Gene Dmel\CG1161

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General Information

Symbol

Dmel\CG1161

Species

D. melanogaster

Name

Annotation symbol

CG1161

Feature type

protein_coding_gene

FlyBase ID

FBgn0037313

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

82F10-82F11

Sequence location

3R:1,180,814..1,182,470 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG1161 (FBgn0037313). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: TMEM9. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1625650_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG1161. Gene sequence location is 3R:1180814..1182470.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82F10-82F11

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG1161 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG1161-RA

FBtr0078785

NM_141271

945

227

CG1161-RC

FBtr0335000

NM_001014606

1241

221

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG1161-PA

FBpp0078431

24.7

227

9.10

NP_649528

AAF52042

CG1161-PC

FBpp0307009

23.5

221

6.49

NP_001014606

AAX52934

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

TMEM9 (IPR008853)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VNA4

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		1348.8
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		1368.2
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		1107.2
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		(627.2)
Larval Hindgut		(748.7)
Larval Malpighian Tubules		(1348.8)
Larval Fat Body		(979.7)
Larval Salivary Gland		(728.1)
Larval Trachea		(822.1)
Larval Carcass		(652.8)
Adult Head		(733.7)
Adult Eye		(1368.2)
Adult Brain		(680)
Adult Thoracic-Abdominal Ganglion		(784.5)
Adult Crop		(721.5)
Adult Midgut		(656.8)
Adult Hindgut		(881.1)
Adult Malpighian Tubules		(825.8)
Adult Fat Body		(783.5)
Adult Salivary Gland		(1107.2)
Adult Heart		(1007.675)
Adult VirginFemale Spermatheca		(960.9)
Adult InseminatedFemale Spermatheca		(847)
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		(626.7)
Adult Carcass		(766.4)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		(1348.8)
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		(1368.2)
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		(1107.2)
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		1348.8
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		1368.2
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		1107.2
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		1348.8
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		1368.2
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		1107.2
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		(1348.8)
Larval Fat Body		(979.7)
Larval Salivary Gland		728.1
Larval Trachea		(822.1)
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		(1368.2)
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		(881.1)
Adult Malpighian Tubules		(825.8)
Adult Fat Body		783.5
Adult Salivary Gland		(1107.2)
Adult Heart		(1007.675)
Adult VirginFemale Spermatheca		(960.9)
Adult InseminatedFemale Spermatheca		(847)
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		1348.8
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		1368.2
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		1107.2
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		461.85
Larval Midgut		627.2
Larval Hindgut		748.7
Larval Malpighian Tubules		1348.8
Larval Fat Body		979.7
Larval Salivary Gland		728.1
Larval Trachea		822.1
Larval Carcass		652.8
Adult Head		733.7
Adult Eye		1368.2
Adult Brain		680
Adult Thoracic-Abdominal Ganglion		784.5
Adult Crop		721.5
Adult Midgut		656.8
Adult Hindgut		881.1
Adult Malpighian Tubules		825.8
Adult Fat Body		783.5
Adult Salivary Gland		1107.2
Adult Heart		1007.675
Adult VirginFemale Spermatheca		960.9
Adult InseminatedFemale Spermatheca		847
Adult Ovary		399.5
Adult Testis		163.7
Adult Male Accessory Gland		626.7
Adult Carcass		766.4
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	733.7
NA	Eye	1368.2
NA	Brain	680
461.85	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	784.5
NA	Crop	721.5
627.2	Midgut	656.8
748.7	Hindgut	881.1
1348.8	Malpighian Tubules	825.8
979.7	Fat Body	783.5
728.1	Salivary Gland	1107.2
NA	Heart	1007.675
822.1	Trachea	NA
NA	VirginFemale Spermatheca	960.9
NA	InseminatedFemale Spermatheca	847
NA	Ovary	399.5
NA	Testis	163.7
NA	Male Accessory Gland	626.7
652.8	Carcass	766.4

