FB2025_01 , released February 20, 2025
Gene: Dmel\Tim17b1
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General Information
Symbol
Dmel\Tim17b1
Species
D. melanogaster
Name
Tim17b1
Annotation Symbol
CG1158
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037310
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (UniProt, Q9VNA0)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
82F8-82F9
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5300145..5301186
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
contributes_to protein transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000050380
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q7PLT4
(Garabedian et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in protein import into mitochondrial matrix
inferred from biological aspect of ancestor with PANTHER:PTN000050380
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q7PLT4
(Garabedian et al., 2011)
involved_in protein insertion into mitochondrial inner membrane
inferred from sequence or structural similarity with UniProtKB:Q7PLT4
(Garabedian et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from sequence or structural similarity with UniProtKB:Q7PLT4
(Garabedian et al., 2011)
part_of TIM23 mitochondrial import inner membrane translocase complex
inferred from biological aspect of ancestor with PANTHER:PTN000050380
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Tim17/Tim22/Tim23 family. (Q9VNA0)
Protein Signatures (InterPro)
    -
    Summaries
    Gene Group (FlyBase)
    TIM17 FAMILY -
    The Tim17 family are paralogous subunits of the core TIM23 complex. The TIM23 complex mediates import of mitochondrial presequence-containing proteins into the mitochondrial matrix and inner membrane. Tim17 is an inner membrane spanning subunit that forms a complex with the channel subunit, Tim23. (Adapted from PMID:32074073.)
    Protein Function (UniProtKB)
    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
    (UniProt, Q9VNA0)
    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\Tim17b1 for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VNA0)

    If you don't see a structure in the viewer, refresh your browser.
    Model Confidence:
    • Very high (pLDDT > 90)
    • Confident (90 > pLDDT > 70)
    • Low (70 > pLDDT > 50)
    • Very low (pLDDT < 50)

    AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Gene model reviewed during 5.39

    Gene model reviewed during 5.46

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    Tim17b1-RA
    FBtr0078784
    NM_141269
    785
    179
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    UniProt
    RefSeq ID
    GenBank
    Tim17b1-PA
    FBpp0078430
    18.7
    179
    9.13
    Q9VNA0
    NP_649526
    AAF52046
    Polypeptides with Identical Sequences

    There is only one protein coding transcript and one polypeptide associated with this gene

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Subunit Structure (UniProtKB)

    Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50. The complex interacts with the Tim44 component of the PAM complex (By similarity).

    (UniProt, Q9VNA0)
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tim17b1 using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    4.84

