, virgin 20-day female    114 head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male    103 head, mated 4-day male    105 head, mated 20-day male    158 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    216 digestive system, larvae L3 wandering    127 digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8    140 carcass, larvae L3 wandering    143 carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult    103 ovary, virgin 4-day female    147 ovary, mated 4-day female    158 testis, mated 4-day male    68 accessory gland, mated 4-day male    167 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    190 central nervous system, larvae L3    174 central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female    114 head, virgin 20-day female    114 head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male    103 head, mated 4-day male    105 head, mated 20-day male    158 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    216 digestive system, larvae L3 wandering    127 digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8    140 carcass, larvae L3 wandering    143 carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult    103 ovary, virgin 4-day female    147 ovary, mated 4-day female    158 testis, mated 4-day male    68 accessory gland, mated 4-day male    167 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (190) central nervous system, larvae L3  (174) central nervous system, pupae P8  (85) head, virgin 1-day female  (84) head, virgin 4-day female  (114) head, virgin 20-day female  (114) head, mated 1-day female  (79) head, mated 4-day female  (88) head, mated 20-day female  (91) head, mated 1-day male  (103) head, mated 4-day male  (105) head, mated 20-day male  (158) salivary gland, larvae L3 wandering  (96) salivary gland, white prepupae  (216) digestive system, larvae L3 wandering  (127) digestive system, 1-day adult  (89) digestive system, 4-day adult  (67) digestive system, 20-day adult  (99) fat body, larvae L3 wandering  (68) fat body, white prepupae  (60) fat body, pupae P8  (140) carcass, larvae L3 wandering  (143) carcass, 1-day adult  (73) carcass, 4-day adult  (78) carcass, 20-day adult  (103) ovary, virgin 4-day female  (147) ovary, mated 4-day female  (158) testis, mated 4-day male  (68) accessory gland, mated 4-day male  (167) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (190) central nervous system, larvae L3  (174) central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female  114 head, virgin 20-day female  114 head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male  103 head, mated 4-day male  105 head, mated 20-day male  (158) salivary gland, larvae L3 wandering    96 salivary gland, white prepupae  (216) digestive system, larvae L3 wandering  127 digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8  140 carcass, larvae L3 wandering  143 carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult  103 ovary, virgin 4-day female  (147) ovary, mated 4-day female  (158) testis, mated 4-day male    68 accessory gland, mated 4-day male  (167) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    190 central nervous system, larvae L3    174 central nervous system, pupae P8    85 head, virgin 1-day female    84 head, virgin 4-day female    114 head, virgin 20-day female    114 head, mated 1-day female    79 head, mated 4-day female    88 head, mated 20-day female    91 head, mated 1-day male    103 head, mated 4-day male    105 head, mated 20-day male    158 salivary gland, larvae L3 wandering    96 salivary gland, white prepupae    216 digestive system, larvae L3 wandering    127 digestive system, 1-day adult    89 digestive system, 4-day adult    67 digestive system, 20-day adult    99 fat body, larvae L3 wandering    68 fat body, white prepupae    60 fat body, pupae P8    140 carcass, larvae L3 wandering    143 carcass, 1-day adult    73 carcass, 4-day adult    78 carcass, 20-day adult    103 ovary, virgin 4-day female    147 ovary, mated 4-day female    158 testis, mated 4-day male    68 accessory gland, mated 4-day male    167 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    284 embryo 02-04hr    398 embryo 04-06hr    365 embryo 06-08hr    350 embryo 08-10hr    378 embryo 10-12hr    488 embryo 12-14hr    224 embryo 14-16hr    292 embryo 16-18hr    224 embryo 18-20hr    216 embryo 20-22hr    201 embryo 22-24hr    189 larva L1    343 larva L2    255 larva L3 12hr old    190 larva L3 puffstage 1-2    185 larva L3 puffstage 3-6    190 larva L3 puffstage 7-9    208 white prepupae new    207 white prepupae 12hr    223 white prepupae 24hr    244 pupae 2d postWPP    192 pupae 3d