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		(32)
central nervous system, pupae P8		(30)
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		(27)
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		(35)
head, mated 4-day male		(38)
head, mated 20-day male		(36)
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		(34)
digestive system, larvae L3 wandering		(39)
digestive system, 1-day adult		24
digestive system, 4-day adult		(27)
digestive system, 20-day adult		21
fat body, larvae L3 wandering		(28)
fat body, white prepupae		23
fat body, pupae P8		(49)
carcass, larvae L3 wandering		(30)
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		(35)
head, mated 4-day male		(38)
head, mated 20-day male		(36)
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		(34)
digestive system, larvae L3 wandering		(39)
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		(49)
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		32
central nervous system, pupae P8		30
head, virgin 1-day female		24
head, virgin 4-day female		26
head, virgin 20-day female		16
head, mated 1-day female		27
head, mated 4-day female		21
head, mated 20-day female		18
head, mated 1-day male		35
head, mated 4-day male		38
head, mated 20-day male		36
salivary gland, larvae L3 wandering		14
salivary gland, white prepupae		34
digestive system, larvae L3 wandering		39
digestive system, 1-day adult		24
digestive system, 4-day adult		27
digestive system, 20-day adult		21
fat body, larvae L3 wandering		28
fat body, white prepupae		23
fat body, pupae P8		49
carcass, larvae L3 wandering		30
carcass, 1-day adult		19
carcass, 4-day adult		21
carcass, 20-day adult		20
ovary, virgin 4-day female		19
ovary, mated 4-day female		24
testis, mated 4-day male		25
accessory gland, mated 4-day male		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(53)
embryo 02-04hr		(65)
embryo 04-06hr		(71)
embryo 06-08hr		(72)
embryo 08-10hr		(69)
embryo 10-12hr		(77)
embryo 12-14hr		(43)
embryo 14-16hr		(44)
embryo 16-18hr		(43)
embryo 18-20hr		(47)
embryo 20-22hr		(38)
embryo 22-24hr		(37)
larva L1		(42)
larva L2		(48)
larva L3 12hr old		(49)
larva L3 puffstage 1-2		(56)
larva L3 puffstage 3-6		(69)
larva L3 puffstage 7-9		(74)
white prepupae new		(77)
white prepupae 12hr		(92)
white prepupae 24hr		(93)
pupae 2d postWPP		(92)
pupae 3d postWPP		(59)
pupae 4d postWPP		(52)
adult male 01day		(49)
adult male 05day		(52)
adult male 30day		(50)
adult female 01day		(50)
adult female 05day		(48)
adult female 30day		(51)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(53)
embryo 02-04hr		(65)
embryo 04-06hr		(71)
embryo 06-08hr		(72)
embryo 08-10hr		(69)
embryo 10-12hr		(77)
embryo 12-14hr		(43)
embryo 14-16hr		(44)
embryo 16-18hr		(43)
embryo 18-20hr		(47)
embryo 20-22hr		(38)
embryo 22-24hr		(37)
larva L1		(42)
larva L2		(48)
larva L3 12hr old		(49)
larva L3 puffstage 1-2		(56)
larva L3 puffstage 3-6		(69)
larva L3 puffstage 7-9		(74)
white prepupae new		(77)
white prepupae 12hr		(92)
white prepupae 24hr		(93)
pupae 2d postWPP		(92)
pupae 3d postWPP		(59)
pupae 4d postWPP		(52)
adult male 01day		(49)
adult male 05day		(52)
adult male 30day		(50)
adult female 01day		(50)
adult female 05day		(48)
adult female 30day		(51)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		53
embryo 02-04hr		65
embryo 04-06hr		71
embryo 06-08hr		72
embryo 08-10hr		69
embryo 10-12hr		77
embryo 12-14hr		43