    Transcript Expression
    RT-PCR
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    adult stage | male
    organism
    (Garabedian et al., 2011)
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\Tim17b1 in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 1 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 5 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Tim17b1
    Transgenic constructs containing regulatory region of Tim17b1
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 5 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
    viable, with Scer\GAL4Mef2.PR
    viable, with Scer\GAL4pnr-MD237
    viable, with Scer\GAL4tin.CΔ4
    Phenotype manifest in
    Allele
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (5)
    Hsap\TIMM17A
    10 of 14
    Yes
    No
    Hsap\TIMM17B
    10 of 14
    Yes
    No
    1  
    Hsap\TIMM22
    2 of 14
    No
    No
    Hsap\TIMM23
    1 of 14
    No
    No
    Hsap\TIMMDC1
    1 of 14
    No
    No
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (4)
    Rnor\Timm17a
    10 of 14
    Yes
    No
    Rnor\Timm17b
    10 of 14
    Yes
    No
    Rnor\Timm22
    2 of 14
    No
    No
    Rnor\Timm23
    2 of 14
    No
    No
    Mus musculus (laboratory mouse) (5)
    Mmus\Timm17b
    10 of 14
    Yes
    No
    Mmus\Timm17a
    9 of 14
    No
    No
    Mmus\Timm22
    2 of 14
    No
    No
    Mmus\Timm23
    1 of 14
    No
    No
    Mmus\Timmdc1
    1 of 14
    No
    No
    Xenopus tropicalis (Western clawed frog) (6)
    Xtro\bach1
    3 of 13
    Yes
    No
    Xtro\timm17a
    3 of 13
    Yes
    No
    Xtro\timm17b
    2 of 13
    No
    No
    Xtro\arsa.1
    1 of 13
    No
    Yes
    Xtro\timm22
    1 of 13
    No
    No
    Xtro\top1.1
    1 of 13
    No
    No
    Danio rerio (Zebrafish) (4)
    Drer\timm17a
    10 of 14
    Yes
    No
    Drer\timm17b
    10 of 14
    Yes
    No
    Drer\timm22
    2 of 14
    No
    No
    Drer\timm23a
    2 of 14
    No
    No
    Caenorhabditis elegans (Nematode, roundworm) (5)
    Cele\timm-17B.1
    13 of 14
    Yes
    No
    Cele\timm-17B.2
    5 of 14
    No
    Yes
    Cele\C47G2.3
    2 of 14
    No
    No
    Cele\tctn-1
    1 of 14
    No
    No
    Cele\timm-23
    1 of 14
    No
    No
    Anopheles gambiae (African malaria mosquito) (3)
    Agam\AgaP_AGAP004657
    6 of 12
    Yes
    No
    Agam\AgaP_AGAP003199
    2 of 12
    No
    No
    Agam\AgaP_AGAP010210
    1 of 12
    No
    No
    Arabidopsis thaliana (thale-cress) (15)
    Atha\TIM17-1
    11 of 13
    Yes
    No
    Atha\TIM17-2
    11 of 13
    Yes
    No
    Atha\TIM17-3
    5 of 13
    No
    Yes
    Atha\AT1G18320
    2 of 13
    No
    No
    Atha\AT4G26670
    2 of 13
    No
    No
    Atha\AT5G55510
    2 of 13
    No
    No
    Atha\MEE67
    2 of 13
    No
    No
    Atha\OEP16-3
    2 of 13
    No
    Yes
    Atha\TIM23-1
    2 of 13
    No
    No
    Atha\AT3G57900
    1 of 13
    No
    Yes
    Atha\AT5G24650
    1 of 13
    No
    No
    Atha\AT5G51150
    1 of 13
    No
    No
    Atha\OEP16-1
    1 of 13
    No
    Yes
    Atha\TIM23-2
    1 of 13
    No
    No
    Atha\TIM23-3
    1 of 13
    No
    No
    Saccharomyces cerevisiae (Brewer's yeast) (3)
    Scer\TIM17
    12 of 13
    Yes
    No
    Scer\TIM22
    2 of 13
    No
    No
    Scer\TIM23
    2 of 13
    No
    No
    Schizosaccharomyces pombe (Fission yeast) (3)
    Spom\tim17
    11 of 12
    Yes
    No
    Spom\tim22
    2 of 12
    No
    No
    Spom\tim23
    2 of 12
    No
    No
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:Tim17b1. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Gene Symbol
    Score
    Source
    Compara
    Domainoid
    eggNOG
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Drosophila melanogaster (Fruit fly) (7)
    CG1724
    11 of 13
    Tim17b2
    11 of 13
    Tim17b
    11 of 13
    Tim17a1
    10 of 13
    Tim17a2
    10 of 13
    CG31229
    2 of 13
    Tim23
    1 of 13
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      TIMM17A; translocase of inner mitochondrial membrane 17A
      10 of 14
      605057
          TIMM17B; translocase of inner mitochondrial membrane 17B
          10 of 14
          300249
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Other Interaction Browsers
              Summary of Genetic Interactions
              esyN Network Diagram
              Other Interaction Browsers
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Subunit Structure (UniProtKB)
              Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50. The complex interacts with the Tim44 component of the PAM complex (By similarity).
              (UniProt, Q9VNA0 )
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map
              3-47.5
              Cytogenetic map
              82F8-82F9
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              82F8-82F9
              Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              3-47.5

              (FlyBase, 2016)

              3-44.1

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (6)
              Genomic Clones (20)
              cDNA Clones (3)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments
                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: Tim17b1 BcDNA:AT16284

                      (FlyBase, 1996-)
                      Additional comments

                      Source for merge of Tim17b1 BcDNA:AT16284 was a shared cDNA ( date:030728 ).

                      (FlyBase, 1996-)
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Tim17b1 CG1158

                      (Swiss-Prot Project Members, 2000.10.1)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (4)
                      Reported As
                      Symbol Synonym
                      BcDNA:AT16284
                      CG1158
                      (Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009)
                      Tim17b
                      (Li et al., 2020)
                      Tim17b1
                      (Transgenic RNAi Project members, 2017-, Garabedian et al., 2011)
                      Name Synonyms
                      Tim17b1
                      Secondary FlyBase IDs
                      • FBgn0063326
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 28 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (27)