postWPP    145 pupae 4d postWPP    172 adult male 01day    147 adult male 05day    149 adult male 30day    182 adult female 01day    308 adult female 05day    245 adult female 30day    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (284) embryo 02-04hr  (398) embryo 04-06hr  (365) embryo 06-08hr  (350) embryo 08-10hr  (378) embryo 10-12hr  (488) embryo 12-14hr  (224) embryo 14-16hr  (292) embryo 16-18hr  (224) embryo 18-20hr  (216) embryo 20-22hr  (201) embryo 22-24hr  (189) larva L1  (343) larva L2  (255) larva L3 12hr old  (190) larva L3 puffstage 1-2  (185) larva L3 puffstage 3-6  (190) larva L3 puffstage 7-9  (208) white prepupae new  (207) white prepupae 12hr  (223) white prepupae 24hr  (244) pupae 2d postWPP  (192) pupae 3d postWPP  (145) pupae 4d postWPP  (172) adult male 01day  (147) adult male 05day  (149) adult male 30day  (182) adult female 01day  (308) adult female 05day  (245) adult female 30day  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (284) embryo 02-04hr  (398) embryo 04-06hr  (365) embryo 06-08hr  (350) embryo 08-10hr  (378) embryo 10-12hr  (488) embryo 12-14hr  (224) embryo 14-16hr  (292) embryo 16-18hr  (224) embryo 18-20hr  (216) embryo 20-22hr  (201) embryo 22-24hr  (189) larva L1  (343) larva L2  (255) larva L3 12hr old  (190) larva L3 puffstage 1-2  (185) larva L3 puffstage 3-6  (190) larva L3 puffstage 7-9  (208) white prepupae new  (207) white prepupae 12hr  (223) white prepupae 24hr  (244) pupae 2d postWPP  (192) pupae 3d postWPP  (145) pupae 4d postWPP  (172) adult male 01day  (147) adult male 05day  (149) adult male 30day  (182) adult female 01day  (308) adult female 05day  (245) adult female 30day  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    284 embryo 02-04hr    398 embryo 04-06hr    365 embryo 06-08hr    350 embryo 08-10hr    378 embryo 10-12hr    488 embryo 12-14hr    224 embryo 14-16hr    292 embryo 16-18hr    224 embryo 18-20hr    216 embryo 20-22hr    201 embryo 22-24hr    189 larva L1    343 larva L2    255 larva L3 12hr old    190 larva L3 puffstage 1-2    185 larva L3 puffstage 3-6    190 larva L3 puffstage 7-9    208 white prepupae new    207 white prepupae 12hr    223 white prepupae 24hr    244 pupae 2d postWPP    192 pupae 3d postWPP    145 pupae 4d postWPP    172 adult male 01day    147 adult male 05day    149 adult male 30day    182 adult female 01day    308 adult female 05day    245 adult female 30day    256 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    284 embryo 02-04hr    398 embryo 04-06hr    365 embryo 06-08hr    350 embryo 08-10hr    378 embryo 10-12hr    488 embryo 12-14hr    224 embryo 14-16hr    292 embryo 16-18hr    224 embryo 18-20hr    216 embryo 20-22hr    201 embryo 22-24hr    189 larva L1    343 larva L2    255 larva L3 12hr old    190 larva L3 puffstage 1-2    185 larva L3 puffstage 3-6    190 larva L3 puffstage 7-9    208 white prepupae new    207 white prepupae 12hr    223 white prepupae 24hr    244 pupae 2d postWPP    192 pupae 3d postWPP    145 pupae 4d postWPP    172 adult male 01day    147 adult male 05day    149 adult male 30day    182 adult female 01day    308 adult female 05day    245 adult female 30day    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (284) embryo 02-04hr  (398) embryo 04-06hr  (365) embryo 06-08hr  (350) embryo 08-10hr  (378) embryo 10-12hr  (488) embryo 12-14hr  (224) embryo 14-16hr  (292) embryo 16-18hr  (224) embryo 18-20hr  (216) embryo 20-22hr  (201) embryo 22-24hr  (189) larva L1  (343) larva L2  (255) larva L3 12hr old  (190) larva L3 puffstage 1-2  (185) larva L3 puffstage 3-6  (190) larva L3 puffstage 7-9  (208) white prepupae new  (207) white prepupae 12hr  (223) white prepupae 24hr  (244) pupae 2d postWPP  (192) pupae 3d postWPP  (145) pupae 4d postWPP  (172) adult male 01day  (147) adult male 05day  (149) adult male 30day  (182) adult female 01day  (308) adult female 05day  (245) adult female 30day  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (284) embryo 02-04hr  (398) embryo 04-06hr  (365) embryo 06-08hr  (350) embryo 08-10hr  (378) embryo 10-12hr  (488) embryo 12-14hr  (224) embryo 14-16hr  (292) embryo 16-18hr  (224) embryo 18-20hr  (216) embryo 20-22hr  (201) embryo 22-24hr  (189) larva L1  (343) larva L2  (255) larva L3 12hr old  (190) larva L3 puffstage 1-2  (185) larva L3 puffstage 3-6  (190) larva L3 puffstage 7-9  (208) white prepupae new  (207) white prepupae 12hr  (223) white prepupae 24hr  (244) pupae 2d postWPP  (192) pupae 3d postWPP  (145) pupae 4d postWPP  (172) adult male 01day  (147) adult male 05day  (149) adult male 30day  (182) adult female 01day  (308) adult female 05day  (245) adult female 30day  (256) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    284 embryo 02-04hr    398 embryo 04-06hr    365 embryo 06-08hr    350 embryo 08-10hr    378 embryo 10-12hr    488 embryo 12-14hr    224 embryo 14-16hr    292 embryo 16-18hr    224 embryo 18-20hr    216 embryo 20-22hr    201 embryo 22-24hr    189 larva L1    343 larva L2    255 larva L3 12hr old    190 larva L3 puffstage 1-2    185 larva L3 puffstage 3-6    190 larva L3 puffstage 7-9    208 white prepupae new    207 white prepupae 12hr    223 white prepupae 24hr    244 pupae 2d postWPP    192 pupae 3d postWPP    145 pupae 4d postWPP    172 adult male 01day    147 adult male 05day    149 adult male 30day    182 adult female 01day    308 adult female 05day    245 adult female 30day    256 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    307 Schneider line 2 Sg4    290 embryonic 1182-4H    396 embryonic GM2    211 embryonic Kc167    201 embryonic S1    287 embryonic S3    127 leg disc CME L1    328 wing disc CME-W2    132 wing disc ML-DmD8    243 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    208 wing disc ML-DmD21    820 wing disc ML-DmD32    362 haltere disc ML-DmD17-c3    247 eye-antennal disc ML-DmD11    328 antennal disc ML-DmD20-c5    296 mixed discs ML-DmD4-c1    305 CNS ML-DmBG1-c1    185 CNS ML-DmBG2-c2    163 tumorous blood cells mbn2    113 ovary fGS/OSS    364 ovary OSC    149 ovary OSS    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (307) Schneider line 2 Sg4  (290) embryonic 1182-4H  (396) embryonic GM2  (211) embryonic Kc167  (201) embryonic S1  (287) embryonic S3  (127) leg disc CME L1  (328) wing disc CME-W2  (132) wing disc ML-DmD8  (243) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (208) wing disc ML-DmD21  (820) wing disc ML-DmD32  (362) haltere disc ML-DmD17-c3  (247) eye-antennal disc ML-DmD11  (328) antennal disc ML-DmD20-c5  (296) mixed discs ML-DmD4-c1  (305) CNS ML-DmBG1-c1  (185) CNS ML-DmBG2-c2  (163) tumorous blood cells mbn2  (113) ovary fGS/OSS  (364) ovary OSC  (149) ovary OSS  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (307) Schneider line 2 Sg4  (290) embryonic 1182-4H  (396) embryonic GM2  (211) embryonic Kc167  (201) embryonic S1  (287) embryonic S3  (127) leg disc CME L1  (328) wing disc CME-W2  (132) wing disc ML-DmD8  (243) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (208) wing disc ML-DmD21  (820) wing disc ML-DmD32  (362) haltere disc ML-DmD17-c3  (247) eye-antennal disc ML-DmD11  (328) antennal disc ML-DmD20-c5  (296) mixed discs ML-DmD4-c1  (305) CNS ML-DmBG1-c1  (185) CNS ML-DmBG2-c2  (163) tumorous blood cells mbn2  (113) ovary fGS/OSS  (364) ovary OSC  (149) ovary OSS    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    307 Schneider line 2 Sg4    290 embryonic 1182-4H    396 embryonic GM2    211 embryonic Kc167    201 embryonic S1    287 embryonic S3    127 leg disc CME L1    328 wing disc CME-W2    132 wing disc ML-DmD8    243 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    208 wing disc ML-DmD21    820 wing disc ML-DmD32    362 haltere disc ML-DmD17-c3    247 eye-antennal disc ML-DmD11    328 antennal disc ML-DmD20-c5    296 mixed discs ML-DmD4-c1    305 CNS ML-DmBG1-c1    185 CNS ML-DmBG2-c2    163 tumorous blood cells mbn2    113 ovary fGS/OSS    364 ovary OSC    149 ovary OSS    99 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    307 Schneider line 2 Sg4    290 embryonic 1182-4H    396 embryonic GM2    211 embryonic Kc167    201 embryonic S1    287 embryonic S3    127 leg disc CME L1    328 wing disc CME-W2    132 wing disc ML-DmD8    243 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    208 wing disc ML-DmD21    820 wing disc ML-DmD32    362 haltere disc ML-DmD17-c3    247 eye-antennal disc ML-DmD11    328 antennal disc ML-DmD20-c5    296 mixed discs ML-DmD4-c1    305 CNS ML-DmBG1-c1    185 CNS ML-DmBG2-c2    163 tumorous blood cells mbn2    113 ovary fGS/OSS    364 ovary OSC    149 ovary OSS    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (307) Schneider line 2 Sg4  (290) embryonic 1182-4H  (396) embryonic GM2  (211) embryonic Kc167  (201) embryonic S1  (287) embryonic S3  (127) leg disc CME L1  (328) wing disc CME-W2  (132) wing disc ML-DmD8  (243) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (208) wing disc ML-DmD21  (820) wing disc ML-DmD32  (362) haltere disc ML-DmD17-c3  (247) eye-antennal disc ML-DmD11  (328) antennal disc ML-DmD20-c5  (296) mixed discs ML-DmD4-c1  (305) CNS ML-DmBG1-c1  (185) CNS ML-DmBG2-c2  (163) tumorous blood cells mbn2  (113) ovary fGS/OSS  (364) ovary OSC  (149) ovary OSS  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (307) Schneider