embryo 14-16hr		44
embryo 16-18hr		43
embryo 18-20hr		47
embryo 20-22hr		38
embryo 22-24hr		37
larva L1		42
larva L2		48
larva L3 12hr old		49
larva L3 puffstage 1-2		56
larva L3 puffstage 3-6		69
larva L3 puffstage 7-9		74
white prepupae new		77
white prepupae 12hr		92
white prepupae 24hr		93
pupae 2d postWPP		92
pupae 3d postWPP		59
pupae 4d postWPP		52
adult male 01day		49
adult male 05day		52
adult male 30day		50
adult female 01day		50
adult female 05day		48
adult female 30day		51
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(65)
Schneider line 2 Sg4		(67)
embryonic 1182-4H		(54)
embryonic GM2		(44)
embryonic Kc167		(80)
embryonic S1		(55)
embryonic S3		(51)
leg disc CME L1		(61)
wing disc CME-W2		(50)
wing disc ML-DmD8		(30)
wing disc ML-DmD9		(43)
wing disc ML-DmD16-c3		(60)
wing disc ML-DmD21		(45)
wing disc ML-DmD32		(72)
haltere disc ML-DmD17-c3		(32)
eye-antennal disc ML-DmD11		(48)
antennal disc ML-DmD20-c5		(64)
mixed discs ML-DmD4-c1		(59)
CNS ML-DmBG1-c1		(77)
CNS ML-DmBG2-c2		(52)
tumorous blood cells mbn2		(48)
ovary fGS/OSS		(30)
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(65)
Schneider line 2 Sg4		(67)
embryonic 1182-4H		(54)
embryonic GM2		(44)
embryonic Kc167		(80)
embryonic S1		(55)
embryonic S3		(51)
leg disc CME L1		(61)
wing disc CME-W2		(50)
wing disc ML-DmD8		30
wing disc ML-DmD9		(43)
wing disc ML-DmD16-c3		(60)
wing disc ML-DmD21		(45)
wing disc ML-DmD32		(72)
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		(48)
antennal disc ML-DmD20-c5		(64)
mixed discs ML-DmD4-c1		(59)
CNS ML-DmBG1-c1		(77)
CNS ML-DmBG2-c2		(52)
tumorous blood cells mbn2		(48)
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		65
Schneider line 2 Sg4		67
embryonic 1182-4H		54
embryonic GM2		44
embryonic Kc167		80
embryonic S1		55
embryonic S3		51
leg disc CME L1		61
wing disc CME-W2		50
wing disc ML-DmD8		30
wing disc ML-DmD9		43
wing disc ML-DmD16-c3		60
wing disc ML-DmD21		45
wing disc ML-DmD32		72
haltere disc ML-DmD17-c3		32
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		59
CNS ML-DmBG1-c1		77
CNS ML-DmBG2-c2		52
tumorous blood cells mbn2		48
ovary fGS/OSS		30
ovary OSC		22
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(27)
cold shock, 4-day adult		20
heat shock, 4-day adult		(27)
Cadmium 50 mM 6 hrs, larvae L3		(36)
Cadmium 50 mM 12 hrs, larvae L3		(32)
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		(28)
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		(27)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		(29)
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		(36)
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		27
cold shock, 4-day adult		20
heat shock, 4-day adult		27
Cadmium 50 mM 6 hrs, larvae L3		36
Cadmium 50 mM 12 hrs, larvae L3		32
Cadmium 50 mM 48 hrs, 4-day adult		24
Cadmium 100 mM 48 hrs, 4-day adult		23
Copper 0.5 mM 12 hrs, larvae L3		19
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		28
Zinc 4.5 mM 48 hrs, 4-day adult		13
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		22
Ethanol 10% 3 hrs, larvae L3		27
Caffeine 1.5 mg/ml 4 hrs, larvae L3		24
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		24
Caffeine 25 mg/ml 48 hrs, 4-day adult		20
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		29
Rotenone 2 μg 12 hrs, larvae L3		24
Rotenone 8 μg 12 hrs, larvae L3		24
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RH45888