line 2 Sg4  (290) embryonic 1182-4H  (396) embryonic GM2  (211) embryonic Kc167  (201) embryonic S1  (287) embryonic S3  127 leg disc CME L1  (328) wing disc CME-W2  132 wing disc ML-DmD8  (243) wing disc ML-DmD9  (476) wing disc ML-DmD16-c3  (208) wing disc ML-DmD21  (820) wing disc ML-DmD32  (362) haltere disc ML-DmD17-c3  (247) eye-antennal disc ML-DmD11  (328) antennal disc ML-DmD20-c5  (296) mixed discs ML-DmD4-c1  (305) CNS ML-DmBG1-c1  (185) CNS ML-DmBG2-c2  (163) tumorous blood cells mbn2  113 ovary fGS/OSS  (364) ovary OSC  (149) ovary OSS    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    307 Schneider line 2 Sg4    290 embryonic 1182-4H    396 embryonic GM2    211 embryonic Kc167    201 embryonic S1    287 embryonic S3    127 leg disc CME L1    328 wing disc CME-W2    132 wing disc ML-DmD8    243 wing disc ML-DmD9    476 wing disc ML-DmD16-c3    208 wing disc ML-DmD21    820 wing disc ML-DmD32    362 haltere disc ML-DmD17-c3    247 eye-antennal disc ML-DmD11    328 antennal disc ML-DmD20-c5    296 mixed discs ML-DmD4-c1    305 CNS ML-DmBG1-c1    185 CNS ML-DmBG2-c2    163 tumorous blood cells mbn2    113 ovary fGS/OSS    364 ovary OSC    149 ovary OSS    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    135 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    120 Cadmium 100 mM 48 hrs, 4-day adult    157 Copper 0.5 mM 12 hrs, larvae L3    121 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    133 Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3    177 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    165 Caffeine 25 mg/ml 48 hrs, 4-day adult    121 Paraquat 5 mM 48 hrs, 4-day adult    164 Paraquat 10 mM 48 hrs, 4-day adult    162 Rotenone 2 μg 12 hrs, larvae L3    125 Rotenone 8 μg 12 hrs, larvae L3    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (135) heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (120) Cadmium 100 mM 48 hrs, 4-day adult  (157) Copper 0.5 mM 12 hrs, larvae L3  (121) Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3  (133) Zinc 4.5 mM 48 hrs, 4-day adult  (68) Ethanol 2.5% 3 hrs, larvae L3  (177) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (105) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (165) Caffeine 25 mg/ml 48 hrs, 4-day adult  (121) Paraquat 5 mM 48 hrs, 4-day adult  (164) Paraquat 10 mM 48 hrs, 4-day adult  (162) Rotenone 2 μg 12 hrs, larvae L3  (125) Rotenone 8 μg 12 hrs, larvae L3  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (135) heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (120) Cadmium 100 mM 48 hrs, 4-day adult  (157) Copper 0.5 mM 12 hrs, larvae L3  (121) Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3  (133) Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3  (177) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (165) Caffeine 25 mg/ml 48 hrs, 4-day adult  (121) Paraquat 5 mM 48 hrs, 4-day adult  (164) Paraquat 10 mM 48 hrs, 4-day adult  (162) Rotenone 2 μg 12 hrs, larvae L3  (125) Rotenone 8 μg 12 hrs, larvae L3  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    135 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    120 Cadmium 100 mM 48 hrs, 4-day adult    157 Copper 0.5 mM 12 hrs, larvae L3    121 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    133 Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3    177 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    165 Caffeine 25 mg/ml 48 hrs, 4-day adult    121 Paraquat 5 mM 48 hrs, 4-day adult    164 Paraquat 10 mM 48 hrs, 4-day adult    162 Rotenone 2 μg 12 hrs, larvae L3    125 Rotenone 8 μg 12 hrs, larvae L3    169 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    135 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    120 Cadmium 100 mM 48 hrs, 4-day adult    157 Copper 0.5 mM 12 hrs, larvae L3    121 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    133 Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3    177 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    165 Caffeine 25 mg/ml 48 hrs, 4-day adult    121 Paraquat 5 mM 48 hrs, 4-day adult    164 Paraquat 10 mM 48 hrs, 4-day adult    162 Rotenone 2 μg 12 hrs, larvae L3    125 Rotenone 8 μg 12 hrs, larvae L3    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  (135) heat shock, 4-day adult  (130) Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (114) Cadmium 50 mM 48 hrs, 4-day adult  (120) Cadmium 100 mM 48 hrs, 4-day adult  (157) Copper 0.5 mM 12 hrs, larvae L3  (121) Copper 15 mM 48 hrs, 4-day adult  (48) Zinc 5 mM 12 hrs, larvae L3  (133) Zinc 4.5 mM 48 hrs, 4-day adult  (68) Ethanol 2.5% 3 hrs, larvae L3  (177) Ethanol 5% 3 hrs, larvae L3  (109) Ethanol 