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037313

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG1161-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

CG1161^GD3907

lethal | pupal stage, with Scer\GAL4^pnr-MD237

CG1161^GD3907

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of CG1161	Mutagen	Stocks	Known lesion
CG1161^G7126	P-element activity	1	--
CG1161^NP3494		1	--
CG1161^f01865	piggyBac transposase	0	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG1161	Class	Mutagen	Stocks	Known lesion
CG1161^GD3907		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG1161^KK108998		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD3907}

P{KK108998}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

P{GawB}CG1161^NP3494

miscellaneous insertions

PBac{WH}CG1161^f01865

insertion of mobile activating element

P{EP}CG1161^G7126

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 2 terms )

Molecular Function ( 0 terms)

Biological Process ( 0 terms)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from electronic annotation with InterPro:IPR008853

(FlyBase Curators et al., 2004-)

membrane

non-traceable author statement

(Swiss-Prot Project Members, 2002.3.1)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

CG1161 - ClC-c

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG1161 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0037313

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

40638

Orthologs

OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG69KGB1

Dipteran inclusive ortholog search

EOG6T4D4N

Insect inclusive ortholog search

EOG6C86PS

Arthropod inclusive ortholog search

EOG6W3R4B

Metazoa inclusive ortholog search

EOG6K6TZS

Orthologs in Drosophila Species (EOG69KGB1)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11097

Drosophila persimilis

Dper\GL21638

Drosophila willistoni

Dwil\GK12969

Drosophila virilis

Dvir\GJ11105

Drosophila mojavensis

Dmoj\GI22547

Drosophila grimshawi

Dgri\GH17779

Orthologs in non-Drosophila Dipterans (EOG6T4D4N)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008195

Anopheles gambiae

Malaria mosquito

Agam\AGAP007259

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002117

Orthologs in non-Dipteran Insects (EOG6C86PS)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB48104

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG015051

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH12338

Atta cephalotes

Leafcutter ant

Acep\ACEP24888

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO19706

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL23615

Linepithema humile

Argentine ant

Lhum\LH21138

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB25864

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009793

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI080202

Bombyx mori

Silkmoth

Bmor\BGIBMGA002115

Pediculus humanus

Human body louse

Phum\PHUM022310

Tribolium castaneum

Red flour beetle

Tcas\TC002414

Orthologs in non-Insect Arthropods (EOG6W3R4B)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_306688

Ixodes scapularis

Deer tick

Isca\ISCW002879

Orthologs in non-Arthropod Metazoa (EOG6K6TZS)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\R12C12.6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_016961gn

Danio rerio

Zebrafish

Drer\tmem9

Danio rerio

Zebrafish

Drer\tmem9b

Gallus gallus

Domestic chicken

Ggal\TMEM9B

Gallus gallus

Domestic chicken

Ggal\TMEM9

Mus musculus

House mouse

Mmus\Tmem9b

Mus musculus

House mouse

Mmus\Tmem9

Rattus norvegicus

Norway rat

Rnor\Tmem9b

Rattus norvegicus

Norway rat

Rnor\Tmem9

Homo sapiens

Human

Hsap\TMEM9

Homo sapiens

Human

Hsap\TMEM9B

Human Orthologs (2)

Gene

OMIM

HGNC

Hsap\TMEM9

Hsap\TMEM9B

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11097

Drosophila persimilis

Dper\GL21638

Drosophila willistoni

Dwil\GK12969

Drosophila virilis

Dvir\GJ11105

Drosophila mojavensis

Dmoj\GI22547

Drosophila grimshawi

Dgri\GH17779

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

32612

w¹¹¹⁸; P{EP}CG1161^G7126

Kyoto

104523

w^*; P{GawB}CG1161^NP3494

VDRC

v102003

P{KK108998}VIE-260B

v44964

w¹¹¹⁸; P{GD3907}v44964

v44965

w¹¹¹⁸; P{GD3907}v44965

Genomic Clones ( 1 )

BACR42H10

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 39 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RH45888

Other clones

GH21395

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0037313

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

40638

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

40638

UniProtKB/Swiss-Prot

•

Q9VNA4

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

TMEM9 (IPR008853)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RH45888

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0037313

DRSC - Results from RNAi screens.

•

FBgn0037313

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0037313

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG1161-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0037313

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

40638

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

40638

modMine - Data generated by the modENCODE project.

•

FBgn0037313

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG1161

(Keleman et al., 2009.8.5)

Name Synonym

Secondary FlyBase IDs

References ( 18 )

Research paper

Sun et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(16): 9428--9433: Protein-DNA interaction mapping using genomic tiling path microarrays in Drosophila. [FBrf0161513]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
Guruharsha et al., 2011, Cell 147(3):: Table S3. [FBrf0218395]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Boutros et al., 2004, Science 303(5659):: Supporting Online Material: Figures S1 to S8; Tables S1 to S6. [FBrf0174218]

Personal communication to FlyBase

Bellen, 2010.10.18, BDGP_2010_1022.GenExel.xml: BDGP_2010_1022.GenExel.xml [FBrf0212107]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project: DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file): Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Gene Disruption Project members, 2001-, (Computer file): (Computer file) [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations.: Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]

Protein sequence record

Swiss-Prot Project Members, 2002.3.1, UniProtKB: Q9VNA4: Hypothetical protein CG1161. [FBrf0151103]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]