10% 3 hrs, larvae L3  (137) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (105) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (165) Caffeine 25 mg/ml 48 hrs, 4-day adult  (121) Paraquat 5 mM 48 hrs, 4-day adult  (164) Paraquat 10 mM 48 hrs, 4-day adult  (162) Rotenone 2 μg 12 hrs, larvae L3  (125) Rotenone 8 μg 12 hrs, larvae L3  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (185) cold shock, 4-day adult  135 heat shock, 4-day adult  130 Cadmium 50 mM 6 hrs, larvae L3  136 Cadmium 50 mM 12 hrs, larvae L3  114 Cadmium 50 mM 48 hrs, 4-day adult  120 Cadmium 100 mM 48 hrs, 4-day adult  (157) Copper 0.5 mM 12 hrs, larvae L3  121 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3  133 Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3  (177) Ethanol 5% 3 hrs, larvae L3  109 Ethanol 10% 3 hrs, larvae L3  137 Caffeine 1.5 mg/ml 4 hrs, larvae L3  105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (165) Caffeine 25 mg/ml 48 hrs, 4-day adult  121 Paraquat 5 mM 48 hrs, 4-day adult  (164) Paraquat 10 mM 48 hrs, 4-day adult  (162) Rotenone 2 μg 12 hrs, larvae L3  125 Rotenone 8 μg 12 hrs, larvae L3  (169) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    185 cold shock, 4-day adult    135 heat shock, 4-day adult    130 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    114 Cadmium 50 mM 48 hrs, 4-day adult    120 Cadmium 100 mM 48 hrs, 4-day adult    157 Copper 0.5 mM 12 hrs, larvae L3    121 Copper 15 mM 48 hrs, 4-day adult    48 Zinc 5 mM 12 hrs, larvae L3    133 Zinc 4.5 mM 48 hrs, 4-day adult    68 Ethanol 2.5% 3 hrs, larvae L3    177 Ethanol 5% 3 hrs, larvae L3    109 Ethanol 10% 3 hrs, larvae L3    137 Caffeine 1.5 mg/ml 4 hrs, larvae L3    105 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    165 Caffeine 25 mg/ml 48 hrs, 4-day adult    121 Paraquat 5 mM 48 hrs, 4-day adult    164 Paraquat 10 mM 48 hrs, 4-day adult    162 Rotenone 2 μg 12 hrs, larvae L3    125 Rotenone 8 μg 12 hrs, larvae L3    169 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD47792 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9769-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage, with Scer\GAL4elav.PU CG9769KK109245 lethal | larval stage, with Scer\GAL4repo CG9769KK109245 lethal | larval stage, with Scer\GAL4sqh.PW CG9769KK109245 lethal | pharate adult stage, with Scer\GAL4repo CG9769KK109245 lethal | pupal stage, with Scer\GAL4dpp.PU CG9769KK109245 lethal | pupal stage, with Scer\GAL4elav.PU CG9769KK109245 lethal | pupal stage, with Scer\GAL4repo CG9769KK109245 Other Phenotypes Allele visible, with Scer\GAL4bbg-C96 CG9769KK109245 Phenotype manifest in Allele wing, with Scer\GAL4bbg-C96 CG9769KK109245 wing margin bristle, with Scer\GAL4bbg-C96 CG9769KK109245
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG9769 Class Mutagen Stocks Known lesion CG9769EP516 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG9769 Class Mutagen Stocks Known lesion CG9769HMS00940 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG9769KK109245 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG9769GD5567 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5567} NA P{KK109245} NA P{TRiP.HMS00940} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG9769EP516 NA P{EPgy2}EY03498 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) positive regulation of Notch signaling pathway inferred from mutant phenotype (Zhang et al., 2012) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from electronic annotation with InterPro:IPR027531 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000)
Biological Process
CV term Evidence References
translational initiation inferred from sequence or structural similarity (Lasko, 2000)
Cellular Component
CV term Evidence References
eukaryotic translation initiation factor 3 complex inferred from electronic annotation with InterPro:IPR027531 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG9769 - ATPsyn-b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Bin1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CAP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG10306 experimental knowledge based (Guruharsha et al., 2011) CG9769 - CG10465 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG10909 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG1115 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG11188 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG11398 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG12519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG12576 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG12818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG1340 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG13950 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14020 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14153 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14507 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14544 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14598 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG14818 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG17121 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG17646 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG1774 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG1882 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG1888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG2519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG2950 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG3009 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG31156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG32850 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG33937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG3492 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG3819 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG3919 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG42235 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG4300 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG4810 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG4866 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG4962 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG5482 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG5642 experimental knowledge based (Guruharsha et al., 2011) CG9769 - CG5656 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG6218 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG6629 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG6763 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG6767 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG6933 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG7272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG7550 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG7686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CG8636 experimental knowledge based (Guruharsha et al., 2011) CG9769 - CG9386 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cbp80 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cct1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Chmp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cpr11A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cpr23B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cpr60D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Csat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Cyt-c-d anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Dgk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Diedel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Dip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Dip3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - E(spl)m5-HLH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - GABPI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - GstE14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Hcs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Hsp60B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Hsp60C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Int6 experimental knowledge based (Guruharsha et al., 2011) CG9769 - Jon44E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - LpR2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - MESK2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Mnn1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Mnt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Mp20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Obp56e anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Obp83g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Opbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Pnn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Pp4-19C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Pten anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Rab11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Ranbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Rbf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Rca1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - RfC3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - RhoGDI anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Sesn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - SoxN anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Spf45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Sry-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Stat92E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Su(var)3-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Tango14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Tango7 experimental knowledge based (Guruharsha et al., 2011) CG9769 - Task7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Tbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Uba1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Vha100-4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Vsx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - Xbp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - asun anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - dac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - dah anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - dome anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - eIF-3p40 experimental knowledge based (Guruharsha et al., 2011) CG9769 - eIF3-S10 experimental knowledge based (Guruharsha et al., 2011) CG9769 - eIF3-S8 experimental knowledge based (Guruharsha et al., 2011) CG9769 - eIF3-S9 experimental knowledge based (Guruharsha et al., 2011) CG9769 - gk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - jigr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - klu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - l(2)35Bc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - l(2)35Be anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - lack anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - mub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - phl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - pnr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - rdx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - rev7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - scyl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG9769 - sug anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG9769 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65804 DroID - A comprehensive database of gene and protein interactions. • FBgn0037270 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40587
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69PBJM Dipteran inclusive ortholog search EOG6PCB1Z Insect inclusive ortholog search EOG6VHJ39 Arthropod inclusive ortholog search EOG66M91G Metazoa inclusive ortholog search EOG6TBH5P
Orthologs in Drosophila Species (EOG69PBJM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG9769     Drosophila simulans   Dsim\GD19663 Y   Drosophila sechellia   Dsec\GM10688 Y   Drosophila erecta   Dere\GG11433 Y   Drosophila yakuba   Dyak\GE25339 Y   Drosophila ananassae   Dana\GF16095 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22021 Y   Drosophila persimilis   Dper\GL21488 Y   Drosophila willistoni   Dwil\GK14430 Y   Drosophila virilis   Dvir\GJ23292 Y   Drosophila mojavensis   Dmoj\GI23834 Y   Drosophila grimshawi   Dgri\GH18119 Y
Orthologs in non-Drosophila Dipterans (EOG6PCB1Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\eIF3-S5   Anopheles gambiae Malaria mosquito  Agam\eIF3-S5   Culex quinquefasciatus Southern house mosquito  Cqui\eIF3-S5
Orthologs in non-Dipteran Insects (EOG6VHJ39)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413145   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG023745   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16506   Atta cephalotes Leafcutter ant  Acep\ACEP25347   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16288   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14630   Linepithema humile Argentine ant  Lhum\LH19976   Linepithema humile Argentine ant  Lhum\LH11498   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13654   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006238   Bombyx mori Silkmoth  Bmor\BGIBMGA008209   Pediculus humanus Human body louse  Phum\PHUM604430   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08220
Orthologs in non-Insect Arthropods (EOG66M91G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ncpGS   Ixodes scapularis Deer tick  Isca\ISCW001816
Orthologs in non-Arthropod Metazoa (EOG6TBH5P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\eif-3.F Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001649gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_030052gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023686gn Y Danio rerio Zebrafish  Drer\CR854964.1 Y Xenopus tropicalis Western clawed frog  Xtro\eif3f Y Gallus gallus Domestic chicken  Ggal\EIF3F Y Mus musculus House mouse  Mmus\Eif3f Y Rattus norvegicus Norway rat  Rnor\Eif3f Y Homo sapiens Human  Hsap\EIF3F Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\EIF3F
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19663 Drosophila sechellia Dsec\GM10688 Drosophila erecta Dere\GG11433 Drosophila yakuba Dyak\GE25339 Drosophila ananassae Dana\GF16095 Drosophila pseudoobscura pseudoobscura Dpse\GA22021 Drosophila persimilis Dper\GL21488 Drosophila willistoni Dwil\GK14430 Drosophila virilis Dvir\GJ23292 Drosophila mojavensis Dmoj\GI23834 Drosophila grimshawi Dgri\GH18119
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	33980 y1 sc* v1; P{TRiP.HMS00940}attP2
VDRC	v101465 P{KK109245}VIE-260B
Genomic Clones ( 1 )
	BACR02C19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 184 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47792
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01914 GH05639 GH05855 GH08578 GH10683 GH11391 GH16614 GH22032 GH28489 GM03251 GM23026 GM28024 LD07822 LD22830 LD23351 LD26314 RE08827 RE11325 RE20666 RE21186 RE22752 RE26208 RE27430 RE31619 RE39583 RE39935 RE41651 RE47341 RE53958 RE58037 RE61848 RE64395 RE70718 RH16501 RH17902 RH22430 RH23165 RH23295 RH23746 RH24601 RH26339 RH27341 RH27732 RH27887 RH34412 RH39594 RH40074 RH42842 RH51871 RH52708 RH52720 RH52951 RH54078 RH57235 RH59022 RH59814 RH60414 RH64984 RH65101 RH70577 RH71582 RH71909 SD15065 SD19202 SD26363 SD27160 SD27254 SD27490
Other clones	15979 19840 34503 44763 55687 55794 103705 104068 172768 524814 572933 Dmel_dig_018423_0681_0693 Dmel_neb_013712_0650_2257 Dmel_neb_014021_0659_0816 EK164139 EK184055 EK191047 EK226860 EK227242 EK274058 EN05956 EN17536 ESG018c.E21_G08 FGH102B10 IP16708 RP003004952 RP003009934 RP003011682 RP003021773 RP003039585 RP003044986 RP003046053 RP003047205 RP003055259 RP003057947 RP003064855 RP003070504 RP003070673 RP003089381 RP003104985 RP003107492 RP003115409 RP003120035 RP003121525 RP003125064 RP003129820 RP003136561 RP003143358 RP003146603 RP003151218 RP003154754 RP003174522 RP003181502 RP003188078 RP003195094 RP003195848 RP003206918 RP003216014 RP003224204 RP003230605 RP003242890 RP003265160 RP003278500 RP003282806 RP003285230 RP003287010 RP003294437 RP003300434 RP003301665 RP003307182 RP003308911 RP003310828 RP003322536 RP003324935 RP003329812 RP003332172 RP003344210 RP003350771 RP003352844 RP003378249 RP003391617 RP003392937 RP003423855 RP003436018 RP003441031 RP003446345 RP003450884 RP003453238 RP003465291 RP003466404 RP003468950 RP003483035 RP003486989 RP003493337 RP003494517 RP003499583 RP003523615 RP003533750 RP003539750 RP003542106 RP003543737 RP003575807 RP003576742 RP003585251 RP003588118 RP003595448 RP003605498 RP003608500 RP003624057 RP003643597 RP003645364 RP003660924 RP003674125 RP003677257 RP003679110
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0037270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40587
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141232 RefSeq (Proteins) • NP_649489 DDBJ / EMBL / GenBank • AAF52101 AAM50832 AI546264 AQ254892 AY118972 Entrez Gene - A searchable database of RefSeq genes. • 40587 UniProtKB/Swiss-Prot • Q9VN50
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • JAB1/Mov34/MPN/PAD-1 (IPR000555) Rpn11/EIF3F C-terminal domain (IPR024969) Eukaryotic translation initiation factor 3 subunit F (IPR027531) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD47792
Linkouts
	BioGRID - A database of protein and genetic interactions • 65804 DroID - A comprehensive database of gene and protein interactions. • FBgn0037270 DRSC - Results from RNAi screens. • FBgn0037270 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0037270 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9769-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0037270 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40587 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40587 modMine - Data generated by the modENCODE project. • FBgn0037270
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG9769 (White et al., 2011, Lee et al., 2010, Lindquist et al., 2011, Zhang et al., 2012, Keleman et al., 2009.8.5, Zhang et al., 2012, Tsou et al., 2012, Ni et al., 2010.12.1, Dekanty et al., 2010) eif3f (Lee et al., 2010) eIF3-S5 (Lasko, 2000, Lindquist et al., 2011)
Name Synonym
Secondary FlyBase IDs
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Tsou et al., 2012, PLoS ONE 7(8): e43112 Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes. [FBrf0219256] Zhang et al., 2012, G3 (Bethesda) 2(12): 1563--1575 A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling. [FBrf0220374] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...